Abstract: The present invention relates to compounds of Formula I, II, IA-VA, IVA1-IVA5, IIIA1-IIIA5 and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more cysteine proteases. Also described are methods where the compounds of Formula I, II, IA-VA, IVA1-IVA5, IIIA1-IIIA5 are used in the prevention and/or treatment of various diseases and conditions in subjects, including cysteine protease-mediated diseases and/or caspase-mediated diseases such as sepsis, myocardial infarction, cancer, tissue atrophy, ischemia, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, and Huntington's disease.

Abstract: A manufacturing method is provided. The manufacturing method includes the following steps. Firstly, a substrate and a light-emitting component are provided, wherein the light-emitting component is disposed on the substrate. Then, a wavelength conversion layer is provided, wherein the wavelength conversion layer includes a high-density phosphor layer and a low-density phosphor layer. Then, the high-density phosphor layer is adhered to the light-emitting component by an adhesive. Then, a reflective layer is formed above the substrate, wherein the reflective layer covers a lateral surface of the light-emitting component, a lateral surface of the adhesive and a lateral surface of the wavelength conversion layer.

Abstract: A method and apparatus to hold pressurized gas is disclosed. Shell halves having opposing apertures with inserted tubes are combined to create an enclosed pressure vessel. Strands of Kevlar fiber and strands of carbon fiber cover the shell by wrapping the shell through the tubes. Resin coats the wrapped strands and fills the tubes. Pressurized gas is injected and retrieved from the pressure vessel.

Abstract: An air sanitation and purification photocatalytic panel includes a frame that has a photocatalytic scrim positioned within the frame and a plurality of UV light sources positioned within the frame proximate to the photocatalytic scrim. The frame is made of a metal and/or alloy. The photocatalytic scrim is a pleated structure. Each of the plurality of UV light sources are oriented towards the photocatalytic scrim. The photocatalytic scrim includes a substrate a photocatalytic coating adhered to the substrate. The frame and photocatalytic scrim are oriented parallel to each other. The UV light sources illuminate the photocatalytic coating and initiate a photocatalytic reaction therein. During operation, the panel is positioned perpendicular to the airstream such that the airstream is forced through the substrate.

Abstract: Disclosed is an autoloading shotgun firearm which shares interchangeable fully compatible modular sub-assemblies, ergonomics, parts commonality, and exterior appearance with the AR rifle platform. Rapidly reversible tool less conversion from rifle to shotgun and vice versa is accomplished by substitution of the AR rifle upper receiver and ammunition detachable magazine with fully compatible shotgun upper receiver and ammunition detachable magazine. Said shotgun utilizes standard rimmed shotgun ammunition via features in the detachable magazine which securely maintain the position and facilitate the feeding of the cartridges during normal operation. No alteration of the AR rifle lower receiver is required. A short-recoil action is integrated into the shotgun upper receiver. The external appearance and functionality of the AR rifle are retained while eliminating the complexity and inherent fouling issues of typical gas systems used in the AR rifle.

Abstract: Implanting ions to form a cleave layer in a semiconductor device causes damage to sensitive materials such as high-K dielectrics. In a process for forming a cleave layer and repairing damage caused by ion implantation, ions are implanted through a circuit layer of a substrate to form a cleave plane. The substrate is exposed to a hydrogen gas mixture for a first time at a first temperature to repair damage caused by the implanted ions. A cleaving process may then be performed, and the cleaved substrate may be stacked in a 3DIC structure.

Abstract: A method for management of a land base includes interfacing a machine or equipment to a computer running a geographical information system (GIS) application such that the computer is configured to monitor the operations performed by the equipment or machine on the land base and store the operations as map points, lines, or polygons on at least one data layer within the GIS application. The method further includes displaying the GIS application to the operator at the point and time of performing the operations.

Abstract: A light emitting device includes a wavelength conversion layer, at least one light emitting unit and a reflective protecting element. The wavelength conversion layer has an upper surface and a lower surface opposite to each other. The light emitting unit has two electrode pads located on the same side of the light emitting unit. The light emitting unit is disposed on the upper surface of the wavelength conversion layer and exposes the two electrode pads. The reflective protecting element encapsulates at least a portion of the light emitting unit and a portion of the wavelength conversion layer, and exposes the two electrode pads of the light emitting unit.

Abstract: A device provides a variety of fracture fixation options should a fracture occur after total hip arthroplasty or total knee arthroplasty, and provides associated methods and apparatus for application of provided fixation. The ability to pre-engineer fracture fixation contingent solutions into femoral or tibial components provides for a distinct clinical advantage in the planning and execution for periprosthetic fracture fixation. Said methods and apparatus include targeting devices which allow for intimate association of fixed angle locking screws in pre-drilled holes in an existing prosthetic, femoral nail, or other components including additional fixation components. Such apparatus and methods further include the use of alignment devices and other components to allow for ease of repair of fractures utilizing the pre-engineered solutions.

Abstract: A protective shield for filter leaf bags utilized in a filtration system is disclosed. In a particular embodiment, the protective shield comprises an upper shield surface comprising an elongated strip having securing ring proximate to a mid-point of the strip. The protective shield embodiment further comprises a forward side strip and a rear side strip extending downwardly and generally perpendicularly to the upper shield surface. When installed over the upper portion of the filter bag, the protective shield deflects liquid streams away from the upper portion of the filter bag decreasing damage and prolonging bag life.

Abstract: The various embodiments disclosed and pictured illustrate a curved hammer for comminuting various materials. The illustrative embodiments pictured and described herein are primarily for use with a rotatable hammermill assembly. The curved hammer includes a connection portion having a rod hole therein, a contact portion for delivery of energy to the material to be comminuted, and a curved neck portion affixing the connection portion to the contact portion. In other embodiments, a shoulder is positioned around the periphery of the rod hole for added strength. In still other embodiments, a neck reinforcement is positioned along a portion of the neck for increased strength. A weld or plurality of welds may be affixed to various surfaces of the contact portion to aide in comminuting and/or longevity of the curved hammer.

Abstract: A light emitting device including a light emitting unit and a phosphor resin layer is provided. The light emitting unit has a top surface and a bottom surface opposite to each other. Each of the light emitting units includes two electrodes. The two electrodes are disposed on the bottom surface. The phosphor resin layer is disposed on the top surface of the light emitting unit. One side of the phosphor resin layer has a mark. One of the two electrodes is closer to the mark with respect to the other one of the two electrodes.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. In the insertion orientation, the biopsy marker is manipulated under force to reduce the lateral span/cross-sectional area of the marker. In the anchored orientation, the biopsy marker is released and free to actively spring into a configuration in which the lateral span/cross-sectional area is greater than the lateral span/cross-sectional area of the biopsy marker when in the insertion orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.

Abstract: A torque transfer device has plural planets arranged for planetary rotation about one or more sun gears and within one or more ring gears. Each planet includes at least one planetary gear set comprising plural planetary gears connected to rotate together, but having a different diameter to form a differential gear system. To improve load sharing, the plural planetary gears of each planetary gear set may have a different helical angle, the plural planetary gear sets being axially movable with respect to one another. Alternatively or in addition, the planetary gears may be made flexible with respect to radial forces.

Abstract: A red light emitting diode including an epitaxial stacked layer, a first and a second electrodes and a first and a second electrode pads is provided. The epitaxial stacked layer includes a first-type and a second-type semiconductor layers and a light emitting layer. A main light emitting wavelength of the light emitting layer falls in a red light range. The epitaxial stacked layer has a first side adjacent to the first semiconductor layer and a second side adjacent to the second semiconductor layer. The first and the second electrodes are respectively electrically connected to the first-type and the second-type semiconductor layers, and respectively located to the first and the second sides. The first and a second electrode pads are respectively disposed on the first and the second electrodes and respectively electrically connected to the first and the second electrodes. The first and the second electrode pads are located at the first side of the epitaxial stacked layer.

Abstract: An actuator for high rotational speed applications using a stator which utilizes laminated features to reduce Eddy current losses in the stator. This construction allows high pole counts while providing the efficiency and high-speed benefits of a laminated construction. Laminated construction is very challenging for a high pole count lightweight motor, but embodiments of the device provide structural strength, and rigidity, as well as other benefits such as low manufacturing cost, high heat dissipation, integrated cooling channels, and light weight construction. Many of these benefits result from the use of a laminate sandwich of non-magnetic, heat conductive material, such as anodized aluminum, as a structural member of the stator.