Patents Assigned to Georgetown University
  • Small molecules for treating breast cancer
    Patent number: 9359299
    Abstract: Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: June 7, 2016
    Assignee: Georgetown University
    Inventors: Sivanesan Dakshanamurthy, Milton L. Brown, Robert Clarke, Ayesha N. Shajahan-Haq, Jacqueline Smith
  • Cadherin-11 Inhibitors and Methods of Use Thereof
    Publication number: 20160151363
    Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 2, 2016
    Applicant: Georgetown University
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown
  • Phenyl-substituted nicotinic ligands, and methods of use thereof
    Patent number: 9346784
    Abstract: Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Lewy Body Dementia, Attention Deficit Hyperactivity Disorder (ADHD), Parkinson's disease, Huntington's disease, Tourette's syndrome, amyotrophic lateral sclerosis, inflammation, stroke, spinal cord injury, dyskinesias, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, autism, mutism, trichotillomania, hypothermia, and disorders of sleep.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: May 24, 2016
    Assignees: Georgetown University, Duke University
    Inventors: Milton L. Brown, Mikell A. Paige, Yingxian Xiao, Kenneth J. Kellar, Venkata M. Yenugonda, Edward D. Levin, Amir H. Rezvani
  • Systems and methods for monitoring health and delivering drugs transdermally
    Patent number: 9332937
    Abstract: The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: May 10, 2016
    Assignees: Georgetown University, Leidos, Inc.
    Inventors: John F. Currie, Makarand Paranjape, Carl C. Peck, Robert White, Thomas W. Schneider
  • System and method of applying state of being to health care delivery
    Patent number: 9305140
    Abstract: A system for assisting a subject to select a proper form of treatment. The system comprises: a monitoring section that remotely monitors a health status of the subject; an inference section that infers medical information about the subject based on information subject posted on social networks; a subject database that stores subject's information; and a symptom engine that stores symptoms of medical situations. The inference section applies the health status and the medical information against symptoms stored in the symptom engine to determine a proper form of treatment.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: April 5, 2016
    Assignee: Georgetown University
    Inventors: Howard Federoff, Ophir Frieder, Eric Burger
  • Systems and process for forming carbon nanotube sensors
    Patent number: 9302908
    Abstract: A process for forming a functionalized sensor for sensing a molecule of interest includes providing at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith on a substrate; providing a third electrode including a decorating material on the substrate a predetermined distance from the at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith, wherein the decorating material has a bonding affinity for a bioreceptors that react with the molecule of interest; and applying a voltage to the third electrode, causing the decorating material to form nanoparticles of the decorating material on the at least one single or multi-wall carbon nanotube.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: April 5, 2016
    Assignee: Georgetown University
    Inventors: Makarand Paranjape, Jianyun Zhou
  • 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
    Patent number: 9303017
    Abstract: Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: April 5, 2016
    Assignees: Georgetown University, Duke University
    Inventors: Yingxian Xiao, Kenneth J. Kellar, Milton L. Brown, Mikell A. Paige, Yong Liu, Edward D. Levin, Amir H. Rezvani
  • Methods and compositions for treating Ewings sarcoma family of tumors
    Patent number: 9290449
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: March 22, 2016
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • Substituted pyrazines as cadherin-11 inhibitors
    Patent number: 9284368
    Abstract: This invention provides for a method of preventing or treating a cadherin-11 related disease in a subject, which includes administering to the subject an effective amount of a compound of the following formula: or a pharmaceutically acceptable salt or prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X1 and X2 are as defined herein.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: March 15, 2016
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Milton L. Brown
  • Immortalization of epithelial cells and methods of use
    Patent number: 9279106
    Abstract: The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: March 8, 2016
    Assignee: Georgetown University
    Inventors: Richard Schlegel, Xuefeng Liu
  • System and method for enhancing the legibility of images
    Patent number: 9269126
    Abstract: A system and method are described for enhancing readability of scanned document images by operating on each document individually. Via principle component analysis, edge detection and local color contrast computation, an automated method removes image background noise and improves sharpness of the scripts and characters.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: February 23, 2016
    Assignee: Georgetown University
    Inventors: Ophir Frieder, Gideon Frieder, Jon Parker
  • Mass spectrometric methods for quantifying NPY 1-36 and NPY 3-36
    Patent number: 9269550
    Abstract: Provided are methods of detecting the presence or amount of NPY 1-36 or NPY 3-36 in a sample using mass spectrometry. Importantly, by methods of the invention, both NPY 1-36 and NPY 3-36 can be quantified simultaneously, separately, and independently in a sample that contains both peptides. The methods provide enhanced specificity, and excellent sensitivity with limits of quantitation (LOQ) of about 0.1 ng/mL, and are accomplished in less time and with less sample preparation than required in other assays for NPY. In certain embodiments, because the methods of the invention are specific for both NPY 1-36 and NPY 3-36, the methods provide a major advantage over existing immunoassays. Therefore, the methods may be used to obtain reliable concentration data in several important patient populations, such as patients with hypertension, heart disease, or cancer.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: February 23, 2016
    Assignee: Georgetown University
    Inventor: Steven J. Soldin
  • ANTIFUNGAL DRUGS
    Publication number: 20160038477
    Abstract: The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of pharmaceutical compositions comprising compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. Subjects suffering from fungal infection and immunocompromised subjects may particularly benefit from the methods and compositions of the invention.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Richard A. Calderone, Nuo Sun
  • STEREODYNAMIC CHEMOSENSORS
    Publication number: 20160039723
    Abstract: The present invention relates to multifunctional chemosensors that can measure the concentration, enandomeric excess (ee), and absolute configuration of chiral compounds. The chemosensors described herein may contain a backbone moiety that is bonded to a fluorescent moiety and a moiety for bonding a chiral compound. Backbone moieties may include aromatic groups, for example, naphthyl. The chemosensors described herein are useful for measuring concentration, enandomeric excess, and absolute configuration of organic molecules in areas such as high throughput screening.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Christian Wolf, Keith W. Bentley
  • 2-Halo-5-Alkynyl-Pyridyl Nicotinic Ligands
    Publication number: 20160031853
    Abstract: Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
    Type: Application
    Filed: March 26, 2014
    Publication date: February 4, 2016
    Applicant: Georgetown University
    Inventors: Yingxian Xiao, Kenneth J. Kellar, Milton L. Brown, Mikell A. Paige, Yong Liu
  • SELECTIVE INHIBITOR OF ANGIOTENSIN II
    Publication number: 20160024151
    Abstract: Peptides and peptide analogs that selectively inhibit angiotensin II and methods for making and using the same.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Kathryn SANDBERG, Jun LIU, Hong JI
  • FMRI BIOMARKER OF NEURODEGENERATIVE DISEASE
    Publication number: 20160025828
    Abstract: Provided herein are methods related to identifying an early, asymptomatic (prodromal) stage of a neurodegenerative disease or identifying a subject with a symptomatic neurodegenerative disease, including, for example, mild cognitive impairment (MCI), Alzheimer's Disease (AD), or HIV-associated neurocognitive disorder (HAND), using functional MRI data from the subject. Methods are also provided for treating a subject identified with the methods taught herein and for modifying or selecting treatment based on the results of fMRI. Methods are also available for staging neurodegenerative disease and for identifying agents useful in treating them.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Xiong Jiang, Maximilian Riesenhuber
  • APPARATUS AND METHODS FOR PLASMA-ASSISTED REACTION CHEMICAL IONIZATION (PARCI) MASS SPECTROMETRY
    Publication number: 20160013037
    Abstract: Plasma-assisted reaction chemical ionization (PARCI) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The PARCI apparatuses, kits, and methods described in this application relate to systems that comprise a chemical reaction interface (CRI) containing reactant gas plasma and an ionization chamber that is downstream from the CRI. The ionization chamber facilitates formation of ions from element-specific products of the CRI by an electron source or an ionization gas. In particular, PARCI provides a method for conducting highly sensitive mass spectrometric elemental analysis of analyte compounds with high ionization potential elements; for example, fluorine, chlorine, and bromine.
    Type: Application
    Filed: January 28, 2014
    Publication date: January 14, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Kaveh Jorabchi, Haopeng Wang
  • Treatment for oxidative stress and/or hypertension
    Patent number: 9233949
    Abstract: One aspect of the invention relates to compounds, compositions and methods for treating oxidative stress and/or hypertension. In certain embodiments, the invention relates to a mixture of tempol and an angiotensin receptor blocker (ARB) and the use of said mixture to treat oxidative stress and/or hypertension. In certain embodiments, the invention relates to a tempol/ARB adduct and the use of said adduct to treat oxidative stress and/or hypertension.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: January 12, 2016
    Assignee: Georgetown University
    Inventors: Milton L. Brown, Yali Kong, Christopher Stuart Wilcox
  • Compositions and Treatments of Metabolic Disorders Using FGF Binding Protein 3
    Publication number: 20160000861
    Abstract: The invention relates to methods of treating a metabolic disorder in a subject, the method comprising administering fibroblast growth factor binding protein 3 (FGFBP3) or a variant thereof to a subject in need of treatment of a metabolic disorder.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: Anton WELLSTEIN