Patents Assigned to Georgetown University
  • AMINO-SUBSTITUTED POLYSILOXANES COMBINED WITH POLYMERIZABLE AND UNPOLYMERIZABLE ORGANIC ACIDS
    Publication number: 20150361224
    Abstract: Provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant amines and (ii) an acid. Also provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant acids and (ii) an amine. The compositions are useful inter alia for chemical or oil spill cleanup, drug delivery systems, transparent films, adhesives, binding agents, conductors, membranes, cross-linking agents, or opticoelectronic applications. Also provided are methods for making the compositions of the invention, as well as a battery and a composition for controlled release of a compound, each comprising a composition of the invention.
    Type: Application
    Filed: January 17, 2014
    Publication date: December 17, 2015
    Applicant: Georgetown University
    Inventors: Richard G. Weiss, Ajaya M.V. Mallya, Yong He, Tao Yu
  • Genes Contributing to Survival of Cancer Cells
    Publication number: 20150353928
    Abstract: The invention relates to methods of inhibiting the growth or proliferation of a cell, the method comprising reducing the expression or activity of at least one gene in the cell selected from the group consisting of BLOC1S1, CDC2L1, CNOT1, CYR61, DDX54, EIF3I, FANCG, FBP1, IER2, KIF1A, LCK, NR2F1, PNRC1, POLR2A, POLR2B, POLR2C, PRPF6, PSMB4, PSMC5, PSMD1, PTK7, RPS2, SCNN1A, SF3A3, TAF2, TOB1, TSC22D4.
    Type: Application
    Filed: September 14, 2012
    Publication date: December 10, 2015
    Applicants: Georgetown University, Fox Chase Cancer Center
    Inventor: Louis M. WEINER
  • Process and Framework For Facilitating Data Sharing Using a Distributed Hypergraph
    Publication number: 20150347480
    Abstract: A knowledge model “overlay” for organizing and analyzing large, dynamic data volumes is implemented as a hypergraph that manifests as a result of a distributed theory-driven data source transformation process. This process maps exponentially growing data into an asymptotically limited information space. Within this space, real-world entities (e.g. people, computers, cities, Earth) and their complex interdependencies (e.g. social networks, connectivity, causal relationships) are represented as attributed hypergraph elements (i.e. both hypervertices and hyperedges). Attributes are represented as state vectors affixed to any hypergraph element. Transformation of source system data into this overlay structure is accomplished with minimal data movement and replication using a universal “pointer” like mechanism that is managed in a decentralized fashion by the respective transformation components.
    Type: Application
    Filed: May 29, 2015
    Publication date: December 3, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: J. Cory Smart
  • Methods for quantifying vitamin D metabolites by mass spectrometry
    Patent number: 9201079
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise associating an amine with a dihydroxyvitamin D metabolite in a sample, ionizing the adduct, and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: December 1, 2015
    Assignee: Georgetown University
    Inventor: Steven J. Soldin
  • Small molecule inhibitors of AGBL2
    Patent number: 9199918
    Abstract: Small molecule inhibitors of AGBL2 are provided, as well as methods of using the inhibitors to treat or prevent cancer and neurologic disorders.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: December 1, 2015
    Assignee: Georgetown University
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Ziad Sahab
  • METAL PARTICLE MRI CONTRAST AGENTS AND METHODS OF USE
    Publication number: 20150338485
    Abstract: Disclosed herein is a novel MRI contrast agent. The MRI contrast agent is a metal particle having particular shape and size parameters that provides the metal particle with the ability to improve contrast by resisting transverse relaxivity saturation. The disclosed metal particle may be used in both medical and research diagnostic procedures, such as MRI, X-ray, and NMR. Also disclosed are compositions comprising the disclosed metal particle, and methods of using the metal particle. In particular disclosed embodiments, the metal particle is a barium ferrite particle.
    Type: Application
    Filed: December 30, 2013
    Publication date: November 26, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Joseph N. YORK, Edward van KEUREN, Christopher ALBANESE, Olga RODRIGUEZ, Yi-Chien LEE
  • Method and system for managing information on mobile devices
    Patent number: 9191811
    Abstract: A method and apparatus that protect information on a mobile device. The method and mobile device obtain a predetermined portion of asymmetric information upon an input of the asymmetric information in the mobile device; generate an identifier by using a first generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate an encryption key by using a second generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate ciphered information by using an encryption algorithm that uses the encryption key and the information as algorithm inputs; associate the identifier with the ciphered information; and store the ciphered information as associated with the identifier.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: November 17, 2015
    Assignee: Georgetown University
    Inventors: Ophir Frieder, Micah Sherr, Jordan Wilberding
  • PLATINUM ADLAYERED RUTHENIUM NANOPARTICLES, METHOD FOR PREPARING, AND USES THEREOF
    Publication number: 20150311556
    Abstract: A superior, industrially scalable one-pot ethylene glycol-based wet chemistry method to prepare platinum-adlayered ruthenium nanoparticles has been developed that offers an exquisite control of the platinum packing density of the adlayers and effectively prevents sintering of the nanoparticles during the deposition process. The wet chemistry based method for the controlled deposition of submonolayer platinum is advantageous in terms of processing and maximizing the use of platinum and can, in principle, be scaled up straightforwardly to an industrial level. The reactivity of the Pt(31)-Ru sample was about 150% higher than that of the industrial benchmark PtRu (1:1) alloy sample but with 3.5 times less platinum loading. Using the Pt(31)-Ru nanoparticles would lower the electrode material cost compared to using the industrial benchmark alloy nanoparticles for direct methanol fuel cell applications.
    Type: Application
    Filed: July 8, 2015
    Publication date: October 29, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Yu Ye Tong, Bingchen DU
  • Dosimetry system based on optically stimulated luminesence
    Patent number: 9151715
    Abstract: Methods for detecting exposure to ionizing radiation are provided. In particular, methods for detecting and measuring the exposure of keratin-rich materials to ionizing radiation using optically stimulated luminescence are provided.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: October 6, 2015
    Assignee: Georgetown University
    Inventor: Marko Moscovitch
  • SYSTEM AND METHOD FOR DETERMINING MALICIOUS NETWORK ATTACKS
    Publication number: 20150281273
    Abstract: A system and method for deterring malicious network attacks. The system and method is configured to execute instructions on at least one of the processors to generate a plurality of random blocks of data; generate a first XOR result by using the XOR function with the plurality of random blocks of data as the XOR function inputs; generate a tail value by using the XOR function with the first XOR result and a random encryption key as the XOR function inputs; encrypt a designated file using the random encryption key; write the plurality of random blocks and tail value to at least one storage medium; and write the encrypted designated file to at least one storage medium.
    Type: Application
    Filed: April 1, 2014
    Publication date: October 1, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: Thomas Clay SHIELDS
  • FLAVIVIRUS PROTEASE INHIBITORS
    Publication number: 20150272976
    Abstract: Methods of treating or preventing a Flavivirus infection in a subject are provided. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus protease inhibitor. These methods are useful in treating and/or preventing Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus. Methods of inhibiting a Flavivirus protease in a cell are also provided.
    Type: Application
    Filed: October 23, 2013
    Publication date: October 1, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Radhakrishnan Padmanabhan, Tadahisa Teramoto, Mark Manzano
  • COMPOSITIONS AND METHODS FOR TREATING MAMMARY TUMORS
    Publication number: 20150265590
    Abstract: The present invention provides methods of inhibiting abnormal growth of cells, with the methods comprising contacting the cells with at least one of the sensitizing compounds disclosed herein in an amount sufficient to inhibit cell growth. The present invention also provides methods of treating and/or reducing the likelihood of being diagnosed with breast cancer, with the methods comprising administering to a subject in need of treatment thereof at least one of the sensitizing compounds disclosed herein.
    Type: Application
    Filed: October 22, 2013
    Publication date: September 24, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Eliot M. Rosen, York A. Tomita
  • Specific Delivery of Toxins Conjugated with Antiobodies to Activate Matripase
    Publication number: 20150250895
    Abstract: Disclosed are antibody drug conjugates (ADC) that include highly potent toxic agents with specific antibodies to target tumors. Also disclosed are related antibodies, polypeptides, nucleic acids, host cells, compositions, and uses.
    Type: Application
    Filed: October 2, 2013
    Publication date: September 10, 2015
    Applicant: Georgetown University
    Inventors: Siang-Yo Lin, Joseph R. Bertino, Chen-Yong Lin, Michael Johnson
  • BENZENETRICARBOXYLIC ACID AND METHODS OF USE
    Publication number: 20150238449
    Abstract: Methods of treating or preventing cancer and/or a neurodegenerative disorder in a subject are provided. The methods comprise administering to a subject a therapeutically effective amount of 1,2,3-benzenetricarboxylic acid or a hydrate or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 22, 2013
    Publication date: August 27, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: Maria Laura Avantaggiati
  • COMPETITIVE INHIBITOR OF GP120
    Publication number: 20150239933
    Abstract: Peptides and peptide analogs that competitively inhibit HIV protein gp120 and methods for making and using the same.
    Type: Application
    Filed: February 24, 2015
    Publication date: August 27, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Italo MOCCHETTI, Valeriya AVDOSHINA
  • Systems and methods of predicting a subject's medical outcome
    Patent number: 9117173
    Abstract: Disclosed are methods of constructing systems for predicting a subject's medical outcome. Also disclosed are methods and systems for predicting a subject's medical outcome. The disclosed methods and systems can include identifying a group of subjects with the same medical condition and classifying this group of subjects into one or more subgroups. The subgroups are classified based on similarity of medical outcome, using classification and regression trees (CART) to generate a classification tree based on the presence of identifying genetic characteristics. Each node in the classification tree describes the presence of a specific genetic marker and each branch in the classification tree describes a genetic profile that predicts a subject's medical outcome.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: August 25, 2015
    Assignee: Georgetown University
    Inventor: Farrokh Alemi
  • SYSTEM, METHOD, AND STORAGE MEDIUM FOR GENERATING HYPOTHESES IN DATA SETS
    Publication number: 20150235138
    Abstract: A method for generating hypotheses in a corpus of data comprises selecting a form of ontology; coding the corpus of data based on the form of the ontology; generating ontology space based on coding results and the ontology; transforming the ontology space into a hypothesis space by grouping hypotheses; weighing hypotheses included in the hypothesis space; and applying a science-based sorting algorithm configured to model a science-based treatment of the weighted hypotheses.
    Type: Application
    Filed: January 15, 2015
    Publication date: August 20, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Ophir Frieder, David Hartley
  • Fast recovery of thixotropy by organogels with low molecular weight gelators
    Patent number: 9109150
    Abstract: Low molecular weight gelators, methods of making such gelators, organogels comprising such gelators and methods of using such organogels are described. In exemplary methods, the gelators can be used in a variety of applications including the delivery of pharmaceutical active pharmaceutical ingredients, in food, cosmetics and consumer products, and in containing the unexpected release of chemical that occur for example in spills.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: August 18, 2015
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Richard G. Weiss, Ajaya Mallia Viswanatha Mallya
  • Platinum adlayered ruthenium nanoparticles, method for preparing, and uses thereof
    Patent number: 9105934
    Abstract: A superior, industrially scalable one-pot ethylene glycol-based wet chemistry method to prepare platinum-adlayered ruthenium nanoparticles has been developed that offers an exquisite control of the platinum packing density of the adlayers and effectively prevents sintering of the nanoparticles during the deposition process. The wet chemistry based method for the controlled deposition of submonolayer platinum is advantageous in terms of processing and maximizing the use of platinum and can, in principle, be scaled up straightforwardly to an industrial level. The reactivity of the Pt(31)-Ru sample was about 150% higher than that of the industrial benchmark PtRu (1:1) alloy sample but with 3.5 times less platinum loading. Using the Pt(31)-Ru nanoparticles would lower the electrode material cost compared to using the industrial benchmark alloy nanoparticles for direct methanol fuel cell applications.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: August 11, 2015
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: YuYe Tong, Bingchen Du
  • Combination therapy based on SRC and aurora kinase inhibition for the treatment of cancer
    Patent number: 9101631
    Abstract: Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: August 11, 2015
    Assignees: Georgetown University, Fox Chase Cancer Center
    Inventors: Vladimir Ratushny, Erica A. Golemis, Ilya G. Serebriiskii, Louis M. Weiner, Igor Astsaturov, Andrew Godwin