Abstract: Disclosed herein are methods and kits for identifying a subject as having liver cancer. Also provided herein are methods and kits for determining the prognosis of a subject having liver cancer and for determining the progression of liver cancer in a subject.

Abstract: Techniques for rewarding users based primarily on performance scores as obtained during play of an application and based secondarily on health metric data (“HMD”) obtained from performing exercise are disclosed. A baseline or minimum exercise requirement is established, where this requirement is generally achievable regardless of one's initial health status. Satisfaction of that baseline exercise requirement then unlocks a user's ability to engage with an application, which generally challenges the user's non-physical abilities. The user's performance in that application is then the deciding factor as to who wins a reward program. Because the exercise aspect is designed to be generally achievable for most if not all users, those users are now equally encouraged or incentivized to participate in the exercise reward program because the determination of who will win is now separated from a user's health status.

Abstract: The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins). These methods accommodate multiple forms and/or modifications of nucleic acid in a sample, such that sequence information can be obtained for multiple forms. The methods also preserve the identity of multiple forms or modified states through processing and analysis, such that analysis of sequence can be combined with epigenetic analysis.

Abstract: Disclosed herein are methods and kits for identifying a subject as having lung cancer. Also provided herein are methods and kits for determining the prognosis of a subject having lung cancer and for determining the progression of lung cancer in a subject.

Abstract: Disclosed herein are compositions comprising one or more polyglutamic acid compounds. The compositions are for treating, ameliorating, preventing, or reducing the symptoms of vaginal dryness and the symptoms associated with menopause. Also described herein are suppository formulations of the compositions.

Abstract: The present embodiments relate generally to ultrasound imaging systems and methods that provide, upon receipt of input of a tap gesture at a location directly on the ultrasound image feed on the touchscreen display, such location indicating on the post scan converted ultrasound image frame a desired focal adjustment point, the processor causes the ultrasound imaging system to i) revert the post scan converted ultrasound image frame comprising the location of the desired focal adjustment point, by way of the cartesian co-ordinates, to its corresponding pre-scan raw ultrasound data frame; ii) calculate, on the pre-scan raw ultrasound data frame, the location of the desired focal adjustment point, by way of polar co-ordinates of the desired focal adjustment point; and iii) adjust at least one beamformer parameter of ultrasound signals being used to transmit and receive the ultrasound image to focus at the desired focal adjustment point, based upon the polar coordinates.

Abstract: Various embodiments of the present invention are directed to the field of treating and preventing osteoporosis, with particular embodiments directed to a method of ameliorating, treating, or preventing osteoporosis in a human subject employing tomatidine, xylitol, rapamycin, etc., as well as modifying an individual's microbiome to reduce the likelihood of osteoporosis.

Abstract: A package dispenser for dispensing at least one stack of wipes, and having a bottom, top, two opposing side and two opposing end walls deliminating a storage space wherein, the top wall includes at least one dispensing opening; each of the at least one stack of wipes has a bottom surface, a top surface, two side and two end surfaces, each of the at least one stack of wipes resting on the bottom wall of the package dispenser, the top surface of the stack facing the top wall of the package dispenser; each of the at least one stack of wipes in the package dispenser is a stack of interfolded wipes; and arranged to be dispensed from the top surface of the stack, the interfolded wipes in the stack being dispensed through a corresponding one of the at least one dispensing opening.

Abstract: A method of monitoring hydration including obtaining biological data for a given period of time, wherein the biological data includes measurements of one or more biological indicators; converting the biological data into a baseline value; obtaining real-time biological data from one or more biological sensors; performing a pre-processing analysis of the real-time biological data; comparing the real-time biological data with baseline value to create a hydration index

Abstract: A sanitary includes a fluid permeable topsheet and a backsheet. The sanitary pad being made up of a front third, a rear third and a central third arranged between the front and the rear third, as seen in the longitudinal direction, the topsheet being provided with a water-soluble formulation applied in a coated zone arranged along the rear edge and the first and the second longitudinal side edges in the rear third of the sanitary pad forming a boundary in the rear third delimiting an inner rear zone including a coated free topsheet area, the inner rear zone extending along the longitudinal centreline, the coated zone being arranged at a distance from the rear edge and from the first and second longitudinal side edges and covers from 25% of a total surface area of the topsheet in the rear third of the sanitary pad.

Abstract: A method of managing fluid conditions in a patient involves advancing at least one medical instrument into a target organ of a patient, the at least one medical instrument comprising an irrigation channel and an aspiration channel, coupling the at least one medical instrument to an irrigation fluid source, providing irrigation from the irrigation fluid source into the target organ through the irrigation channel of the at least one medical instrument, determining an irrigation pressure limit based at least in part on one or more case-specific parameters, providing irrigation into the target organ through the irrigation channel, and limiting the irrigation based at least in part on the determined irrigation pressure limit.

Abstract: Disclosed is a foldable locking rollator constructed and arranged to be pivotably operable between an open position and a closed storage position. The folding locking rollator assembly is comprised of a support structure having two spaced apart front support members and two rear support members. Each rear support member is pivotally attached to the ends of the front support members with hinge assemblies. The front support members each have a sliding joint member constructed and arranged to slide between the front support members ends. A set of crossbar members are pivotally connected at a predetermined point in an X-configuration. At least one sliding joint member is comprised of a locking mechanism constructed and arranged to be hand operated with a lever by the user.

Abstract: A catheter comprises a flexible polymer catheter body including a proximal shaft section and a distal working section, a wire support structure embedded within the distal working section of the catheter body, a proximal adapter mounted to the proximal shaft section of the catheter body, and a wire disposed within the catheter body. The wire has a proximal end and a distal end. The proximal end of the wire being operably connected to the proximal adapter, and the distal end of the wire is anchored to the wire support structure.

Abstract: Methods are provided for the epigenetic analysis of cell-free DNA using organic boranes to convert oxidized 5-methylcytosine residues in the cell-free DNA to dihydrouracil (DHU) residues. Cell-free DNA is contacted with an organic borane selected to successively bring about reduction, deamination, and decarboxylation of oxidized 5-methylcytosine residues such as 5-carboxylcytosine and 5-formylcytosine, resulting in DHU residues in place thereof. Following amplification, the treated cell-free DNA is sequenced, with the DHU residues read as thymine residues. Reaction mixtures, kits and additional methods are also provided, as are related methods for the epigenetic analysis of DNA, including cell-free DNA.

Abstract: A facility for securely accessing a backend resource from a mobile app is described. In a hidden webview of the mobile app, the facility (1) sends a first request with respect to a remote backend resource on behalf of a user for whom a distinguished user account was established with a backend service; the sending is performed in such a way that active SSO session state information stored in the hidden webview of the mobile app is attached to the first request; and (2) receives in response to the first request a first response acknowledging user signin at the backend resource.

Abstract: Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside, pterostilbene and a phosphodiesterase (PDE) inhibitor, including a PDE4 inhibitor such as ibudilast, and also including a thiol/cysteine donor, such as acetylcysteine.

Abstract: A patient health management platform determines of a metabolic state for a first time period. The platform generates a patient-specific treatment recommendation for a second time period following the first time period that identifies objectives for the patient to complete to improve the metabolic state determined for the first time period. Periodically during the second time period, the platform receives recordings of patient data indicating foods consumed by the patient, medication taken by the patient, and/or symptoms experienced by the patient. The platform compares the received recordings of patient data from the second time period to the generated patient-specific treatment recommendation to determine a number of objectives completed by the patient and updates a score representing n adherence of the patient to the patient-specific treatment recommendation based the number of completed objectives.

Abstract: Described herein are techniques of using machine learning to automatically extract clinical variable values for subjects from clinical record data. The techniques designate certain clinical variables as hybrid variables that can be assigned values by machine learning model prediction. The techniques process, using a machine learning model trained to predict a value of a hybrid variable, clinical record data associated with a subject to obtain a predicted hybrid variable value and an associated confidence score. The techniques set the value of the hybrid variable for the subject to the predicted hybrid variable value when the model prediction is of sufficiently high confidence.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: Disclosed herein are methods and kits for identifying a subject as having colon cancer. Also provided herein are methods and kits for determining the prognosis of a subject having colon cancer and for determining the progression of colon cancer in a subject.