Abstract: A method of providing sensory stimulation to a user is described. The method includes alternating sensory stimulation between a first sensory stimulation including simultaneously providing a left visual stimulus pattern to a left eye and a right auditory stimulus pattern to the right side of a head and a second sensory stimulation including simultaneously providing a right visual stimulus pattern to a right eye and a left auditory stimulus pattern to the left side of the head. The first sensory stimulation and the second sensory stimulation each include a first stimulus pattern having a first pulse frequency, a second stimulus pattern having a second pulse frequency less than the first pulse frequency, and a third stimulus pattern having a third pulse frequency less than the second pulse frequency. The first pulse frequency, the second pulse frequency, or the third pulse frequency is between approximately 3.75 Hz and 4.25 Hz.

Abstract: An ex-vivo lung perfusion (EVLP) method may include ventilating a donor lung with a gas mixture that comprises carbon dioxide and circulating a perfusate through a perfusion circuit and the donor lung while ventilating the donor lung. The perfusion circuit does not have a membrane gas exchanger.

Abstract: A method of preserving a donor organ for transplantation may include flushing the donor organ with flush solution comprising itaconate and storing the flushed donor organ. The flush solution may comprise dimethyl itaconate (DI) in an amount greater than or equal to 0.1 mM and less than or equal to 0.75 mM. Following removal from storage, the donor organ may be perfused using an ex vivo organ perfusion (EVOP) process. The perfusate may also include itaconate.

Abstract: Disclosed is a sterile MRI probe infusion device for preparing and administering a hyperpolarized MRI probe to a patient in need thereof. The device includes one or more reaction chambers, where a hyperpolarized MRI probe is prepared, separated from the reaction mixture, concentrated, and a solution of suitable concentration for administration to a patient is prepared. Also disclosed is a method of preparing and administering a hyperpolarized MRI probe by the use of the device to a patient in need thereof for diagnosing stages of a disease or an adverse condition or monitoring progress of a treatment of the patient having a disease or an adverse condition.

Abstract: System, method, and device is presented for generating and processing tissue-monitoring signals. An emitting driver is operable to control, upon receipt of at least one emitted signal, an optical emitter to emit at least one emitted signal. A processor is coupled to the at least one optical emitter and operable to execute instructions to generate the at least one emitted signal. At least one photodetector is operable to detect one or more photons transmitted through tissue and to convert the detected photons into a detected signal. A hardware processing sequence is coupled to the photodetector and processor. The hardware processing sequence is operable to filter and condition the detected signal. The processor is operable to execute instructions to demodulate the at least one emitted signal and the detected signal.

Abstract: The present disclosure relates to novel peptide-based vaccines, methods of manufacturing the novel peptide-based vaccines and uses thereof for delivering peptide antigens to induce an immune response, and in particular a T cell response to a subject.

Abstract: In some embodiments, a method of manufacturing a metabolic sensor includes assembling a working wire for a metabolic sensor and exposing the interference layer to an oxidizing agent such as a gas. The assembly comprises forming an interference layer on a substrate, the substrate having an electrically conductive surface; forming an enzyme layer on the interference layer; and forming a glucose limiting layer on the enzyme layer. The exposing is performed prior to sterilizing the working wire.

Abstract: Antibodies and antigen binding fragments that specifically bind to IL-7R? are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R? using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R?, such as acute lymphoblastic leukemia.

Abstract: Provided are compositions and methods for prophylaxis and/or therapy of a variety of cancers which express a NY-ESO-1 antigen. Included are recombinant T cell receptors (TCRs), polynucleotides encoding them, expression vectors that include the polynucleotides, and cells into which the polynucleotides have been introduced to produce modified cells, including CD4+ T cells, CD8+ T cells, natural killer T cells, ?? T cells, and progenitor cells, such as haematopoietic stem cells. The modified cells are capable of direct recognition of a cancer cell expressing a NY-ESO-1 antigen by human leukocyte antigen (HLA) class II-restricted binding of the TCR to the NY-ESO-1 antigen expressed by the cancer cell without presentation of the antigen by antigen presenting cells. In embodiments, the NY-ESO-1 antigen is displayed by the tumor cells. Also included is a method for prophylaxis and/or therapy of cancer by administering modified cells that express a recombinant TCR.

Abstract: A radiography system having multiple digital radiographic detectors captures an image in each of the detectors when the x-ray source is fired. The detectors evaluate the captured images and a controller prioritizes the captured images according to the evaluations to determine which captured images are forwarded and in what order. At least one of the DR detectors captures a suitable diagnostic x-ray image.

Abstract: The present disclosure relates to a cosmetic manufacturing device and a discharge information determination method for the cosmetic manufacturing device, wherein the device and method provide a method for determining discharge information for providing customized cosmetics. The method can include determining a target color, determining a coverage level, determining a texture, and determining discharge information on the basis of the target color, the coverage level, and the texture, wherein the determining the discharge information may include determining cartridges of interest such that the cartridge discharging a cosmetic material varies according to the coverage level even if the target color is the same.

Abstract: The disclosed apparatus, systems and methods relate to an anterior mitral valve leaflet laceration catheter. The catheter has a plurality of lumens so as to allow for the introduction of the device via a guide wire, the inflation of a balloon and the manipulation of an introducer having a curved distal end cutting portion that can be rotated into a charged position for the laceration of the anterior mitral valve leaflet.

Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of guaifenesin, naproxen and at least one further active which is selected to be an antitussive, a decongestant or an antihistamine.

Abstract: Provided are processes for the use of a single dried blood sample for the preparation of test samples including targets of differing structures. The processes allow the same dried blood sample to be used for preparation of a first test sample including a non-nucleic acid target, and the same dried blood sample to be subsequently processed for preparation of a test sample that includes a nucleic acid target whereby the processes preserve the ability of the nucleic acid to be detected in subsequent detection assays following prior isolation of non-nucleic acid targets.

Abstract: Zeolites for extraction of heavy metals are given enhanced purification in a first method stage and further processed in a second method stage to form liquid and solid phases including swollen clinoptilolite fragments ranging from 200 to 2000 Daltons and formed as liposomes and usable to substantially reduce heavy metal ppm burdens for purposes of safe ingestion by mammals and reduction of heavy metal contaminants of gut, vascular and lymphatic systems of a mammalian host.

Abstract: A diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The sample can be processed for data collection and analysis to provide interpretative results indicative of a disorder, condition, disease or infection of the patient. For example, the data collection and analysis can determine one or more hemozoin characteristics.

Abstract: The present invention relates to an isoindol-sulfilimine compound and its preparation and its use as a sigma-2 receptor inhibitor. Compared with the prior art, the isoindol-sulfilimine compound prepared by the present invention can effectively inhibit the sigma-2 receptor activity by binding to the sigma-2 receptor and deformationally regulating the sigma-2 receptor complex, which will lead to the instability of the binding of adjacent A? oligomers to the receptor on the synapse, thus leading to the removal of AB oligomers from the synapse. It can be further used for the preparation of new therapeutic drugs for tumor and neurodegenerative diseases.

Abstract: The multi-way coupler ring assembly is configured to couple a first end of a receiving vessel with a second end of the receiving vessel, and is further configured to couple a donor vessel to the first and second ends of the receiving vessel in a three-way junction. The multi-way coupler ring assembly includes a first receiving coupler ring configured to receive a first receiving vessel and a second receiving coupler ring configured to receive a second receiving vessel and couple with the first receiving coupler ring. The multi-way coupler ring assembly further includes a donor coupler ring configured to receive the donor vessel and couple with the first receiving coupler ring and the second receiving coupler ring. The first receiving coupler ring, the second receiving coupler ring and the donor coupler ring each respectively define a wedged face to enable three-way simultaneous or stepwise coupling with one another.

Abstract: Systems and methods are provided for estimating the 3D joint location of skeleton joints from an image segment of an object and a 2D joint heatmaps comprising 2D locations of skeleton joints on the image segment. This includes applying the image segment and 2D joint heatmaps to a convolutional neural network containing at least one 3D convolutional layer block, wherein the 2D resolution is reduced at each 3D convolutional layer and the depth resolution is expanded to produce an estimated depth for each joint. Combining the 2D location of each kind of joint with the estimated depth of the kind of joint generates an estimated 3D joint position of the skeleton joint.