Abstract: Provided are systems and methods for path-based navigation of tubular networks. In one aspect, the method includes receiving location data from at least one of a set of location sensors and a set of robot command inputs, the location data being indicative of a location of an instrument configured to be driven through a luminal network. The method also includes determining a first estimate of the location of the instrument at a first time based on the location data, determining a second estimate of the location of the instrument at the first time based on the path, and determining the location of the instrument at the first time based on the first estimate and the second estimate.

Abstract: A system enables management of dispensable units by supporting functions such as retrieval, scheduled distribution, analysis, and notifications. To this end, a dispensable retrieval mechanism may be programmed to carry out blind retrievals of dispensable units using a retrieval strategy with a predetermined sequence of retrieval attempts (e.g., fixed or varying two-dimensional retrieval patterns), which may be open loop or closed loop. Techniques may also include the identification of dispensable units through optical sensors and weight measurement devices that can detect, e.g., a texture, a shape, and a size of dispensable units. Such identification can be used to program retrieval attempts by a retrieval robot and in the formulation of the retrieval pattern. Additionally, networked notification systems for dispensable units can be used for updating rules or schedules related to the dispensable units, or alerting users and remote resources of any potential misuse or hazards of the dispensable units.

Abstract: A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers.

Abstract: Provided herein are newly discovered methods of analyzing abaloparatide samples for abaloparatide isomers. Additionally, methods of storing and treating with abaloparatide in view of the newly discovered abaloparatide isomers are described.

Abstract: A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.

Abstract: An electric blanket is provided with a novel wiring structure, which includes an electric blanket body having resistance wires laid inside and a controller connected to the resistance wire circuit. The electric blanket body includes an upper layer of fabric and a middle layer that has a heating wire quilted to it by a sewing thread in a zig-zag manner. The spacing between adjacent portions of the sewing thread is one to five times the diameter of the resistance wire. The wiring structure of the electric blanket is firm, reliable, and highly safe, and can effectively avoid the problem of local high temperature and subsequent fire danger that might be caused by the resistance wires getting tangled together during long-term use or cleaning.

Abstract: The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status.

Abstract: In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and/or posterior tibial nerves. The therapy may be adjusted based on leg restlessness or movement.

Abstract: An adjustable toilet seat riser that includes at least two arms, a left arm and a right arm, where a rib protrudes from the left arm, a rib protrudes from the right arm, and at least two platforms, a left platform and a right platform, wherein the left platform has a left platform sleeve, the right platform has a right platform sleeve, a rib protrudes from the left platform, a rib protrudes from the right platform, and a flexible coupling with a plurality of openings, where the ribs of the left arm and right arm and the ribs of the left platform and right platform are removably secured to the plurality of openings in the flexible coupling.

Abstract: A disposable insert for an endoscope. The disposable insert includes a flexible shaft and a cap. The flexible shaft has a distal end, a proximal end, and a lumen extending therebetween and is configured to be inserted into a lumen of an endoscope. The cap is operably coupled to the distal end of the flexible shaft and is configured to form a fluid-tight seal and secure the flexible shaft to a distal end of the endoscope. The cap also has a lumen extending therethrough that is coaxial to the lumen of the flexible shaft.

Abstract: The present invention provides a method for determining glomerular filtration ability on the basis of the amount of D-serine in the blood. The present invention provides a blood analysis system which includes a storage unit, an analysis measurement unit, a data processing unit and a glomerular filtration ability output unit, wherein: the storage unit stores the correlation equation between the amount of D-serine in the blood and glomerular filtration ability; the analysis measurement unit separates and quantifies the amount of D-serine in the blood; the data processing unit calculates glomerular filtration ability by inputting the D-serine amount into the correlation equation stored in the storage unit; and a pathology information output unit outputs glomerular filtration ability information.

Abstract: Disclosed herein is a benign prostatic hyperplasia treatment device. The benign prostatic hyperplasia treatment device includes: anchor assemblies including a first anchor arranged at the outer surface of the prostate gland, which obstructs the prostatic urethra, a second anchor arranged inside the prostate gland to be opposed to the first anchor, and a ligature connecting the first anchor and the second anchor with each other so that the second anchor compresses the prostate tissue to secure the opening of the prostatic urethra; and a sheath inserted into the urethra and having a needle, which guides the anchor assembly to be deployed at the prostate gland.

Abstract: A vehicle system includes a controller programmed to display a plurality of icons on a heads-up-display (HUD) of the vehicle, receive electroencephalography (EEG) data from a driver of the vehicle, perform a Fast Fourier Transform of the EEG data to obtain an EEG spectrum, input the EEG spectrum into a trained machine learning model, determine which of the plurality of icons the driver is viewing based on an output of the trained machine learning model, and perform one or more vehicle operations based on the output of the trained machine learning model.

Abstract: Systems and methods are disclosed for analyzing data from oncology treatments such as immune checkpoint inhibitor or radiotherapy therapies, including predicting adverse events of the oncology therapies, predicting objective response of the oncology therapies, predicting symptoms from the oncology therapies, and use of such predictions by technological implementations to achieve improved system and medical outcomes. An example technique for generating a predicted treatment outcome includes: receiving patient data for a human subject, which provides patient-reported outcomes collected from the human subject relating to a particular oncology treatment; processing the patient data with a trained artificial intelligence (AI) prediction model, which receives the patient data as input and produces a prediction of a treatment outcome as output; and outputting data to modify a treatment workflow of an oncology treatment for the human subject, based on the prediction of the treatment outcome.

Abstract: Disclosed herein are methods and kits for identifying a subject as having liver cancer. Also provided herein are methods and kits for determining the prognosis of a subject having liver cancer and for determining the progression of liver cancer in a subject.

Abstract: Techniques for rewarding users based primarily on performance scores as obtained during play of an application and based secondarily on health metric data (“HMD”) obtained from performing exercise are disclosed. A baseline or minimum exercise requirement is established, where this requirement is generally achievable regardless of one's initial health status. Satisfaction of that baseline exercise requirement then unlocks a user's ability to engage with an application, which generally challenges the user's non-physical abilities. The user's performance in that application is then the deciding factor as to who wins a reward program. Because the exercise aspect is designed to be generally achievable for most if not all users, those users are now equally encouraged or incentivized to participate in the exercise reward program because the determination of who will win is now separated from a user's health status.

Abstract: Disclosed herein are compositions comprising one or more polyglutamic acid compounds. The compositions are for treating, ameliorating, preventing, or reducing the symptoms of vaginal dryness and the symptoms associated with menopause. Also described herein are suppository formulations of the compositions.

Abstract: Disclosed herein are methods and kits for identifying a subject as having lung cancer. Also provided herein are methods and kits for determining the prognosis of a subject having lung cancer and for determining the progression of lung cancer in a subject.

Abstract: The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins). These methods accommodate multiple forms and/or modifications of nucleic acid in a sample, such that sequence information can be obtained for multiple forms. The methods also preserve the identity of multiple forms or modified states through processing and analysis, such that analysis of sequence can be combined with epigenetic analysis.

Abstract: A subcutaneous sensor for use with a continuous glucose monitor includes a working electrode and a reference electrode. The reference electrode comprises a reference substrate, an ion limiting layer over the reference substrate and a composition for releasing nitric oxide (NO). The composition has a NO release compound, a hydrophilic material and a hydrophobic material. A subcutaneous sensor for use with a continuous glucose monitor includes a reference electrode comprising a composition for releasing nitric oxide (NO). The composition has a NO release compound, a hydrophilic material and a hydrophobic material. The reference electrode is positioned separate from a working electrode.