Abstract: Opioid-free, anesthetic, analgesic, antalgesic, anti-nociceptive, anti-inflammatory, antiemetic formulations, and methods for reducing pain, controlling pain, preventing pain, reducing or eliminating exposure to opioids, decreasing nausea and vomiting, featuring administration of the anesthetic/analgesic formulations. The opioid-free/sparing anesthetic/analgesic formulations comprise a local anesthetic, a cyclooxygenase (COX) inhibitor, and an alpha agonist. The formulations may optionally comprise additional compositions including but not limited to NMDA receptor antagonists, Buprenorphine, Dexketoprofen, Carprofen, an antifibrinolytic, an antibiotic, a steroid, a cyclooxygenase 3 inhibitor, a Transient Receptor Potential Vanilloid (TRPV) receptor agonist or antagonist, a protein kinase inhibitor, a competitive or non-competitive glycine or glutamate agonist, a glutamate or glycine inhibitor or antagonist, a neurokinin-1 receptor antagonist, an alpha agonist, a second alpha agonist, and combinations thereof.

Abstract: The present invention relates to a method for reducing localized fat deposits in a subject in need thereof in need thereof by topically treating the subject with rare-earth element doped calcium carbonate particles in combination with low-intensity ultrasound. The rare-earth element doped calcium carbonate particles have good biocompatibility and can increase reactive oxygen species (ROS) production and produce carbon dioxide (CO2) and calcium ions (Ca2+) in the region of administration under the ultrasonic irradiation. The method of the present invention is effective in inducing adipocyte necrosis, inhibiting adipogenesis, and decreasing body weight and useful for body sculpture.

Abstract: The disposable absorbent insert for a reusable outer shell has an extension in the longitudinal direction and the transversal direction, longitudinal and transversal side edges and having a front portion, a back portion and a crotch portion located between the front and the back portions. The insert includes an absorbent core having longitudinal and transversal side edges and being sandwiched between a liquid-permeable and user-facing topsheet and a liquid-impermeable and garment-facing backsheet and wherein the absorbent core includes an absorbent component enclosed by a core cover including an upper and a lower side. The insert further includes a first longitudinal extending standing gather along a first longitudinal side edge of the insert and a second longitudinal extending standing gather along a second longitudinal side edge of the insert.

Abstract: The disposable absorbent insert for a reusable outer shell has an extension in the longitudinal direction and the transversal direction, longitudinal and transversal side edges and having a front portion, a back portion and a crotch portion located between the front and the back portions. The insert includes an absorbent core having longitudinal and transversal side edges and being sandwiched between a liquid-permeable and user facing topsheet and a liquid-impermeable and garment facing backsheet and wherein the absorbent core includes an absorbent component enclosed by a core cover including an upper and a lower side. The insert further includes a first longitudinal extending standing gather along a first longitudinal side edge of the insert and a second longitudinal extending standing gather along a second longitudinal side edge of the insert.

Abstract: The invention relates to a method for prognosing ACS in a subject, the method comprising determining plasma MIF and Nt-proBNP (or BNP) concentrations in a sample from the subject, diagnosing ACS when the subject plasma concentrations are greater than a reference MIF and Nt-proBNP (or BNP) plasma concentration, and prognosing the magnitude of ACS from the subject plasma MIF and Nt-proBNP (or BNP) concentrations. Also provided is a method of treating ACS in a subject, a device, a kit, and a cardiac biomarker related to the methods of prognosing ACS.

Abstract: An aspect of the invention provides nucleic acids comprising a nucleotide sequence encoding chimeric antigen receptor (CAR) amino acid constructs. Polypeptides, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CAR constructs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

Abstract: The present invention relates to influenza virus immunisation using at least one influenza HA stem polypeptide in conjunction with squalene emulsion adjuvants, and to related aspects.

Abstract: The present invention is related to the development of novel compounds and methods for the treatment and/or prevention of malaria. The compounds prevent the formation by the malaria parasite of the plasmodium surface anion channel (PSAC) on the surface of the host cell. The compounds and methods described herein are effective against infection by a wide variety of Plasmodia strains known as the causative agent of malaria.

Abstract: Methods, systems, and computer-readable media for generating a statistically covaried machine learning model for performance measurement of service providers. The method receives a configuration file that includes one or more parameters associated with a plurality of individuals and parses it to generate and executing the database query on input data to generate sets of tabulated data of individuals of the plurality of individuals. The method next determines one or more measures of service providers listed in the configuration file using two or more tabulated data of individuals from the sets of tabulated data of individuals. The method finally generates a covaried machine learning model by training a machine learning model by statistically covarying measures and using them as training data.

Abstract: An acquisition control unit acquires spot urine nutritional component indexes of nutritional component indexes contained in one spot urine excreted by a human. The nutritional component indexes two or more selected from a sodium/potassium ratio indicating a ratio, a magnesium/creatinine ratio, an urea-nitrogen/creatinine ratio, and a sodium/creatinine ratio. The determination control unit compares the spot urine nutritional component index with a reference value preset for the spot urine nutritional component index for each of spot urine nutritional component indexes, and determines whether or not the spot urine nutritional component index is equal to or more than the reference value. The decision control unit decides a diet evaluation pattern indicating a balance of the diet of the human from the determination result for each of the determined spot urine nutritional component indexes. The output control unit outputs a diet evaluation comment improving the balance of the diet of the human.

Abstract: Various systems and methods are described herein that facilitate the automatic monitoring, evaluating, and analysis of information gathered during a telemedicine appointment. The systems and methods are further adapted to generate automated clinical notes. Such systems, methods and apparatuses further allow for flexible, dynamic pricing and scheduling of telemedicine services based on a number of different factors including patient preferences and physician characteristics.

Abstract: An ultrasound imaging system comprises an ultrasound imaging apparatus operable to acquire ultrasound image data and comprising a power accepting interface; and a dual function charging and cooling unit configured to detachably couple to the ultrasound imaging apparatus; wherein the dual function charging and cooling unit comprises i) a power conveying element to convey power to the ultrasound imaging apparatus and ii) an active cooling element for removing heat from the ultrasound imaging apparatus.

Abstract: There is provided an apparatus for extraction of at least one object from a cavity. The apparatus includes a sleeve including an inflatable section configured to surround the at least one object during inflation; a handle configured to enable a user to hold the sleeve, the handle defining a holding edge of an opening at a first portion of the sleeve; and a handle-mount mounted to a peripheral area around the opening, the handle-mount being for attachment of a pump used for inflating the inflatable section. There is also provided a pressure limitation apparatus configured to operate with a birth assistance device when attached via a conduit.

Abstract: There is provided a method for preparing surface modified microcapsules that increase fiber adhesion of fragrance capsules, have excellent fragrance durability even after use, and are environmentally friendly due to biodegradation of ester groups, by preparing a pickering emulsion using inorganic nanoparticles and acrylic monomers comprising biodegradable ester groups, and then, preparing capsules through the polymerization thereof, and modifying the surface of the capsules with amine-based monomers.

Abstract: The present invention is a washing device with a handle, tensioning member, and loofah. The tensioning member is rotatably attached to the handle by means of a pivot. A plurality of capture features extend from the tensioning member, around which a rope of the loofah is configured to removably attach the loofah to the handle. The tensioning member is rotated away from the handle to expose the capture features, and is rotated towards the handle to create tension is the rope, which secures the loofah to the handle. The loofah further comprises a sponge portion which is configured against a loofah plate at a washing end of the handle. The washing device is used to wash oneself by grasping a handle portion of the handle and using the washing end of the handle with the loofah attached to wash oneself.

Abstract: A detection chip is disclosed. The detection chip includes a sample injection structure, a filter structure, and a reaction structure which are sequentially connected. The filter structure includes a first main body, and a first inlet portion and a first outlet portion respectively on two sides of the first main body. A width of the first inlet portion gradually decreases in a direction away from the first main body, and a width of the first outlet portion gradually decreases in a direction away from the first main body.

Abstract: Patients being treated successfully with a drug of abuse and at low risk for abusing the drug nevertheless may be at high risk of being misidentified as a high risk of abuse. These patients may need and benefit from treatment with the drug but restricted or cut off from the treatment altogether due to the misidentification and then abandoned. Evaluating a patient's risk of drug treatment change due to a category misidentification may include developing a model for identifying such abandoned patients, applying the model to data of a patient, and determining a patient risk score for the patient based on a result of applying the model.

Abstract: A digital radiographic detector includes a planar multilayer core having a two-dimensional array of photo-sensitive cells. An enclosure having only one open side and upper and lower halves is joined together using a three-sided bumper configured to provide impact absorption for sides of the enclosure. An end cap covers the only one open side of the enclosure.

Abstract: Certain aspects relate to systems and techniques for a medical device. The medical device can include an elongated shaft having a proximal end, a distal end, and a bendable section between the proximal end and the distal end. The medical device can include a tip assembly at the distal end of the elongated shaft. The tip assembly include a control member and a distal tip component attached to the control member. At least one cable can extend through the elongated shaft and be anchored to the control member. The at least one cable can be configured to bend the bendable section based on a force applied thereto. At least one electronic component can be embedded in the distal tip component.