Abstract: A method of identifying and quantifying copy number variations in a gene of interest for a genomic DNA sample includes (i) fragmenting a genomic DNA sample to produce a plurality of polynucleotide fragments, (ii) isolating a plurality of target polynucleotide fragments, (iii) sequencing the plurality of target polynucleotide fragments, (iv) aligning fragment sequences to a reference sequence, (v) calculating read depths for base positions of the plurality of target polynucleotide fragments, (vi) calculating copy number likelihoods for each base position of the reference sequence, (vii) performing a breakpoint analysis on a set of fragment sequences to identify at least one sequence variation located between selected breakpoint regions of the target gene and calculate modified copy number likelihoods for base positions of the reference sequence based on the at least one sequence variation, and (viii) determining whether the target gene includes at least one copy number variation.

Abstract: A method for analyzing a diagnostic test may include receiving an image depicting a diagnostic test, wherein the diagnostic test comprises a test region indicating a test result, validating quality of the image, locating a test region image portion of the image depicting the test region of the diagnostic test; and predicting the test result based on the test region image portion. Furthermore, a method for facilitating analysis of a diagnostic test may include receiving one or more images depicting one or more control markings on a scan surface, wherein the one or more control markings are representative of one or more predetermined test results for the diagnostic test, and verifying detection of the one or more control markings in the one or more images using at least one computer vision technique.

Abstract: The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state. Such probabilities can be used to inform a health care provider as to particular courses of treatment to maximize probability of a desired outcome for the subject.

Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.

Abstract: A facility for organizing worker records is configured to assist users in assigning training classes to the workers. The facility obtains new worker records identifying one or more workers and accesses existing worker records from a repository of worker records. The facility merges the new worker records and the existing worker records, and identifies duplicate records within the merged records. The facility removes the duplicate record from the merged records. The facility presents visual information describing one or more training classes which may be assigned to the one or more workers. The facility obtains user input specifying that at least one of the one or more training classes be assigned to at least one of the one or more workers.

Abstract: Certain aspects relate to systems with robotically controllable field generators and applications thereof. In one application, a robotic medical system, comprising a first robotic arm coupled to an electromagnetic (EM) field generator configured to generate an EM field, an EM sensor, and a processor. The processor may be configured to transmit a command to the first robotic arm to cause movement of the EM field generator along a robotic trajectory while the EM sensor remains at a location. An EM sensor trajectory of the EM sensor within the EM field corresponding to a period of time in which the EM field generator moved along the robotic trajectory may be detected. The robotic trajectory and the EM sensor trajectory may be analyzed to determine a difference between the robotic trajectory and the EM sensor trajectory; and EM distortion at the location may be detected comparing the difference and a threshold.

Abstract: Embodiments disclosed herein generally relate to detecting variants in a data set. A variant-specific unique data set, which includes a variant-inclusive portion that includes a particular variant and one or more other portions is accessed. The variant-specific unique data set corresponds to a particular region of a reference data set. A plurality of reads is received, with each read of the plurality of reads having been generated by processing a material collected from a subject. For each read of a subset of the plurality of reads, a first matching criterion and a second matching criterion can be determined to be satisfied, with the first matching criterion being more stringent than the second matching criterion. A data set associated with the subject can be determined to include the particular variant based on a quantity of reads in the subset. A result identified based on the particular variant can be output.

Abstract: A method for calculating a current illumination level of a target scene capable of quantitatively evaluating an illumination level in a scene through a camera, and a method for automatically adjusting an illumination level of the target scene capable of automatically performing a constant light control over a scene, and a camera, capable of quantitatively evaluating the illumination level in the scene and a smart illumination control system are provided. The smart illumination control system is capable of quantitatively evaluating the illumination level in the scene and automatically adjusting an illumination brightness, a color temperature, a color or a contrast in the scene to realize a constant control over a light environment. In addition, by setting the illumination level on a setting terminal, an illumination product also performs a light-supplementing automatically for the camera to realize a constant light control over a shooting.

Abstract: An exercise apparatus includes a motor, an operating member driven by the motor, a sensor operable to detect engagement of a user with the operating member, a controller in communication with the operating member and the sensor, and a communication interface in communication with the controller. The controller is configured to generate exercise use data in response to movement of the operating member and the sensor detecting engagement of the user with the operating unit, and the controller transmits the exercise use data to the communication interface.

Abstract: The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.

Abstract: Provided are methods of preparing organoids and compositions for use in such methods. In some embodiments, a method of depositing a plurality of the cells into a reservoir are provided, the method comprising depositing a gelatin composition into a reservoir; adding a composition comprising a plurality of cells into the gelatin composition, wherein the composition is added into the gelatin composition at a position below the surface of the gelatin composition and at least a portion of the composition and/or plurality of cells are suspended in the gelatin composition; curing at least a portion of the composition comprising the plurality of cells in the gelatin composition; and removing at least a portion of the gelatin composition in the reservoir, thereby depositing the plurality of cells in the reservoir.

Abstract: A cleaning device and a cleaner are provided. The cleaner includes the cleaning device and at least one liquid storage device. The cleaning device includes an outer housing, at least one first connecting component, a liquid spraying structure, and a liquid driving structure. The outer housing includes a liquid inlet and a liquid outlet. First connecting components having different structures and liquid storage devices having different structures are provided, one of the first connecting components is matched with a corresponding one of the liquid storage devices, and the one of the first connecting components matched with the corresponding one of the liquid storage devices is connected to the outer housing. The outer housing is connected to the first connecting components having different structures to connect to the liquid storage devices having different structures.

Abstract: An oral health device includes an oral insert and a fluid delivery system. The oral insert includes a plurality of manifolds for conveying fluid to orifices in the oral insert. The fluid delivery system including a manifold switching mechanism that selectively delivers pressurized fluid to a manifold selected from the plurality of manifolds. The manifold switching mechanism selectively aligns a gateway with one of the manifolds.

Abstract: Certain aspects relate to a handle mechanism that permits control of linear motion of a shaft secured within the handle via two different interfaces for actuating the linear motion. In some aspects, a rotational interface can allow for fine control linear positioning of the shaft, for example by allowing a user to rotate the rotational interface to extend or retract the shaft. In some aspects, a plunging interface can enable a faster linear motion, for example by implementing a biasing mechanism that releases to drive rapid linear motion.

Abstract: A device may operate a guide wire and be operable by a single operator digit. The device may include an insertion control device for advancing the guide wire in a forward and in a reverse direction and along a longitudinal axis of the guide wire; and a rotary device for rolling a guide wire about the longitudinal axis. A robotic instrument driver may be operatively coupled to the device and configured to control axial movement of the guide wire along the longitudinal axis according to input received from the insertion control device and to control rotational movement of the guide wire according to input received from the rotary device.

Abstract: Opioid-free, anesthetic, analgesic, analgesic, anti-nociceptive, anti-inflammatory, antiemetic formulations, and methods for reducing pain, controlling pain, preventing pain, reducing or eliminating exposure to opioids, decreasing nausea and vomiting, featuring administration of the anesthetic/analgesic formulations. The opioid-free/sparing anesthetic/analgesic formulations comprise a local anesthetic, a cyclooxygenase (COX) inhibitor, and an alpha agonist. The formulations may optionally comprise additional compositions including but not limited to NMDA receptor antagonists, Buprenorphine, Dexketoprofen, Carprofen, an antifibrinolytic, an antibiotic, a steroid, a cyclooxygenase 3 inhibitor, a Transient Receptor Potential Vanilloid (TRPV) receptor agonist or antagonist, a protein kinase inhibitor, a competitive or non-competitive glycine or glutamate agonist, a glutamate or glycine inhibitor or antagonist, a neurokinin-1 receptor antagonist, an alpha agonist, a second alpha agonist, and combinations thereof.