Abstract: Brain activity of a user is detected, and a mental state of the user is determined. In one technique, life/work context is automatically presented to the user in a manner that modulates the mental state of the user. In another technique, an entertainment selection is presented to the user, and an entertainment selection list is automatically modified in response to the determined mental state of the user. In still another technique, the mental state that is determined is a negative emotional state, and life/work context is automatically presented to the user in a manner that promotes a cognitive state of the user in response to the determined emotional state of the user. In yet another technique, the wellness of the user is automatically tracked over a time period based on the determined mental state.

Abstract: A mental state awareness system comprises a non-invasive brain interface assembly configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.

Abstract: A wearable system for use by a user includes a photodetector configured to detect a photon of a light pulse after the photon reflects from a target internal to the user. The photodetector includes a single photon avalanche diode (SPAD) and a capacitor configured to be charged, while the SPAD is in a disarmed state, with a bias voltage by a voltage source, and supply, when the SPAD is put in an armed state, the bias voltage to an output node of the SPAD such that a voltage across the SPAD is greater than a breakdown voltage of the SPAD.

Abstract: An exemplary non-invasive wearable brain interface system includes a headgear configured to be worn on a head of a user, a plurality of self-contained photodetector units configured to removably attach to the headgear, the photodetector units each comprising a plurality of photodetectors configured to detect photons of light after the photons reflect from a target within a brain of the use, and a master control unit coupled to each of the photodetector units and configured to control the photodetector units.

Abstract: A magnetic field measurement system that includes at least one magnetometer; at least one magnetic field generator; a processor coupled to the at least one magnetometer and the at least one magnetic field generator and configured to: measure an ambient background magnetic field using at least one of the at least one magnetometer in a first mode selected from a scalar mode or a vector mode; generate, in response to the measurement of the ambient background magnetic field, a compensation field using the at least one magnetic field generator; and measure a target magnetic field using at least one of the at least one magnetometer in a spin exchange relaxation free (SERF) mode which is different from the first mode.

Abstract: An optical measurement system and method are provided. Pump sample light and probe sample light are delivered through into an anatomical structure of a user. The anatomical structure has molecules having a resonant vibrational frequency equal to the difference between a first optical frequency of the pump sample light and a second optical frequency of the probe sample light, whereby a portion of the probe sample light is inelastically scattered by the molecules as signal light encoded with a physiological event occurring in the molecules, and whereby sample light comprising the signal light exits the anatomical structure. Signal light in the exiting sample light is detected, and an electrical signal representative of the signal light is outputted. The electrical signal is analyzed, and based on this analysis, the presence and the depth of the physiological event in the anatomical structure is determined.

Abstract: An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity.

Abstract: A mental impairment detection system and non-invasive method of detecting mental impairment of a user are provided. A test (e.g., an inhibitory reflex test or a sustained attention test) is administered to the user, brain activity in a frontal lobe of the user is non-invasively detected while the test is administered to the user, and a level of mental impairment of the user is determined based on the brain activity detected in the frontal lobe of the user.

Abstract: Described herein are systems and methods for reducing the size of data payloads delivered to downstream processing from a raw series of biological sensor recordings. In one variation, the system comprises a low-power hardware architecture that combines serially sampled neural signal data with a transformation matrix (TFM) using a novel systolic random-logic-macro (RLM) array.

Abstract: An exemplary stacked photodetector assembly includes a first wafer and a second wafer bonded to the first wafer. The first wafer includes a SPAD and has a thickness T1 configured to minimize absorption by the first wafer of photons included in light incident upon the first wafer while the SPAD is in a disarmed state. The second wafer has a thickness T2 configured to provide structural support for the first wafer. The stacked photodetector assembly includes a fast gating circuit electrically coupled to the SPAD and configured to arm and disarm the SPAD.

Abstract: An optical source sweeps a source light over an optical wavelength range. An interferometer splits the source light into sample light and reference light, delivers the sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, and combines the signal light and the reference light into an interference light pattern having an array of spatial components and a plurality of oscillation frequency components. An optical detector array detects intensity values of the array of spatial components.

Abstract: An optical measurement system comprises an optical source configured for generating source light having an optical wavelength spectrum. The optical measurement system compises an interferometer configured for splitting the source light into sample light and reference light. The interferometer is further configured for delivering the sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure. The interferometer is further configured for combining the signal light and the reference light into interference light having the optical wavelength spectrum encoded with depths of the anatomical structure. The optical measurement system further comprises a dispersive spectrometer configured for generating an optical wavelength spectrum-intensity profile from the interference light.

Abstract: In a non-invasive optical detection system and method, sample light is delivered into a scattering medium. A first portion of the sample light passing through a volume of interest exits the scattering medium as signal light, and a second portion of the sample light passing through a volume of non-interest exits the scattering medium as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to create an interference light pattern having a holographic beat component. Ultrasound is emitted into the volume of non-interest in a manner that decorrelates the background light of the sample light pattern from the holographic beat component. The holographic beat component is detected during the measurement period. An optical parameter of the volume of interest is determined based on the detected holographic beat component.

Abstract: A non-invasive optical measurement system comprises an optical source for generating source light, and an interferometer for splitting the source light into sample light and reference light, delivering the sample light into an anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, and combining the signal light and the reference light into at least three phase-modulated interference light patterns. The optical path lengths of the respective source light and sample light match within a coherence length of the source light.

Abstract: An optical measurement system comprises an optical source assembly configured for intensity modulating sample light at multiple frequencies within a frequency range, and delivering the intensity modulated sample light along an optical path of an anatomical structure during a single measurement period, such that the intensity modulated sample light is scattered by the anatomical structure, resulting in signal light that exits the anatomical structure. The optical measurement system further comprises an optical detection assembly configured for detecting the signal light over the frequency range within the measurement period. The optical measurement system further comprises a processor configured for analyzing the detected signal light, and, based on this analysis, determining an occurrence and spatial depth of a physiological event in the anatomical structure.

Abstract: A non-invasive optical measurement system comprises a two-dimensional array of photonic integrated circuits (PICs) mechanically coupled to each other. Each PIC is configured for emitting sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure. Each PIC is further configured for detecting the signal light. The non-invasive optical measurement system further comprises processing circuitry configured for analyzing the detected signal light from each of the PICs, and based on this analysis, determining an occurrence and a three-dimensional spatial location of the physiological event in the anatomical structure.

Abstract: A non-invasive optical detection system and method are provided. Sample light is delivered into a target volume of interest, whereby the sample light is scattered by the target volume of interest, resulting in a sample light pattern that exits the anatomical structure. Reference light is combined with the sample light pattern to generate at least one interference light pattern, each of which may have a time varying interference component that integrates to a first value in the absence of the physiological event, and that integrates to a second greater value in the presence of the physiological event. Intensities of spatial components of each interference light pattern are detected during a measurement period. A function of the detected spatial component intensities of the interference light pattern(s) is analyzed, and a presence of the physiological event in the target volume of interest is determined based on the analysis.

Abstract: An exemplary photodetector includes a SPAD and a capacitor. The capacitor is configured to be charged, while the SPAD is in a disarmed state, with a bias voltage by a voltage source. The capacitor is further configured to supply, when the SPAD is put in an armed state, the bias voltage to an output node of the SPAD such that a voltage across the SPAD is greater than a breakdown voltage of the SPAD.

Abstract: A non-invasive system and method. Sample light is delivered into an anatomical structure, such that a portion of the sample light passes through a target voxel comprising brain matter in the head and is scattered by the head as signal light. The signal light is detected, changes in the level of water concentration or relative water concentration of the target voxel are detected based on the detected signal light, and a level of neural activity is determined within the target voxel based on the determined changes level of the water concentration or relative water concentration of the target voxel.

Abstract: A system includes a photodetector array and a processor. The photodetector array includes a plurality of photodetectors and is configured to detect light that exits a body and output a plurality of electronic signals representative of the detected light as a function of time. The processor is configured to sample the electronic signals output by the photodetector array at a plurality of delay times during a predetermined time period to generate a sequence of frames, apply a plurality of temporal-based and spatial-based correlation measurement operations to sample values in each of the frames, generate, based on the application of the temporal-based and spatial-based correlation measurement operations to the sample values in each of the frames, a plurality of spatiotemporal correlation measure values for the light detected by the photodetector array, and include the plurality of spatiotemporal correlation measure values in a correlation map.