Abstract: A magnetic field measurement system includes at least one magnetometer; and at least one flux concentrator made of a high magnetic permeability material and configured to receive magnetic field signals from a source, to concentrate the magnetic field signals or reorient the magnetic field signals in a preselected direction, and to direct the concentrated or reoriented magnetic field signals toward at least one of the at least one magnetometer. In addition to, or as an alternative to, the flux concentrator, the system can include a passive shield made of the high magnetic permeability material. The system may also include active shielding.

Abstract: A magnetic field measurement system includes an array of magnetometers; at least one magnetic field generator configured to generate a compensation field across the array of magnetometers; and a controller coupled to the magnetometers and the at least one magnetic field generator and configured for adjusting a dynamic range and sensitivity of the array by adjusting a spatial variation of the compensation field to alter which of the magnetometers of the array operate in a measurement mode. Another magnetic field measurement system utilizes at least one magnetometer instead of the array. The controller is configured for adjusting a dynamic range and sensitivity of the array by adjusting a spatial variation of the compensation field to alter which of multiple domains within the at least one magnetometer operate in the measurement mode.

Abstract: Described herein are systems and methods for noninvasive functional brain imaging using low-coherence interferometry (e.g., for the purpose of creating a brain computer interface with higher spatiotemporal resolution). One variation of a system and method comprises optical interference components and techniques using a lock-in camera. The system comprises a light source and a processor configured to rapidly phase-shift the reference light beam across a pre-selected set of phase shifts or offsets, to store a set of interference patterns associated with each of these pre-selected phase shifts, and to process these stored interference patterns to compute an estimate of the number of photons traveling between a light source and the lock-in camera detector for which the path length falls within a user-defined path length range.

Abstract: A magnetic field measurement system that includes at least one magnetometer; at least one magnetic field generator; a processor coupled to the at least one magnetometer and the at least one magnetic field generator and configured to: measure an ambient background magnetic field using at least one of the at least one magnetometer in a first mode selected from a scalar mode or a vector mode; generate, in response to the measurement of the ambient background magnetic field, a compensation field using the at least one magnetic field generator; and measure a target magnetic field using at least one of the at least one magnetometer in a spin exchange relaxation free (SERF) mode which is different from the first mode.

Abstract: A non-invasive system and method are provided. Brain activity of a user is detected using a non-invasive brain interface when the user is exposed to an external stimulus. The user is determined to be negatively primed by the external stimulus based on the detected brain activity. An alert that the user is being negatively primed by the external stimulus is automatically provided. A tagged training session may be automatically provided to the user in response determining that the user has a negative mental state, thereby promoting a positive mental state of the user. A training session list containing the tagged training session may be automatically modified based on the determined mental state of the user.

Abstract: An exemplary photodetector system includes a photodetector and a time-to-digital converter (TDC) coupled to the photodetector. The TDC is configured to receive, during a predetermined event detection time window that commences in response to an application of a light pulse to a target, a signal triggered by an event in which the photodetector detects a photon of the light pulse after the light pulse reflects from the target. The TDC is further configured to enable, in response to the receiving the signal, a gated ring oscillator (GRO) of the TDC, measure, using the GRO, a time interval between when the event occurred and an end of the predetermined event detection time window, and determine, based on the time interval and the predetermined event detection time window, an arrival time of the photon at the photodetector.

Abstract: A wearable system includes a stacked photodetector assembly including a first wafer including a single photon avalanche diode (SPAD), the first wafer having a thickness T1 configured to minimize absorption by the first wafer of photons included in light incident upon the first wafer while the SPAD is in a disarmed state, and a second wafer having a thickness T2 including a fast gating circuit electrically coupled to the SPAD and configured to arm and disarm the SPAD, the second wafer bonded to the first wafer in a stacked configuration. The fast gating circuit includes a capacitor configured to be charged, while the SPAD is in the disarmed state, with a bias voltage by a voltage source, and supply, while the SPAD is in an armed state, the bias voltage to the SPAD such that a voltage across the SPAD is greater than a breakdown voltage of the SPAD.

Abstract: A non-invasive product customization system and a method of customizing a product formulation is provided. Brain activity of a user is detected in response to an input of a product formulation into a brain of the user via a sensory nervous system of the user. A mental state of the user is detected based on the detected brain activity. The product formulation is modified based on the determined mental state of the user. The modified product formulation may be presented to the user in a manner that modulates the mental state of the user.

Abstract: Source light having a range of optical wavelengths is generated. The source light is split into sample light and reference light. The sample light is delivered into a sample, such that the sample light is scattered by the sample, resulting in signal light that exits the sample. The signal light and the reference light are combined into an interference light pattern having optical modes, each having a direct current (DC) component and at least one alternating current (AC) component. Different subsets of the optical modes of the interference light pattern are respectively detected, and analog signals representative of the optical modes of the interference light pattern are output. Pair of the analog signals are subtracted from each other, and differential analog signals are output. The sample is analyzed based on the differential analog signals.

Abstract: The source light having a range of optical wavelengths is split into sample light and reference light. The sample light is delivered into a sample, such that the sample light is scattered by the sample, resulting in signal light that exits the sample. The signal light and the reference light are combined into an interference light pattern having optical modes having oscillation frequency components respectively corresponding to optical pathlengths extending through the sample. Different sets of the optical modes of the interference light pattern are respectively detected, and high-bandwidth analog signals representative of the optical modes of the interference light pattern are output. The high-bandwidth analog signals are parallel processed, and mid-bandwidth digital signals are output. The mid-bandwidth digital signals are processed over an i number of iterations, and a plurality of low-bandwidth digital signals are output on the ith iteration.

Abstract: Source light having a range of optical wavelengths is generated. The source light is split into sample light and reference light. The sample light is delivered into a sample, such that it is scattered by the sample, resulting in signal light that exits the sample. The signal light and reference light are combined into an interference light pattern having optical modes. Different subsets of the optical modes of the interference light pattern are respectively detected, and high-bandwidth analog signals respectively corresponding to the different subsets of optical modes of the interference light pattern are output. At least one characteristic is extracted from each of the plurality of high-bandwidth analog signals, and low-bandwidth digital signals respectively comprising the extracted characteristics are output. The sample is analyzed based on the low-bandwidth digital signals.

Abstract: Brain activity of a user is detected, and a mental state of the user is determined. In one technique, life/work context is automatically presented to the user in a manner that modulates the mental state of the user. In another technique, an entertainment selection is presented to the user, and an entertainment selection list is automatically modified in response to the determined mental state of the user. In still another technique, the mental state that is determined is a negative emotional state, and life/work context is automatically presented to the user in a manner that promotes a cognitive state of the user in response to the determined emotional state of the user. In yet another technique, the wellness of the user is automatically tracked over a time period based on the determined mental state.

Abstract: A mental state awareness system comprises a non-invasive brain interface assembly configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.

Abstract: A wearable system for use by a user includes a photodetector configured to detect a photon of a light pulse after the photon reflects from a target internal to the user. The photodetector includes a single photon avalanche diode (SPAD) and a capacitor configured to be charged, while the SPAD is in a disarmed state, with a bias voltage by a voltage source, and supply, when the SPAD is put in an armed state, the bias voltage to an output node of the SPAD such that a voltage across the SPAD is greater than a breakdown voltage of the SPAD.

Abstract: An exemplary non-invasive wearable brain interface system includes a headgear configured to be worn on a head of a user, a plurality of self-contained photodetector units configured to removably attach to the headgear, the photodetector units each comprising a plurality of photodetectors configured to detect photons of light after the photons reflect from a target within a brain of the use, and a master control unit coupled to each of the photodetector units and configured to control the photodetector units.

Abstract: A magnetic field measurement system that includes at least one magnetometer; at least one magnetic field generator; a processor coupled to the at least one magnetometer and the at least one magnetic field generator and configured to: measure an ambient background magnetic field using at least one of the at least one magnetometer in a first mode selected from a scalar mode or a vector mode; generate, in response to the measurement of the ambient background magnetic field, a compensation field using the at least one magnetic field generator; and measure a target magnetic field using at least one of the at least one magnetometer in a spin exchange relaxation free (SERF) mode which is different from the first mode.

Abstract: An optical measurement system and method are provided. Pump sample light and probe sample light are delivered through into an anatomical structure of a user. The anatomical structure has molecules having a resonant vibrational frequency equal to the difference between a first optical frequency of the pump sample light and a second optical frequency of the probe sample light, whereby a portion of the probe sample light is inelastically scattered by the molecules as signal light encoded with a physiological event occurring in the molecules, and whereby sample light comprising the signal light exits the anatomical structure. Signal light in the exiting sample light is detected, and an electrical signal representative of the signal light is outputted. The electrical signal is analyzed, and based on this analysis, the presence and the depth of the physiological event in the anatomical structure is determined.

Abstract: An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity.

Abstract: A mental impairment detection system and non-invasive method of detecting mental impairment of a user are provided. A test (e.g., an inhibitory reflex test or a sustained attention test) is administered to the user, brain activity in a frontal lobe of the user is non-invasively detected while the test is administered to the user, and a level of mental impairment of the user is determined based on the brain activity detected in the frontal lobe of the user.

Abstract: Described herein are systems and methods for reducing the size of data payloads delivered to downstream processing from a raw series of biological sensor recordings. In one variation, the system comprises a low-power hardware architecture that combines serially sampled neural signal data with a transformation matrix (TFM) using a novel systolic random-logic-macro (RLM) array.