Abstract: A construction machine is capable of preventing degradation in efficiency of excavation work while preventing an increase in excavation resistance in the excavation work. A controller of a construction machine determines an accommodation state of earth and sand accommodated in a bucket, and outputs a resistance reduction command signal that is a command signal for operating a work device such that the bucket is displaced in a resistance reduction direction that is a direction where excavation resistance acting on the bucket is capable of being reduced, in accordance with a result of determining the accommodation state.

Abstract: A hydraulic excavator specifies acceleration data being operation data in an acceleration period of a manipulation target and deceleration data being operation data in a deceleration period of the manipulation target among operation data, calculates, on the basis of the acceleration data and acceleration evaluation data, an acceleration evaluation value indicating a skill of an operator in the acceleration period, calculates, on the basis of the deceleration data and deceleration evaluation data, a deceleration evaluation value indicating a skill of the operator in the deceleration period, determines, on the basis of the acceleration evaluation value and the deceleration evaluation value, a manipulation type of the operator, and outputs support information associated with the manipulation type.

Abstract: An automatic operating device includes: a position estimation part that includes an interaction model, and calculates, as estimative position data, actual position data corresponding to force data which is input; a force computation part that includes a force computation model, calculates force data corresponding to a deviation which is input, and inputs the force data to the position estimation part; a database that stores a base parameter that is a parameter having been calculated in past; and a parameter setting part that calculates, on the basis of the base parameter, a target parameter corresponding to each of a norm y(t) of an actual position and a norm u(t) of a force, and sets the target parameter to a parameter of each of the interaction model and the force computation model.

Abstract: Provided is a control device capable of operating a work machine in cooperation with an operator while performing appropriate work support according to the skill level of the operator. The control device includes a work operation device and a control unit. The control unit controls a work attachment by setting an input amount of a command input to a work drive device by changing each of a designation operation amount that is an operation amount corresponding to a designation operation by a worker and a support operation amount that is an operation amount of a support operation for moving the work attachment along a target motion according to an assist rate for supporting an operation of the worker, and setting the assist rate so that a difference between the target motion and an actual motion decreases from a detection result of the actual motion of the work attachment.

Abstract: A bucket information acquisition device for acquiring information regarding the shape of a bucket that rotates about a rotational center axis along a predetermined moving plane in a construction machine includes: a distance distribution acquisition unit that acquires the three-dimensional distance distribution of the bucket with respect to a reference point; a reference cross section extraction unit that extracts, from the distance distribution acquired by the distance distribution acquisition unit, a reference cross section which is a cross section of the bucket obtained by cutting the bucket along a plane parallel to the moving plane; an approximate line identification unit that identifies, based on the reference cross section, an approximate line approximating the reference cross section composed of a straight line and a curve; and a bucket shape calculation unit that calculates bucket shape information regarding the shape of the bucket based on the approximate line.

Abstract: The purpose of the present invention is to provide sperm having high motility. The present invention is a sperm treatment composition that contains an exosome. A sperm treatment composition according to the present invention is used as a sperm preparation solution, a sperm diluent, a sperm storage solution, an artificial insemination solution, an in vitro fertilization solution, a sperm motility improving solution, or a sperm fertility maintaining solution.

Abstract: Provided is means for achieving increase in the amounts of triacylglycerol accumulated in algae with high lipid accumulation. An alga having the following characteristics (1) and (2): (1) having reduced expression of a class 3 lipase gene; and (2) having reduced expression of an SPX2 gene.

Abstract: Provided is means for achieving increase in the amounts of triacylglycerol accumulated in algae with high lipid accumulation. An alga having the following characteristics (1) and (2): (1) having reduced expression of a class 3 lipase gene; and (2) having an exogenous diacylglycerol acyltransferase gene introduced or having enhanced expression of an endogenous diacylglycerol acyltransferase gene.

Abstract: The purpose of the present invention is to provide an excellent infertility treatment with which it is possible to increase the implantation rate of an embryo (fertilized egg) by improving the uterine environment. The present invention is a uterine treatment composition containing a mesenchymal stem cell culture supernatant, and is used as a uterine environment-improving agent, an implantation aid, an embryo transplant liquid, a sperm transplantation liquid, or an implantation rate-improving agent. The mesenchymal stem cells are preferably derived from adipose tissue, umbilical cord tissue, or bone marrow tissue.

Abstract: A control device includes: a static compensator that calculates, on the basis of a static parameter, a static compensatory input; a dynamic compensator that calculates, on the basis of a dynamic parameter, a dynamic compensatory input; a subtractor that calculates an actual input by synthesizing the static compensatory input and the dynamic compensatory input; an ideal output calculator that calculates an ideal output responsive to a control input by using an input and output model defining an ideal input and output relation between a control input and a control output; and a parameter adjuster that adjusts the static parameter and the dynamic parameter to minimize a difference between the control output and the ideal output.

Abstract: Therapeutic agents and treatment methods for urologic cancers, particularly urologic cancers with reduced lysine (K)-specific demethylase 6A (KDM6A) function, the agents and methods being characterized by suppressing both IL-6 activity and CCR2/CCL2 activity, are provided.

Abstract: Objective discrimination of a disease label of a depressive symptom with respect to an active state of a brain is achieved. One means for solving the problems of the present invention is to provide a discriminating device for assisting in determination of whether a subject has a depressive symptom. The discriminating device includes a storage device for storing information for identifying a classifier generated by classifier generation processing based on a signal obtained by using a brain activity detecting apparatus to measure, in advance and time-sequentially, a signal indicating a brain activity of a plurality of predetermined regions of each brain of a plurality of participants in a resting state, the plurality of participants including healthy individuals and patients with depression.

Abstract: An object of the present invention is to provide a cell penetrating peptide having a penetrating ability into cells. The present inventors provided a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 2 and a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 3; and a complex comprising any one of the cell penetrating peptide and a functional molecule.

Abstract: A device for controlling percutaneously extracellular impedance according to an aspect of the present disclosure includes a terminal pair to which an electrode pair is to be connected, the electrode pair being attached to a subject's body surface to capture a subject's bioelectrical potential, wherein the device adds negative impedance of which resistance and reactance components are adjustable to the electrode pair via the terminal pair.

Abstract: A controller includes a drive part, a posture information acquisition part, and a control part, the control part calculates a gravity center velocity of a working device on the basis of posture information about the working device detected by the posture information acquisition part and calculates a target gravity center velocity being a target value of the gravity center velocity on the basis of a difference between a grounding work to be exerted to the ground by the working device and a target grounding work, and provides a feedback correction to an instruction signal to make the gravity center velocity approach the target gravity center velocity and inputs the corrected instruction signal into the drive part.

Abstract: The purpose of the present invention is to provide an agent for improving intestinal flora, the agent being capable of improving intestinal flora by increasing the number of bacteria belonging to the genus Bifidobacterium and/or the genus Lactobacillus in the intestines. In the present invention, an enzyme-containing substance derived from fungi belonging to the genus Penicillium increases the number of both bacteria belonging to the genus Bifidobacterium and bacteria belonging to the genus Lactobacillus in the intestines, and is capable of exhibiting the excellent effect of improving the intestinal flora.

Abstract: A measurement device is configured to calculate, based on second measurement data provided by a distance detector, second contour data indicating a surface contour of an object contained in the container at a second time after a first time; calculate differential information indicating a difference between first posture data and second posture data which is posture data provided by a posture detector at the second time; rotate, based on the differential information, the second contour data in a three-dimensional coordinate space of the distance detector; and specify a region defined by the rotated second contour data and the first contour data, and calculate, based on the specified region, a volume of the object contained in the container at the second time.

Abstract: The object of the present invention is to provide a method for producing a silicon film having high uniformity of film thickness or high step coverage through reduction of the thermal history of a cyclic silane compound. The present invention relates to a method for producing a silicon film, including the steps of heating a substrate inserted into a reactor of a cold-wall type thermal CVD system, supplying the cyclic silane compound to the reactor, and forming the silicon film on the substrate.

Abstract: The present invention aims to provide a meniscus regeneration material having high meniscus regeneration ability.

Abstract: Improved nerve regeneration scaffolds are disclosed, which include a plurality of modified nanotube yarn bundles disposed of within the scaffold lumen. The modified nanotube yarn bundles have enhanced hydrophilicity and water absorption. They are separated by distances to form channels corresponding to nerve fiber diameters to be occupied by regenerative nerve tissues. The channel walls have gaps between the yarn bundles for enhanced permeability. The scaffolds have reduced inflammatory infiltration and rejection response and support individual nerve fiber regrowth with a reduced likelihood of undesirable outcomes, such as nerve pain or reduced nerve function.