Patents Assigned to Hiroshima University
  • Patent number: 12668954
    Abstract: A bucket information acquisition device for acquiring information regarding the shape of a bucket that rotates about a rotational center axis along a predetermined moving plane in a construction machine includes: a distance distribution acquisition unit that acquires the three-dimensional distance distribution of the bucket with respect to a reference point; a reference cross section extraction unit that extracts, from the distance distribution acquired by the distance distribution acquisition unit, a reference cross section which is a cross section of the bucket obtained by cutting the bucket along a plane parallel to the moving plane; an approximate line identification unit that identifies, based on the reference cross section, an approximate line approximating the reference cross section composed of a straight line and a curve; and a bucket shape calculation unit that calculates bucket shape information regarding the shape of the bucket based on the approximate line.
    Type: Grant
    Filed: September 21, 2022
    Date of Patent: June 30, 2026
    Assignees: HIROSHIMA UNIVERSITY, KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Ryota Hashimoto, Yasuhiko Shimazu, Takunori Yamaguchi, Sho Okimoto
  • Publication number: 20260167924
    Abstract: The purpose of the present invention is to provide sperm having high motility. The present invention is a sperm treatment composition that contains an exosome. A sperm treatment composition according to the present invention is used as a sperm preparation solution, a sperm diluent, a sperm storage solution, an artificial insemination solution, an in vitro fertilization solution, a sperm motility improving solution, or a sperm fertility maintaining solution.
    Type: Application
    Filed: October 31, 2023
    Publication date: June 18, 2026
    Applicants: HIROSHIMA UNIVERSITY, ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Masayuki SHIMADA, Takashi UMEHARA, Noriyasu ISHIKAWA, Takashi TAKIJIRI
  • Publication number: 20260167921
    Abstract: Provided is means for achieving increase in the amounts of triacylglycerol accumulated in algae with high lipid accumulation. An alga having the following characteristics (1) and (2): (1) having reduced expression of a class 3 lipase gene; and (2) having reduced expression of an SPX2 gene.
    Type: Application
    Filed: December 10, 2025
    Publication date: June 18, 2026
    Applicants: PHYTOLIPID TECHNOLOGIES CO., LTD., HIROSHIMA UNIVERSITY, MAZDA MOTOR CORPORATION
    Inventors: Hiroyuki OHTA, Mie SHIMOJIMA, Masako IWAI, Atsushi SAKAMOTO, Takashi YAMAMOTO, Kumiko OKAZAKI, Tomokazu KURITA, Shinichiro MAEDA
  • Publication number: 20260167996
    Abstract: Provided is means for achieving increase in the amounts of triacylglycerol accumulated in algae with high lipid accumulation. An alga having the following characteristics (1) and (2): (1) having reduced expression of a class 3 lipase gene; and (2) having an exogenous diacylglycerol acyltransferase gene introduced or having enhanced expression of an endogenous diacylglycerol acyltransferase gene.
    Type: Application
    Filed: December 10, 2025
    Publication date: June 18, 2026
    Applicants: PHYTOLIPID TECHNOLOGIES CO., LTD., HIROSHIMA UNIVERSITY, MAZDA MOTOR CORPORATION
    Inventors: Hiroyuki OHTA, Mie SHIMOJIMA, Masako IWAI, Natsuko KATO, Atsushi SAKAMOTO, Takashi YAMAMOTO, Kumiko OKAZAKI, Tomokazu KURITA, Shinichiro MAEDA
  • Publication number: 20260166086
    Abstract: The purpose of the present invention is to provide an excellent infertility treatment with which it is possible to increase the implantation rate of an embryo (fertilized egg) by improving the uterine environment. The present invention is a uterine treatment composition containing a mesenchymal stem cell culture supernatant, and is used as a uterine environment-improving agent, an implantation aid, an embryo transplant liquid, a sperm transplantation liquid, or an implantation rate-improving agent. The mesenchymal stem cells are preferably derived from adipose tissue, umbilical cord tissue, or bone marrow tissue.
    Type: Application
    Filed: October 31, 2023
    Publication date: June 18, 2026
    Applicants: HIROSHIMA UNIVERSITY, ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Masayuki SHIMADA, Takashi UMEHARA, Noriyasu ISHIKAWA, Takashi TAKIJIRI
  • Patent number: 12625476
    Abstract: A control device includes: a static compensator that calculates, on the basis of a static parameter, a static compensatory input; a dynamic compensator that calculates, on the basis of a dynamic parameter, a dynamic compensatory input; a subtractor that calculates an actual input by synthesizing the static compensatory input and the dynamic compensatory input; an ideal output calculator that calculates an ideal output responsive to a control input by using an input and output model defining an ideal input and output relation between a control input and a control output; and a parameter adjuster that adjusts the static parameter and the dynamic parameter to minimize a difference between the control output and the ideal output.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: May 12, 2026
    Assignees: HIROSHIMA UNIVERSITY, KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Shin Wakitani, Toru Yamamoto
  • Patent number: 12583918
    Abstract: Therapeutic agents and treatment methods for urologic cancers, particularly urologic cancers with reduced lysine (K)-specific demethylase 6A (KDM6A) function, the agents and methods being characterized by suppressing both IL-6 activity and CCR2/CCL2 activity, are provided.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: March 24, 2026
    Assignees: Tokyo Women's Medical University, Hiroshima University, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hiroaki Honda, Kohei Kobatake
  • Patent number: 12573042
    Abstract: Objective discrimination of a disease label of a depressive symptom with respect to an active state of a brain is achieved. One means for solving the problems of the present invention is to provide a discriminating device for assisting in determination of whether a subject has a depressive symptom. The discriminating device includes a storage device for storing information for identifying a classifier generated by classifier generation processing based on a signal obtained by using a brain activity detecting apparatus to measure, in advance and time-sequentially, a signal indicating a brain activity of a plurality of predetermined regions of each brain of a plurality of participants in a resting state, the plurality of participants including healthy individuals and patients with depression.
    Type: Grant
    Filed: April 22, 2024
    Date of Patent: March 10, 2026
    Assignees: ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL, HIROSHIMA UNIVERSITY
    Inventors: Giuseppe Lisi, Jun Morimoto, Mitsuo Kawato, Takashi Yamada, Naho Ichikawa, Yasumasa Okamoto
  • Patent number: 12559522
    Abstract: An object of the present invention is to provide a cell penetrating peptide having a penetrating ability into cells. The present inventors provided a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 2 and a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 3; and a complex comprising any one of the cell penetrating peptide and a functional molecule.
    Type: Grant
    Filed: May 10, 2024
    Date of Patent: February 24, 2026
    Assignees: Astellas Pharma Inc., National Center for Global Health and Medicine, Hiroshima University
    Inventors: Hideki Endo, Yukihito Ishizaka, Akira Ishiguro, Tomoki Takashina, Takashi Yamamoto, Tetsushi Sakuma
  • Patent number: 12533514
    Abstract: A device for controlling percutaneously extracellular impedance according to an aspect of the present disclosure includes a terminal pair to which an electrode pair is to be connected, the electrode pair being attached to a subject's body surface to capture a subject's bioelectrical potential, wherein the device adds negative impedance of which resistance and reactance components are adjustable to the electrode pair via the terminal pair.
    Type: Grant
    Filed: September 28, 2023
    Date of Patent: January 27, 2026
    Assignee: HIROSHIMA UNIVERSITY
    Inventor: Ayumu Matani
  • Patent number: 12534886
    Abstract: A controller includes a drive part, a posture information acquisition part, and a control part, the control part calculates a gravity center velocity of a working device on the basis of posture information about the working device detected by the posture information acquisition part and calculates a target gravity center velocity being a target value of the gravity center velocity on the basis of a difference between a grounding work to be exerted to the ground by the working device and a target grounding work, and provides a feedback correction to an instruction signal to make the gravity center velocity approach the target gravity center velocity and inputs the corrected instruction signal into the drive part.
    Type: Grant
    Filed: December 28, 2022
    Date of Patent: January 27, 2026
    Assignees: HIROSHIMA UNIVERSITY, KOBELCO CONSTRUCTION MACHINERY CO. , LTD.
    Inventors: Masatoshi Kozui, Toru Yamamoto, Hideo Yoshihara, Kazushige Koiwai
  • Publication number: 20260021166
    Abstract: The purpose of the present invention is to provide an agent for improving intestinal flora, the agent being capable of improving intestinal flora by increasing the number of bacteria belonging to the genus Bifidobacterium and/or the genus Lactobacillus in the intestines. In the present invention, an enzyme-containing substance derived from fungi belonging to the genus Penicillium increases the number of both bacteria belonging to the genus Bifidobacterium and bacteria belonging to the genus Lactobacillus in the intestines, and is capable of exhibiting the excellent effect of improving the intestinal flora.
    Type: Application
    Filed: July 18, 2023
    Publication date: January 22, 2026
    Applicants: AMANO ENZYME INC., Hiroshima University, KEIO University
    Inventors: Manabu Kuroda, Shotaro Yamaguchi, Norihisa Kato, Thanutchaporn Kumrungsee, Yongshou Yang, Shinji Fukuda
  • Patent number: 12529211
    Abstract: A measurement device is configured to calculate, based on second measurement data provided by a distance detector, second contour data indicating a surface contour of an object contained in the container at a second time after a first time; calculate differential information indicating a difference between first posture data and second posture data which is posture data provided by a posture detector at the second time; rotate, based on the differential information, the second contour data in a three-dimensional coordinate space of the distance detector; and specify a region defined by the rotated second contour data and the first contour data, and calculate, based on the specified region, a volume of the object contained in the container at the second time.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: January 20, 2026
    Assignees: KOBELCO CONSTRUCTION MACHINERY CO. , LTD., HIROSHIMA UNIVERSITY
    Inventors: Yukihiro Hoso, Sho Fujiwara, Yusuke Funahara, Toru Tamaki
  • Publication number: 20260002256
    Abstract: The object of the present invention is to provide a method for producing a silicon film having high uniformity of film thickness or high step coverage through reduction of the thermal history of a cyclic silane compound. The present invention relates to a method for producing a silicon film, including the steps of heating a substrate inserted into a reactor of a cold-wall type thermal CVD system, supplying the cyclic silane compound to the reactor, and forming the silicon film on the substrate.
    Type: Application
    Filed: June 27, 2023
    Publication date: January 1, 2026
    Applicants: NIPPON SHOKUBAI CO., LTD., HIROSHIMA UNIVERSITY
    Inventors: Tetsuya YAMAMOTO, Takashi ABE, Tatsuhiko AKIYAMA, Akinobu TERAMOTO
  • Publication number: 20250387539
    Abstract: The present invention aims to provide a meniscus regeneration material having high meniscus regeneration ability.
    Type: Application
    Filed: September 3, 2025
    Publication date: December 25, 2025
    Applicants: HIROSHIMA UNIVERSITY, SANYO CHEMICAL INDUSTRIES, LTD.
    Inventors: Nobuo ADACHI, Naosuke KAMEI, Masakazu ISHIKAWA, Tomoyuki NAKASA, Shingo KAWABATA, Tsubasa YAMANAKA
  • Publication number: 20250345491
    Abstract: Improved nerve regeneration scaffolds are disclosed, which include a plurality of modified nanotube yarn bundles disposed of within the scaffold lumen. The modified nanotube yarn bundles have enhanced hydrophilicity and water absorption. They are separated by distances to form channels corresponding to nerve fiber diameters to be occupied by regenerative nerve tissues. The channel walls have gaps between the yarn bundles for enhanced permeability. The scaffolds have reduced inflammatory infiltration and rejection response and support individual nerve fiber regrowth with a reduced likelihood of undesirable outcomes, such as nerve pain or reduced nerve function.
    Type: Application
    Filed: August 25, 2023
    Publication date: November 13, 2025
    Applicants: LINTEC OF AMERICA, INC., HIROSHIMA UNIVERSITY
    Inventors: Akira KODAMA, Masakazu ISHIKAWA, Takahiro UEDA, Marcio D. LIMA
  • Patent number: 12427228
    Abstract: The present invention provides a meniscus regeneration material having high meniscus regeneration ability. The meniscus regeneration material includes protein (A), which has a total percentage of ?-turns and random coils of 60 to 85% as determined by circular dichroism spectroscopy, and the meniscus regeneration material may further include meniscus tissue fragment (B). The present invention also provides the use of the meniscus regeneration material for promoting meniscus regeneration and treating meniscus damage, cartilage defects, or osteoarthritis.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: September 30, 2025
    Assignees: HIROSHIMA UNIVERSITY, SANYO CHEMICAL INDUSTRIES, LTD.
    Inventors: Nobuo Adachi, Naosuke Kamei, Masakazu Ishikawa, Tomoyuki Nakasa, Shingo Kawabata, Tsubasa Yamanaka
  • Patent number: 12416737
    Abstract: A neutron detection element 100 includes: a neutron detector configured to detect a neutron and convert the neutron into an electrical signal; and an amplifier configured to amplify an output of the neutron detector. The neutron detector includes: a semiconductor layer of a first conductivity type; a detector diffusion layer of a second conductivity type in the semiconductor layer; and a neutron conversion layer on the detector diffusion layer. The neutron conversion layer converts a neutron into an ?-ray. The amplifier includes a plurality of transistors in the semiconductor layer. The neutron conversion layer is a metal film including a layer containing boron 10 or a layer containing lithium 6.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: September 16, 2025
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Shinichiro Kuroki, Manabu Taniguchi, Kenta Nishigaito, Tatsuya Meguro
  • Patent number: 12392112
    Abstract: A system capable of improving accuracy of information relating to the degree of instability of a work machine such as an excavator, the information being provided to an operator of the work machine. Instability degree information, which indicates instability degrees Is1, Is2 of a base body (lower traveling body 410 and upper turning body 420) for which instability values have been assessed as continuous variables, is output to a remote image output device 221 (information output device) such that the form of the output varies continuously depending on continuous changes in the instability degrees Is1, Is2. An operator of a work machine 40 can highly accurately recognize the closeness of the current instability degree of the base body to a threshold value at which the base body becomes unstable, and consequently a tolerable range in which the work mechanism, etc. are operated while avoiding instability of the base body.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: August 19, 2025
    Assignees: Kobelco Construction Machinery Co., Ltd., Hiroshima University
    Inventors: Masaru Ito, Yuichi Kurita
  • Publication number: 20250243088
    Abstract: It is an object of the present invention to provide a method for water clarification and greening that can simply and efficiently adsorb and remove nitrogen and/or phosphorus in a smaller horizontal area than in conventional methods, and that exhibits improved water clarification performance per unit area. It is also an object of the present invention to provide a method for water clarification and greening that can stably adsorb and remove nitrogen and/or phosphorus not only in summer but also in winter.
    Type: Application
    Filed: June 9, 2023
    Publication date: July 31, 2025
    Applicants: FujiClean Co., Ltd., HIROSHIMA UNIVERSITY, THE CHUGOKU ELECTRIC POWER CO., INC.
    Inventors: Tsuyoshi ICHINARI, Hiroyuki SAITO, Akiko NAGAOKA, Mayu ISHIDA, Satoshi ASAOKA, Shota MIYAMOTO