Abstract: The present invention provides a novel antisense oligonucleotide and a composition for preventing or treating glycogen storage disease type Ia. The present invention provides an antisense oligonucleotide which hybridizes with a pre-mRNA sequence derived from a region including at least one of a base at position 42911000, a base at position 42911004, and a base at position 42911005 in a base sequence of human chromosome 17 of GRCh38/hg38 and has activity to inhibit aberrant splicing of pre-mRNA of c.648G>T variant G6PC.

Abstract: A pump control device and a valve control device each includes: an instruction calculator that calculates a control instruction of causing a controlled object to operate by using a manipulation amount of a manipulation and at least one control parameter, and inputs the calculated control instruction to the controlled object; and an ideal output calculator that calculates an ideal output of an actuator, the ideal output being associated with the manipulation amount of the manipulation. The pump control device adjusts at least one pump control parameter to reduce a difference between a control output and the ideal output when an operation of a movable part is a power running operation. The valve control device adjusts at least one valve control parameter to reduce a difference between a control output and the ideal output when the operation of the movable part is a non-power running operation.

Abstract: A device for controlling percutaneously extracellular impedance according to an aspect of the present disclosure includes a terminal pair to which an electrode pair is to be connected, the electrode pair being attached to a subject's body surface to capture a subject's bioelectrical potential, wherein the device adds negative impedance of which resistance and reactance components are adjustable to the electrode pair via the terminal pair.

Abstract: Based on operation trajectory data an operation analysis device identifies all open points indicating positions at which the crusher is opened during the operation period and all close points indicating positions at which a crusher is closed during an operation period, calculates, as a shortest distance, a distance between each open point of the all open points and a close point nearest to the each open point, and identifies, as a sorting destination open point, an open point at which the shortest distance exceeds a first threshold value, identifies data until the crusher grasping the dismantling part moves to the sorting destination and returns to the dismantling target again from among the operation trajectory data as movement data of the crusher having moved in the dismantling operation, and identifies data in which the movement data has been removed from the operation trajectory data as grasping operation data.

Abstract: Blood pressure is estimated in a non-constraining manner continuously and in real time. A biological signal collected from a person's dorsal part is analyzed, vibration in the human body ascribable to a blood flow rate change in a period from the ventricular filling period to the isovolumetric systole is captured, and the state of fluctuation of an index indicating the state of the in vivo vibration is further captured. This fluctuation index correlates with a person's blood pressure. Therefore, it is possible to estimate whether the blood pressure is in a range indicating a normal-range blood pressure or in a range indicating a high blood pressure, only by having the person sit or lie supine on a surface provided with a biological signal measurement device to measure a biological signal in a non-constraining manner, so as to make the biological signal measurement device contiguous with the person's dorsal part.

Abstract: A sensibility meter detects biometric information relating to an operator corresponding to an output from a target appliance, and determines a comfort level of the operator based on the biometric information. A first control unit determines a second target value relating to the output based on a difference between a first target value relating to the comfort level and the comfort level. A second control unit determines a control input to the target appliance based on a difference between the second target value and the output. A ? setting unit performs weighting corresponding to an operation level of the operator, for an operation input to the target appliance by the operator, and for the control input. An adder adds the weighted operation input and control input, and inputs the resultant to the target appliance.

Abstract: A mechanical measuring device includes a body case, a probe 10 extending from the body case and abutting against a predetermined portion of a biological soft tissue, a load measuring means 12 which is integrally connected to the probe 10 and which measures a load applied to the biological soft tissue by the probe 10, a moving means 14 for moving the probe 10 at a constant speed, and a distance measuring means 20 for measuring a moving distance by the moving means 14, and in a measuring operation of the biological soft tissue such as muscle and cartilage, the load applied to the biological soft tissue and the moving distance of the probe 10 are simultaneously measured in a state where the probe 10 is moved at a constant speed, thereby realizing inspection and diagnose of a mechanical state of the biological soft tissue.

Abstract: A blood pressure measuring apparatus includes a pressure control unit that controls an applied pressure applied to a region of a living body in which a vein and artery exist by a cuff mountable to the region, a detection unit that detects pressure waveforms in which pulse wave components from the region overlap with the applied pressure, and an analysis unit that obtains a respiratory variation on the waveform of artery and a venous pressure based on the pressure waveforms detected by the detection unit through one-time blood pressure measurement. The analysis unit obtains the respiratory variation on the waveform of artery based on data of a first pressure waveform in a first process, and the venous pressure based on data of a second pressure waveform in a second process and the data of the first pressure waveform.

Abstract: A plant vitality adjuvant for suppressing bacterial wilt disease of plants is provided, the plant vitality adjuvant containing, as a main raw material, a fermented composition obtained by fermenting and aging a plurality of items belonging to fruits, citrus fruits, burdock and carrot belonging to edible roots, grains, sesames, seaweed, and saccharides.

Abstract: A neutron detection element 100 includes: a neutron detector configured to detect a neutron and convert the neutron into an electrical signal; and an amplifier configured to amplify an output of the neutron detector. The neutron detector includes: a semiconductor layer of a first conductivity type; a detector diffusion layer of a second conductivity type in the semiconductor layer; and a neutron conversion layer on the detector diffusion layer. The neutron conversion layer converts a neutron into an ?-ray. The amplifier includes a plurality of transistors in the semiconductor layer. The neutron conversion layer is a metal film including a layer containing boron 10 or a layer containing lithium 6.

Abstract: [Problem] To develop novel therapeutic agents for viral diseases such as coronavirus infections. [Solution] The present invention provides a therapeutic or prophylactic agent for viral diseases containing a compound with inhibitory activity against the function of Pin1 or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: Provided is a Fe-based sintered body which has both of a high hardness and a high thermal conductivity and which can be more stably produced. The Fe-based sintered body includes: a matrix (1) containing Fe as a main component; and a hard phase (4) dispersed in the matrix (1). The matrix (1) is formed in a network shape and contains ?Fe. The hard phase (4) contains TiC.

Abstract: A control device includes: a static compensator that calculates, on the basis of a static parameter, a static compensatory input; a dynamic compensator that calculates, on the basis of a dynamic parameter, a dynamic compensatory input; a subtractor that calculates an actual input by synthesizing the static compensatory input and the dynamic compensatory input; an ideal output calculator that calculates an ideal output responsive to a control input by using an input and output model defining an ideal input and output relation between a control input and a control output; and a parameter adjuster that adjusts the static parameter and the dynamic parameter to minimize a difference between the control output and the ideal output.

Abstract: A construction machine includes: a lower travelling body; an upper slewing body attached to the lower travelling body with a structure allowing the upper slewing body to slew with respect to the lower travelling body; a work device attached to the upper slewing body with a structure allowing the work device to swing in a vertical direction with respect to the upper slewing body; a motion state acquisition unit acquiring a motion state amount; an equivalent system forming unit which forms a transfer function which uses a driving force for moving the work device as an input and uses the motion state amount as an output as an equivalent system which equivalently expresses an operation of the work device; and a parameter estimation unit which estimates a system attenuation coefficient and a natural angular frequency of the transfer function as an operation skill evaluation value.

Abstract: An automatic operating device includes: a position estimation part that includes an interaction model, and calculates, as estimative position data, actual position data corresponding to force data which is input; a force computation part that includes a force computation model, calculates force data corresponding to a deviation which is input, and inputs the force data to the position estimation part; a database that stores a base parameter that is a parameter having been calculated in past; and a parameter setting part that calculates, on the basis of the base parameter, a target parameter corresponding to each of a norm y(t) of an actual position and a norm u(t) of a force, and sets the target parameter to a parameter of each of the interaction model and the force computation model.

Abstract: A method for improving intestinal flora increases the number of beneficial bacteria such as lactic acid bacteria and Bifidobacterium to improve intestinal flora by using an enzyme. The method involves providing a protease, which is a polypeptide having an amino acid sequence shown in SEQ ID NO: 1 that can increase beneficial bacteria such as lactic acid bacteria and Bifidobacterium in intestines to exert an excellent effect of improving intestinal flora.

Abstract: A sorting destination determining device extracts first records indicating a reversal to a slewing direction of a slewing body, extracts from records before the first records a second record indicating opening of an opening/closing state, extracts from the first records a third record immediately before which the second record is registered, and determines a sorting destination of a dismantled part on the basis of a slewing angle registered in the third record.

Abstract: A construction machine is capable of reducing a decrease in work efficiency due to maintenance for capturing dust. The construction machine includes: an engine; a heat exchanger; a cooling fan that sucks air into an engine chamber to pass the air through the heat exchanger; an intake chamber independent of the engine chamber; an intake tube connected to the intake chamber; and a dust receiving part. The intake tube has a curved part, which has an outside inner wall surface allowing dust in the air to contact it. The dust receiving part is located downstream of the outside inner wall surface to be capable of receiving dust.

Abstract: A method for editing a target DNA comprising: a step of bringing (1) a fusion protein containing a TALE and a nucleic acid base converting enzyme and (2) a CRISPR-Cas9 system containing a Cas9 protein which has lost part or all of a nuclease activity and a guide RNA thereof into contact with a target DNA to edit a base in a target site of the target DNA by using a nucleic acid base converting enzyme activity of the fusion protein, wherein a TALE recognition sequence recognized by the TALE in the fusion protein or a complementary sequence thereof is present on a 5? side of the target site via a spacer 1 having a chain length of 7 to 31 bp, and a guide RNA-target sequence recognized by the guide RNA in the CRISPR-Cas9 system is present to contain a complementary base of the target site.

Abstract: The present disclosure provides a technique whereby the influence of an endogenous TCR is eliminated in TCR gene transfer. A TCR gene is edited using a genome editing enzyme, said genome editing enzyme having one characteristic that amino acids at two specific positions in DNA-binding modules contained in a DNA-binding domain thereof show repeating patterns which differ from one module to another among the four DNA-binding modules. Thus, a lowering in the expression efficiency of the transferred TCR caused by mispairing with an endogenous TCR and the occurrence of a self-reactive TCR are avoided.