Abstract: The present invention provides an artificial nucleic acid-cleaving enzyme comprising: a nuclease domain which is a polypeptide containing an amino acid sequence set forth at positions 391 to 585 of SEQ ID NO: 1 or positions 389 to 579 of SEQ ID NO: 3, or a mutant polypeptide thereof; and a nucleic acid-binding domain.

Abstract: The purpose of the present invention is to provide sperm having high motility. The present invention is a composition for treating sperm that comprises medium for mesenchymal stem cells. This composition for treating sperm is used as a sperm preparing solution, a sperm diluting solution, a sperm storage solution, an artificial insemination solution, an in vitro fertilization solution, a solution for improving sperm motility, or a solution for retaining sperm fertilizing capabilities. Additionally, the medium for mesenchymal stem cells contained in the composition for treating sperm is preferably a serum-free medium.

Abstract: An object of the present invention is to provide a gas separation membrane having more excellent gas separation performance than a conventional gas separation membrane. The gas separation membrane of the present invention has an intermediate layer on a polymer membrane substrate, and has a separation layer on the intermediate layer, where the intermediate layer has a non-porous structure, the separation layer is a silica-based separation layer, and the silica-based separation layer has a different chemical composition or layer structure in a thickness direction.

Abstract: A controller includes a drive part, a posture information acquisition part, and a control part, the control part calculates a gravity center velocity of a working device on the basis of posture information about the working device detected by the posture information acquisition part and calculates a target gravity center velocity being a target value of the gravity center velocity on the basis of a difference between a grounding work to be exerted to the ground by the working device and a target grounding work, and provides a feedback correction to an instruction signal to make the gravity center velocity approach the target gravity center velocity and inputs the corrected instruction signal into the drive part.

Abstract: A controller of a work machine control system stores a plurality of data groups including manipulation ability past data and control parameter past data associated with the manipulation ability past data, determines manipulation ability of an operator, sets a control parameter using operation information that is information including the manipulation ability and using the plurality of data groups, calculates an assist amount for assisting the manipulation by the operator using the control parameter, calculates a control command for operating an object to be controlled using a manipulation amount of manipulation given to a manipulation device and using the assist amount, and inputs the control command to the object to be controlled.

Abstract: A method for producing catalyst particles, which are for an electrochemical reaction and in which catalytic noble metal particles are carried on conductive oxide particles, includes: using metal atom-containing organic compounds as a precursor of the conductive oxide particles and a precursor of the catalytic noble metal particles, and dissolving the metal atom-containing organic compounds in an organic solvent to obtain a precursor solution; and spraying and combusting the precursor solution.

Abstract: Provided are a method for separating mammalian sperm, by which even a large amount of sperm can be separated in a short time and decrease in motility of the separated sperm can be prevented; and an artificial insemination method, and an in vitro fertilization method. The method for separating mammalian sperm includes incubating the sperm in a medium containing a TLR7 ligand, and separating them into sperm floating in the upper layer and sperm sinking in the lower layer of the medium. The artificial insemination and in vitro fertilization methods include artificial insemination or in vitro fertilization for a non-human mammal using sperm of the non-human mammal separated by the method for separating mammalian sperm.

Abstract: A feedback control device determines a first target angular velocity that is a target angular velocity of an output angular velocity of the target device, using a first transfer function, determines a control input to the target device, based on a difference between the first target angular velocity and the output angular velocity, determines, based on the operation input, a second target angular velocity that is the target angular velocity requested by an operator, determines a degree of comfort of the operator, based on a difference between the output angular velocity and the second target angular velocity, sequentially accumulates the first target angular velocity, the degree of comfort, and a target degree of comfort in a database, and adjusts a first moment of inertia in such a way as to reduce a difference between the target degree of comfort and the degree of comfort, using data accumulated in the database.

Abstract: A bucket information acquisition device for acquiring information regarding the shape of a bucket that rotates about a rotational center axis along a predetermined moving plane in a construction machine includes: a distance distribution acquisition unit that acquires the three-dimensional distance distribution of the bucket with respect to a reference point; a reference cross section extraction unit that extracts, from the distance distribution acquired by the distance distribution acquisition unit, a reference cross section which is a cross section of the bucket obtained by cutting the bucket along a plane parallel to the moving plane; an approximate line identification unit that identifies, based on the reference cross section, an approximate line approximating the reference cross section composed of a straight line and a curve; and a bucket shape calculation unit that calculates bucket shape information regarding the shape of the bucket based on the approximate line.

Abstract: It is an object of an aspect of the present invention to provide (i) transformants, whose proliferation depends on phosphite, of various species of organism and (ii) a method for detecting the presence of a reduced phosphorous compound with use of such a transformant. Use is made of a transformant which is defective in functions of a gene encoding a phosphate transporter protein and a gene encoding a phosphate ester transporter protein and into which a gene encoding a hypophosphite transporter protein is introduced, a signal peptide of a hypophosphite binding protein being substituted with a signal peptide derived from a host or a species of organism closely related to the host.

Abstract: A pump control device and a valve control device each includes: an instruction calculator that calculates a control instruction of causing a controlled object to operate by using a manipulation amount of a manipulation and at least one control parameter, and inputs the calculated control instruction to the controlled object; and an ideal output calculator that calculates an ideal output of an actuator, the ideal output being associated with the manipulation amount of the manipulation. The pump control device adjusts at least one pump control parameter to reduce a difference between a control output and the ideal output when an operation of a movable part is a power running operation. The valve control device adjusts at least one valve control parameter to reduce a difference between a control output and the ideal output when the operation of the movable part is a non-power running operation.

Abstract: An extreme ultraviolet light generation chamber device includes a chamber including a plasma generation region in which a droplet target irradiated with laser light is turned into plasma and extreme ultraviolet light is generated, a light concentrating mirror arranged in the chamber and concentrating the extreme ultraviolet light, a gas curtain forming device injecting a gas to form a gas curtain intersecting an optical path of the extreme ultraviolet light propagating from the plasma generation region to the light concentrating mirror, an etching gas supply unit supplying an etching gas into the chamber, and a gas exhaust unit exhausting a residual gas in the chamber. Pressure in a second space that is a space on a side toward the light concentrating mirror from the gas curtain is lower than pressure in a first space that is a space on a side toward the plasma generation region from the gas curtain.

Abstract: Objective discrimination of a disease label of a depressive symptom with respect to an active state of a brain is achieved. One means for solving the problems of the present invention is to provide a discriminating device for assisting in determination of whether a subject has a depressive symptom. The discriminating device includes a storage device for storing information for identifying a classifier generated by classifier generation processing based on a signal obtained by using a brain activity detecting apparatus to measure, in advance and time-sequentially, a signal indicating a brain activity of a plurality of predetermined regions of each brain of a plurality of participants in a resting state, the plurality of participants including healthy individuals and patients with depression.

Abstract: A molecular memory recording molecular polarization of a single-molecule electret, and the single-molecule electret includes a cluster skeleton 100 having a continuous hole 101 and a plurality of stable ionic sites 102a, 102b and a metal ion M. The molecular polarization is shown in a state in which the metal ion is included in the stable ionic site. The molecular polarization is changed by movement of the metal ion to the other hollow stable ionic site by application of an electric field. The recordkeeping time of the molecular memory in a temperature range of ?100° C. to 100° C. based on the ion radius of the metal ion is 3.0×10?2 seconds to 9.1×1022 seconds. Based on the recordkeeping time, the molecular memory is used as any of a volatile memory, a non-volatile memory, and a storage class memory.

Abstract: The present invention provides a method for simply isolating exosomes from a sample containing exosomes. The present invention includes a complex forming step of forming a complex by binding an exosome in a sample to a particular peptide that contains lysines and is supported on a carrier and a dissociating step of dissociating the exosome from the complex by bringing the complex into contact with a dissociation buffer containing metal cations.

Abstract: An object of the present invention is to provide a cell penetrating peptide having a penetrating ability into cells. The present inventors provided a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 2 and a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 3; and a complex comprising any one of the cell penetrating peptide and a functional molecule.

Abstract: A remote operation device and a remote operation system that can reduce or eliminate deviation of the position of an indicator image of a working unit such as a line image in an image with respect to the position of the working unit in a real space. In some case, because of a cause such as a communication failure, a position posture coordinate value of a working unit corresponding to captured image data in a work environment image deviates from a position posture coordinate value of the working unit estimated according to an operation form of a remote operation mechanism. In this case, a semitransparent indicator image Img2(?2) simulating a bucket is superimposed on a work environment image Img1(?2) in a position where the bucket is estimated to be originally present and deviating from an image region representing the bucket.

Abstract: A construction machine is capable of preventing degradation in efficiency of excavation work while preventing an increase in excavation resistance in the excavation work. A controller of a construction machine determines an accommodation state of earth and sand accommodated in a bucket, and outputs a resistance reduction command signal that is a command signal for operating a work device such that the bucket is displaced in a resistance reduction direction that is a direction where excavation resistance acting on the bucket is capable of being reduced, in accordance with a result of determining the accommodation state.

Abstract: Provided is a method of producing a composite having high strength and high thermal conductivity. The method includes: an alloy preparation step including preparing an alloy which is a solid solution containing ?-Fe as a solvent and at least one type of ?-phase stabilizing element as a solute; a first mixing step including mixing at least one type of ?-phase stabilizing element in powder form and SiC to prepare a first mixture; a second mixing step including mixing the alloy and the first mixture to prepare a second mixture; and a sintering step including sintering the second mixture.

Abstract: Objective discrimination of a disease label of a depressive symptom with respect to an active state of a brain is achieved. One means for solving the problems of the present invention is to provide a discriminating device for assisting in determination of whether a subject has a depressive symptom. The discriminating device includes a storage device for storing information for identifying a classifier generated by classifier generation processing based on a signal obtained by using a brain activity detecting apparatus to measure, in advance and time-sequentially, a signal indicating a brain activity of a plurality of predetermined regions of each brain of a plurality of participants in a resting state, the plurality of participants including healthy individuals and patients with depression.