Abstract: The present disclosure provides a technique whereby the influence of an endogenous TCR is eliminated in TCR gene transfer. A TCR gene is edited using a genome editing enzyme, said genome editing enzyme having one characteristic that amino acids at two specific positions in DNA-binding modules contained in a DNA-binding domain thereof show repeating patterns which differ from one module to another among the four DNA-binding modules. Thus, a lowering in the expression efficiency of the transferred TCR caused by mispairing with an endogenous TCR and the occurrence of a self-reactive TCR are avoided.

Abstract: The present disclosure provides a technique for producing regulatory T cells specific to a desired antigen. Regulatory T cells specific to an antigen are produced by a method that includes: a step for identifying a T cell receptor (TCR) clone present in an effector T cell population specific to an antigen in an effector T cell donor; and a step for introducing all or part of the nucleic acid sequence of the TCR? gene and all or part of the nucleic acid sequence of the TCR? gene included in the clone into a regulatory T cell, said step comprising introducing the TCR? and the TCR? so as to be expressed in pairs.

Abstract: A microorganism having at least one SPX gene encoding SPX protein responsive to phosphorus deficiency, and characterized in that a function of the SPX protein is decreased or lost by introducing gene mutation into the SPX gene.

Abstract: There is provided a therapy selection support device that generates a discriminator (identifier) as a diagnostic marker or a classifier as a stratification marker through machine learning on the basis of measurement data on brain activities and that uses the discriminator or the classifier as a biomarker. A therapy selection support system 300a, 300b, 500 includes a clustering device 300b that executes stratification in which the results of measurement of brain functional connectivity correlation values acquired from a plurality of second subjects are divided into a plurality of clusters through a clustering process.

Abstract: A biometric system includes: a camera that captures a subject; a pressure information collection unit that detects a pressure value of at least one sole of the subject; a skeleton direction vector calculation unit that calculates a skeleton direction vector of the subject captured by the camera; a floor reaction force vector calculation unit that calculates a floor reaction force vector on a basis of information on pressure from the pressure information collection unit; and an analysis result output unit that displays, in a superimposing manner, the skeleton direction vector calculated by the skeleton direction vector calculation unit and the floor reaction force vector calculated by the floor reaction force vector calculation unit.

Abstract: A hydraulic excavator specifies acceleration data being operation data in an acceleration period of a manipulation target and deceleration data being operation data in a deceleration period of the manipulation target among operation data, calculates, on the basis of the acceleration data and acceleration evaluation data, an acceleration evaluation value indicating a skill of an operator in the acceleration period, calculates, on the basis of the deceleration data and deceleration evaluation data, a deceleration evaluation value indicating a skill of the operator in the deceleration period, determines, on the basis of the acceleration evaluation value and the deceleration evaluation value, a manipulation type of the operator, and outputs support information associated with the manipulation type.

Abstract: Provided is a photosensitizer that can make a compound having a polymerizable group be efficiently cured by irradiation with an active energy ray. A photosensitizer comprising graphene, the graphene having a number average molecular weight (Mn) in terms of polystyrene of 500 or more and 1,000,000 or less, the number average molecular weight measured by gel permeation chromatography.

Abstract: The present invention aims at providing a method of assisting the detection of pancreatic cancer with high accuracy.

Abstract: Disclosed is a method of assisting the detection of Alzheimer's disease, assisting in highly accurate detection of Alzheimer's disease. In the method of assisting the detection of Alzheimer's disease, the abundance of at least one of miRNAs or the like contained in a test sample isolated from a living body, whose nucleotide sequence is represented by any one of SEQ ID NOs: 1 to 85, is used as an index. A higher abundance of at least one of the miRNAs or the like whose nucleotide sequence is represented by any one of SEQ ID NOs: 1 to 22 and 66 to 71 than that of healthy subjects or a lower abundance of at least one of the miRNAs or the like whose nucleotide sequence is represented by any one of SEQ ID NOs: 23 to 65 and 72 to 85 than that of healthy subjects indicates a higher likelihood of having Alzheimer's disease.

Abstract: A composite semipermeable membrane capable of forming, on a surface of a porous support in a highly reproducible manner, a separation layer that is extremely thin and that exhibits superior separability. It provides, on a surface of a porous support, a composite semipermeable membrane that has an organic/inorganic hybrid separation layer that is extremely thin and that exhibits superior separability. A method for manufacturing a composite semipermeable membrane includes forming, on a surface of a porous support, a separation layer containing a cross-linked condensate having a siloxane bond by bringing an organic solution that contains an organic silicon compound containing three or more reactive functional groups, each of which is at least one type selected from a hydrolyzable group and a hydroxyl group, into contact with water or an aqueous solution on the porous support, and by performing interfacial polycondensation of the organic silicon compound.

Abstract: [Problem] To develop a group of novel compounds with an inhibitory activity against the function of Pin1 so as to use them as candidate compounds for medicaments.

Abstract: A transmitter/receiver (1) up-converts, using an LO signal as a local oscillation signal, an IF signal having a predetermined frequency band, thereby generating a transmission signal RFTX. Moreover, the transmitter/receiver (1) generates a (LO+IF)2 signal and a (LO?IF)2 signal based on the IF signal and the LO signal. Using the LO signal obtained by adding-up of the (LO+IF)2 signal and the (LO?IF)2 signal, a reception signal RFRX is down-converted. Thus, a local oscillation signal generation unit of a receiving unit is not necessary.

Abstract: An insulin detection method includes: adding a sample to an electrode having an insulin binding protein immobilized on a surface of the electrode, the insulin binding protein specifically recognizing insulin; and detecting an electrochemical change associated with formation of a complex of the insulin and the insulin binding protein. The insulin binding protein includes: a first region that includes an ?-CT segment of an insulin receptor and does not include a ? subunit of the insulin receptor, and a second region that includes an L1 domain of the insulin receptor and does not include the ? subunit of the insulin receptor; and one of the first region and the second region is immobilized on the surface of the electrode.

Abstract: A method for manufacturing a composite semipermeable membrane is capable of forming, on a surface of a porous support in a highly reproducible manner, a separation layer that is extremely thin and that exhibits superior separability. It provides, on a surface of a porous support, a composite semipermeable membrane that has an organic/inorganic hybrid separation layer that is extremely thin and that exhibits superior separability. A method for manufacturing a composite semipermeable membrane includes forming, on a surface of a porous support, a separation layer containing a cross-linked condensate having a siloxane bond by bringing an organic solution that contains an organic silicon compound containing three or more reactive functional groups, each of which is at least one type selected from a hydrolyzable group and a hydroxyl group, into contact with water or an aqueous solution on the porous support, and by performing interfacial polycondensation of the organic silicon compound.

Abstract: A measurement device is configured to: calculate first contour data of a container in an empty state at a first time; calculate second contour data indicating a surface contour of an object at a second time in execution of a scooping operation by the container; rotate the second contour data, based on differential information indicating a difference between second posture data of a working gear 4 at the second time and first posture data of the working gear 4 at the first time; specify a region defined by supplemental contour data for supplementing the surface contour of the object contained in the container in the execution of the scooping operation, the rotated second contour data, and the first contour data; and calculate, based on the specified region, a first volume indicating a volume of the object contained in the container.

Abstract: One mode is a method for the structural analysis of an organic compound by MALDI mass spectrometry, including: a sample preparation process (S1) which includes preparing a sample by mixing a specimen containing an organic compound to be analyzed with a predetermined matrix at a mixture ratio within a range from 1:5 to 1:5000 in molar ratio; a mass spectrometry process (S3) which includes irradiating the prepared sample with a laser beam having a spot size equal to or smaller than 15 ?m to generate ions originating from a component of the specimen in the sample, and performing a mass spectrometric analysis of the generated ions; and an analyzing process (S4) which includes detecting, from a mass spectrum acquired in the mass spectrometry process, ions including product ions resulting from in-source decay, and estimating the structure of the organic compound to be analyzed based on information concerning the ions.

Abstract: A measurement device is configured to calculate, based on second measurement data provided by a distance detector, second contour data indicating a surface contour of an object contained in the container at a second time after a first time; calculate differential information indicating a difference between first posture data and second posture data which is posture data provided by a posture detector at the second time; rotate, based on the differential information, the second contour data in a three-dimensional coordinate space of the distance detector; and specify a region defined by the rotated second contour data and the first contour data, and calculate, based on the specified region, a volume of the object contained in the container at the second time.

Abstract: A feedback control device determines a first target angular velocity that is a target angular velocity of an output angular velocity of the target device, using a first transfer function, determines a control input to the target device, based on a difference between the first target angular velocity and the output angular velocity, determines, based on the operation input, a second target angular velocity that is the target angular velocity requested by an operator, determines a degree of comfort of the operator, based on a difference between the output angular velocity and the second target angular velocity, sequentially accumulates the first target angular velocity, the degree of comfort, and a target degree of comfort in a database, and adjusts a first moment of inertia in such a way as to reduce a difference between the target degree of comfort and the degree of comfort, using data accumulated in the database.

Abstract: The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting of 35 to 55 amino acid residues wherein amino acid residues at two sites in a DNA-binding module contained in a DNA-binding domain exhibit a mode of repetition that is different for every four DNA-binding modules; a vector for expressing said artificial nuclease; a vector library for preparing said vector; and a vector set for preparing said vector library.

Abstract: The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.