Patents Assigned to Hiroshima University
  • Patent number: 9709576
    Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 18, 2017
    Assignee: Hiroshima University
    Inventors: Michihiro Hide, Takaaki Hiragun, Kaori Ishii, Shoji Mihara, Makiko Hiragun, Jens-M Schroeder
  • Patent number: 9695235
    Abstract: The present invention provides a composition for regulating cell proliferation comprising a peptide having a partial amino acid sequence of BBF2H7 or an antibody capable of binding to the peptide. The problem has been solved by preparation of the peptide having a partial amino acid sequence of BBF2H7 which has a cell proliferation activity.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: July 4, 2017
    Assignee: Hiroshima University
    Inventors: Kazunori Imaizumi, Atsushi Saito
  • Patent number: 9656351
    Abstract: Provided is a solder material that has a high melting point and exhibits superior mechanical characteristics, and therefore can form a connecting portion with high heat-resistant reliability.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: May 23, 2017
    Assignee: Hiroshima University
    Inventors: Kazuhiro Matsugi, Kenichiro Suetsugu
  • Patent number: 9609872
    Abstract: Disclosed is an antibacterial agent composition which is highly safe and has excellent antibacterial abilities, by using a silicon-containing compound that is obtained by a specific manufacturing method. The antibacterial agent composition has a more stable antibacterial component, and is capable of imparting antibacterial abilities to teeth, while being also capable of cleaning an article or the mouth. Also disclosed are: an antiviral agent composition which is highly safe and has excellent virus deactivation abilities; an antibacterializing method, a cleaning/mouth rinsing method, each using the antibacterial agent composition or the antiviral agent composition; and a method for fixing an antibacterial agent or an antiviral agent. The antibacterial agent composition may contain a silicon-containing compound which is represented by general formula (1) and obtained by reacting a specific triethoxysilyl compound in an ethanol solvent.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: April 4, 2017
    Assignee: Hiroshima University
    Inventors: Hiroki Nikawa, Hironori Takeda, Toshio Kakihara, Takemasa Sakaguchi
  • Publication number: 20170044597
    Abstract: An object of the present invention is to provide a method of detecting a nucleic acid binding protein and a method of screening for a binding inhibitor or promoter for a nucleic acid binding protein. According to the present invention, there is provided a method of detecting binding between a nucleic acid and a nucleic acid binding protein, comprising determining the degree of structural change in a nucleic acid complex having at least two nucleic acid duplex moieties.
    Type: Application
    Filed: August 23, 2016
    Publication date: February 16, 2017
    Applicant: Hiroshima University
    Inventors: Hidetoshi TAHARA, Toru MIYAGI
  • Publication number: 20160363598
    Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.
    Type: Application
    Filed: August 26, 2016
    Publication date: December 15, 2016
    Applicant: Hiroshima University
    Inventors: Michihiro Hide, Takaaki Hiragun, Kaori Ishii, Shoji Mihara, Makiko Hiragun, Jens-M Schroeder
  • Publication number: 20160326246
    Abstract: The present invention provides a composition for regulating cell proliferation comprising a peptide having a partial amino acid sequence of BBF2H7 or an antibody capable of binding to the peptide. The problem has been solved by preparation of the peptide having a partial amino acid sequence of BBF2H7 which has a cell proliferation activity.
    Type: Application
    Filed: July 28, 2016
    Publication date: November 10, 2016
    Applicant: Hiroshima University
    Inventors: Kazunori Imaizumi, Atsushi Saito
  • Patent number: 9457071
    Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: October 4, 2016
    Assignee: Hiroshima University
    Inventors: Michihiro Hide, Takaaki Hiragun, Kaori Ishii, Shoji Mihara, Makiko Hiragun, Jens-M Schroeder
  • Patent number: 9445605
    Abstract: Provided herein is a method for disinfection or infection control against a non-enveloped virus using a composition including, as an active ingredient, a persimmon extract containing tannin from an astringent fruit of a plant of the genus Diospyros, such as the plant Diospyros kaki. The non-enveloped virus is a non-enveloped virus belonging to the genus Betanodavirus, Aquavirnavirus, Ranavirus, Enterovirus, Mastadenovirus, Vesivirus, or Rotavirus. In certain embodiments, the persimmon extract is prepared by heating a squeezed juice or an extract from an astringent fruit of a plant of the genus Diospyros, or obtained by treating a squeezed juice or an extract from an astringent fruit of the plant of the genus Diospyros with an alcohol, in order to inactivate an enzyme contained therein. The persimmon extract may also contain at least condensed tannin.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: September 20, 2016
    Assignees: Hiroshima University, Altan Co., Ltd.
    Inventors: Tadashi Shimamoto, Yasushi Okinaka, Takemasa Sakaguchi, Toru Tsuji, Yoshiaki Nakai
  • Patent number: 9381287
    Abstract: A blood supply flow rate controlling device (2), which is a device for controlling the blood supply flow rate in an extracorporeal circulation device connected to a living body (10), includes rotational frequency detecting means that detects the rotational frequency of the centrifugal pump (40) of the extracorporeal circulation device, inlet pressure detecting means and outlet pressure detecting means that detect the inlet pressure and the outlet pressure of the centrifugal pump (40), respectively, flow rate regulating means that regulates a flow rate of blood supplied to the living body by adjusting a flow path cross section area of the blood circulation circuit (20), and controlling means that controls the flow rate regulating means.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: July 5, 2016
    Assignees: Hiroshima University, Josho Gakuen Educational Foundation
    Inventors: Shinji Ninomiya, Taijiro Sueda, Tatsuya Kurosaki, Masaaki Kudo, Naoya Okamura
  • Patent number: 9380786
    Abstract: Provided are: an agent for preventing bacterial wilt disease, which agent can prevent the development of bacterial wilt disease caused by various different bacterial wilt disease strains, that is, the development of bacterial wilt disease in various different plant varieties; and a method for preventing bacterial wilt disease utilizing the agent for preventing bacterial wilt disease. The agent for preventing bacterial wilt disease comprises as an active ingredient a wilt bacterium (Ralstonia solanacearum) infected with the ?RSM1-type filamentous phage and/or the ?RSM3-type filamentous phage. The method for preventing bacterial wilt disease comprises the step of inoculating the agent for preventing bacterial wilt disease to a plant. The plant is preferably any one of tomato, potato, green pepper, eggplant, tobacco, capsicum, Japanese basil, Japanese radish, strawberry, banana, marguerite, chrysanthemum and sunflower.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: July 5, 2016
    Assignee: Hiroshima University
    Inventors: Takashi Yamada, Makoto Fujie, Takeru Kawasaki
  • Patent number: 9343576
    Abstract: The present invention provides a thin film forming method. The method includes the steps of: providing a first substrate, of which a surface is covered with a thin film; forming a plurality of openings through the thin film; forming a hollow portion between the first substrate and the thin film by etching the first substrate through the openings; bringing the thin film into contact with a second substrate with a liquid interposed between the thin film and the second substrate; and heating the first substrate and/or the second substrate. In the step of heating, the liquid interposed between the thin film and the second substrate evaporates off, which results in that the thin film is separated from the first substrate and transferred onto the second substrate.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: May 17, 2016
    Assignee: Hiroshima University
    Inventors: Seiichiro Higashi, Kohei Sakaike, Yoshitaka Kobayashi, Shogo Nakamura, Muneki Akazawa
  • Patent number: 9322822
    Abstract: In order to provide a method for more efficiently, easily, and accurately detecting asbestos without changing the asbestos detection criterion of the phase-contrast microscope/electron microscope method as compared with the phase-contrast microscope/electron microscope method, a phase-contrast microscope and a fluorescence microscope are used in combination to detect asbestos contained in a test sample after the test sample is made contact with an asbestos-binding protein having a fluorescent label.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: April 26, 2016
    Assignee: Hiroshima University
    Inventors: Akio Kuroda, Takenori Ishida, Tomoki Nishimura
  • Patent number: 9314498
    Abstract: Provided is a bacteriocin that is capable of being easily mass-produced, has high antimicrobial activity even at low concentration, has a wide antimicrobial spectrum, and is less likely to produce resistant microorganisms. The bacteriocin has the amino acid sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 in SEQUENCE LISTING, or has the same amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 2 in SEQUENCE LISTING except that one or several amino acids are deleted, substituted, inserted and/or added, wherein the amino acid sequence provides antimicrobial activity and the isoelectric point is not less than 12.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: April 19, 2016
    Assignee: Hiroshima University
    Inventor: Hiroki Nikawa
  • Patent number: 9287577
    Abstract: The biofuel cell has a positive electrode, a negative electrode, an external circuit electrically connecting the positive electrode and the negative electrode, a positive electrode region where the positive electrode is disposed, a negative electrode region where the negative electrode is disposed, and a proton permeable membrane disposed between the positive electrode region and the negative electrode region, and the negative electrode region houses a biocatalyst together with the crushed material. The negative electrode region is separated by a mesh into an electrode region and a crushed material region, the negative electrode is housed in the electrode region, and the crushed material is housed in the crushed material region.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: March 15, 2016
    Assignees: Unicharm Corporation, Hiroshima University
    Inventors: Takayoshi Konishi, Toshio Hiraoka, Toshihide Kakizono
  • Patent number: 9278107
    Abstract: Disclosed is an antibacterial agent composition which is highly safe and has excellent antibacterial abilities, by using a silicon-containing compound that is obtained by a specific manufacturing method. The antibacterial agent composition has a more stable antibacterial component, and is capable of imparting antibacterial abilities to teeth, while being also capable of cleaning an article or the mouth. Also disclosed are: an antiviral agent composition which is highly safe and has excellent virus deactivation abilities; an antibacterializing method, a cleaning/mouth rinsing method, each using the antibacterial agent composition or the antiviral agent composition; and a method for fixing an antibacterial agent or an antiviral agent. The antibacterial agent composition may contain a silicon-containing compound which is represented by general formula (1) and obtained by reacting a specific triethoxysilyl compound in an ethanol solvent.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: March 8, 2016
    Assignee: Hiroshima University
    Inventors: Hiroki Nikawa, Hironori Takeda, Toshio Kakihara, Takemasa Sakaguchi
  • Patent number: 9209409
    Abstract: A naphthobisthiadiazole derivative is represented by Formula 1. In Formula 1, Z is selected from a hydrogen atom, a boronic acid group, a boronic acid ester group, a trifluoroborate salt group and a triolborate salt group, and at least one Z is a boronic acid group, a boronic acid ester group, a trifluoroborate salt group or a triolborate salt group. The naphthobisthiadiazole derivative is an organoboron compound, and can be converted to various compounds by a Suzuki-Miyaura coupling reaction; thus, is applicable as a precursor of complex compounds. Using the naphthobisthiadiazole derivative, research, development, and practical applications of low molecular weight compounds and high-molecular compounds useful for various organic semiconductor materials and the like can be ensured.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: December 8, 2015
    Assignees: National University of Corporation Hiroshima University, Sankyo Kasei Co., Ltd.
    Inventors: Kazuo Takimiya, Itaru Osaka, Kazuaki Kawashima
  • Patent number: 9181557
    Abstract: The present invention provides uracil-requiring Moorella bacteria obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase; and transforming-gene-introduced Moorella bacteria obtained by introducing a gene coding for orotidine-5-phosphate decarboxylase and a transforming-gene to a chromosome of the uracil-requiring Moorella bacteria. The present invention was accomplished by uracil-requiring Moorella bacteria, comprising an MTA-D-pF strain that is obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase on a chromosome of Moorella bacteria.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: November 10, 2015
    Assignees: Mitsui Engineering & Shipbuilding Co., Ltd., Hiroshima University, Gifu University
    Inventors: Yutaka Nakashimada, Akihisa Kita, Tohru Suzuki, Shinsuke Sakai, Kazue Takaoka
  • Publication number: 20150238581
    Abstract: Provided arc a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.
    Type: Application
    Filed: June 25, 2013
    Publication date: August 27, 2015
    Applicant: Hiroshima University
    Inventors: Michihiro Hide, Takaaki Hiragun, Kaori Ishii, Shoji Mihara, Makiko Hiragun, Jens-M Schroeder
  • Publication number: 20150225469
    Abstract: The present invention provides a composition for regulating cell proliferation comprising a peptide having a partial amino acid sequence of BBF2H7 or an antibody capable of binding to the peptide. The problem has been solved by preparation of the peptide having a partial amino acid sequence of BBF2H7 which has a cell proliferation activity.
    Type: Application
    Filed: August 28, 2013
    Publication date: August 13, 2015
    Applicant: Hiroshima University
    Inventors: Kazunori Imaizumi, Atsushi Saito