Abstract: An object of the present invention is to provide a cell penetrating peptide having a penetrating ability into cells. The present inventors provided a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 2 and a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 3; and a complex comprising any one of the cell penetrating peptide and a functional molecule.

Abstract: The present invention provides a power generation device that can not only reduce the generation of vibration but also increase thermal efficiency. A power generation device (10A) includes: an engine (1) in which a right crankshaft (31) and a left crankshaft (32) rotate in opposite directions to each other; a right flywheel (41) and left flywheel (42) as a primary inertia body; and a power generation motor (2) as a secondary inertia body, a total inertia moment in a first rotation direction and a total inertia moment in a second rotation direction being balanced with each other by not less than 50%.

Abstract: A light-modulating material of which the light transmittance can be controlled over a wide region from visible light to infrared light by voltage application is provided. The light-modulating material comprises a graphene-like carbon material having an aspect ratio of 3 or more and 330 or less.

Abstract: A method for treating or repairing osteochondral damage in a subject in need thereof, including administering to the subject a cell preparation comprising pluripotent stem cells positive for SSEA-3 isolated from a body mesenchymal tissue or cultured mesenchymal cells. The pluripotent stem cells have all of the following properties: (i) CD105-positivity; (ii) low or absent telomerase activity; (iii) having ability to differentiate into any of three germ layers; (iv) absence of demonstration of neoplastic proliferation; and (v) self-renewal ability. The pluripotent stem cells are administered at 1×103 cells to 2×107 cells as individual.

Abstract: A molecular memory recording molecular polarization of a single-molecule electret, and the single-molecule electret includes a cluster skeleton 100 having a continuous hole 101 and a plurality of stable ionic sites 102a, 102b and a metal ion M. The molecular polarization is shown in a state in which the metal ion is included in the stable ionic site. The molecular polarization is changed by movement of the metal ion to the other hollow stable ionic site by application of an electric field. The recordkeeping time of the molecular memory in a temperature range of ?100° C. to 100° C. based on the ion radius of the metal ion is 3.0×10?2 seconds to 9.1×1022 seconds. Based on the recordkeeping time, the molecular memory is used as any of a volatile memory, a non-volatile memory, and a storage class memory.

Abstract: The present application provides a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 2 and a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 3; and a complex comprising any one of the cell penetrating peptide and a functional molecule.

Abstract: The simulator includes a chemical liquid information acquisition section configured to acquire an amount of contrast medium, a target value acquisition section configured to acquire a target duration for which a target pixel value is maintained, a protocol acquisition section configured to acquire a contrast medium injection protocol, and a prediction section for determining a predicted duration, the prediction section configured to simulate the time-dependent change in the pixel value in the tissue of the subject based on the injection protocol and the amount of the contrast medium, and the prediction section compares the predicted duration with the target duration to re-simulate, in a case where the predicted duration is shorter than the target duration, the time-dependent change in a condition where a greater amount of the contrast medium than the amount of the contrast medium used in the simulation is injected to redetermine the predicted duration, and in a case where the predicted duration is longer than

Abstract: A construction machine includes: a flow rate regulating part which regulates a flow rate of hydraulic oil supplied from a hydraulic pump to a hydraulic actuator, and a control device—which controls driving of a work device. The control device includes: an acquiring part for acquiring a motion state amount of a combined center of gravity of a plurality of members which constitute the work device; and a generating part which generates an instruction value for controlling an operation of the flow rate regulating part such that the motion state amount follows a predetermined first target value, the instruction value being used for executing a feedback control based on the first target value and the motion state amount, and inputs the instruction value to the flow rate regulating part.

Abstract: It is intended to provide a fusion polypeptide that regulates the transcription of a target gene. The present inventors have provided a fusion polypeptide comprising: a cell-penetrating peptide; a DNA-binding polypeptide; and a transcriptional regulator.

Abstract: Therapeutic agents and treatment methods for urologic cancers, particularly urologic cancers with reduced lysine (K)-specific demethylase 6A (KDM6A) function, the agents and methods being characterized by suppressing both IL-6 activity and CCR2/CCL2 activity, are provided.

Abstract: The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting of 35 to 55 amino acid residues wherein amino acid residues at two sites in a DNA-binding module contained in a DNA-binding domain exhibit a mode of repetition that is different for every four DNA-binding modules; a vector for expressing said artificial nuclease; a vector library for preparing said vector; and a vector set for preparing said vector library.

Abstract: Based on operation trajectory data an operation analysis device identifies all open points indicating positions at which the crusher is opened during the operation period and all close points indicating positions at which a crusher is closed during an operation period, calculates, as a shortest distance, a distance between each open point of the all open points and a close point nearest to the each open point, and identifies, as a sorting destination open point, an open point at which the shortest distance exceeds a first threshold value, identifies data until the crusher grasping the dismantling part moves to the sorting destination and returns to the dismantling target again from among the operation trajectory data as movement data of the crusher having moved in the dismantling operation, and identifies data in which the movement data has been removed from the operation trajectory data as grasping operation data.

Abstract: A construction machine is capable of reducing a decrease in work efficiency due to maintenance for capturing dust. The construction machine includes: an engine; a heat exchanger; a cooling fan that sucks air into an engine chamber to pass the air through the heat exchanger; an intake chamber independent of the engine chamber; an intake tube connected to the intake chamber; and a dust receiving part. The intake tube has a curved part, which has an outside inner wall surface allowing dust in the air to contact it. The dust receiving part is located downstream of the outside inner wall surface to be capable of receiving dust.

Abstract: A method for designing a protein capable of binding in a DNA base selective manner or DNA base sequence specific manner is provided. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (-2) A.A. contained in L of the formula 1, the aforementioned object could be achieved.

Abstract: A sensibility meter detects biometric information relating to an operator corresponding to an output from a target appliance, and determines a comfort level of the operator based on the biometric information. A first control unit determines a second target value relating to the output based on a difference between a first target value relating to the comfort level and the comfort level. A second control unit determines a control input to the target appliance based on a difference between the second target value and the output. A ? setting unit performs weighting corresponding to an operation level of the operator, for an operation input to the target appliance by the operator, and for the control input. An adder adds the weighted operation input and control input, and inputs the resultant to the target appliance.

Abstract: An object of the present invention is to develop a therapeutic agent for an inflammatory disease such as an inflammatory bowel disease or NASH, which therapeutic agent shows less side effects and high effectiveness. The present invention provides a compound represented by Formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic agent or a prophylactic agent for an inflammatory disease, and a therapeutic agent or a prophylactic agent for colon cancer, containing the compound.

Abstract: One mode is a method for the structural analysis of an organic compound by MALDI mass spectrometry, including: a sample preparation process (S1) which includes preparing a sample by mixing a specimen containing an organic compound to be analyzed with a predetermined matrix at a mixture ratio within a range from 1:5 to 1:5000 in molar ratio; a mass spectrometry process (S3) which includes irradiating the prepared sample with a laser beam having a spot size equal to or smaller than 15 ?m to generate ions originating from a component of the specimen in the sample, and performing a mass spectrometric analysis of the generated ions; and an analyzing process (S4) which includes detecting, from a mass spectrum acquired in the mass spectrometry process, ions including product ions resulting from in-source decay, and estimating the structure of the organic compound to be analyzed based on information concerning the ions.

Abstract: The purpose of the present invention is to provide an agent for improving intestinal flora which can increase the number of beneficial bacteria such as lactic acid bacteria and Bifidobacterium to improve intestinal flora by using an enzyme. A protease consisting of a polypeptide having an amino acid sequence shown in SEQ ID NO: 1 can increase beneficial bacteria such as lactic acid bacteria and Bifidobacterium in intestines to exert an excellent effect of improving intestinal flora.

Abstract: A construction machine includes: a lower travelling body; an upper slewing body attached to the lower travelling body with a structure allowing the upper slewing body to slew with respect to the lower travelling body; a work device attached to the upper slewing body with a structure allowing the work device to swing in a vertical direction with respect to the upper slewing body; a motion state acquisition unit acquiring a motion state amount; an equivalent system forming unit which forms a transfer function which uses a driving force for moving the work device as an input and uses the motion state amount as an output as an equivalent system which equivalently expresses an operation of the work device; and a parameter estimation unit which estimates a system attenuation coefficient and a natural angular frequency of the transfer function as an operation skill evaluation value.

Abstract: The present invention aims to provide a meniscus regeneration material having high meniscus regeneration ability.