Abstract: A construction machine includes: a flow rate regulating part which regulates a flow rate of hydraulic oil supplied from a hydraulic pump to a hydraulic actuator, and a control device—which controls driving of a work device. The control device includes: an acquiring part for acquiring a motion state amount of a combined center of gravity of a plurality of members which constitute the work device; and a generating part which generates an instruction value for controlling an operation of the flow rate regulating part such that the motion state amount follows a predetermined first target value, the instruction value being used for executing a feedback control based on the first target value and the motion state amount, and inputs the instruction value to the flow rate regulating part.

Abstract: The present invention provides an artificial nucleic acid-cleaving enzyme comprising: a nuclease domain which is a polypeptide containing an amino acid sequence set forth at positions 391 to 585 of SEQ ID NO: 1 or positions 389 to 579 of SEQ ID NO: 3, or a mutant polypeptide thereof; and a nucleic acid-binding domain.

Abstract: The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteristic. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (-2) A.A.

Abstract: A microorganism having at least one SPX gene encoding SPX protein responsive to phosphorus deficiency, and characterized in that a function of the SPX protein is decreased or lost by introducing gene mutation into the SPX gene.

Abstract: In order to provide a transformant by which a high containment effect is obtained and which can be prepared by a simple procedure, a method for producing the transformant, and a method for detecting the presence of a reduced phosphorous compound with use of the transformant, a transformant in accordance with an embodiment of the present invention is a transformant which is defective in functions of a gene encoding a phosphate transporter protein and a gene encoding a phosphate ester transporter protein and into which a gene encoding a hypophosphite transporter protein is introduced.

Abstract: The purpose of the present invention is to provide an agent for improving intestinal flora which can increase the number of beneficial bacteria such as lactic acid bacteria and Bifidobacterium to improve intestinal flora by using an enzyme. An amylase that is derived from a microorganism belonging to Aspergillus can increase beneficial bacteria such as lactic acid bacteria and Bifidobacterium in intestines to exert an excellent effect of improving intestinal flora.

Abstract: Provided is a new polycyclic aromatic hydrocarbon derivative. The polycyclic aromatic hydrocarbon derivative is a derivative of a polycyclic aromatic hydrocarbon having 6 or more aromatic rings and has a substituent represented by the following formula (1). (In the formula (1), R1 and R2 are carbon atoms of the aromatic rings in the polycyclic aromatic hydrocarbon, and R3 to R5 are carbon atoms of an aromatic ring or a heterocyclic ring in a group having the aromatic ring or the heterocyclic ring. n is 0 or 1, and m is the number of substituents.

Abstract: The purpose of the invention is to develop a novel therapeutic agent for fatty liver diseases such as NASH or NAFLD. The invention provides a therapeutic or prophylactic agent for fatty liver diseases that comprises, as an active ingredient, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The invention also provides a therapeutic or prophylactic agent for adiposity that comprises, as an active ingredient, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: An object is to provide a novel means for ameliorating mastitis or improving milk production. An ameliorating or therapeutic agent for mastitis that contains a biosurfactant, or a milk production promoting agent that contains a biosurfactant, is provided.

Abstract: An object of the present invention is to provide a cell penetrating peptide having a penetrating ability into cells. The present inventors provided a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 2 and a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 3; and a complex comprising any one of the cell penetrating peptide and a functional molecule.

Abstract: Disclosed herein is a technique for observing the insular cortex activity by using electroencephalograms. A method for sampling cerebral insular cortex activity includes: recording electroencephalograms (EEGs) provided by a plurality of EEG electrodes; creating a three-dimensional model in the form of a mesh in which a subject's brain is decomposed into a plurality of sites according to the subject's brain structure and positioning the plurality of EEG electrodes by reference to an image representing the subject's brain and head structure; creating a forward model by modeling a correlation between the activities of the respective brain sites of the three-dimensional model and an electroencephalogram distribution of the positioned EEG electrodes; and associating, by reference to information about a region of interest measured by functional magnetic resonance imaging (fMRI) and the forward model, data about the electroencephalograms recorded with the cerebral activity of the region of interest.

Abstract: Disclosed is a method of assisting the detection of breast cancer, assisting in highly accurate detection of breast cancer. In the method of assisting the detection of breast cancer, the abundance of at least one of miRNAs, isomiRs, precursor miRNAs, or transfer RNA fragments contained in a test sample isolated from a living body and having a specific nucleotide sequence is used as an index. A higher abundance of at least one of the miRNAs or the like whose nucleotide sequence is represented by any one of, for example, SEQ ID NOs: 1 to 19, 27, 28, and 34 to 51 than that of healthy subjects or a lower abundance of at least one of the miRNAs or the like whose nucleotide sequence is represented by any one of, for example, SEQ ID NOs: 20 to 26, 29 to 33, and 52 to 54 than that of healthy subjects indicates a higher likelihood of having breast cancer.

Abstract: The present invention aims at providing a method of assisting the detection of head and neck cancer with high accuracy. The present invention provides a method of assisting the detection of head and neck cancer, which includes using as an index the abundance of at least one of miRNAs, isoform miRNAs (isomiRs), precursor miRNAs, transfer RNA fragments (tRFs), or non-coding RNA fragments (LincRNAs or MiscRNAs) contained in a test sample isolated from a living body.

Abstract: A hydride secondary battery includes: a pressure vessel; a positive electrode disposed in the pressure vessel; a negative electrode disposed in the pressure vessel; and hydrogen gas with which the pressure vessel is filled. The negative electrode contains a hydrogen-absorbing alloy. In a pressure-composition-temperature diagram, a desorption curve at 25° C. of the hydrogen-absorbing alloy has a plateau pressure of 0.15 MPa or more and 10 MPa or less. The hydrogen gas has a pressure equal to or higher than the plateau pressure at 25° C. of the hydrogen-absorbing alloy.

Abstract: Objective discrimination of a disease label of a depressive symptom with respect to an active state of a brain is achieved. One means for solving the problems of the present invention is to provide a discriminating device for assisting in determination of whether a subject has a depressive symptom. The discriminating device includes a storage device for storing information for identifying a classifier generated by classifier generation processing based on a signal obtained by using a brain activity detecting apparatus to measure, in advance and time-sequentially, a signal indicating a brain activity of a plurality of predetermined regions of each brain of a plurality of participants in a resting state, the plurality of participants including healthy individuals and patients with depression.

Abstract: The invention provides a molded article having excellent mechanical strength, heat resistance, surface roughness, and ferroelectricity. The molded article contains a crystal of a vinylidene fluoride/tetrafluoroethylene copolymer. The crystal is a ? crystal and is a nano-oriented crystal that has a size of 100 nm or smaller. The molded article has an arithmetic average roughness of 3.0 ?m or lower.

Abstract: The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.

Abstract: The purpose of the invention is to develop a novel therapeutic agent for fatty liver diseases such as NASH or NAFLD. The invention provides a therapeutic or prophylactic agent for fatty liver diseases that comprises, as an active ingredient, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The invention also provides a therapeutic or prophylactic agent for adiposity that comprises, as an active ingredient, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.

Abstract: Blood pressure is estimated in a non-constraining manner continuously and in real time. A biological signal collected from a person's dorsal part is analyzed, vibration in the human body ascribable to a blood flow rate change in a period from the ventricular filling period to the isovolumetric systole is captured, and the state of fluctuation of an index indicating the state of the in vivo vibration is further captured. This fluctuation index correlates with a person's blood pressure. Therefore, it is possible to estimate whether the blood pressure is in a range indicating a normal-range blood pressure or in a range indicating a high blood pressure, only by having the person sit or lie supine on a surface provided with a biological signal measurement device to measure a biological signal in a non-constraining manner, so as to make the biological signal measurement device contiguous with the person's dorsal part.