Patents Assigned to IDEXX Laboratories
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Patent number: 10775365Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.Type: GrantFiled: February 19, 2016Date of Patent: September 15, 2020Assignee: IDEXX LABORATORIES, Inc.Inventors: Murthy V S N Yerramilli, Hongzhi Xie, Daniel Wayne Patch, Giosi Farace
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Patent number: 10725052Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.Type: GrantFiled: March 2, 2017Date of Patent: July 28, 2020Assignee: IDEXX LABORATORIES, INC.Inventors: Mahalakshmi Yerramilli, Giosi Farace, John J. Quinn, Murthy V. S. N. Yerramilli
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Patent number: 10640551Abstract: Methods, devices, kits and compositions for detecting the presence or absence of hookworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of hookworm in a fecal sample from a mammal that may also be infected with one or more of roundworm, whipworm, and heartworm. Confirmation of the presence or absence of hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: GrantFiled: December 18, 2015Date of Patent: May 5, 2020Assignee: IDEXX Laboratories, Inc.Inventors: Jinming Geng, David Allen Elsemore
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Publication number: 20200049719Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.Type: ApplicationFiled: September 16, 2019Publication date: February 13, 2020Applicant: IDEXX Laboratories, Inc.Inventors: Mahalakshmi YERRAMILLI, Michael Randolph Atkinson, Murthy V.S.N. Yerramilli
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Patent number: 10436797Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.Type: GrantFiled: June 3, 2011Date of Patent: October 8, 2019Assignee: IDEXX Laboratories, Inc.Inventors: Mahalakshmi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
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Patent number: 10429388Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: GrantFiled: January 5, 2018Date of Patent: October 1, 2019Assignees: Idexx Laboratories, Inc., Monsanto CompanyInventors: David Allen Elsemore, Jinming Geng, Laurie A Flynn, Michael Crawford
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Patent number: 10359352Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.Type: GrantFiled: March 16, 2017Date of Patent: July 23, 2019Assignee: IDEXX Laboratories, Inc.Inventors: Jeremy Hammond, James Russell
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Patent number: 10174373Abstract: The invention provides components and methods for polymerase chain reaction assays. The assays minimize both handling of material and time spent running samples. For example, a single internal positive control (SPC) polynucleotide pair can provide a means to ensure proper nucleic acid purification for both RNA and DNA test targets. Additionally, standard cycling conditions for ali diagnostic tests allow the user to run both RNA and DNA targets side-by-side.Type: GrantFiled: October 18, 2013Date of Patent: January 8, 2019Assignee: IDEXX Laboratories, Inc.Inventors: Christian Leutenegger, Michael John Angelichio
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Patent number: 9970927Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.Type: GrantFiled: February 28, 2014Date of Patent: May 15, 2018Assignee: IDEXX Laboratories, Inc.Inventors: Murthy V. S. N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
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Patent number: 9933428Abstract: An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements.Type: GrantFiled: January 7, 2013Date of Patent: April 3, 2018Assignee: IDEXX Laboratories, Inc.Inventors: Eugene Chan, Keith Nassif
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Patent number: 9823109Abstract: A chemical analyzer includes a slide transport mechanism having a slide track adapted to hold a plurality of reagent test slides, a sample metering device, an incubator formed as a part of the slide transport mechanism to precisely maintain the temperature of the reagent test slides, a slide ejector mechanism to remove the slides from the slide transport mechanism, a sample preparation station, which includes a centrifuge, and associated electronics and software. The slide transport mechanism holds a plurality of trapezoidally-shaped reagent test slides about its circumference, which slides are loaded onto the transport mechanism by the slide inserter mechanism. The slide transport mechanism positions the reagent test slides under the sample metering device, which device deposits a predetermined volume of sample onto each slide. The slide transport mechanism also carries the slides above a reflectometer.Type: GrantFiled: July 20, 2015Date of Patent: November 21, 2017Assignee: IDEXX Laboratories, Inc.Inventors: Mark Christopher Garrepy, Stephan Hersey
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Patent number: 9797916Abstract: A medical apparatus for analyzing fluid samples includes an outer casing, a slide loading mechanism disposed within the outer casing for loading fluid analysis slides, a slide ejecting mechanism disposed within the outer casing for ejecting fluid analysis slides, an evaporation cap opening mechanism disposed within the outer casing for opening an evaporation cap, an evaporation cap closing mechanism disposed within the outer casing for closing an evaporation cap, a drawer locking mechanism disposed within the outer casing for locking a drawer associated with the outer casing, a camera disposed within the outer casing, and a robot disposed within the outer casing. The robot is movable in three dimensions and has means for conducting three or more of the following operations: slide loading; slide ejecting; evaporation cap opening; evaporation cap closing; drawer locking; and camera manipulation.Type: GrantFiled: January 8, 2015Date of Patent: October 24, 2017Assignee: IDEXX Laboratories, Inc.Inventors: David Lance Connolly, Mark Raymond Dumont, Justin Jay Griffin, John Harvey McGibbon, Garland Christian Misener, Jeffrey Eric Phelps, Carl Russell Rich, Kenneth Eugene Smith, Dragan Vidacic
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Patent number: 9746469Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.Type: GrantFiled: April 23, 2015Date of Patent: August 29, 2017Assignees: IDEXX Laboratories, Inc., Monsanto CompanyInventors: David Allen Elsemore, Jinming Geng, Laurie A Flynn, Michael Crawford
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Patent number: 9644230Abstract: A method for detecting bacteria and determining the concentration thereof in a liquid sample includes the steps of taking an optical section through a container holding a volume of the liquid sample at a predetermined field of view and at a predetermined focal plane depth or angle and after a period of time has elapsed to allow non-bacteria in the sample to settle to the bottom of the container. Since bacteria auto arranges in the liquid sample, forming a lattice-like grid pattern, an optical section through the volume of auto-arranged bacteria may be used to measure the quantity of bacteria residing in that section. A container for holding the liquid sample has particular structure which aids in separating the non-bacteria from the bacteria.Type: GrantFiled: October 28, 2014Date of Patent: May 9, 2017Assignee: IDEXX Laboratories, Inc.Inventors: Jeremy Hammond, James Russell
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Patent number: 9453796Abstract: A method of deriving correction for instrument-to-instrument variations in the illumination band centroid wavelengths and wavelength band shapes of the optical systems of clinical chemistry instruments includes the steps of determining the centroid wavelength and wavelength band shape of a light source used in the optical system of a clinical chemistry instrument to provide a determined wavelength band shape and centroid wavelength, comparing the determined wavelength band shape and centroid wavelength with a known reflection density or absorbance wavelength spectrum of a specific type of chemical reagent test to provide a correction value, and calculating the correction value, which is to be used to modify a reflection density or absorbance measurement taken by the instrument of a reagent test of the a specific type of chemical reagent test.Type: GrantFiled: December 26, 2014Date of Patent: September 27, 2016Assignee: IDEXX Laboratories, Inc.Inventor: Garland Christian Misener
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Patent number: 9354225Abstract: The invention provides methods for detection in stored biological samples of PrPsc and other analytes that are present in exosomes.Type: GrantFiled: November 5, 2009Date of Patent: May 31, 2016Assignee: IDEXX Laboratories, Inc.Inventors: Sergio Agustin Lizano-González, Lisa Ann Estey
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Patent number: D876960Type: GrantFiled: March 30, 2018Date of Patent: March 3, 2020Assignee: IDEXX LABORATORIES, INC.Inventors: Michael Fletcher, David L. Connolly, Anne Leavitt, Matthew M. Furtney, Christopher Labak, Christopher Aiston, Daniel O'Sullivan
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Patent number: D876961Type: GrantFiled: April 2, 2019Date of Patent: March 3, 2020Assignee: IDEXX LABORATORIES, INC.Inventors: Michael Fletcher, David L. Connolly, Anne Leavitt, Matthew M. Furtney, Daniel O'Sullivan, Christopher Labak, Christopher Aiston
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Patent number: D879622Type: GrantFiled: October 10, 2019Date of Patent: March 31, 2020Assignee: IDEXX Laboratories, Inc.Inventors: Michael Fletcher, David L. Connolly, Anne Leavitt, Matthew M. Furtney, Christopher Labak, Christopher Aiston, Daniel O'Sullivan
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Patent number: D880313Type: GrantFiled: October 10, 2019Date of Patent: April 7, 2020Assignee: IDEXX LABORATORIES, INC.Inventors: Michael Fletcher, David L. Connolly, Anne Leavitt, Matthew M. Furtney, Daniel O'Sullivan, Christopher Labak, Christopher Aiston