Patents Assigned to Indena S.p.A.
  • Publication number: 20070104661
    Abstract: The present invention relates to compositions containing anthocyanosides and/or procyanidins in combination with floroglucinols for the treatment of the affections of the oral cavity and upper respiratory tract.
    Type: Application
    Filed: November 11, 2004
    Publication date: May 10, 2007
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • Patent number: 7214395
    Abstract: Pharmaceutical and cosmetic compositions for the prevention of skin aging, containing phospholipid complexes of extracts of Vitis vinifera, and phospholipid complexes of standardized extract from Centella asiatica.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: May 8, 2007
    Assignee: Indena S.p.A.
    Inventor: Francesco Di Pierro
  • Patent number: 7201931
    Abstract: Pharmaceutical and/or cosmetic compositions for the treatment and the prevention of scalp disorders, containing as active components extracts of Serenoa repens and of Vitis vinifera.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: April 10, 2007
    Assignee: Indena S.p.A.
    Inventor: Francesco Di Pierro
  • Publication number: 20070071839
    Abstract: The present invention relates to topical compositions containing: a) Ginkgo biloba terpenes; b) floroglucinols pure or in mixture thereof, extracted from Humulus lupulus, Hypericum sp and Mirtus sp; c) Zanthoxylum bungeanum or Echinacea angustifolia lipophilic extract; for the treatment of atopic dermatitis, skin allergic conditions and acne.
    Type: Application
    Filed: November 8, 2004
    Publication date: March 29, 2007
    Applicant: Indena S.P.A.
    Inventor: Ezio Bombardelli
  • Patent number: 7153884
    Abstract: Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R1 is t-butoxycarbonyl or benzoyl; R2 is hydroxy; R3 is hydrogen or, together with R2, it forms the residue of a cyclic carbonate of formula: II with the proviso that when R3 is hydrogen, R is different from phenyl.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: December 26, 2006
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Arturo Battaglia, Samanta Cimitan
  • Publication number: 20060275246
    Abstract: The invention relates to a process for the preparation of ferutinine (Ia) from Ferula spp extracts comprising basic hydrolysis of the extracts and treatment with p-pivaloyloxybenzoic acid. The invention relates also to the use of the extracts and ferutinine in the cosmetic and dermatological field.
    Type: Application
    Filed: March 23, 2004
    Publication date: December 7, 2006
    Applicant: INDENA S. P. A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Aldo Cristoni, Enrico Mercalli
  • Patent number: 7128932
    Abstract: Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in the weight ratio of 1.5–3.5:1–2:0.1–0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiologically equivalent esters salts or precursor thereof. The compositions according to the invention are useful in the treatment of male and female sexual dysfunctions.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: October 31, 2006
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Roberto Seghizzi
  • Patent number: 7112687
    Abstract: Methods for obtaining paclitaxel from plants containing paclitaxel are disclosed. Plant material is first obtained from plants containing paclitaxel. Paclitaxel is then extracted from the plant material. Subsequently, paclitaxel is separated from the paclitaxel extract using a series of column chromatography separation steps to obtain at least one fraction containing paclitaxel. The paclitaxel in a fraction that is obtained from the final chromatography step is crystallized. Using these methods, high purity paclitaxel may be efficiently obtained from plants containing paclitaxel.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: September 26, 2006
    Assignee: Indena, S.p.A.
    Inventors: Bruno Gabetta, Gianfranco Zini
  • Patent number: 7108871
    Abstract: A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group 3 soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administering the extract to treat conditions such as pre- or post-menopausal symptoms, cancer, such as breast or prostate cancer, or alcoholism. The extracts are made by a process which includes the steps of treating ripe whole soya beans or oil-free soya flour with an aliphatic alcohol to obtain a first extract; concentrating the first extract to form a concentrated first extract; purifying the concentrated first extract by treatment with at least one aliphatic hydrocarbon; and extracting active components from the purified concentrated first extract with a water-immiscible aliphatic alcohol to obtain a second extract. Preferably, the final extract is concentrated dried to form the desired soya extract.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: September 19, 2006
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta
  • Patent number: 7105705
    Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: September 12, 2006
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
  • Patent number: 7078538
    Abstract: A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: July 18, 2006
    Assignee: INDENA S.p.A.
    Inventors: Alessandro Pontiroli, Ezio Bombardelli
  • Patent number: 7078432
    Abstract: A process for the preparation of 14?-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 18, 2006
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Maria Luisa Gelmi, Donato Pocar
  • Publication number: 20060142185
    Abstract: A method for the use of lupin conglutin gamma or of proteins showing homology higher than 50% with lupin conglutin gamma, for the preparation of a medicament, food supplements or foods for the treatment of type II diabetes, pharmaceutical and nutritional compositions containing lupin conglutin gamma, and the use of lupin conglutin gamma as therapeutical agent, in particular as hypoglycemizing agent. Lupin conglutin gamma may be used in pure form or in form of extracts, mixtures or concentrates.
    Type: Application
    Filed: February 6, 2004
    Publication date: June 29, 2006
    Applicant: Indena S.P.A.
    Inventors: Paolo Morazzoni, Marcello Duranti
  • Patent number: 7057078
    Abstract: Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment of depression, and Alzheimer's disease.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: June 6, 2006
    Assignee: INDENA S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
  • Patent number: 7053222
    Abstract: A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid conditions and in a single step. In formula (II) R1 is aryl or heteroaryl.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: May 30, 2006
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • Publication number: 20050220905
    Abstract: Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in tile weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiologically equivalent esters salts or precursor thereof. The compositions according to the invention are useful in the treatment of male and female sexual dysfunctions.
    Type: Application
    Filed: April 30, 2003
    Publication date: October 6, 2005
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva
  • Publication number: 20050165117
    Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmanceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, ii particular in the treatment of depression and Alzheimer's disease.
    Type: Application
    Filed: April 18, 2003
    Publication date: July 28, 2005
    Applicant: Indena S. P.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
  • Patent number: 6911325
    Abstract: A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from aspergillus niger.
    Type: Grant
    Filed: May 29, 2000
    Date of Patent: June 28, 2005
    Assignee: Indena S.p.A.
    Inventors: Cesare Ponzone, Mario De Rosa, Alessandra Morana, Antonella Di Lazzaro
  • Patent number: 6906101
    Abstract: A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-?-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: June 14, 2005
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta, Alessandro Pontiroli
  • Publication number: 20050113585
    Abstract: A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed.
    Type: Application
    Filed: October 26, 2004
    Publication date: May 26, 2005
    Applicant: INDENA S.P.A.
    Inventors: Alessandro Pontiroli, Ezio Bombardelli