Abstract: The present invention relates to compositions containing anthocyanosides and/or procyanidins in combination with floroglucinols for the treatment of the affections of the oral cavity and upper respiratory tract.
Abstract: Pharmaceutical and cosmetic compositions for the prevention of skin aging, containing phospholipid complexes of extracts of Vitis vinifera, and phospholipid complexes of standardized extract from Centella asiatica.
Abstract: Pharmaceutical and/or cosmetic compositions for the treatment and the prevention of scalp disorders, containing as active components extracts of Serenoa repens and of Vitis vinifera.
Abstract: The present invention relates to topical compositions containing: a) Ginkgo biloba terpenes; b) floroglucinols pure or in mixture thereof, extracted from Humulus lupulus, Hypericum sp and Mirtus sp; c) Zanthoxylum bungeanum or Echinacea angustifolia lipophilic extract; for the treatment of atopic dermatitis, skin allergic conditions and acne.
Abstract: Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R1 is t-butoxycarbonyl or benzoyl; R2 is hydroxy; R3 is hydrogen or, together with R2, it forms the residue of a cyclic carbonate of formula: II with the proviso that when R3 is hydrogen, R is different from phenyl.
Abstract: The invention relates to a process for the preparation of ferutinine (Ia) from Ferula spp extracts comprising basic hydrolysis of the extracts and treatment with p-pivaloyloxybenzoic acid. The invention relates also to the use of the extracts and ferutinine in the cosmetic and dermatological field.
Abstract: Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in the weight ratio of 1.5–3.5:1–2:0.1–0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiologically equivalent esters salts or precursor thereof. The compositions according to the invention are useful in the treatment of male and female sexual dysfunctions.
Type:
Grant
Filed:
April 30, 2003
Date of Patent:
October 31, 2006
Assignee:
Indena S.p.A.
Inventors:
Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Roberto Seghizzi
Abstract: Methods for obtaining paclitaxel from plants containing paclitaxel are disclosed. Plant material is first obtained from plants containing paclitaxel. Paclitaxel is then extracted from the plant material. Subsequently, paclitaxel is separated from the paclitaxel extract using a series of column chromatography separation steps to obtain at least one fraction containing paclitaxel. The paclitaxel in a fraction that is obtained from the final chromatography step is crystallized. Using these methods, high purity paclitaxel may be efficiently obtained from plants containing paclitaxel.
Abstract: A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group 3 soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administering the extract to treat conditions such as pre- or post-menopausal symptoms, cancer, such as breast or prostate cancer, or alcoholism. The extracts are made by a process which includes the steps of treating ripe whole soya beans or oil-free soya flour with an aliphatic alcohol to obtain a first extract; concentrating the first extract to form a concentrated first extract; purifying the concentrated first extract by treatment with at least one aliphatic hydrocarbon; and extracting active components from the purified concentrated first extract with a water-immiscible aliphatic alcohol to obtain a second extract. Preferably, the final extract is concentrated dried to form the desired soya extract.
Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.
Type:
Grant
Filed:
April 18, 2003
Date of Patent:
September 12, 2006
Assignee:
Indena S.p.A.
Inventors:
Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
Abstract: A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed.
Abstract: A process for the preparation of 14?-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.
Type:
Grant
Filed:
July 18, 2002
Date of Patent:
July 18, 2006
Assignee:
Indena S.p.A.
Inventors:
Ezio Bombardelli, Gabriele Fontana, Maria Luisa Gelmi, Donato Pocar
Abstract: A method for the use of lupin conglutin gamma or of proteins showing homology higher than 50% with lupin conglutin gamma, for the preparation of a medicament, food supplements or foods for the treatment of type II diabetes, pharmaceutical and nutritional compositions containing lupin conglutin gamma, and the use of lupin conglutin gamma as therapeutical agent, in particular as hypoglycemizing agent. Lupin conglutin gamma may be used in pure form or in form of extracts, mixtures or concentrates.
Abstract: Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment of depression, and Alzheimer's disease.
Type:
Grant
Filed:
April 15, 2003
Date of Patent:
June 6, 2006
Assignee:
INDENA S.p.A.
Inventors:
Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
Abstract: A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid conditions and in a single step. In formula (II) R1 is aryl or heteroaryl.
Abstract: Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in tile weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiologically equivalent esters salts or precursor thereof. The compositions according to the invention are useful in the treatment of male and female sexual dysfunctions.
Type:
Application
Filed:
April 30, 2003
Publication date:
October 6, 2005
Applicant:
INDENA S.P.A.
Inventors:
Ezio Bombardelli, Paolo Morazzoni, Antonella Riva
Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmanceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, ii particular in the treatment of depression and Alzheimer's disease.
Type:
Application
Filed:
April 18, 2003
Publication date:
July 28, 2005
Applicant:
Indena S. P.A.
Inventors:
Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
Abstract: A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from aspergillus niger.
Type:
Grant
Filed:
May 29, 2000
Date of Patent:
June 28, 2005
Assignee:
Indena S.p.A.
Inventors:
Cesare Ponzone, Mario De Rosa, Alessandra Morana, Antonella Di Lazzaro
Abstract: A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-?-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue.
Type:
Grant
Filed:
July 3, 2000
Date of Patent:
June 14, 2005
Assignee:
Indena S.p.A.
Inventors:
Ezio Bombardelli, Bruno Gabetta, Alessandro Pontiroli
Abstract: A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed.