Patents Assigned to Indena S.p.A.
  • Compositions for the treatment of affections of the oral cavity and upper respiratory tract
    Patent number: 7910139
    Abstract: Compositions for the treatment of the affections of the oral cavity and upper respiratory tract include anthocyanosides, procyanidins and phloroglucinols. The anthocyanosides are derived from Vaccinium myrtillus extract, the procyanidins are derived from a Vitus vinifera extract, a Camellia sinensis extract or from other edible plants containing procyanidins, and the phloroglucinols are derived from Hypericum spp., Myrtus spp. or Humulus lupulus extracts.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: March 22, 2011
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • Process for the extraction, purification and enzymatic modification of soy 7S globulin ?? subunit for use as hypocholesterolemizing agent
    Patent number: 7901718
    Abstract: A process for the extraction, purification and enzymatic modification of ?-conglycinin ?? subunit, wherein ?-conglycinin is selectively extracted from ground, defatted soy, then precipitated by treatment with aqueous ethanol; the enriched fraction is then subjected to Metal Affinity Chromatography (MAC) in denaturant conditions to obtain the ?? subunit, which is treated with chymotrypsin, then subjected to a further MAC to recover the amino-terminal region of this polypeptide (MW 28,000 Da).
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: March 8, 2011
    Assignee: Indena S.p.A.
    Inventors: Marcello Duranti, Paolo Morazzoni
  • USE OF ISOTHIOCYANATE DERIVATIVES AS ANTI-MYELOMA AGENTS
    Publication number: 20110053870
    Abstract: The invention concerns the use of glucomoringin and of its des-thio-glucoside having the following formulae (I, II): for the preparation of a medicament for the treatment of myeloma.
    Type: Application
    Filed: December 17, 2008
    Publication date: March 3, 2011
    Applicant: INDENA S.P.A.
    Inventors: Paolo Morazzoni, Carla Manzotti, Gabriele Fontana, Antonella Riva, Renato Iori
  • SOLID FORMS OF ORTATAXEL
    Publication number: 20110054015
    Abstract: The present invention relates to solid forms of 13-(N-Boc-?-isobutylserinyl)-14-?-hydroxybaccatin III 1,14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.
    Type: Application
    Filed: January 12, 2009
    Publication date: March 3, 2011
    Applicant: Indena S.p.A.
    Inventors: Daniele Ciceri, Nicola Sardone, Bruno Gabetta, Maurizio Ricotti
  • Formulations containing and extracts which are useful in the treatment of obesity
    Patent number: 7887855
    Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitizing the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: February 15, 2011
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Formulations containing and extracts which are useful in the treatment of obesity
    Patent number: 7887854
    Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: February 15, 2011
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • FORMULATIONS WITH SANGUINARINE, CHELERYTHRINE OR CHELIDONINE FOR THE TREATMENT OF WARTS, VERRUCAS AND PSORIATIC PLAQUES
    Publication number: 20110014306
    Abstract: The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.
    Type: Application
    Filed: March 9, 2009
    Publication date: January 20, 2011
    Applicant: INDENA S.P.A
    Inventors: Ezio Bombardelli, Gabriele Fontana, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • ANTITUMORAL AGENTS WITH A BENZOPHENANTHRIDINE STRUCTURE AND FORMULATIONS CONTAINING THEM
    Publication number: 20100331525
    Abstract: The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.
    Type: Application
    Filed: February 16, 2009
    Publication date: December 30, 2010
    Applicant: INDENA S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Paolo Morazzoni, Antonella Riva
  • COMPOSITIONS FOR THE TREATMENT OF BENIGN PROSTATE HYPERTROPHY, PROSTATITIS, PROSTATOSIS AND PROSTATE CANCER
    Publication number: 20100316740
    Abstract: Compositions including Serenoa repens, Echinacea and Hypericum perforatum extracts and selenium compounds for the treatment of prostate disorders, in particular for the treatment of prostate cancer, prostatitis, prostatosis and urinary incontinence.
    Type: Application
    Filed: February 17, 2009
    Publication date: December 16, 2010
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • FORMULATIONS FOR THE TREATMENT OF MUCOSITIS INDUCED BY ANTITUMOR OR IMMUNOSUPPRESSIVE THERAPY
    Publication number: 20100284945
    Abstract: Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients for the treatment and/or prevention of mucositis.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 11, 2010
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • PROCESS FOR COSMETIC TREATMENT USING FERUTININE FROM FERULA GENUS PLANTS
    Publication number: 20100255125
    Abstract: The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine from Ferula spp extracts.
    Type: Application
    Filed: June 16, 2010
    Publication date: October 7, 2010
    Applicant: INDENA S.P.A.
    Inventors: Ezio BOMBARDELLI, Gabriele FONTANA, Aldo CRISTONI, Enrico MERCALLI
  • P185 -encoding DNA and therapeutical uses thereof
    Patent number: 7795016
    Abstract: Plasmids containing sequences encoding different fragments of p185neu oncoprotein, able to induce an immune response against tumours expressing oncogenes of the ErbB family, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: September 14, 2010
    Assignee: Indena S.p.A.
    Inventors: Augusto Amici, Federica Cavallo, Guido Forni, Cristina Marchini
  • STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF LYCOPENE FOR SKIN AND HAIR
    Publication number: 20100190867
    Abstract: The present invention relates to a method of manufacturing a stable composition enriched in cis-lycopene (z-isomers) by prolonged heating in solvents of tomatoes, parts of tomatoes, derivative thereof or tomato extracts in solvents.
    Type: Application
    Filed: July 30, 2007
    Publication date: July 29, 2010
    Applicant: INDENA S.P.A.
    Inventors: Andrea Giori, Federico Franceschi
  • COMBINATIONS OF VASOACTIVE SUBSTANCES WITH ESTROGENS AND THEIR USE IN THE TREATMENT OF FEMALE SEXUAL DYSFUNCTIONS
    Publication number: 20100183751
    Abstract: Compositions comprising: vasokinetic natural coumarins or extracts containing them; anti-phosphodiesterase agents selected from 3,7-O-di-(2-hydroxyethyl)icaritin or 7-O-hydroxyethyl-icariside II and/or forskolin or extracts containing them; phytoestrogens selected from ferutinine or ferutinine-containing extracts of Ferula sp. or p-pivaloylferutinine.
    Type: Application
    Filed: June 26, 2008
    Publication date: July 22, 2010
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • METHOD OF TREATING VASCULAR INJURIES INDUCED BY AN EXCESS OF PLASMA LIPIDS USING COMBINATIONS OF VASOPROTECTIVE AGENTS
    Publication number: 20100160427
    Abstract: Combinations of vasoprotective agents useful for the prevention and the treatment of vascular injuries induced by an excess of plasma lipids comprising polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.
    Type: Application
    Filed: March 10, 2010
    Publication date: June 24, 2010
    Applicant: INDENA S.P.A.
    Inventor: EZIO BOMBARDELLI
  • FORMULATIONS CONTAINING CYNARA SCOLYMUS AND PHASEOLUS VULGARIS EXTRACTS WHICH ARE USEFUL IN THE TREATMENT OF OBESITY
    Publication number: 20100136145
    Abstract: A Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing the Cynara scolymus extract with a Phaseolus vulgaris extract. The composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.
    Type: Application
    Filed: March 6, 2008
    Publication date: June 3, 2010
    Applicant: INDENA S.P.A.
    Inventors: Ezio BOMBARDELLI, Gabriele FONTANA, Andrea GIORI, Paolo MORAZZONI, Cesare PONZONE, Massimo RONCHI
  • CAMPTOTHECIN DERIVATIVES WITH ANTITUMOR ACTIVITY
    Publication number: 20100120816
    Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
    Type: Application
    Filed: July 13, 2007
    Publication date: May 13, 2010
    Applicant: INDENA S.P.A.
    Inventors: Gabriele Fontana, Ezio Bombardelli, Carla Manzotti, Arturo Battaglia, Cristian Samori
  • Oral compositions for the treatment of cellulite
    Patent number: 7691422
    Abstract: The present invention relates to oral pharmaceutical and cosmetic compositions for the treatment of cellulite containing Vitis vinifera extracts, Centella asiatica triterpenes and dimeric Ginkgo biloba flavonoids, in the free form or complexed with phospholipids.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: April 6, 2010
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them
    Patent number: 7687545
    Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antinflammatory, antiarthritic and antiviral activity.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: March 30, 2010
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • Colchicoside analogues
    Patent number: 7683163
    Abstract: The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: March 23, 2010
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana