Patents Assigned to Indena S.p.A.
  • TRPV1 agonists, formulations containing them and uses thereof
    Patent number: 7429673
    Abstract: The compounds of the general formula (I) in which X is represents two hydrogen atoms, a ?-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: September 30, 2008
    Assignee: Indena S.p.A.
    Inventors: Paolo Morazzoni, Antonella Riva, Gabriele Fontana, Giovanni Appendino, Vincenzo Di Marzo
  • FORMULATIONS CONTAINING CYNARA SCOLYMUS AND PHASEOLUS VULGARIS EXTRACTS WHICH ARE USEFUL IN THE TREATMENT OF OBESITY
    Publication number: 20080220097
    Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio BOMBARDELLI, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • FORMULATIONS OF ALPHA-AMYLASE INHIBITORS WITH ALPHA-GLUCOSIDASE INNHIBITORS USEFUL IN THE TREATMENT OF DIABETES AND OBESITY
    Publication number: 20080220098
    Abstract: This invention relates to the combination of ?-amylase inhibitors prepared from Phaseolus vulgaris with ?-glucosidase inhibitors obtained from Salacia oblonga and other species. The ?-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with ?-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio BOMBARDELLI, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • CYNARA SCOLYMUS EXTRACTS AND COMPOSITIONS CONTAINING THEM
    Publication number: 20080220096
    Abstract: The present invention relates to a Cynara scolymus extract with a high caffeoylquinic acid content, obtainable by extraction from undried globe artichoke heads with alcohols having up to three carbon atoms.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: INDENA S. P. A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • SEMISYNTHESIS PROCESS FOR THE PREPARATION OF 10 DEACETYL-N-DEBENZOYL-PACLITAXEL
    Publication number: 20080200700
    Abstract: The invention relates to a process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel (I) a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof. The invention also discloses a process for the preparation of Docetaxel starting from said compound of formula (I).
    Type: Application
    Filed: April 17, 2008
    Publication date: August 21, 2008
    Applicant: INDENA S.P.A.
    Inventors: Bruno GABETTA, Andrea Gambini, Ezio Bombardelli, Gabriele Fontana
  • Pharmaceutical and cosmetic compositions for the protection of the skin from damages induced by sun radiations
    Publication number: 20080175802
    Abstract: Pharmaceutical and cosmetic compositions for the protection of the skin from damages induced by sun radiations, containing ingredients of vegetable origin, in addition to conventional sun filters and excipients.
    Type: Application
    Filed: May 25, 2007
    Publication date: July 24, 2008
    Applicant: INDENA S.P.A.
    Inventor: Francesco Di Pierro
  • N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them
    Patent number: 7399788
    Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —COHN—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula (I) have antiproliferative, antinflammatory, antiarthritic and antiviral activity.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: July 15, 2008
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • Semisynthesis Process for the Preparation of 10-Deacytyl-N-Debenzoyl-Paclitaxel
    Publication number: 20080167369
    Abstract: The invention relates to a process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel, a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof. The invention also discloses a process for the preparation of Docetaxel starting from said compound of formula (I).
    Type: Application
    Filed: October 7, 2005
    Publication date: July 10, 2008
    Applicant: INDENA S.P.A.
    Inventors: Bruno Gabetta, Andrea Gambini, Ezio Bombardelli, Gabriele Fontana
  • FORMULATIONS USEFUL IN THE TREATMENT OF MALE AND FEMALE IMPOTENCE
    Publication number: 20080145458
    Abstract: Pharmaceutical compositions containing: extracts of Tribulus terrestris, Epimedium koreanum, Cinnamon cassia in the weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; and optionally arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions are useful in the treatment of male and female sexual dysfunctions. A method of treatment using the pharmaceutical compositions is also described.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 19, 2008
    Applicant: INDENA S.p.A
    Inventors: Ezio BOMBARDELLI, Paolo MORAZZONI, Antonella RIVA, Roberto SEGHIZZI
  • Pharmaceutical and cosmetic compositions for the protection of the skin from damages induced by sun radiations
    Patent number: 7374748
    Abstract: Pharmaceutical and cosmetic compositions for the protection of the skin from damages induced by sun radiations, containing ingredients of vegetable origin, in addition to conventional sun filters and excipients.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: May 20, 2008
    Assignee: Indena S.p.A.
    Inventor: Francesco Di Pierro
  • Process for the preparation of ferutinine from genus plants
    Patent number: 7371886
    Abstract: The invention relates to a process for the preparation of ferutinine (Ia) from Ferula spp extracts comprising basic hydrolysis of the extracts and treatment with p-pivaloyloxybenzoic acid.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: May 13, 2008
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombarrdelli, Gabriele Fontana, Aldo Cristoni, Enrico Mercalli
  • Formulations useful in the treatment of male and female impotence
    Patent number: 7361370
    Abstract: Pharmaceutical compositions containing: extracts of Tribulus terrestris, Epimedium koreanum, Cinnamon cassia in the weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; and optionally arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions are useful in the treatment of male and female sexual dysfunctions. A method of treatment using the pharmaceutical compositions is also described.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: April 22, 2008
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Roberto Seghizzi
  • Pharmaceutical and cosmetic composition against skin aging
    Patent number: 7354610
    Abstract: Pharmaceutical and cosmetic compositions for the prevention of skin aging, containing phospholipid complexes of extracts of Vitis vinifera, and phospholipid complexes of standardized extract from Centella asiatica.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: April 8, 2008
    Assignee: Indena S.p.A.
    Inventor: Francesco Di Pierro
  • Use Of Medicinal Plants And Extracts Thereof With Growth Promoting Activity In Veterinary Medicine And Zootechnics
    Publication number: 20080075799
    Abstract: The present invention relates to the use of extracts of plants or fruits of the Lycium genus, in particular of Lycium barbarum, for the preparation of growth promoters for use in livestock.
    Type: Application
    Filed: July 20, 2005
    Publication date: March 27, 2008
    Applicant: INDENA S.P.A.
    Inventors: Andrea Giori, Gianpaolo Forni, Giancomo Mombelli
  • Use of lupin conglutin for the treatment of type II diabetes
    Patent number: 7323441
    Abstract: A method for the use of lupin conglutin gamma or of proteins showing homology higher than 50% with lupin conglutin gamma, for the preparation of a medicament, food supplements or foods for the treatment of type II diabetes, pharmaceutical and nutritional compositions containing lupin conglutin gamma, and the use of lupin conglutin gamma as therapeutical agent, in particular as hypoglycemizing agent. Lupin conglutin gamma may be used in pure form or in form of extracts, mixtures or concentrates.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: January 29, 2008
    Assignee: Indena S.p.A.
    Inventors: Paolo Morazzoni, Marcello Duranti
  • Process for the preparation of the 14?-hydroxy-baccatin III-1,14-carbonate
    Patent number: 7317113
    Abstract: A process for the preparation of 14?-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: January 8, 2008
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Arturo Battaglia, Andrea Guerrini, Eleonora Baldelli
  • Pharmaceutical and cosmetic composition against skin aging
    Publication number: 20070184134
    Abstract: Pharmaceutical and cosmetic compositions for the prevention of skin aging, containing phospholipid complexes of extracts of Vitis vinifera, and phospholipid complexes of standardized extract from Centella asiatica.
    Type: Application
    Filed: April 9, 2007
    Publication date: August 9, 2007
    Applicant: INDENA S.P.A..
    Inventor: Francesco Di Pierro
  • Process for the preparation of a taxane derivative
    Patent number: 7232916
    Abstract: The invention relates to an improved process for the synthesis of 13-(N-Boc-?-isobutylserinyl)-14-?-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarbonate and the 7-hydroxy group is protected with a trichloroacetyl group.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: June 19, 2007
    Assignee: Indena S.p.A.
    Inventors: Bruno Gabetta, Daniele Ciceri
  • Semi-synthetic taxanes with antitumor and antiangiogenetic activities
    Patent number: RE39723
    Abstract: Seco-baccatin III derivatives of formula: wherein R, R1-R4, R1 R?, R11 R?, and R111 R?? are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; and methods for treating cancer, arthritis, and inhibiting angiogenesis in an animal comprising administrating to a patient in need thereof a therapeutically effective amount of a seco-baccatin III derivative are disclosed.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: July 10, 2007
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Alessandro Pontiroli
  • Process for the preparation of taxanes from 10-deacetylbaccatin III
    Patent number: RE40120
    Abstract: A process for the preparation of taxane derivatives by reacting 10-deacetylbaccatin III protected at the 7-and 1-positions with trichloroacetyl groups with a compound of formula and subsequent removal of the protective groups and hydrolysis of the oxazolidine ring.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: February 26, 2008
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli