Patents Assigned to Indena S.p.A.
  • Process for the preparation of (2R,3S)-3-phenylisoserine methyl ester acetate salt
    Patent number: 8106231
    Abstract: A process for the enantioselective preparation of (2R,3S)-3-phenylisoserine methyl ester acetate salt of formula (I) which is an useful building block for the synthesis of taxane derivatives. The process involves the resolution of racemic threo-phenylisoserine amide and its conversion into (I).
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: January 31, 2012
    Assignee: Indena S.p.A.
    Inventors: Daniele Ciceri, Bruno Gabetta, Nicola Vignola, Frieder Mitzel, Beat T. Weber
  • Process for cosmetic treatment using ferutinine from genus plants
    Patent number: 8101215
    Abstract: The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine from Ferula spp extracts.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: January 24, 2012
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombarrdelli, Gabriele Fontana, Aldo Cristoni, Enrico Mercalli
  • COMPOSITIONS COMPRISING A LIPOPHILIC EXTRACT OF ZINGIBER OFFICINALE AND AN EXTRACT OF CYNARA SCOLYMUS, WHICH ARE USEFUL FOR THE PREVENTION AND TREATMENT OF OESOPHAGEAL REFLUX AND IRRITABLE BOWEL SYNDROME
    Publication number: 20120015060
    Abstract: The present invention relates to compositions consisting of a combination of a lipophilic extract of Zingiber officinale and an extract of Cynara scolymus, which are useful for the prevention and treatment of oesophageal reflux and irritable bowel syndrome, to reduce postprandial drowsiness, and having prokinetic and anti-dyspeptic activities.
    Type: Application
    Filed: January 15, 2010
    Publication date: January 19, 2012
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • COMBINATIONS OF VASOACTIVE AGENTS AND THEIR USE IN THE TREATMENT OF SEXUAL DYSFUNCTIONS
    Publication number: 20120009283
    Abstract: Combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication are provided. The vasoactive compounds are esculoside, visnadine, forskolin or extracts thereof, purified lipophilic extracts from plants of the genus Ipomea, esters of ximenynic acid, icarin or icarin derivatives, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 12, 2012
    Applicant: INDENA S.P.A.
    Inventor: Ezio BOMBARDELLI
  • Combinations of vasoactive agents and their use in the treatment of sexual dysfunctions
    Patent number: 8092844
    Abstract: This invention relates to combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication. The active compounds are selected from a: esculoside or visnadine; forskolin or extracts containing it, or alternatively, purified lipophilic extracts of plants of the genus Ipomea; esters of ximenynic acid; optionally, at least one compound selected from a icarin or derivatives or extracts thereof which contain it, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: January 10, 2012
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • Phospholipid complexes of olive fruits extracts having improved bioavailability
    Patent number: 8084067
    Abstract: Phospholipids complexes of olive fruits extracts or compositions containing it having improved bioavailability.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: December 27, 2011
    Assignee: Indena S.p.A.
    Inventors: Andrea Giori, Federico Franceschi
  • Camptothecin derivatives with antitumor activity
    Patent number: 8076351
    Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: December 13, 2011
    Assignee: Indena S.p.A.
    Inventors: Gabriele Fontana, Ezio Bombardelli, Carla Manzotti, Arturo Battaglia, Maria Grazia Allegri, legal representative, Cristian Samori
  • P185NEU-ENCODING DNA AND THERAPEUTICAL USES THEREOF
    Publication number: 20110245330
    Abstract: Methods for inhibiting the formation and growth of a p185neu positive tumor in a subject, and for treating a subject having a p185neu positive tumor, utilizing a DNA vector coding for a chimeric rat/human Her-2/neu/ErbB-2 protein are provided.
    Type: Application
    Filed: May 17, 2011
    Publication date: October 6, 2011
    Applicant: INDENA S.P.A.
    Inventors: Augusto AMICI, Federico Cavallo, Guido Forni, Cristina Marchini
  • Process for the preparation of galanthamine hydrobromide
    Patent number: 8013151
    Abstract: A process for the purification of galanthamine (I) comprising precipitation of galanthamine hydrobromide from a mixture of alkaloids obtained from a plant of the Amaryllidaceae family containing galanthamine, treatment of the hydrobromide with alkali, extraction and crystallization of galanthamine with a solvent of general formula (II), in which R1 is hydrogen or methyl and R2 is selected from n-butyl, isobutyl, sec-butyl and t-butyl. The resulting pure galanthamine can be conveniently used for the preparation of galanthamine hydrobromide.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: September 6, 2011
    Assignee: Indena S.p.A.
    Inventors: Bruno Gabetta, Enrico Mercalli
  • Compositions for the treatment of chronic degenerative inflammatory conditions
    Patent number: 7993683
    Abstract: Compositions comprising: saligenin or derivatives thereof or Salix ssp extracts containing from 10 to 50% of saligenin; substantially pure andrographolide or andrographolide enriched Andrographis paniculata extract containing from 5 to 30% of andrographolide; optionally N-acetyl-glucosamine and/or glucuronic acid or glucuronolactone.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: August 9, 2011
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni
  • Combinations of vasoactive agents, their use in the pharmaceutical and cosmetic field, and formulations containing them
    Patent number: 7976881
    Abstract: Combinations of vasoactive substances which act at venous or arterial level with phosphodiesterase inhibitors including phosphodiesterase V, in particular: visnadin or esculoside; at least one compound selected from icarin or derivatives thereof or extracts containing it, Gingko biloba dimeric flavones either in the free form or complexed with phospholipids, amentoflavone; at least one compound selected from escin, escin beta-sitosterol complexed with phospholipids, sericoside, sericoside complexed with phospholipids or Centella asiatica extract in the free form or complexed with phospholipids. The formulations are useful in reducing parmiculopathy and problems associated with venous insufficiency of the lower limbs.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: July 12, 2011
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • Use of winter savory () or the extracts thereof for the preparation of medicaments for the treatment of the premature ejaculation
    Patent number: 7976878
    Abstract: The use of Winter savory or its purified extracts rich in rosmarinic acid, the use of rosmarinic acid and the extracts containing it for the preparation of medicaments for the treatment of premature ejaculation.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: July 12, 2011
    Assignee: Indena S.p.A.
    Inventor: Mario Baraldi
  • METHOD OF REDUCING BLOOD CHOLESTEROL AND TRIGLYCERIDE LEVELS USING COMBINATIONS OF VASOPROTECTIVE AGENT
    Publication number: 20110142967
    Abstract: Combinations of vasoprotective agents useful for the treatment of reducing blood cholesterol and triglyceride levels induced by an excess of plasma lipids. The agents include polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.
    Type: Application
    Filed: February 24, 2011
    Publication date: June 16, 2011
    Applicant: INDENA S.P.A.
    Inventor: Ezio BOMBARDELLI
  • COMPOSITIONS FOR THE TREATMENT OF DISORDERS OF THE UPPER RESPIRATORY TRACT AND INFLUENZA SYNDROMES
    Publication number: 20110135769
    Abstract: The present invention relates to compositions based on benzophenanthridine alkaloids, extract of Hippophae rhamnoides and extract of Echinacea angustifolia which possess antibacterial, antiviral and anti-inflammatory activity, and are useful in the treatment of bacterial and viral infections of the upper respiratory tract, and in the treatment of influenza.
    Type: Application
    Filed: May 25, 2009
    Publication date: June 9, 2011
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • PROCESS FOR THE GLYCOSIDATION OF COLCHICINE AND THIOCOLCHICINE
    Publication number: 20110130554
    Abstract: A process for the preparation of compounds having formula (I) is disclosed, wherein: —R1 is a methoxy or methylthio group; —R2 is a O-glycosyloxy residue. Compounds having formula (I) are prepared by reacting the corresponding precursor having R2=OH and the suitably protected 1-acetyl-glycose.
    Type: Application
    Filed: April 9, 2009
    Publication date: June 2, 2011
    Applicant: INDENA S.P.A.
    Inventors: Stephen Beszant, Bruno Gabetta
  • PROCESS FOR THE EXTRACTION, PURIFICATION AND ENZYMATIC MODIFICATION OF SOY 7S GLOBULIN ALPHA' SUBUNIT FOR USE AS HYPOCHOLESTEROLEMIZING AGENT
    Publication number: 20110118182
    Abstract: A purified amino-terminal polypeptide fragment of the soy ?-conglycinin ?? subunit is prepared by selective extraction of defatted soy with an aqueous solution of sodium bisulfite, precipitation with ethanol, and Metal Affinity Chromatography (MAC) under denaturing conditions to obtain the ?? subunit. The ?? subunit is then enzymatically treated with chymotrypsin and subjected to further MAC to recover the amino-terminal fragment of the polypeptide (MW 28,000 Da).
    Type: Application
    Filed: January 26, 2011
    Publication date: May 19, 2011
    Applicant: INDENA S.P.A.
    Inventors: Marcello DURANTI, Paolo Morazzoni
  • COMPOSITIONS FOR THE TREATMENT OF VAGINAL INFECTIONS WITH CHRONIC INFLAMMATION
    Publication number: 20110104313
    Abstract: The present invention relates to compositions comprising benzofuran compounds and benzophenanthridine alkaloids, which possess anti-inflammatory, antibacterial and antifungal activity useful in the treatment of vaginal infections and the resulting inflammatory states.
    Type: Application
    Filed: April 6, 2009
    Publication date: May 5, 2011
    Applicant: INDENA S.P.A
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF INFECTIONS OF THE ORAL CAVITY
    Publication number: 20110091392
    Abstract: The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.
    Type: Application
    Filed: April 6, 2009
    Publication date: April 21, 2011
    Applicant: INDENA S.P.A
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • P185NEU-ENCODING DNA AND THERAPEUTICAL USES THEREOF
    Publication number: 20110071212
    Abstract: Plasmids containing sequences encoding different fragments of p185neu oncoprotein, able to induce an immune response against tumours expressing oncogenes of the ErbB family, and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 2, 2010
    Publication date: March 24, 2011
    Applicant: INDENA S.P.A.
    Inventors: AUGUSTO AMICI, FEDERICO CAVALLO, GUIDO FORNI, CRISTINA MARCHINI
  • Biotransformation of colchicinoid compounds
    Patent number: 7910334
    Abstract: The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: March 22, 2011
    Assignee: Indena S.p.A.
    Inventor: Cesare Ponzone