Patents Assigned to Indena S.p.A.
  • CAMPTOTHECIN DERIVATIVES WITH ANTITUMOR ACTIVITY
    Publication number: 20100010032
    Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
    Type: Application
    Filed: June 16, 2007
    Publication date: January 14, 2010
    Applicant: Indena S.p.A.
    Inventors: Gabriele Fontana, Ezio Bombardelli, Carla Manzotti, Arturo Battaglia, Cristian Samori
  • COMBINATIONS OF VASOACTIVE AGENTS AND THEIR USE IN THE TREATMENT OF SEXUAL DYSFUNCTIONS
    Publication number: 20090269426
    Abstract: This invention relates to combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication. The active compounds are selected from a:—esculoside or visnadine;—forskolin or extracts containing it, or alternatively, purified lipophilic extracts of plants of the genus Ipomea;—esters of ximenynic acid;—optionally, at least one compound selected from a icarin or derivatives or extracts thereof which contain it, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 29, 2009
    Applicant: INDENA S.P.A.
    Inventor: Ezio BOMBARDELLI
  • Compositions for the treatment of atopic dermatitis, skin allergic conditions and acne
    Patent number: 7597915
    Abstract: The present invention relates to topical compositions containing: a) Ginkgo biloba terpenes; b) floroglucinols pure or in mixture thereof, extracted from Humulus lupulus, Hypericum sp and Mirtus sp; c) Zanthoxylum bungeanum or Echinacea angustifolia lipophilic extract; for the treatment of atopic dermatitis, skin allergic conditions and acne.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: October 6, 2009
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them
    Patent number: 7582639
    Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antiinflammatory, antiarthritic and antiviral activity.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: September 1, 2009
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • Process for the preparation of tomato extracts with high content in lycopene
    Patent number: 7582325
    Abstract: A process for the extraction of lycopene from whole tomatoes, in which process tomatoes are heat concentrated and extracted with water-saturated ethyl acetate.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: September 1, 2009
    Assignee: Indena S.p.A.
    Inventor: Andrea Giori
  • N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them
    Patent number: 7579364
    Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antiinflammatory, antiarthritic and antiviral activity.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: August 25, 2009
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • Formulations of alpha-amylase inhibitors with alpha-glucosidase inhibitors useful in the treatment of diabetes and obesity
    Patent number: 7553502
    Abstract: This invention relates to the combination of ?-amylase inhibitors prepared from Phaseolus vulgaris with ?-glucosidase inhibitors obtained from Salacia oblonga and other species. The ?-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with ?-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: June 30, 2009
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Taxane derivatives functionalized at the 14-position and a process for the preparation thereof
    Patent number: 7498452
    Abstract: A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: March 3, 2009
    Assignee: Indena S.p.A.
    Inventors: Gabriele Fontana, Ezio Bombardelli, Arturo Battaglia, Eleonora Baldelli, Andrea Guerrini, Maria Luisa Gelmi, Giacomo Carenzi, Donato Pocar
  • Pharmaceutical and/or cosmetic compositions for the treatment of localised adiposities and cellulite
    Patent number: 7476392
    Abstract: The present invention relates to pharmaceutical and/or cosmetic compositions containing a combination of the following active principles: a) complex of escin/beta-sitosterol with phospholipids, b) complex of Gingko biloba dimeric flavonoids with phospholipids, c) complex of Centella asiatica triterpenes with phospholipids, and optionally one or both of: d) ethyl ximeninate e) Coleus forskolii standardized extract.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: January 13, 2009
    Assignee: Indena S.p.A.
    Inventor: Francesco Di Pierro
  • Biotransformation of colchicinoid compounds
    Publication number: 20090011479
    Abstract: The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.
    Type: Application
    Filed: May 12, 2004
    Publication date: January 8, 2009
    Applicant: INDENA S.p.A.
    Inventor: Cesare Ponzone
  • Process for the semisynthesis of deserpidine
    Patent number: 7468438
    Abstract: The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: December 23, 2008
    Assignee: Indena S.p.A.
    Inventors: Gabriele Fontana, Ezio Bombardelli, Cristian Samori, Eleonora Baldelli, Andrea Guerrini, Arturo Battaglia, Bruno Danieli
  • Process for the extraction, purification and enzymatic modification of soy 7S globulin ?' subunit for use as hypocholesterolemizing agent
    Patent number: 7465467
    Abstract: A process for the extraction, purification and enzymatic modification of ?-conglycinin ?? subunit, wherein ?-conglycinin is selectively extracted from ground, defatted soy, then precipitated by treatment with aqueous ethanol; the enriched fraction is then subjected to Metal Affinity Chromatography (MAC) in denaturant conditions to obtain the ?? subunit, which is treated with chymotrypsin, then subjected to a further MAC to recover the amino-terminal region of this polypeptide (MW 28,000 Da).
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: December 16, 2008
    Assignee: Indena S.p.A.
    Inventors: Marcello Duranti, Paolo Morazzoni
  • N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM
    Publication number: 20080287499
    Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antiinflammatory, antiarthritic and antiviral activity.
    Type: Application
    Filed: June 19, 2008
    Publication date: November 20, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
    Patent number: 7446126
    Abstract: A process is provided for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel (I) a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof. Also described is a process for the preparation of Docetaxel starting from the compound of formula (I).
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: November 4, 2008
    Assignee: Indena S.p.A.
    Inventors: Bruno Gabetta, Andrea Gambini, Ezio Bombardelli, Gabriele Fontana
  • N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM
    Publication number: 20080269292
    Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antinflammatory, antiarthritic and antiviral activity.
    Type: Application
    Filed: June 19, 2008
    Publication date: October 30, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • PROCESS FOR THE EXTRACTION, PURIFICATION AND ENZYMATIC MODIFICATION OF SOY 7S GLOBULIN ALPHA' SUBUNIT FOR USE AS HYPOCHOLESTEROLEMIZING AGENT
    Publication number: 20080261885
    Abstract: A process for the extraction, purification and enzymatic modification of ?-conglycinin ?? subunit, wherein ?-conglycinin is selectively extracted from ground, defatted soy, then precipitated by treatment with aqueous ethanol; the enriched fraction is then subjected to Metal Affinity Chromatography (MAC) in denaturant conditions to obtain the ?? subunit, which is treated with chymotrypsin, then subjected to a further MAC to recover the amino-terminal region of this polypeptide (MW 28,000 Da).
    Type: Application
    Filed: April 17, 2008
    Publication date: October 23, 2008
    Applicant: INDENA S.P.A.
    Inventors: Marcello DURANTI, Paolo MORAZZONI
  • Formulations useful in the treatment of male and female impotence
    Patent number: 7438934
    Abstract: Pharmaceutical compositions containing: extracts of Tribulus terrestris, Epimedium koreanum, Cinnamon cassia in the weight ratio of 1.5-3.5:1-2:0.1-0.4 respectively; and optionally arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions are useful in the treatment of male and female sexual dysfunctions. A method of treatment using the pharmaceutical compositions is also described.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: October 21, 2008
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Roberto Seghizzi
  • N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM
    Publication number: 20080255151
    Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antiinflammatory, antiarthritic and antiviral activity.
    Type: Application
    Filed: June 19, 2008
    Publication date: October 16, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • PROCESS FOR THE PREPARATION OF FERUTININE FROM FERULA GENUS PLANTS
    Publication number: 20080248139
    Abstract: The invention relates to a process for the preparation of ferutinine (Ia) from Ferula spp extracts comprising basic hydrolysis of the extracts and treatment with p-pivaloyloxybenzoic acid. The invention relates also to the use of the extracts and ferutinine in the cosmetic and dermatological field.
    Type: Application
    Filed: March 31, 2008
    Publication date: October 9, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Aldo Cristoni, Enrico Mercalli
  • Taxane derivatives and processes for the preparation thereof
    Patent number: RE40901
    Abstract: A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-?-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: September 1, 2009
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta, Alessandro Pontiroli