Patents Assigned to Institute for Basic Science
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Patent number: 11155604Abstract: The present invention relates to the preparation of an antibody analogue capable of being activated reversibly, and uses thereof, and provides a fusion protein comprising an inactive first fragment of an antibody analogue is fused to a stimulus-induced dimerization protein.Type: GrantFiled: December 21, 2016Date of Patent: October 26, 2021Assignee: INSTITUTE FOR BASIC SCIENCEInventors: Won Do Heo, Yun Ju Lee, Daseuli Yu, Byung Ouk Park
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Patent number: 11149281Abstract: The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA ribonucleoprotein (RNP). According to the present invention, the method of increasing the production efficiency of gene-edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.Type: GrantFiled: October 6, 2016Date of Patent: October 19, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, AICTInventors: Jin Soo Kim, Jungeun Kim, Sunghwa Choe, Je Wook Woo, Soon Il Kwon, Hyeran Kim
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Patent number: 11136588Abstract: The present invention relates to method for preparing a plant from a protoplast comprising knocking-out or knocking-in one or more the endogenous gene of the protoplast, and the plant regenerated from a genome-modified protoplast prepared by the above method.Type: GrantFiled: October 6, 2016Date of Patent: October 5, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, AICTInventors: Jin Soo Kim, Jungeun Kim, Sunghwa Choe, Je Wook Woo, Soon Il Kwon
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Patent number: 11123409Abstract: Provided are a method of preventing and/or treating an eye disease, using a Cas9 protein and a guide RNA targeting VEGF-A, and a ribonucleoprotein including a Cas9 protein and a guide RNA targeting VEGF-A.Type: GrantFiled: July 27, 2017Date of Patent: September 21, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Jin-Soo Kim, Jeong Hun Kim, Sung Wook Park, Kyoungmi Kim
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Patent number: 11117958Abstract: Provided is an antibody that binds to human interleukin-2 (hIL-2), and more particularly to an anti-hIL-2 antibody that binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25. The anti-hIL-2 antibody of the subject matter binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25, thereby minimizing expansion of Treg cells. In addition, it stimulates the CD8+ T cells and NK cells that exhibit anti-tumor activity. Thus, the anti-hIL-2 antibody of the present invention is useful as a new anticancer therapeutic agent.Type: GrantFiled: May 25, 2018Date of Patent: September 14, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Charles D. Surh, Jun-Young Lee
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Patent number: 11085875Abstract: The present invention relates to a high-speed imaging system for measuring a target object within a sample, comprising: a light source emitting a plane wave; an angle-adjustment mirror adjusting an angle of the plane wave emitted from the light source; an optical interferometer dividing the plane wave whose angle was adjusted by the angle-adjustment mirror into a reference wave and a sample wave and forming an interference wave between the reference wave reflected from a reference mirror and the sample wave reflected from the target object; a camera module obtaining the interference wave, and an imaging controller controlling the angle-adjustment mirror to adjust the angle of the plane wave sequentially, forming a time-gated reflection matrix by using the interference waves obtained by the camera module in accordance with each angle of the plane wave, and imaging the target object based on the time-gated reflection matrix.Type: GrantFiled: October 3, 2019Date of Patent: August 10, 2021Assignees: Korea University Research and Business Foundation, Institute For Basic ScienceInventors: Won-Shik Choi, Moon-Seok Kim, Yong-Hyeon Jo, Seok-Chan Yoon
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Patent number: 11078594Abstract: The present invention relates to a manufacturing method for single crystalline metal foil including: thermally treating poly-crystalline metal foil positioned to be spaced apart from a base to manufacture single crystalline metal foil, and a single crystalline metal foil manufactured thereby. According to the present invention, single crystalline metal foil having a large area may be obtained by thermally treating the poly-crystalline metal foil under a condition at which stress applied to the poly-crystalline metal foil is minimized.Type: GrantFiled: July 12, 2017Date of Patent: August 3, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)Inventors: Rodney S. Ruoff, Sunghwan Jin
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Patent number: 11046661Abstract: The present invention relates to a method for producing a lactam compound from dioxazolone in the presence of a catalyst having a particular ligand, and to a lactam compound produced thereby, and can produce a lactam compound with excellent selectivity and an excellent yield by using the combination of a starting material having a particular functional group and a particular catalyst having a particular ligand.Type: GrantFiled: January 2, 2019Date of Patent: June 29, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Sukbok Chang, Seung Youn Hong, Yoon Su Park, Yeongyu Hwang, Yeong Bum Kim
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Publication number: 20210191098Abstract: According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.Type: ApplicationFiled: October 16, 2018Publication date: June 24, 2021Applicants: Korea University Research and Business Foundation, Institute for Basic ScienceInventors: Sang Hee SHIM, Ji Woong KWON
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Publication number: 20210179719Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.Type: ApplicationFiled: December 3, 2020Publication date: June 17, 2021Applicants: INSTITUTE FOR BASIC SCIENCE, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Gou Young Koh, Jeomil Bae, Jaeryung Kim
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Patent number: 11013221Abstract: The present invention relates to: a transgenic Caenorhabditis elegans in which a glutamine tRNA 5? terminus-derived fragment (Gln 5?-tsRNA) is overexpressed; a preparation method therefor; and a method for screening for aging-associated factors by using the transgenic Caenorhabditis elegans. A transgenic Caenorhabditis elegans model provided in the present invention is an animal model in which Gln 5?-tsRNA is overexpressed such that aging is inhibited. When the model of the present invention is used, anti-aging mechanisms can be easily investigated, thereby significantly contributing to various research fields such as that of developing new anti-aging drugs and screening for age-inducing materials.Type: GrantFiled: April 21, 2017Date of Patent: May 25, 2021Assignees: POSTECH ACADEMY-INDUSTRY FOUNDATION, INSTITUTE FOR BASIC SCIENCE, DAEGU GYEONGBUK INSTITUTE OF SCIENCEInventors: Hong Gil Nam, Gyoo Yeol Jung, Seung Jae Lee, Woo Seon Hwang, Gi Won Shin, Mi Hwa Seo
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Publication number: 20210079083Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention provides an angiogenesis inhibitor and a composition for prevention and treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.Type: ApplicationFiled: August 17, 2020Publication date: March 18, 2021Applicants: INSTITUTE FOR BASIC SCIENCE, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Gou Young Koh, Jeomil Bae, Mi Jeong Kim, Jin-Sung Park, Su Jin Seo, Jaeryung Kim, Jang Ryul Park, Pilhan Kim, Wangyuhl Oh
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Patent number: 10934320Abstract: Provided are a transition metal compound including a novel carbene compound as a ligand, a preparation method thereof, and an application thereof. The transition metal compound according to the present invention may form a structurally stable complex and also have a HOMO-LUMO energy gap and singlet-triplet transition energy which are significantly low as compared with a conventional transition metal compound. In addition, according to the present invention, the transition metal compound may be synthesized in large quantities by a very simple method, thereby having high commercial utility, and thus, an application using the compound is expected.Type: GrantFiled: March 13, 2019Date of Patent: March 2, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Hayoung Song, Kimoon Kim, Eunsung Lee, Hyunho Kim
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Publication number: 20210054267Abstract: According to the present invention, an organic light-emitting composite and a method of manufacturing the organic light-emitting composite are provided. According to exemplary embodiments, an organic light-emitting composite includes a polymer matrix; a first light-emitting material provided in the polymer matrix; and a second light-emitting material provided in the polymer matrix and obtained by oxidizing the first light-emitting material, wherein the second light-emitting material may have the same molecular weight as that of the first light emitting-material.Type: ApplicationFiled: January 22, 2019Publication date: February 25, 2021Applicants: Institute for Basic Science, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Hee Cheul CHOI, Jin Young KOO, Minkyung LEE
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Patent number: 10874854Abstract: The present invention relates to a mesh electrode for cardiac resynchronization therapy, and a manufacturing method therefor. More specifically, the present invention relates to: a mesh electrode for cardiac resynchronization therapy, formed from a wire composed of a first biocompatible rubber layer in which silver nanowires are dispersed, and a second biocompatible rubber layer famed so as to be adjacent to the first biocompatible rubber layer; and a manufacturing method therefor.Type: GrantFiled: March 31, 2015Date of Patent: December 29, 2020Assignees: Seoul National University R&DB Foundation, INSTITUTE FOR BASIC SCIENCEInventors: Dae-Hyeong Kim, Taeghwan Hyeon, Hye Jin Hwang, Jinkyung Park, Suji Choi
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Patent number: 10858662Abstract: The present invention relates to a method for regulating gene expression, comprising introducing into a cell each of a recombinant vector which expresses a first domain comprising N-terminus of a Cas9 protein, and a recombinant vector which expresses a second domain comprising C-terminus of a Cas9 protein, a composition comprising the recombinant vectors, a kit for regulating gene expression, and a method for intracellular production of Cas9 protein. Moreover, the present invention relates to a transformed cell introduced with a viral vector which packages the first domain, and a viral vector which packages the second domain, and to a composition comprising a virus produced therefrom.Type: GrantFiled: November 19, 2015Date of Patent: December 8, 2020Assignee: INSTITUTE FOR BASIC SCIENCEInventors: Jin Soo Kim, Tae Young Koo
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Publication number: 20200292734Abstract: A wavelength multiplexing device is disclosed. When light is irradiated on a first longitudinal end region of a metal nano-structure, surface plasmon polaritons are generated in the first longitudinal end region. The surface plasmon polaritons and the light are coupled with each other to form first coupled surface plasmon polaritons, wherein the first coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure. When the first coupled surface plasmon polaritons reach a two-dimensional material layer, excitons are induced in the two-dimensional material layer, wherein the induced excitons and the first coupled surface plasmon polaritons are coupled with each other to form second coupled surface plasmon polaritons. The second coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure toward a second longitudinal end thereof.Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Applicants: Research & Business Foundation Sungkyunkwan University, Institute for Basic ScienceInventors: Hyun Seok LEE, Young Hee LEE
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Publication number: 20200292733Abstract: A wavelength multiplexing device is disclosed. When light is irradiated on a first longitudinal end region of a metal nano-structure, surface plasmon polaritons are generated in the first longitudinal end region. The surface plasmon polaritons and the light are coupled with each other to form first coupled surface plasmon polaritons, wherein the first coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure. When the first coupled surface plasmon polaritons reach a two-dimensional material layer, excitons are induced in the two-dimensional material layer, wherein the induced excitons and the first coupled surface plasmon polaritons are coupled with each other to form second coupled surface plasmon polaritons. The second coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure toward a second longitudinal end thereof.Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Applicants: Research & Business Foundation Sungkyunkwan University, Institute for Basic ScienceInventors: Hyun Seok LEE, Young Hee LEE
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Patent number: 10767174Abstract: Provided are a composition for ribonucleoprotein delivery, comprising a guide RNA free of 5?-terminal phosphates, and a method for ribonucleoprotein delivery, using the same.Type: GrantFiled: November 10, 2016Date of Patent: September 8, 2020Assignee: INSTITUTE FOR BASIC SCIENCEInventors: Jin-Soo Kim, So Jung Kim
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Patent number: 10770718Abstract: A lithium-sulfur secondary battery includes a cathode current collector and a cathode electrode on the cathode current collector. The cathode electrode includes a porous carbon interlayer electrode including a plurality of carbon fibers, metal sulfide catalyst particles dispersed and positioned on the porous carbon interlayer electrode, and sulfur-based active material particles dispersed on the porous carbon interlayer electrode to be attached thereto and including sulfur.Type: GrantFiled: March 6, 2018Date of Patent: September 8, 2020Assignees: Seoul National University R&DB Foundation, Institute For Basic ScienceInventors: Yung-Eun Sung, Chunjoong Kim, Jungjin Park