Patents Assigned to Institute for Basic Science
  • Publication number: 20180145342
    Abstract: A flow field including graphene foam for a fuel cell. The flow field is made of graphene foam that enhances mass transport and suffers no corrosion under operating conditions of the fuel cell when compared with conventional flow fields. In addition, compressed graphene foam has smaller in-plane pores due to the compression and has more tortuous pathways for flowing reactants, thereby increasing retention time of reactants and accelerating diffusion of reactants into a gas diffusion layer (GDL). Further, large through-plane pores inside the graphene foam transport reactants to entire areas of a catalyst layer, and faster flow velocity compared with the conventional membrane electrode assembly (MEA) is derived from a decreased flow field width due to compression. Therefore, mass transport of reactants and products is enhanced, and performance of the fuel cell is improved at high current density regions.
    Type: Application
    Filed: November 16, 2017
    Publication date: May 24, 2018
    Applicants: Seoul National University, R&DB Foundation, Institute for Basic Science, Kangwon National University, University-Industry Cooperation Foundation
    Inventors: Yung-Eun SUNG, Yong-Hun CHO, Ji Eun PARK, Chi-Yeong AHN, Sungjun KIM
  • Publication number: 20180145341
    Abstract: The present invention relates to a component including graphene foam and functioning as a flow field and a gas diffusion layer (GDL) for a fuel cell. More particularly, a component functioning as a flow field and a GDL for a fuel cell according to the present invention is made of graphene foam that enhances mass transport and suffers no corrosion under operating conditions of the fuel cell when compared with a conventional flow field, thereby realizing excellent performance and durability. Furthermore, the component functions as the GDL so a thickness of a membrane electrode assembly is reduced thereby improving cell performance significantly.
    Type: Application
    Filed: November 16, 2017
    Publication date: May 24, 2018
    Applicants: Seoul National University, R&DB Foundation, Institute for Basic Science, Kangwon National University, University-Industry Cooperation Foundation
    Inventors: Yung-Eun SUNG, Yong-Hun CHO, Ji Eun PARK, Chi-Yeong AHN, Sungjun KIM
  • Publication number: 20180119213
    Abstract: The present disclosure provides a new protocol for sequencing the 3? end of messenger RNA (mRNA). The present disclosure can be very favorably used in analyzing the repetitive sequences of nucleic acids, which are difficult to analyze by current sequencing methods, especially, homopolymeric sequences (poly[A] sequence) of mRNA. The present disclosure has significantly improved sensitivity to mRNA compared with an existing method, thereby obtaining a lot of genetic information from a small amount of sample. The method of the present disclosure reduces the time and cost for sequencing the 3? end of mRNA and can be applied to various samples, and thus, can be used as a useful tool in the study of RNA synthesis/degradation and protein production in association with all life phenomena, including embryogenesis, cancer, and neurotransmission.
    Type: Application
    Filed: July 21, 2017
    Publication date: May 3, 2018
    Applicants: Seoul National University R&DB Foundation, INSTITUTE FOR BASIC SCIENCE
    Inventors: V. Narry KIM, Jaechul LIM, Hyeshik CHANG
  • Patent number: 9827313
    Abstract: The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: November 28, 2017
    Assignees: SNU R&DB FOUNDATION, THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC, INSTITUTE FOR BASIC SCIENCE
    Inventors: Taeghwan Hyeon, Kun Na, Daishun Ling, Wooram Park, Sin-jung Park, Yang Lu, Kyoung Sub Kim, Michael J. Hackett, Byung Hyo Kim, Hyeona Yim, Yong Sun Jeon
  • Patent number: 9812333
    Abstract: Provided is a nanoscale patterning method using self-assembly, wherein nanoscale patterns having desirable shapes such as a lamella shape, a cylinder shape, and the like, may be formed by using a self-assembly property of a block copolymer, and low segment interaction caused in a structure of 10 nm or less which is a disadvantage of the block copolymer may be prevented. In addition, even though single photolithography is used, pattern density may double as that of the existing nano patterns, and pitch and cycle of the patterns may be controlled to thereby be largely utilized for electronic apparatuses requiring high integration of circuits such as a semiconductor device, and the like.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: November 7, 2017
    Assignees: Korea Advanced Institute of Science and Technology, Institute for Basic Science
    Inventors: Sang Ouk Kim, Hyoung-Seok Moon
  • Publication number: 20170312313
    Abstract: Disclosed is a ceria-zirconia nanoparticles comprising a core layer consisting of particles made of ceria-zirconia; and a surfactant layer formed by binding a surfactant on the surface of the core layer so as to easily react in vivo, and more particularly, to applying a ceria-zirconia nano complex to an application field as an activator and a sepsis treating agent.
    Type: Application
    Filed: May 4, 2016
    Publication date: November 2, 2017
    Applicants: Seoul National University R&DB Foundation, INSTITUTE FOR BASIC SCIENCE
    Inventors: Taeg Hwan HYEON, Seung Hoon LEE, Min SOH, Chi Kyung KIM
  • Patent number: 9765187
    Abstract: The present invention relates to MRI contrasting agent for contrasting cancer cell which contains ultrafine nanoparticles. More particularly, the present invention is directed to a self-assembled ligand composition comprising a ligand A, which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range, MRI contrast agent for contrasting cancer cell comprising said ligand composition and MRI contrasting nanoparticles, and the methods for preparing them.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: September 19, 2017
    Assignees: SNR R&DB FOUNDATION, INSTITUTE FOR BASIC SCIENCE, THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC
    Inventors: Taeghwan Hyeon, Kun Na, Daishun Ling, Wooram Park, Byung Hyo Kim, Hyeona Yim, Kyoung Sub Kim, Michael J. Hackett, Sin-jung Park, Yang Lu, Yong Sun Jeon
  • Patent number: 9762696
    Abstract: Disclosed herein are a data storage communication apparatus, and data transmission and management methods using the same. The data storage communication apparatus includes a data request signal reception unit, a main control unit, massive storage, and a data transmission unit. The data request signal reception unit receives a data request signal from one of a plurality of user terminals. The main control unit analyzes the data request signal received by the data request signal reception unit, and determines whether data is present in the apparatus itself by searching the apparatus. The massive storage stores and manages a variety of types of data found by the main control unit. The data transmission unit transmits the data to the user terminal. The data is found in the storage by the main control unit.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: September 12, 2017
    Assignee: INSTITUTE FOR BASIC SCIENCE
    Inventor: Sangsu Jung
  • Patent number: 9745329
    Abstract: Provided is a method of preparing a silylative-reduced N-heterocyclic compound by reducing an N-heteraromatic compound including a sp2 hybridized nitrogen atom while simultaneously introducing a silyl group into a beta-position with respect to a nitrogen atom of the N-heteroaromatic compound, using a silane compound, in the presence of an organoboron catalyst.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: August 29, 2017
    Assignees: Institute for Basic Science, Korea Advanced Institute of Science and Technology
    Inventors: Sukbok Chang, Sehoon Park, Narasimhulu Gandhamsetty, Seewon Joung, Sung-Woo Park
  • Patent number: 9707548
    Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 18, 2017
    Assignees: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Kimoon Kim, Gyeongwon Yun, Zahid Hassan, Jiyeong Lee, Jeehong Kim, Nam Hoon Kim, Kangkyun Baek, Iiha Hwang
  • Publication number: 20170191123
    Abstract: The present invention relates to a method for analyzing a genotype using a target-specific nuclease and, specifically, to a method for diagnosing cancer or analyzing a genotype by removing wild type DNA or particular genotype DNA using a target-specific nuclease or a variant thereof to amplify or concentrate only a small amount of DNA which has a difference in variation, such as a mutation, or genotype, and to a method for separating target DNA sesusing a target-specific nuclease or a variant thereof. Such methods are novel paradigm methods contrary to existing simple target-specific nucleases for post-PCR recognition of normal genotype and carcinogenic genotype, and can be favorably used in the early diagnosis of cancer or analysis of similar genotypes.
    Type: Application
    Filed: May 28, 2015
    Publication date: July 6, 2017
    Applicants: Toolgen Incorporated, Institute for Basic Science
    Inventors: Jin Soo Kim, So Jung Kim, Seung Hwan Lee, Seok Joong Kim
  • Publication number: 20170076039
    Abstract: The present invention relates to a method of selecting a nuclease target sequence for gene knockout based on microhomology.
    Type: Application
    Filed: April 24, 2015
    Publication date: March 16, 2017
    Applicant: INSTITUTE FOR BASIC SCIENCE
    Inventors: Jin Soo Kim, Sang Su Bae
  • Publication number: 20170033356
    Abstract: The disclosure describes a nanowire for an anode material of a lithium ion cell and a method of preparing the same. The nanowire includes silicon (Si) and germanium (Ge). The nanowire has a content of the silicon (Si) higher than a content of the germanium (Ge) at a surface thereof, and has the content of germanium (Ge) higher than the content of the silicon (Si) at an inner part thereof.
    Type: Application
    Filed: April 5, 2016
    Publication date: February 2, 2017
    Applicants: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Hee Cheul CHOI, Hyungki KIM
  • Patent number: 9514549
    Abstract: A method for reducing metal artifacts in computed tomography (CT) is disclosed. The method for reducing metal artifacts in CT includes: obtaining a sinogram reduced in size from an original sinogram; setting up a linear algebraic equation according to remaining data excluding data damaged by a metal based on the obtained sinogram; restoring a low-resolution image based on the set up linear algebraic equation; calculating a sinogram from the restored low-resolution image; restoring a sinogram by disposing the calculated sinogram data in the original sinogram and by utilizing the calculated sinogram data as pre-information; and restoring a final CT image from the restored sinogram. Through introduction of a novel metal artifact reduction (MAR) technique referred to as an algebraic correction technique (ACT) using an intermediate image of an attenuation coefficient of an outside of a metal area, an image closest to an original image can be obtained by minimizing metal artifacts in CT.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: December 6, 2016
    Assignee: INSTITUTE FOR BASIC SCIENCE
    Inventors: Sung Whan Kim, Ki Wan Jeon, Chi Young Ahn
  • Publication number: 20160263277
    Abstract: The present invention relates to a partial skull replacement consisting of polydimethylsiloxane (PDMS) and a method of monitoring biological tissues within a skull using the partial skull replacement. The method of monitoring using the partial skull replacement of the present invention has a minimal influence on intracranial pressure and cerebrospinal fluid flow as compared to a conventional cranial window technique using glass, and, by way of visualizing biological tissues within a skull with enhanced clarity, is expected to be usefully employed as a method of monitoring biological tissues within the skull.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 15, 2016
    Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, INSTITUTE FOR BASIC SCIENCE
    Inventors: Seong-Gi KIM, Minah SUH, Chaejeong HEO, Hyoung Won BAAC
  • Patent number: 9354187
    Abstract: An apparatus and method for computed tomography image processing is provided. The apparatus includes: an X-ray detection unit that detects an X-ray beam having passed through a subject and outputs an energy value thereof; a line integral calculation unit that calculates line integral values of attenuation coefficients representing attenuation of the energy value of the X-ray beam having passed through the subject and been detected, based on the energy value; an image processing unit that reconstructs a tomogram based on the line integral values; and an image output unit that outputs the tomogram. The apparatus and method for computed tomography image processing can calculate line integral values of attenuation coefficients constituting an integrand of an X-ray projection function using the mean value theorem for integrals in order to restore an image of a subject from an X-ray beam detected in computed tomography image processing.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: May 31, 2016
    Assignee: INSTITUTE FOR BASIC SCIENCE
    Inventors: Ki Wan Jeon, Chi Young Ahn, Sung Whan Kim
  • Publication number: 20160137507
    Abstract: A graphene transfer method using water vapor-assisted determination of CVD-grown graphene film on the Cu foil. By using the polymer film as a supporting layer, we found that graphene can be directly detached from the Cu foil as a consequence of water intercalated at the graphene-Cu interface(s), by a ‘dry transfer’ method. The delaminated graphene films are continuous over large area. This nondestructive method also worked for the transfer of graphene grown on a Cu single crystal without sacrificing the expensive crystal, thus affording the possibility of producing high-quality graphene and reusing the substrate. The Cu foil and single crystal can both be repeatedly used for many times, which may reduce the cost of graphene synthesis and is environmentally more benign. Our method affords the advantages of high efficiency, likely industrial scalability, minimal use of chemicals, and the reusability of the Cu foil in multiple growth and delamination cycles.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 19, 2016
    Applicants: INSTITUTE FOR BASIC SCIENCE, UNIST ACADEMY-INDUSTRY RESEARCH CORPORATION
    Inventors: Xuequi YOU, Da Luo, Rodney S. Ruoff
  • Publication number: 20160125625
    Abstract: A method for reducing metal artifacts in computed tomography (CT) is disclosed. The method for reducing metal artifacts in CT includes: obtaining a sinogram reduced in size from an original sinogram; setting up a linear algebraic equation according to remaining data excluding data damaged by a metal based on the obtained sinogram; restoring a low-resolution image based on the set up linear algebraic equation; calculating a sinogram from the restored low-resolution image; restoring a sinogram by disposing the calculated sinogram data in the original sinogram and by utilizing the calculated sinogram data as pre-information; and restoring a final CT image from the restored sinogram. Through introduction of a novel metal artifact reduction (MAR) technique referred to as an algebraic correction technique (ACT) using an intermediate image of an attenuation coefficient of an outside of a metal area, an image closest to an original image can be obtained by minimizing metal artifacts in CT.
    Type: Application
    Filed: June 24, 2015
    Publication date: May 5, 2016
    Applicant: INSTITUTE FOR BASIC SCIENCE
    Inventors: Sung Whan KIM, Ki Wan JEON, Chi Young AHN
  • Publication number: 20150366531
    Abstract: Disclosed is an ultrasonic diagnostic apparatus.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 24, 2015
    Applicant: Institute for Basic Science
    Inventors: Chi Young Ahn, Ki Wan Jeon, Jung II Choi
  • Publication number: 20150366533
    Abstract: Disclosed is a method for generating a 3D image of a left ventricle of the heart. The method includes: acquiring, by an image processor, a 2D left ventricle image; extracting, by the image processor, left ventricle boundary coordinates from the 2D image; calculating, by a controller, a position of the left ventricle in 3D space through transformation of the extracted left ventricle boundary coordinates; and generating, by the controller, a 3D left ventricle image based on the calculated position of the left ventricle in 3D space.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 24, 2015
    Applicant: Institute for Basic Science
    Inventors: Chi Young Ahn, Ki Wan Jeon, Sang Woon Yun