Abstract: Articles, compositions, and methods describing particles comprising micelles are generally described. In some embodiments, the micelles are configured to absorb pollutants from water and subsequently release the pollutants to a non-aqueous environment.
Type:
Application
Filed:
November 9, 2021
Publication date:
January 9, 2025
Applicant:
Massachusetts Institute of Technology
Inventors:
Patrick Seamus Doyle, Devashish Gokhale
Abstract: A method is disclosed for 3D printing thermally curable polymeric inks and their composites for scaffolds or devices. In this method, an extrusion based direct ink writing printing technology was used. The method includes an in-situ curing process and print layer height adjustment steps after each print layer to compensate for shrinkage during a thermal treatment step.
Type:
Grant
Filed:
August 30, 2022
Date of Patent:
January 7, 2025
Assignee:
New Jersey Institute of Technology
Inventors:
Murat Guvendiren, Chya-Yan Liaw, Andrew House
Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.
Type:
Grant
Filed:
March 29, 2019
Date of Patent:
January 7, 2025
Assignees:
NOF Corporation, Tokyo Institute of Technology
Abstract: Reversible phase-change materials (PCMs) can be added to or incorporated into meta-lenses, wave plates, waveguides, gratings, and other optical components to form active optical devices with controllable and adjustable optical characteristics. Local heating can be used to induce solid-state phase changes and large refractive index changes in the PCMs. The phase and index changes can provide large changes in the device's optical characteristics. Optical devices with PCM can be used for imaging applications, orbital angular momentum control, photonic integrated circuits and optical communication systems, beam steering, and other application.
Type:
Grant
Filed:
February 23, 2021
Date of Patent:
January 7, 2025
Assignee:
Massachusetts Institute of Technology
Inventors:
Juejun Hu, Tian Gu, Yifei Zhang, Carlos Andres Rios Ocampo, Mikhail Shalaginov, Xiaoming Qiu
Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.
Abstract: A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal.
Type:
Grant
Filed:
January 29, 2021
Date of Patent:
January 7, 2025
Assignees:
The Broad Institute, Inc., The General Hospital Corporation, Massachusetts Institute of Technology
Inventors:
Paul Blainey, Dwayne Vickers, Nir Hacohen
Abstract: Increasing the power conversion efficiency of silicon (Si) photovoltaics is a key enabler for continued reductions in the cost of solar electricity. Disclosed herein is a multi-junction photovoltaic cell that does not utilize a conventional interconnection layer and instead places a wide bandgap oxide conductor, for example, a metal oxide such as TiO2, between a top light absorption layer having a relatively large bandgap and a bottom light absorption layer having a relatively small bandgap. The advantageous omission of a conventional interconnection layer between the two subcells is enabled by low contact resistivity between the top and bottom light absorbing layers provided by the wide bandgap oxide conductor. The absence of the conventional interconnect between the subcells significantly reduces both optical losses and processing steps. The disclosed photovoltaic cell may thus enable low-cost, high-efficiency multi-junction devices through less complex manufacturing processes and lower material costs.
Type:
Grant
Filed:
April 26, 2019
Date of Patent:
January 7, 2025
Assignee:
California Institute of Technology
Inventors:
Stefan Omelchenko, Sisir Yalamanchili, Nathan S Lewis
Abstract: An optical system and a method for producing it is disclosed. The optical system has at least two separate optical components and an optical connection between them. In the inventive method, first and second optical component are provided, each having respective beam profiles. An arrangement of the first and second optical components and the form and target position of at least one beam-shaping element are specified. The beam-shaping element is produced using a three-dimensional direct-writing lithography method in situ at the target position to thereby obtain an optical component supplemented by the beam-shaping element. The supplemented optical component is placed and fixed on common base plate to thereby obtain the optical system. The optical systems produced with the present method can be used in optical data transfer, measurement technology and sensors, life sciences and medical technology, or optical signal processing.
Abstract: Systems and methods for multifunctional catalyst systems supported on carbon nanotubes (CNTs) for olefin oligomerization are described. The catalyst systems can directly convert CO2 to jet-range (C12-C18) hydrocarbons. This conversion can be achieved by a cooperative, tandem catalyst system supported on CNTs converting CO2 to olefins (C2-C9) with the catalyst systems followed by oligomerization.
Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.
Type:
Grant
Filed:
May 2, 2022
Date of Patent:
December 31, 2024
Assignees:
Abiomed, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
Inventors:
Ahmad El Katerji, Qing Tan, Christian Moyer, Alexander Ship, Sonya Sanat Bhavsar, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller
Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
Type:
Grant
Filed:
June 12, 2023
Date of Patent:
December 31, 2024
Assignees:
California Institute of Technology, Boyce Thompson Institute for Plant Research
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
Abstract: Exemplary embodiments relate to systems, methods, and apparatus to objectively assess binocular dysfunction for screening, diagnoses, and evaluation of vision/oculomotor function before, during, and after various forms of therapeutic interventions. Systems and methods diagnose and assess binocular dysfunction objectively and automatically, can render a visual stimulus on one or more displays, and can control accommodative and proximal vergence stimulation of a user's eyes.
Abstract: The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.
Type:
Grant
Filed:
December 23, 2022
Date of Patent:
December 31, 2024
Assignee:
Massachusetts Institute of Technology
Inventors:
Mohammad Movassaghi, Chase Robert Olsson, Tony Z. Scott, Jaime Cheah, Joshua Nathaniel Payette
Abstract: An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.
Abstract: Use a computerized trained graph neural network model to classify an input instance with a predicted label. With a computerized graph neural network interpretation module, compute a gradient-based saliency matrix based on the input instance and the predicted label, by taking a partial derivative of class prediction with respect to an adjacency matrix of the model. With a computerized user interface, obtain user input responsive to the gradient-based saliency matrix. Optionally, modify the trained graph neural network model based on the user input; and re-classify the input instance with a new predicted label based on the modified trained graph neural network model.
Type:
Grant
Filed:
September 30, 2020
Date of Patent:
December 31, 2024
Assignees:
International Business Machines Corporation, Massachusetts Institute of Technology
Inventors:
Dakuo Wang, Sijia Liu, Abel Valente, Chuang Gan, Bei Chen, Dongyu Liu, Yi Sun
Abstract: Binary-phase-shift-key, phase-modulated waveforms with gigahertz bandwidths, suitable for kilowatt-class fiber amplifiers, can be narrowed back to the source laser's linewidth via second-harmonic, sum-frequency, or difference-frequency generation in a second-order nonlinear crystal. The spectrum of an optical signal phase-modulated with a pseudo-random bit sequence (PRBS) waveform recovers its original optical spectrum when frequency-doubled using second-harmonic generation (SHG). Conceptually, the PRBS waveform is cancelled by the SHG process, and the underlying laser spectrum is converted to the second-harmonic wavelength as though the PRBS modulation were not present. The same cancellation is possible with sum-frequency generation (SFG) and difference frequency generation (DFG), making it possible to construct high-power, narrow-linewidth lasers at wavelengths from the visible to the long-wave infrared.
Abstract: Femto-satellites are very small satellites that can be deployed in constellations from a larger mothership satellite for distributed measurement. They are too small to accommodate the GNSS receivers that many satellites use for navigation, but they can be located with an electromagnetic beam from the mothership satellite. The mothership satellite scans this beam across a constellation of femto-satellites. When the beam scans across a particular femto-satellite, the femto-satellite transmits an acknowledgement to the mothership satellite, e.g., by retroreflecting the beam or via a separate radio link. The beam can be modulated with commands for the femto-satellite, such as to make a measurement or transmit previously acquired data, as well with commands for determining the femto-satellite's location, such as a time stamp or beam pointing information.
Type:
Grant
Filed:
May 3, 2022
Date of Patent:
December 31, 2024
Assignee:
Massachusetts Institute of Technology
Inventors:
Kerri Cahoy, Christian Haughwout, Paul Serra, Ruonan Han, Anantha Chandrakasan
Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
Type:
Grant
Filed:
March 19, 2018
Date of Patent:
December 31, 2024
Assignee:
Massachusetts Institute of Technology
Inventors:
Alexander K. Shalek, Alexander S. Genshaft, Carly G. K. Ziegler, Jeffrey F. Van Humbeck, Ryan Philip King