Abstract: A distance measurement device and method based on secondary mixing of inter-mode self-interference signals of optical frequency combs are provided, which relate to the field of high precision laser distance measurement technologies. A dual-comb light source emits a dual-comb laser into a detection optical module to obtain the inter-mode self-interference signals carrying the to-be-measured distance information. The detection optical module outputs the inter-mode self-interference signals into a generation, acquisition and calculation module of inter-mode self-interference secondary mixing signals to generate the inter-mode self-interference secondary mixing signals, to thereby achieve signal acquisition and obtain a distance measurement result.
Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
Type:
Grant
Filed:
December 23, 2021
Date of Patent:
March 25, 2025
Assignee:
California Institute of Technology
Inventors:
Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
Abstract: The present disclosure provides methods of collecting electron diffraction patterns from nanocrystals to obtain a three-dimensional structural model of a compound, as well as methods of identifying compounds and methods of determining polymorphic forms. In addition, the present disclosure provides methods of characterizing a first compound from a sample, as well as methods of screening compounds from a sample. The present disclosure also provides systems for characterizing a compound from a sample, which systems include modules for high-performance liquid chromatography, dispensing, and electron microscopy.
Type:
Grant
Filed:
September 10, 2020
Date of Patent:
March 25, 2025
Assignees:
The Regents of the University of California, California Institute of Technology
Inventors:
Hosea M. Nelson, Jose A. Rodriguez, Brian M. Stoltz, Tamir Gonen, Michael Martynowycz
Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
Type:
Grant
Filed:
November 29, 2023
Date of Patent:
March 25, 2025
Assignee:
Massachusetts Institute of Technology
Inventors:
Ruixuan Gao, Linyi Gao, Chih-Chieh Yu, Edward Stuart Boyden
Abstract: A system and method provide a hybrid communication scheme that achieves high communication rates with post-quantum computational security guarantees. Messages to be securely communicated are first mixed using an individually secure encoding, such as a linear network code, and some of the encoded messages are further encrypted. The encrypted and unencrypted messages are sent via different communications channels. Each unencrypted message becomes almost as secure as the encrypted messages because of the pre-mixing, since decoding any one of the messages requires all of the messages, including the encrypted messages. Thus, a very few encrypted messages may be used, allowing the rate of communication to approach one as the number of channels increases. This is particularly beneficial when a classical public-key cryptosystem can only be used in part of the data transmitted or stored, in the presence of noisy channels, in distributed data storage, and other applications.
Type:
Grant
Filed:
August 30, 2021
Date of Patent:
March 25, 2025
Assignee:
Massachusetts Institute of Technology
Inventors:
Muriel Medard, Alejandro Cohen, Rafael Gregorio Lucas D'Oliveira, Salman Salamatian
Abstract: A closed leak-free, diffusion-blocking one-way check valve is composed of a substrate having a flow passage through the substrate, the flow passage has a sealing surface between the substrate and a membrane preventing flow through the flow passage. A thin film having internal stress is disposed on the membrane which induces deformation of the membrane biasing the membrane resulting in the sealing surface in a closed orientation. A method for fabrication and pump utilizing the check valve are disclosed.
Type:
Grant
Filed:
February 10, 2023
Date of Patent:
March 25, 2025
Assignee:
Rochester Institute of Technology
Inventors:
David A. Borkholder, Farzad Forouzandeh
Abstract: The present invention relates to a method for estimating lung morphometry based on aerosol deposition characteristics using an imaging means such as a gamma camera to scan the lungs. An adaptive image threshold technique is used to determine the ratio of deposition in central to peripheral region of the lung (C/P ratio). The morphometric parameters such as length and diameter of distal lung airways (P8 and P9 respectively) and mean alveolar diameter (dalv) are determined from aerosol retention data and clearance data.
Type:
Grant
Filed:
October 13, 2020
Date of Patent:
March 25, 2025
Assignees:
Indian Institute of Technology Madras, Sri Venkateswara Institute of Medical Sciences (SVIMS)
Inventors:
Mahesh V Panchagnula, Karthiga Devi S G, Mohan Alladi
Abstract: The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.
Type:
Grant
Filed:
December 28, 2022
Date of Patent:
March 25, 2025
Assignees:
Honda Motor Co., Ltd., California Institute of Technology
Inventors:
Qingmin Xu, Christopher J. Brooks, Kaoru Omichi, Ryan K. McKenney, Simon Jones, Victoria Davis, Stephen Munoz, Jeongmin Kim, Keith Billings, Thomas Miller, III, Robert H. Grubbs, William Wolf, Nam Hawn Chou
Abstract: Provided is a living cell microbeam directional and quantitative irradiation imaging apparatus. The problem that qualitative analysis of the mechanism of action of biological cells irradiated cannot accurately study the mechanism of action of different irradiation doses on biological cells as the cell irradiation technology can be only used to perform qualitative irradiation on living biological cells is solved. The apparatus includes a vertical microbeam terminal, a living cell directional irradiation module, a wide-field microscopic module, a mode switching module, and a single-proton counting and radiation synchronous control module.
Abstract: The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.
Type:
Application
Filed:
January 2, 2024
Publication date:
March 20, 2025
Applicant:
Massachusetts Institute of Technology
Inventors:
Jeremiah A. Johnson, Peyton Shieh, Wenxu Zhang
Abstract: The disclosure features compositions, systems, and methods for preparation and use of efficient RNA nuclear export of ribozyme-assisted circular RNA molecules (racRNAs). In embodiments, the methods involve characterizing a cell or tissue using racRNAs.
Type:
Application
Filed:
November 22, 2024
Publication date:
March 20, 2025
Applicants:
The Broad Institute, Inc., Massachusetts Institute of Technology
Abstract: Compositions including solid forms of polypeptides such as crystalline antibodies, and related methods, are generally described. The compositions may include carriers such as hydrogels that at least partially encapsulate the solid form of the polypeptides (e.g., crystals, amorphous solids). Encapsulation with certain of the materials described may result in compositions containing relatively high loadings of polypeptides while in some instances retaining structural and functional properties of the polypeptides useful for certain types of administration to subjects (e.g., for prophylactic or therapeutic applications). In some instances, compositions having relatively low dynamic viscosities while having relatively high polypeptide loadings are provided.
Type:
Application
Filed:
July 30, 2021
Publication date:
March 20, 2025
Applicants:
Massachusetts Institute of Technology, Merck Sharp & Dohme Corp
Inventors:
Patrick S. Doyle, Jeremy Schieferstein, Paul Reichert, Chakravarthy Narasimhan, Amir Erfani-Khaneghahi
Abstract: A micro-probe laser frequency modulation interferometric ranging method and system, under the premise of not introducing an absolute laser rangefinder to introduce new uncertainties, continuously and slowly changes the modulated laser wavelength, resulting in a continuous periodic phase change in the interference signal obtained by the detector. The laser modulation absorption spectrum shifts from the initial locked absorption peak to another locked peak, and the wavelength changes of the two locked absorption peaks before and after are obtained by checking the table. Meanwhile, calculating the phase difference demodulated by the phase generated carrier (PGC) before and after, and the initial length of optical dead-path is calculated using wavelength scanning technology. Afterwards, utilizing the advantages of high relative distance measurement accuracy of micro-probe fiber optic laser interferometer, real-time measurement of the measured distance is achieved.
Abstract: The present invention relates to a method of reducing blind decoding attempts by a User Equipment (UE) in a telecommunication network. The method comprises configuring a Search Space (SS) configuration to the UE. A Base Station (BS) signals one of a subset of Aggregation Levels (ALs) to be monitored based on channel quality of the UE and an associated time period, and a value of multiplication factor (k) and an associated time period. The UE iteratively monitors a Physical Downlink Control Channel (PDCCH) on the ALs signalled by the BS till the UE stops receiving a new configuration. The UE performs one of adopting an original configuration, requesting the BS for a new configuration, utilizing a default configuration or utilizing an original configuration.
Type:
Grant
Filed:
August 4, 2023
Date of Patent:
March 18, 2025
Assignees:
Centre of Excellence in Wireless Technology, Indian Institute of Technology Madras
Abstract: The present invention relates to a method of reducing blind decoding attempts by a User Equipment (UE) in a telecommunication network. The method comprises configuring a Search Space (SS) configuration to the UE. A Base Station (BS) signals one of a subset of Aggregation Levels (ALs) to be monitored based on channel quality of the UE and an associated time period, and a value of multiplication factor (k) and an associated time period. The UE iteratively monitors a Physical Downlink Control Channel (PDCCH) on the ALs signalled by the BS till the UE stops receiving a new configuration. The UE performs one of adopting an original configuration, requesting the BS for a new configuration, utilizing a default configuration or utilizing an original configuration.
Type:
Grant
Filed:
August 4, 2023
Date of Patent:
March 18, 2025
Assignees:
Centre of Excellence in Wireless Technology, Indian Institute of Technology Madras
Abstract: Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described. For example, methods comprising producing an acid and a base via electrolysis; dissolving a material comprising calcium using the acid to produce ions comprising calcium in a region of a reactor with a pH of 6 or less; precipitating solid calcium hydroxide from the ions comprising calcium using the base in a region of a reactor with a pH of 10 or higher; and utilizing the calcium hydroxide in a downstream process to form a cement are described.
Type:
Grant
Filed:
December 22, 2023
Date of Patent:
March 18, 2025
Assignee:
Massachusetts Institute of Technology
Inventors:
Yet-Ming Chiang, Leah Ellis, Andres Badel
Abstract: Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
Type:
Grant
Filed:
September 1, 2023
Date of Patent:
March 18, 2025
Assignee:
Massachusetts Institute of Technology
Inventors:
David Brancazio, Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, Gerard Capellades Mendez, Clemence Neurohr, Kersten Rapp, Naomi Elizabeth Barbara Briggs
Abstract: The invention describes a tsunami warning system utilizing properties of light in optical fibers within submarine telecommunication cables. Enhanced by microwave frequency modulation and High-Loss Loop Back (HLLB) techniques, this system measures photoelastic changes for more stable, long-period tsunami wave detection.