Abstract: System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.

Abstract: A green-engineered mulch product and methods for making same are disclosed. The mulch product includes a coating of aluminum-based water treatment residuals which makes the product “green.” Furthermore, coating aluminum-based water treatment residuals on mulch eliminates the problem of the low hydraulic conductivity of aluminum-based water treatment presiduals and makes it feasible to utilize its pollutant removal potential without requiring any modification to existing best management practices or additional maintenance.

Abstract: A device including a stack of silicon meta-optical layers forming a meta-material comprising an input surface for receiving terahertz electromagnetic radiation, an output surface for outputting a plurality of beams of the electromagnetic radiation; and a spatially varying permittivity varying with sub-wavelength precision across a volume of the stack, wherein the spatially varying permittivity is configured to focus different spectral bands of the electromagnetic radiation into different spatially separated electromagnetic modes.

Abstract: A method for hiding data within cover audio uses a set of sample codebook waveforms that are each assigned a unique representative digit value. A hidden data sequence representing the data is formed from the waveforms by concatenation of the waveforms assigned to the digit values of the data. The sequence is superimposed upon segments of the cover audio at a fractional amplitude. After transmission, the received signal is decompressed if necessary, the hidden data sequence is recovered from the cover audio, and the data is recovered from the hidden data sequence. This may be done by recovering the locations of the codebook waveforms and interpolating the time markers of the locations. The recovered data may be cleaned up by using estimated distances between successive cross-correlations to discard extraneous correlation peaks and sequence recurrence to probabilistically delete overlapping correlation peaks.

Abstract: The present disclosure describes functional oligomers or functional polymers. The functional oligomers or functional polymers may contain functional groups, e.g., —OH and/or —CHO. The functional oligomers or functional polymers may be obtained from hydrolyzing certain copolymers and may be soluble in commercially available solvents. The copolymers may be thermosetting polymers. The functional oligomers and functional polymers may be useful for recycling thermosetting polymers and may be useful as starting materials for preparing additional oligomers or polymers.

Abstract: The present disclosure generally relates to a magnetic recording head comprising a read head. The read head comprises a first sensor disposed at a media facing surface (MFS) comprising at least one free layer, a second sensor disposed at the MFS comprising at least one free layer, a first spin generator spaced from the first sensor and recessed from the MFS, and a second spin generator spaced from the second sensor and recessed from the MFS. The first and second spin generators each individually comprises at least one spin orbit torque (SOT) layer. The SOT layer may comprise BiSb. The first and second sensors are configured to detect a read signal using a first voltage lead and a second voltage lead. The first and second spin generators are configured to inject spin current through non-magnetic layers to the first and second sensors using a plurality of current leads.

Abstract: What is disclosed relates to a novel reactor system design for chemical looping solar fuel production processes incorporating temperature swing between two or more zones, wherein two or more individual reactors are employed, and heat is recuperated between the reactors by means including radiative heat exchange. Each individual reactor comprising the overall system is isolated from other reactors and the external environment for gas exchange purposes, so that the inflow and outflow of chemical species from individual reactors can be controlled. Individual reactors are arranged in the form of a moving train, and heat exchange between a pair of reactors is facilitated by radiative exchange. External heat addition and removal between the system and its environment may be achieved by means including radiative heat exchange with the hot source and convective exchange with the cold source. This may include, in a particular embodiment, the use of solar irradiation.

Abstract: Systems and methods for activating mechanochemical reactions remotely using biocompatible ultrasound in the presence of gas-filled structures are described. The collapse of gas-filled structures is achieved using biocompatible ultrasound. In turn, collapse of the gas-filled structures can mechanochemically activate mechanophore-functionalized polymers in solution. Mechanochemical activation of mechanophore-functionalized polymers under physiological conditions can trigger the release and/or delivery of a variety of cargos with the spatial and temporal precision and deep tissue penetration afforded by focused ultrasound.

Abstract: A computer-implemented method useful for performing seismic tomography, including obtaining seismic data comprising distributed acoustic sensing (DAS) data, comprising at least one of P-wave or S-wave travel times from a plurality of seismic events to a plurality of recording stations coupled to a network of optical fibers in a geological structure; and generating tomography data from the DAS data, wherein tomography data is useful for characterizing the geological structure. We employ distributed acoustic sensing data recorded along a 100-km fiber-optic cable traversing the caldera to image its subsurface structure. Our images highlight a definite separation between the shallow hydrothermal system and the large magma chamber located at ˜12 km depth. The combination of the geological evidence with our results shows how fluids exsolved through second boiling provide the source of the observed uplift and seismicity.

Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.

Abstract: Component errors prevent linear photonic circuits from being scaled to large sizes. These errors can be compensated by programming the components in an order corresponding to nulling operations on a target matrix X through Givens rotations X?T†X, X?XT†. Nulling is implemented on hardware through measurements with feedback, in a way that builds up the target matrix even in the presence of hardware errors. This programming works with unknown errors and without internal sources or detectors in the circuit. Modifying the photonic circuit architecture can reduce the effect of errors still further, in some cases even rendering the hardware asymptotically perfect in the large-size limit. These modifications include adding a third directional coupler or crossing after each Mach-Zehnder interferometer in the circuit and a photonic implementation of the generalized FFT fractal.

Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.

Abstract: Programmable photonic circuits of reconfigurable interferometers can be used to implement arbitrary operations on optical modes, providing a flexible platform for accelerating tasks in quantum simulation, signal processing, and artificial intelligence. A major obstacle to scaling up these systems is static fabrication error, where small component errors within each device accrue to produce significant errors within the circuit computation. Mitigating errors usually involves numerical optimization dependent on real-time feedback from the circuit, which can greatly limit the scalability of the hardware. Here, we present a resource-efficient, deterministic approach to correcting circuit errors by locally correcting hardware errors within individual optical gates. We apply our approach to simulations of large-scale optical neural networks and infinite impulse response filters implemented in programmable photonics, finding that they remain resilient to component error well beyond modern day process tolerances.

Abstract: Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject.

Abstract: The typical approach to transfer quantum information between two superconducting quantum computers is to transduce the quantum information into the optical regime at the first superconducting quantum computer, transmit the quantum information in the optical regime to the second superconducting quantum computer, and then transduce the quantum information back into the microwave regime at the second superconducting quantum computer. However, direct microwave-to-optical and optical-to-microwave transduction have low fidelity due to the low microwave-optical coupling rates and added noise. These problems compound in consecutive microwave-to-optical and optical-to-microwave transduction steps. We break this rate-fidelity trade-off by heralding end-to-end entanglement with one detected photon and teleportation. In contrast to cascaded direct transduction, our technology absorbs the low optical-microwave coupling efficiency into the entanglement heralding step.

Abstract: Described herein is a semiconductor structure, comprising: a drain region; a drift region comprised of a wide band gap material disposed over the drain region; and a channel structure disposed over the drift region. In some embodiments, the channel structure comprises: an optically active material disposed over the drift region, wherein the optically active material generates charge carriers in response to an optical signal; and a source region disposed over the optically active material, wherein in an off state charge carriers in the optically active material are depleted to turn off the semiconductor structure, and in an on state charge carriers in the optically active material conduct a current in the semiconductor structure when an electric field is applied across the source region and drain region, causing the current to substantially flow directly between the source region and the drain region.

Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.

Abstract: The subject matter disclosed herein is generally directed to compositions and methods for treating diffuse gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-gliomas). Disclosed herein are gene signatures specific for tumor cell types and compositions for treatment of H3K27M gliomas. In one embodiment, PRC1 is targeted in a treatment regimen for H3K27M-gliomas.

Abstract: The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

Abstract: A method of polynucleotide synthesis includes a series of enzymatic reactions for restriction, ligation, and amplification using a machine and system that provide efficient droplet-based reactions. The method enables hierarchical assembly with minimal handling in order to address challenges associated with traditional polynucleotide synthesis methods, such as high cost, limited throughput, long synthesis times, and limited ability to synthesize long sequences.