Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.

Abstract: An executing mechanism for a rotary guide device includes a driving valve core, a driven valve core, a first cavity, a second cavity and a high-pressure slurry driving channel. The first cavity includes a first low-pressure port communicating with a low-pressure slurry; and a first high-pressure port communicating with a high-pressure slurry. The driving valve core adjusts a pressure in the first cavity; and the driven valve core moves in response to a pressure difference between the first cavity and the second cavity. The high-pressure slurry driving channel switches between an open state and a close state in response to movement of the driven valve core. A rotary guide device includes a rotary main shaft, a drill bit, a push mechanism, and the executing mechanism. The push mechanism includes a push block and a push plunger piston, the high-pressure slurry driving channel communicates with one end, distal from the push block, of the push plunger piston.

Abstract: In an embodiment, a pose estimation device obtains an image of an object, and generates a pose estimate of the object. The pose estimate includes a respective heatmap for each of a plurality of pose components of a pose of the object, and the respective heatmap for each of the pose components includes a respective uncertainty indication of an uncertainty of the pose component at each of one or more pixels of the image.

Abstract: A halogen-containing compound as shown in a formula I can be used as a ligand for an ethylene oligomerization catalyst composition. The ethylene oligomerization catalyst composition containing the halogen-containing compound can be used to catalyze ethylene oligomerization, trimerization and tetramerization reactions. As a ligand of a catalyst for ethylene oligomerization, a fluoropolymer can effectively improve the catalytic performance of a catalyst system, and particularly exhibits improved activity and selectivity in an ethylene oligomerization reaction.

Abstract: The present invention provides novel engineered Ebolavirus GP proteins and polypeptides, as well as scaffolded vaccine compositions that display the engineered proteins. The invention also provides methods of using such engineered Ebolavirus GP proteins and vaccine compositions in various therapeutic applications, e.g., for preventing or treating Ebolavirus infections.

Abstract: This disclosure provides methods for bisulfite-free identification in a nucleic acid sequence of the locations of 5-methylcytosine, 5-hydroxymethylcytosine, 5-carboxylcytosine and 5-formylcytosine.

Abstract: A semiconductor apparatus according to an embodiment of the present invention includes: a plurality of semiconductor chips that are laminated; and a plurality of penetration electrodes that penetrate in a lamination direction through the plurality of semiconductor chips and that electrically connect together the plurality of semiconductor chips, wherein a semiconductor chip has at least one sub-memory array, and a penetration electrode penetrates through an outer circumferential part of the sub-memory array.

Abstract: The present application relates to a scheduling device and method of a mobile communication system. In the packet scheduling method, a base station performs packet scheduling for a terminal station in a mobile communication system, and a transport channel comprising an uplink shared channel (UL-SCH) and a physical channel comprising an uplink grant channel (UL-GCH) between the terminal and the base station are classified into a plurality of channels. In addition, in the packet scheduling method: a) the base station receives scheduling information from the terminal; b) the base station allocates an uplink resource for uplink traffic transmission for terminal based on the received scheduling information; and c) information for the allocated uplink resource is transmitted to the terminal through the UL-GCH of the physical channel.

Abstract: Fentanyl is an addictive prescription opioid that is over 80 times mora potent than morphine. The synthetic nature of fentanyl has enabled the creation of dangerous “designer drug’ analogues that escape toxicology screening, yet display comparable potency to the parent drug. Alarmingly, a large number of fatalities have been linked to overdose of fentanyl derivatives. Herein, we report an effective immunotherapy for reducing the psychoactive effects of fentanyl class drugs. A single conjugate vaccine was created that elicited high levels of antibodies with cross-reactivity for a wide panel of fentanyl analogues, Moreover, vaccinated mice gained significant protection from lethal fentanyl doses. Lastly, a surface plasmon resonance (SPR)-based technique was established enabling drug specificity profiling of antibodies derived directly from serum. Our newly developed fentanyl vaccine and analytical methods may assist in the battle against synthetic opioid abuse.

Abstract: A method for modifying a polymeric surface is disclosed. The polymeric surface is activated utilizing atmospheric pressure plasma. An atom transfer radical polymerization initiator is then coupled to the activated surface. A monomer is then polymerized on the activated surface utilizing an activators regenerated by electron transfer (ARGET) atom transfer radical polymerization (ATRP) process. The method enables brush-modification of the polymeric surface, even if the polymeric surface is substantially chemically inert. By way of example, the method enables a chemically inert, substantially hydrophobic polymer surface to be functionalized with substantially hydrophilic polymer brushes. The methods of the present disclosure have general applicability to a myriad of implementations where tunable surface chemistry is advantageous, such as filtration membranes, marine surfaces, and medical devices seeking a biocompatible coating.

Abstract: Provided are an optical waveform shaping apparatus and an optical waveform shaping method. According to an embodiment, the optical waveform shaping apparatus includes a multiplexer/demultiplexer (D/MUX) unit demultiplexing an optical signal in which optical signals of a plurality of wavelengths are multiplexed, a micro lens system refracting the demultiplexed optical signal into a collimated beam of light, and a wavelength level controller unit shaping a waveform of the optical signal. The wavelength level controller unit includes a 2D LCoS for adjusting and reflecting an amplitude or a phase value of the demultiplexed optical signal to have a distribution that is desired for each cell, and a controller for controlling the distribution.

Abstract: A silicon-based optical modulator. An optical modulator of a Mach-Zehnder type includes an optical coupler configured to separate a single optical signal into two optical signals having same output power, two phase shifters having a PN junction through which the two optical signals separated through the optical coupler pass respectively, a plurality of electrodes configured to apply an electrical signal to the two phase shifters, and two PN diodes disposed between the two phase shifters and configured to adjust an operating bandwidth of the optical modulator. The optical signals respectively passing through the two phase shifters have phases that change as a width of a depletion region changes based on a magnitude of a reverse voltage provided to the two phase shifters through the electrodes and a refractive index changes.

Abstract: The disclosure relates to the technical field of veterinary biological products, and discloses an avian influenza and fowl adenovirus type 4 bi-combined genetic engineering subunit vaccine. An antigen in the vaccine is a fusion antigen; the fusion antigen has a) avian influenza virus HA protein; b) fowl adenovirus fiber2 protein; c) a specific linker peptide located between the avian influenza virus HA protein and the fowl adenovirus fiber2 protein; the amino acid sequence of the specific linker peptide is as shown in SEQ ID NO:2. This vaccine contains the fusion antigen which can induce poultries to produce a high-level specific antibody to protect poultries from avian influenza and fowl adenovirus infection. Meanwhile, the disclosure also discloses a method for preparing the vaccine.

Abstract: An audio encoding apparatus and method that encodes hybrid contents including an object sound, a background sound, and metadata, and an audio decoding apparatus and method that decodes the encoded hybrid contents are provided. The audio encoding apparatus may include a mixing unit to generate an intermediate channel signal by mixing a background sound and an object sound, a matrix information encoding unit to encode matrix information used for the mixing, an audio encoding unit to encode the intermediate channel signal, and a metadata encoding unit to encode metadata including control information of the object sound.

Abstract: The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.

Abstract: A self-powered wearable electronic device comprises a rechargeable battery and an automatic power generation device adapted to automatically charge the rechargeable battery. The automatic power generation device comprises a swing lump, an automatic power generation gear driving device, and a micro generator. The micro generator is connected to the rechargeable battery and comprises a permanent magnet rotor, a stator, and a coil which is set on the stator. The permanent magnet rotor comprises a driving gear. The swing lump is fixed with an automatic power generation gear. The automatic power generation gear is meshed with the automatic power generation gear driving device, and the automatic power generation gear driving device is meshed with the driving gear of the permanent magnet rotor.

Abstract: Methods for the preparation of oligosaccharide products from polysaccharide starting materials are disclosed. The methods include: hydrolyzing a glucosamine-containing polysaccharide starting material, such as heparin or heparosan, under conditions sufficient to form an oligosaccharide intermediate (e.g., a GlcN-IdoA disaccharide intermediate or a GlcA-GlcN disaccharide intermediate), and converting the oligosaccharide intermediate to the oligosaccharide product. Conversion of the oligosaccharide intermediates to the oligosaccharide products may include one or more esterification, acylation, epimerization, protection, and deprotection steps. Preparation of higher-order oligomers is described, as well as methods for selective oligosaccharide sulfation.

Abstract: A novel synthetic uniform circular array (SUCA) method for generating vortex electromagnetic (EM) wave carrying high orbital angular momentum (OAM) mode has the following steps. N antenna elements are placed radially to form a uniform circular array (UCA), where N is a positive integer. By rotating the array elements to various spatial locations, modifying their feeding phases, and superimposing the generated fields at various spatial locations, SUCA can beat the limit of space and configure more array elements to generate vortex electromagnetic (EM) waves carrying high mode OAMs. Meanwhile, due to the more synthetic array elements and smaller aperture than the traditional UCA, the purity of OAM mode is higher and it is more flexible to adjust the main lobe directions of these vortex waves carrying different OAM modes, and can generate vortex EM waves.