Patents Assigned to INSTITUTE
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Publication number: 20220111040Abstract: Provided is a method for activating CD4+ T cells using a polymer-based antigen complex. The method comprises the steps of bringing the polymer-based antigen complex into contact with B cells so that B cells process and present the antigen complex, and of bringing the B cells into contact with CD4+ T cells to activate CD4+ T cells. Also provided are a method for promoting the differentiation of CD4+ T cells into Tfh cells and Thl cells using the antigen complex, and a method for treating diseases by activating CD4+ T cells and/or promoting the differentiation of CD4+ T cells.Type: ApplicationFiled: August 6, 2019Publication date: April 14, 2022Applicants: INSTITUTE OF BIOPHYSCIS, CHINESE ACADEMY OF SCIENCES, INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCESInventors: Baidong HOU, Sheng HONG, Zhaolin HUA, Hong TANG
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Publication number: 20220112553Abstract: Methods for single-molecule analysis of structure and sequence of linearized polynucleotides are provided.Type: ApplicationFiled: October 13, 2021Publication date: April 14, 2022Applicants: Massachusetts Institute of Technology, The Broad Institute, Inc.Inventors: Edward S. Boyden, Fei Chen, Nikita Obidin, Andrew Colin Payne
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Publication number: 20220113450Abstract: A method is provided of calculating the total amount of artificial precipitation in a seeded area compared to a non-seeded area, which is capable of increasing the reliability of quantitative determination of seeding effect, observation data, and numerical model prediction data obtained from artificial precipitation experiments, of increasing the amount of water resources through weather modification experiments, of accomplishing various effects (drought reduction, forest fire prevention, fine dust reduction, fog reduction, hail suppression, etc.Type: ApplicationFiled: December 17, 2020Publication date: April 14, 2022Applicant: National Institute of Meteorological SciencesInventors: Yonghun RO, Ki-Ho CHANG, Joo-Wan CHA, Sanghee CHAE, Woonseon JUNG, Chulkyu LEE
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Publication number: 20220110916Abstract: The present invention provides a new antioxidant. An antioxidant of the present invention includes: a compound represented by the following formula (1) or a salt thereof: where in the formula (1), an A ring and a B ring may be the same or different and are a pyrazole ring having a substituent or a pyrazoline ring having a substituent, and L is a saturated or unsaturated hydrocarbon group.Type: ApplicationFiled: December 18, 2019Publication date: April 14, 2022Applicant: Bioradical Research Institute Corp.Inventors: Keisuke Makino, Toshiyuki Arai, Yoko Arai, Masaichi Lee
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Publication number: 20220111113Abstract: A method of making a cellulose-nanoclay hemostatic nanocomposite fiber, including the steps of preparing a homogenous cellulose solution including cellulose and a room temperature ionic liquid, preparing a nanoclay suspension including halloysite and distilled water, electrospinning the cellulose solution into a first bath including the nanoclay suspension, transferring solidified cellulose-halloysite fibers from the first bath to a second bath including ethanol and distilled water, removing the solidified cellulose-halloysite fibers from the second bath, and freeze-drying the solidified cellulose-halloysite fibers.Type: ApplicationFiled: January 31, 2020Publication date: April 14, 2022Applicant: RENSSELAER POLYTECHNIC INSTITUTEInventors: Ranodhi Nilochani Udangawa, Chiara Diamante Mancinelli, Caitlyn A. Chapman, Charles Frederick Willard, Trevor John Simmons, Robert John Linhardt
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Publication number: 20220114419Abstract: A classification device and a classification method based on a neural network are provided. A heterogeneous integration module includes a convolutional layer, a data normalization layer, a connected layer and a classification layer. The convolutional layer generates a first feature map according to a first image data. The data normalization layer normalizes a first numerical data to generate a first normalized numerical data. The first numerical data corresponds to the first image data. The connected layer generates a first feature vector according to the first feature map and the first normalized numerical data. The classification layer generates a first classification result corresponding to a first time point according to the first feature vector. The heterogeneous integration module generates a second classification result corresponding to a second time point.Type: ApplicationFiled: December 15, 2020Publication date: April 14, 2022Applicant: Industrial Technology Research InstituteInventors: Yu-Shan Deng, An-Chun Luo, Po-Han Chang, Chun-Ju Lin, Ming-Ji Dai
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Publication number: 20220115588Abstract: The output voltage of an MRAM is increased by means of an Fe(001)/MgO(001)/Fe(001) MTJ device, which is formed by microfabrication of a sample prepared as follows: A single-crystalline MgO (001) substrate is prepared. An epitaxial Fe(001) lower electrode (a first electrode) is grown on a MgO(001) seed layer at room temperature, followed by annealing under ultrahigh vacuum. A MgO(001) barrier layer is epitaxially formed on the Fe(001) lower electrode (the first electrode) at room temperature, using a MgO electron-beam evaporation. A Fe(001) upper electrode (a second electrode) is then formed on the MgO(001) barrier layer at room temperature. This is successively followed by the deposition of a Co layer on the Fe(001) upper electrode (the second electrode). The Co layer is provided so as to increase the coercive force of the upper electrode in order to realize an antiparallel magnetization alignment.Type: ApplicationFiled: December 23, 2021Publication date: April 14, 2022Applicants: Japan Science and Technology Agency, National Institute of Advanced Industrial Science and TechnologyInventor: Shinji YUASA
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Publication number: 20220115697Abstract: The electrolyte for a lithium secondary battery includes: a lithium salt; a solvent; and a functional additive, wherein the functional additive includes 1,2-bis((maleimido)ethane, represented by the following formula 1:Type: ApplicationFiled: June 7, 2021Publication date: April 14, 2022Applicants: HYUNDAI MOTOR COMPANY, KIA CORPORATION, UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)Inventors: Yoon Sung Lee, Seung Min Oh, Ji Eun Lee, Sung Ho Ban, Ik Kyu Kim, Ko Eun Kim, Sang Kyu Kwak, Nam Soon Choi, Woo Gyum Kim, Hyeon Gyu Moon, Sung You Hong, Dae Yeon Hwang
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Publication number: 20220114297Abstract: A system and method for improved occupancy simulations. A method includes executing a scheduler algorithm based on input data in order to output a plurality of synthetic schedules, wherein the input data includes space data, persona data, and work pattern data, wherein the scheduler algorithm includes a plurality of sub-algorithms executed according to an order of priority, wherein at least an output of one of the plurality of sub-algorithms is input to another of the plurality of sub-algorithms; and inputting the plurality of synthetic schedules to a simulation engine, wherein the simulation engine runs a plurality of simulations using the plurality of synthetic schedules.Type: ApplicationFiled: October 12, 2021Publication date: April 14, 2022Applicant: The Joan and Irwin Jacobs Technion-Cornell InstituteInventors: Davide SCHAUMANN, Pierre PASQUET
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Patent number: 11298676Abstract: The invention concerns new types of porous coordination polymers (MOF) and a method for their preparation. MOFs have been prepared through synthesis of salts of trivalent cations M3+, the source of which are aluminium, chromium, iron or yttrium salts, it is advantageous if of chlorides, nitrates or sulphates, with linkers carrying two or more phosphinic groups under presence of solvent. Linkers are phenylene-1,4-bis(R phosphinic acid) (PBPA) and biphenylene-4,4?-bis(R phosphinic acid) (BBPA). For the prepared MOFs, the structure has been tested using x-ray powder diffraction, specific surface and porousness which have been characterised through adsorption isotherm of nitrogen and further the stability of prepared MOFs has been determined using thermogravimetric analysis. All the prepared MOFs have been stable around 400° C. and have contained mesopores or micropores where hydrogen or CO2, for example, can be stored.Type: GrantFiled: October 16, 2018Date of Patent: April 12, 2022Assignee: Institute of Inorganic Chemistry, CASInventors: Jan Demel, Jan Hynek
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Patent number: 11303593Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.Type: GrantFiled: June 21, 2021Date of Patent: April 12, 2022Assignee: Salk Institute for Biological StudiesInventors: Patrick D. Hsu, Silvana Konermann
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Patent number: 11299427Abstract: The present application relates to a magnesium oxide based dielectric ceramics with ultrahigh dielectric breakdown strength and a preparation method thereof. The composition of the magnesium oxide based dielectric ceramic material comprises: (1?x)MgO—xAl2O3, wherein 0<x?0.12 and x is a mole percentage. The material has a specific composite structure with magnesium aluminate spinel acting as a second phase surrounding a principal crystalline phase, MgO.Type: GrantFiled: March 18, 2020Date of Patent: April 12, 2022Assignee: SHANGHAI INSTITUTE OF CERAMICS, CHINESE ACADEMY OF SCIENCESInventors: Xianlin Dong, Chi Zhang, Ying Chen
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Patent number: 11299646Abstract: An inkjet-printing-base process for depositing functional materials, for example PZT, on a substrate, in various instances platinized silicon. Substrate templating (via SAMs) and material deposition are both performed by an inkjet printing process. Additionally, a composition to be used as a SAM precursor ink which is a thiol in a solvent mixture, wherein the composition can be 1 dodecanethiol in a solvent mixture of 2-methoxyethanol and glycerol.Type: GrantFiled: April 27, 2018Date of Patent: April 12, 2022Assignee: Luxembourg Institute of Science And Technology (LIST)Inventors: Nicolas Godard, Daniele Sette, Sebastjan Glinsek, Emmanuel Defay
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Patent number: 11304271Abstract: A compound heating apparatus includes a microwave generating unit and an infrared radiation generator disposed in a casing outwardly of a heating chamber of the casing. A light shield is disposed around the infrared radiation generator, and has a shield opening facing toward the heating chamber. A microwave blocker plate covers the shield opening. An air supply module is connected to the light shield to blow air to the light shield for causing heat radiant energy generated from the infrared radiation generator to pass acceleratedly by forced heat convection through microwave blocking holes of the microwave block plate to the heating chamber.Type: GrantFiled: October 13, 2020Date of Patent: April 12, 2022Assignee: Food Industry Research and Development InstituteInventors: Feng-Chi Liu, Jia-Yan Hou, Binghuei-Barry Yang
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Patent number: 11299782Abstract: The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.Type: GrantFiled: December 28, 2018Date of Patent: April 12, 2022Assignees: Children's Medical Center Corporation, The Technical University of Denmark, Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.Inventors: Zoltan Szallasi, Nicolai Juul Birkbak, Aron Eklund, Daniel Silver, Zhigang Wang, Andrea Richardson
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Patent number: 11302167Abstract: A sanitizable audio device for use in neonatal care and method of use are provided herein. The audio device comprises a smooth shell defining an outer surface and an inner surface. The outer surface forms a curved continuous smooth surface. The inner surface supports electronic elements. The shell defines one or more switch apertures, housing one or more actuatable electrical switches, in communication with the electronic elements. The method of use comprises generating an audio output including selecting content that is age appropriate for a particular infant, altering a sound emission of a recording of a care-giver of the particular infant, and programming a music player to emit the audio output below an age dependent volume, for an age dependent number of intervals per day and per week, for an age dependent duration.Type: GrantFiled: September 18, 2017Date of Patent: April 12, 2022Assignee: The Research Institute at Nationwide Children's HospitalInventors: Nathalie Maitre, Will Ray, Olena Chorna, Ellyn Evans
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Patent number: 11302379Abstract: A semiconductor apparatus according to an embodiment of the present invention includes: a plurality of semiconductor chips that are laminated; a plurality of penetration electrodes that penetrate in a lamination direction through the plurality of semiconductor chips and that electrically connect together the plurality of semiconductor chips; and a plurality of input/output elements that are configured to perform a signal input/output operation to the plurality of penetration electrodes, wherein the semiconductor chips are joined together via no bump, one of the plurality of input/output elements is connected to each of the plurality of penetration electrodes such that a functional element connected to each of the plurality of penetration electrodes performs an ON or OFF operation at a predetermined timing, and the input/output element connected to a first of two adjacent penetration electrodes among the plurality of penetration electrodes and the input/output element connected to a second of two adjacent peneType: GrantFiled: September 17, 2020Date of Patent: April 12, 2022Assignees: HONDA MOTOR CO., LTD., TOKYO INSTITUTE OF TECHNOLOGYInventors: Koji Sakui, Takayuki Ohba
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Patent number: 11300687Abstract: A system and method for discriminating and mitigating spoofing signals incoming to a satellite navigation system. Beam steering techniques are used to steer a null toward a legitimate satellite signal that is being spoofed. The spoofing signal is then tracked and its angle of arrival measured. A null is steered toward the measured angle of arrival of the spoofing signal, and the spoofing signal is confirmed by determining if there is a signal remaining with nulls on both the legitimate satellite signal and the spoofing signal. The null toward the legitimate satellite signal is then replaced with unity gain.Type: GrantFiled: April 12, 2020Date of Patent: April 12, 2022Assignee: Southwest Research InstituteInventors: Thomas Howard Jaeckle, Wayne D. Music, Donald R. Van Rheeden, Thomas Tillotson, Jeffery C. Sanders
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Patent number: 11300430Abstract: A method for acquiring a canal flow rate, comprising: measuring an actual measure value of an upstream water depth and an actual measure value of a downstream water depth of a target canal; presetting the upstream canal flow rate and surface water infiltration rate of the target canal, and respectively acquiring preset values of each; substituting the actual measured value of the upstream water depth, the preset value of the upstream canal flow rate, and the preset value of the surface water infiltration rate into Saint-Venant equations, so as to solve the equations and obtain a downstream water depth simulation value of the target canal; when the relative error between the downstream water depth simulation value and the actual measured value of the downstream water depth is less than or equal to the preset threshold value, acquiring a viable upstream canal flow rate and a viable surface water infiltration rate; otherwise, optimizing the preset value of the upstream canal flow rate and the preset value of theType: GrantFiled: June 30, 2016Date of Patent: April 12, 2022Assignee: China Institute of Water Resources and Hydropower ResearchInventors: Shaohui Zhang, Di Xu, Wei Dai, Meijian Bai, Qunchang Liu, Fuxiang Li
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Patent number: 11303191Abstract: A three-degree-of-freedom bearingless switched reluctance motor excited by a constant current source includes a rotor and a stator. The rotor consisting of a rotating shaft and a rotor core, where a plurality of rotor teeth is uniformly distributed on an outer circumference of the rotor core. The stator includes a stator core, a magnetic isolation ring, an axial suspension winding, and a magnetic conduction ring that are sequentially connected, and axial control cores and annular constant current source windings which are symmetrically arranged on both sides of the stator core. Outer edges of the axial control cores are connected to the magnetic conduction ring, and inner edges extend to the rotor core. The stator core and the magnetic isolation ring both consist of an axial part and a radial part of which an outer end is connected to an inner wall of the axial part.Type: GrantFiled: June 14, 2019Date of Patent: April 12, 2022Assignee: HUAIYIN INSTITUTE OF TECHNOLOGYInventors: Tao Zhang, Wei Ni, Yue Zhang, Zhujun Ding, Yeqing Wang, Zhongyi Tang, Weihong Ding