Abstract: The present disclosure provides compounds of Formula (I), and salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be useful for inhibiting kinases, e.g., glycogen synthase kinase 3 (GSK3). The provided compounds may be able to selectively inhibit GSK3a, as compared to GSK3P and/or other kinases. The present disclosure further provides pharmaceutical compositions, kits, and methods of use, each of which involve the compounds. The compounds, pharmaceutical compositions, and kits may be useful for treating diseases associated with aberrant activity of GSK3a (e.g., Fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood seizure, intellectual disability, diabetes, acute myeloid leukemia (AML), autism, and psychiatric disorder).

Abstract: A process that includes pre-cooling a H2 gas feedstock with a compressed liquid natural gas via a heat exchanger, introducing the pre-cooled H2 gas feedstock into an active magnetic regenerative refrigerator H2 liquefier module, and delivering liquid H2 from the active magnetic regenerative refrigerator H2 liquefier module to a liquid H2 vehicle dispenser.

Abstract: Methods for synthesizing crystalline Ni-rich cathode materials are disclosed. The Ni-rich cathode material may have a formula LiNixMnyMzCo1?x?y?zO2, where M represents one or more dopant metals, x?0.6, 0.01?y<0.2, 0?z?0.05, and x+y+z?1.0. The methods are cost-effective, and include methods for solid-state, molten-salt, and flash-sintering syntheses.

Abstract: The present invention relates to a patterned fiber substrate comprising: a fiber substrate; and a pattern consisting of a functional material and formed on the fiber substrate, wherein at least a part of the functional material that constitutes the pattern is present in inside of the fiber substrate, the fiber substrate has a contact angle of 100 to 170° with pure water on its surface, and the pattern has a narrowest line width of 1 to 3000 ?m.

Abstract: A method of determining hysteresis according to an example embodiment may include capturing a real-time image of the surgical robot driven according to a drive input, and measuring a drive angle of the surgical robot by comparing the real-time image to a previously rendered image data set of the surgical robot, and calculating a difference between the drive input and the measured drive angle.

Abstract: A method for cleanly extracting metallic silver includes: mixing an acidic solution containing Ce4+ and NO3? with a silver-containing material for leaching; after the leaching is completed, carrying out a solid-liquid separation to obtain a leaching solution containing Ce3+ and Ag+; and electrolyzing the leaching solution, wherein an oxidation reaction of Ce? occurs at an anode to realize a regeneration of Ce4+ and an electrolytic reduction occurs at a cathode to reduce Ag+ to obtain the metallic silver. Ce4+ is used as a leaching agent and an intermediate oxidant to implement a cyclic operation of solution leaching and electrolytic regeneration on the silver-containing material. Almost no NOx and waste liquid are caused by the extraction process, and the invention is clean and environmentally friendly.

Abstract: Meta-lens based ocular imaging, near-eye display, and eye-tracking systems are described. The systems can include a single focusing optic and an integrated circuit that provides illumination light and includes an imaging array. The focusing optic includes meta-atoms formed on a substrate. The systems may have no moving parts and achieve imaging or image-projection fields-of-view approaching or exceeding 180 degrees. Because of their low part count, the systems can be robust and have a very small form factor.

Abstract: Disclosed herein are methods of treating and making prognostic prediction of, monitoring of therapeutic outcome for treatment of cervical carcinoma in a patient in need thereof by quantifying gene expression in a sample, wherein the genes include 10 high risk genes; calculating the subject's survival risk score by determining the protein expression levels and their relationships using machine learning (ML) and artificial intelligence. The survival risk category of a patient is determined by the consensus or plurality voting of a large number of ML models that individually have excellent predictive potential, thus providing a very robust prognostic biomarker for cervical carcinoma.

Abstract: An apparatus includes a processor to: within a performance container, execute a performance routine to derive an order of performance of tasks of a job flow based on dependencies, begin performing the tasks, and store, within a job queue, a job performance status indication including task performance statuses; identify a set of sub flows within the job flow based on branches in the job flow; correlate each of the task performance statuses to a corresponding sub flow performance status; reduce the job performance status indication size by, for each sub flow in which all tasks have been completed, replace the corresponding task performance statuses with the corresponding sub flow performance status of completed, and for each sub flow with no task performed, replace the corresponding task performance statuses with the corresponding sub flow performance status of not executed; and transmit the job performance status indication to the requesting device.

Abstract: Embodiments relate to a system and method for calibrating a ratio of body size of a subject including setting a body coordinate system of each body segment of the subject, calculating a first rotation matrix from a world coordinate system set based on the ground to a sensor coordinate system of each motion sensor when the subject takes a first basic pose, calculating a second rotation matrix from the world coordinate system to the sensor coordinate system of each motion sensor when the subject takes a second basic pose, calculating a third rotation matrix from the world coordinate system to the body coordinate system of a trunk for a first motion sensor attached to the trunk of the subject, and calculating a ratio of body size of the subject based on the third rotation matrix.

Abstract: A solid electrolyte having high electrical conductivity even in a low-temperature region is provided. A solid electrolyte containing a hexagonal perovskite-related compound, in which the compound is a compound represented by the following general formula (1), and an electrolyte layer and a battery using the solid electrolyte are disclosed. Ba7-?Nb(4?x-y)Mo(1+x)MyO(20+z) (1), in the formula (1), M is a cation of at least one element; a represents a Ba deficiency amount and represents a value of 0 or more and 0.5 or less, x represents a value of ?1.1 or more and 1.1 or less, y represents a value of 0 or more and 1.1 or less, and z represents an oxygen non-stoichiometry and represents a value of ?2.0 or more and 2.0 or less, provided that in the formula (1), |x|+y?0.01 is satisfied.

Abstract: The present application provides bifunctional compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 8 (CDK8). The present application also relates to methods for the targeted degradation of CDK8 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK8 which can be utilized in the treatment of disorders modulated by CDK8.

Abstract: Disclosed are macrocyclic compounds that possess inhibitory activity against DYRK, TRK, TLK, and/or RET. Also disclosed are pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to treat diseases and disorders that are characterized or mediated by aberrant DYRK, TRK, TLK, and/or RET activity such as cancer, neurodegenerative disorders and genetic disorders.

Abstract: A method of forming graphene on a flexible substrate includes providing a polymer substrate including a metal structure and providing a carbon source and a carrier gas. The method also includes subjecting the polymer substrate to a plasma enhanced chemical vapor deposition (PECVD) process and growing a graphene layer on the copper structure.

Abstract: The electrolyte for a lithium secondary battery comprises: a lithium salt; a solvent; and a functional additive, wherein the functional additive comprises naphthalen-1-yl sulfurofluoridate, represented by the following formula 1:

Abstract: Electrolytes for lithium ion batteries with carbon-based, silicon-based, or carbon- and silicon-based anodes include a lithium salt; a nonaqueous solvent comprising at least one of the following components: (i) an ester, (ii) a sulfur-containing solvent, (iii) a phosphorus-containing solvent, (iv) an ether, (v) a nitrile, or any combination thereof, wherein the lithium salt is soluble in the solvent; a diluent comprising a fluoroalkyl ether, a fluorinated orthoformate, a fluorinated carbonate, a fluorinated borate, a fluorinated phosphate, a fluorinated phosphite, or any combination thereof, wherein the lithium salt has a solubility in the diluent at least 10 times less than a solubility of the lithium salt in the solvent; and an additive having a different composition than the lithium salt, a different composition than the solvent, and a different composition than the diluent. In some electrolytes, the nonaqueous solvent comprises an ester.

Abstract: Disclosed herein is a method of decoding an image. The method includes acquiring intra chroma prediction information of a current block from a bitstream, deriving an intra chroma prediction mode of the current block based on the intra chroma prediction information, and performing intra prediction with respect to the current block based on the intra chroma prediction mode. The intra chroma prediction mode may be any one of a linear model (LM)) mode, a derived luma (DM) mode, a Planar mode, a Vertical mode, a Horizontal mode and a DC mode, and a first bit of the intra chroma prediction information may be used to determine whether the intra chroma prediction mode is an LM mode.

Abstract: Systems and methods for a self-powered wireless wearable sensor system include a freestanding triboelectric nanogenerator (FTENG), used as a power source for a wearable sensor. The FTENG includes stator panels and corresponding slider panels with a grating pattern. Movement, such as cardiovascular exercise causes the slider panel(s) to slide across the stator panel(s) inducing a charge and powering a wearable device sufficiently to support data transmission and continuous monitoring. An integrated self-powered wireless wearable sensor system includes a microfluidic sweat sensor patch which may be connected to lower-power wireless sensor circuitry for regulating power efficiently and is powered by the FTENG.

Abstract: Provided is a method for activating CD4+ T cells using a polymer-based antigen complex. The method comprises the steps of bringing the polymer-based antigen complex into contact with B cells so that B cells process and present the antigen complex, and of bringing the B cells into contact with CD4+ T cells to activate CD4+ T cells. Also provided are a method for promoting the differentiation of CD4+ T cells into Tfh cells and Thl cells using the antigen complex, and a method for treating diseases by activating CD4+ T cells and/or promoting the differentiation of CD4+ T cells.

Abstract: A method of making a cellulose-nanoclay hemostatic nanocomposite fiber, including the steps of preparing a homogenous cellulose solution including cellulose and a room temperature ionic liquid, preparing a nanoclay suspension including halloysite and distilled water, electrospinning the cellulose solution into a first bath including the nanoclay suspension, transferring solidified cellulose-halloysite fibers from the first bath to a second bath including ethanol and distilled water, removing the solidified cellulose-halloysite fibers from the second bath, and freeze-drying the solidified cellulose-halloysite fibers.