Abstract: The development of a new, targeted drug delivery paradigm coupled to improved PI3K inhibitors (e.g., PI3K? inhibitors) represents a significant advance in cancer therapy. Provided herein are compounds, such as compounds of Formula (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds provided herein are PI3K (e.g., PI3K?) inhibitors and are therefore useful for the treatment and/or prevention of various diseases (e.g., proliferative diseases such as cancer). Also provided herein are nanoparticles and nanogels (e.g., P-selectin targeting nanoparticles) comprising PI3K inhibitors, such a compound described herein. In certain embodiments, a nanoparticle or nanogel described herein encapsulates a compound described herein for targeting delivery to cancer cells or tumors.

Abstract: Disclosed is a method of producing an olefin using a circulating fluidized bed process, including: (a) supplying a hydrocarbon mixture including propane and a dehydrogenation catalyst to a riser which is in a state of a fast fluidization regime, and thus inducing a dehydrogenation reaction; (b) separating an effluent from the dehydrogenation reaction into the catalyst and a propylene mixture; (c) stripping, in which a residual hydrocarbon compound is removed from the catalyst separated in step (b); (d) mixing the catalyst stripped in step (c) with a gas containing oxygen and thus continuously regenerating the catalyst; (e) circulating the catalyst regenerated in step (d) to step (a) and thus resupplying the catalyst to the riser; and (f) cooling, compressing, and separating the propylene mixture, which is a reaction product separated in step (b), and thus producing a propylene product.

Abstract: The disclosure relates to methods for increasing the speed and efficiency of computational genomics. In particular, the disclosure relates to methods of scaling computational genomics by using one or more specialized architectures for highly parallelized computations, such as graphics processing units (GPUs), tensor processing units (TPUs), and field programmable gate arrays (FPGAs), and the like, to compute the computational genomics calculations.

Abstract: Provides is a laser bonding method. The method includes forming a bonding part on a substrate; aligning a bonding target on the bonding part and bonding the bonding part and the bonding target. The bonding includes heating the bonding part using a laser. The bonding part formed on the substrate includes an adhesive layer and a conductive particle located in the adhesive layer.

Abstract: An optical tweezer phonon laser system and method for modulating mechanical vibrations of an optically levitated mechanical oscillator to produce coherence is disclosed. A feedback loop is configured to simultaneously supply an electro-optic modulator with an amplification signal and a cooling signal representing an amplification force linear in the mechanical oscillator momentum and a cooling force nonlinear in the mechanical oscillator variable position and linear in the momentum, respectively controlling the intensity of a trap beam levitating the mechanical oscillator.

Abstract: A substrate inspection apparatus generates, when anomalies of a plurality of second solder pastes among a plurality of first solder pastes printed on a first substrate is detected, at least one image indicating a plurality of second solder pastes with anomalies detected by using an image about a first substrate, applies the at least one image to a machine-learning-based model, acquires a plurality of first values indicating relevance of respective first fault types to the at least one image and a plurality of first images indicating regions associated with one of a plurality of first fault types, determines a plurality of second fault types, which are associated with the plurality of second solder pastes by using the plurality of first values and the plurality of first images, and determines at least one third solder paste, which is associated with the respective second fault types.

Abstract: An aerial vehicle with a plurality of selectively collapsible arms capable of transitioning between an extended state and a contracted state is described. In the extended position, the distance between the main body of the vehicle and the rotor associated with each arm is maximized. In the contracted state, the distance between the main body of the vehicle and the rotor associated with each arm is minimized. In certain embodiments, each of the arms may include one or more tape springs that are biased to selectively move the associated one or more rotors of each arm between the retracted and extended states.

Abstract: A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at ?20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).

Abstract: An electrode catalyst is configured such that non-noble metal particles, noble metal particles or nitride-doped noble metal particles are supported on a carbon support, wherein the carbon support has a 2D planar crystal structure or a 3D polyhedral crystal structure and is doped with nitrogen, thereby exhibiting increased catalytic activity.

Abstract: A drive circuit 3 includes a power source 11; current control units 12-1 to 12-n configured to control the amount of currents supplied to a light emitting element in accordance with a pulse modulation signal; and a calculation unit 13 configured to change a duty ratio of a pulse modulation signal. The current control units 12-1 to 12-n include a first switching element 21 configured to be switched on/off in accordance with a pulse modulation signal; and a second switching element 22 configured to be switched on/off in accordance with an inversion signal of the pulse modulation signal input to the first switching element 21; and an inductor 23. The first switching element 21 and the inductor 23 are serially connected between the power source and the light emitting element. The second switching element 22 is connected between ground 25 and a contact point 24 of the first switching element 21 and the inductor 23. The two or more current control units 12-1 to 12-n are connected in parallel.

Abstract: The invention relates to methods of using choline supplementation for treating APOE4-related disorders. In particular the methods are accomplished by administering choline treatment paradigms to re-establish lipid homeostasis in APOE4 carriers.

Abstract: The present disclosure relates to a photoelectrochemical photoelectrode for water splitting, which includes a plate-type photoelectrode including a transparent electrode substrate and a photoanode layer disposed on the transparent electrode substrate, wherein the plate-type photoelectrode exists in a plural number, and the plural plate-type photoelectrodes are disposed in such a manner that the transparent electrode substrate of one photoelectrode may face the photoanode layer of the other photoelectrode, while being spaced apart from each other. In this manner, it is possible to scale-up the photoelectrochemical photoelectrode for water splitting, while providing improved water splitting performance.

Abstract: Methods and apparatus for tracking fluid flows are disclosed. Fast-moving fluids can be non-invasively tracked, including those at supersonic and hypersonic speeds. To track such flows, atoms of an inert gas can be introduced into the fluid. To monitor the tracer, a laser excites a series of molecules along a “write line,” which can be tracked by a series of cameras in order to estimate flow velocity.

Abstract: Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.

Abstract: The disclosure relates to doubly attenuated malaria parasites that have had the functionality of LISP2 and PlasMei2 genes interrupted through genetic manipulation. The double attenuated malaria parasites disclosed herein are useful for methods and compositions for stimulating of vertebrate host immune systems because of the complete cessation of lifecycle progression in the late liver stage, while providing a comprehensive antigenic presentation representing wildtype liver stage parasites. The disclosure also relates to the additional blood stage and gametocyte antigens to compositions of genetically attenuated malaria parasites (GAPs) to enhance efficient immune stimulation and prevention of disease and transmission related to the presence of blood stage parasites.

Abstract: An underwater liquid supply unit includes a first bladder containing a first liquid, a second bladder containing a second liquid, and a third bladder containing a third liquid. The combined volume of the first liquid, second liquid, and third liquid is neutrally buoyant relative to a surrounding medium the liquid supply unit is disposed in (e.g., in seawater). As the first liquid, second liquid, and third liquid are dispensed from the bladders, the bladders may reduce in size in at least one dimension. As the liquids are dispensed, the liquids may be dispensed in a predetermined volumetric ratio based on the density of the liquids to maintain neutral buoyancy of the combined volume of liquid. The underwater liquid supply unit may also include an integrated generator such as a fuel cell, as well as a propeller.

Abstract: A method and apparatus for multi-level stepwise quantization for neural network are provided. The apparatus sets a reference level by selecting a value from among values of parameters of the neural network in a direction from a high value equal to or greater than a predetermined value to a lower value, and performs learning based on the reference level. The setting of a reference level and the performing of learning are iteratively performed until the result of the reference level learning satisfies a predetermined value and there is no variable parameter that is updated during learning among the parameters.

Abstract: A water-air amphibious cross-medium bio-robotic flying fish includes a body, pitching pectoral fins, variable-structure pectoral fins, a caudal propulsion module, a sensor module and a controller. The caudal propulsion module is controlled to achieve underwater fish-like body-caudal fin (BCF) propulsion, and the variable-structure pectoral fins is adjusted to achieve air gliding and fast splash-down diving motions of the bio-robotic flying fish. The coordination between the caudal propulsion module and the pitching pectoral fins is controlled to achieve the motion of leaping out of water during water-air cross-medium transition. The ambient environment is detected by the sensor module, and the motion mode of the bio-robotic flying fish is controlled by the controller.

Abstract: Disclosed herein is a method for rectifying a 2D multi-view image. The method for rectifying a 2D multi-view image according to an embodiment of the present disclosure may include: detecting uniformly the at least one feature point in each region unit distinguished by considering a distribution of feature points of a plurality of input images: removing an error of the least one feature point; determining a corresponding pair for a vertical or horizontal direction of the at least one feature point; by considering an arrangement relationship of the plurality of input images, projecting the at least one feature point onto a projection plane; determining a disparity error for a corresponding pair for the at least one feature point that is projected onto the projection plane; and, by considering the disparity error, performing image rectification based on the at least one feature point.

Abstract: A strain measurement method includes disposing a 3D camera module at a first measurement position; using the 3D camera module to acquire a first 3D image of a to-be-measured object at a first to-be-measured position; acquiring a second 3D image of the to-be-measured object at the first to-be-measured position; and splicing the first and second 3D images to obtain an initial 3D image. The method still includes: moving the 3D camera module from the first measurement position to a second measurement position; using the 3D camera module to acquire a third 3D image of the to-be-measured object at a second to-be-measured position; acquiring a fourth 3D image of the to-be-measured object at the second to-be-measured position; and splicing the third and fourth 3D images to obtain a deformed 3D image. The method further includes comparing the initial 3D image and the deformed 3D image to output 3D deformation information.