Abstract: The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of cancer.

Abstract: The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

Abstract: Virus vectors wherein each of the virus vectors expresses a sequence targeting a consensus conserved nucleic acid sequence, which when expressed in cells, functions as a modulator for nucleic acid encoding a domain.

Abstract: A deployable reflectarray has a plurality of strips arranged in quadrants forming the reflectarray. The copper ground plane and the copper dipoles are supported by facesheets made of epoxy reinforced by quartz fibers. The copper ground plane is separated from the copper dipoles by S-shaped springs made of epoxy reinforced by quartz fibers, which allow folding and deployment of the reflectarray.

Abstract: The present invention provides an application of triacetyl-3-hydroxyphenyladenosine represented by formula (I) in preventing or treating non-alcoholic fatty liver disease. The triacetyl-3-hydroxyphenyladenosine can significantly reduce the levels of serum AST, ALT and TG, significantly improve liver functions, and alleviate liver steatosis. The invention provides significant curative effects for preventing or treating non-alcoholic fatty liver and has limited toxic side effects.

Abstract: In a method provided herein for forming a chalcogenide film on a substrate, an elemental solid is exposed to a hydrogen halide gas in a heated reaction environment at a temperature at which the hydrogen halide gas promotes the elemental solid to evolve into an elemental halide-based gas. The elemental halide-based gas is then exposed to a chalcogen gas provided in the heated reaction environment, at a temperature at which the elemental halide-based gas is reactive with the chalcogen gas to produce a solid chalcogenide reaction product. A substrate is provided in the heated reaction environment for deposition thereon of a solid film of the solid chalcogenide reaction product that results from exposure of the elemental halide-based gas to the chalcogen gas in the heated reaction environment.

Abstract: Provided are a method for treating sulfur hexafluoride and an apparatus for collecting and treating by-products. The method for treating sulfur hexafluoride, and the apparatus for collecting and treating by-products according to the present invention are a significantly effective method and apparatus capable of safely treating sulfur hexafluoride at low cost.

Abstract: Provided is a system for creating a news article containing an indirect advertisement, the system including an advertisement database including an advertisement item and an indirect advertisement composed of text matching the advertisement item, an advertisement search unit configured to, when a text-type original news article to be exposed to a webpage is input, search the database for an indirect advertisement candidate matching the original news article and select an advertisement candidate list, an advertisement position determination unit configured to determine a paragraph of the original news article into which a selected advertisement is to be inserted, and an advertisement phrase creation unit configured to create a news article containing an advertisement by inserting the selected advertisement into the paragraph of the original news article and expose the created news article.

Abstract: A power module including a main housing, a power element, and at least one assembling component is provided. The main housing has at least one side wall and at least two ribs extending from the side wall. The power element is disposed in the main housing and is closely pressed against a heat dissipation structure by the side wall. The assembling component includes a main section and two bending sections. The main section is located between the two ribs and includes a central portion, at least one movable component, and a peripheral portion. The central portion has a fastening portion, the peripheral portion surrounds the central portion, and the movable component is connected between the central portion and the peripheral portion. The two bending sections are respectively connected to two opposite sides of the peripheral portion and are respectively embedded in the two ribs.

Abstract: An apparatus and method for producing heat and electricity including a burner to produce radiant heat. A thermal-to-electric conversion device is integrated with the burner and proximate to the radiant heat. The conversion device provides a first side disposed toward the radiant heat and a second side disposed toward a cooling fluid flow path, such as combustion air for the burner or a media to be heated by the burner.

Abstract: A composition can include a copper containing nanocrystal.

Abstract: Provided are a fire extinguishing method and a fire extinguishing system for a lithium ion battery, an electronic device and a storage medium. The method includes: real-timely collecting environmental parameter values in a battery box where a lithium ion batteries are placed; determining a safety level of the lithium ion battery according to the environmental parameter values and a preset threshold of each environmental parameter, and sending a fire extinguishing command to a fire extinguishing device according to a preset fire extinguishing control program, where the fire extinguishing control program is a fire extinguishing strategy corresponding to the safety level of the lithium ion battery; and enabling the fire extinguishing device to execute a fire extinguishing operation according to the fire extinguishing command.

Abstract: The present invention relates to a dual-arm clamping type holder for transmission electron microscopy grids and preparation method thereof. The preparation method comprises: firstly manufacturing a frame with two adjacent arms located on a same plane and have a clamping structure by a hard material; then putting the frame in a molten adhering liquid so that the frame is dipped with the adhering liquid; and finally, taking out the frame dipped with the adhering liquid, and waiting for the adhering liquid to solidify into adhering layers along the arms. The dual-arm clamping type holder manufactured by the method of the present invention comprises a frame and adhering layers; and the adhering layers adhere to the inner sides of the clamping structure between the two adjacent arms of the frame.

Abstract: A power module including a circuit board, a chip, a first heat-conduction and insulation substrate and a second heat-conduction and insulation substrate is provided. The circuit board includes a board and a metal block embedded in the board and exposed from a first surface and a second surface of the board opposite to one another. The chip is disposed on a side of the second surface of the board corresponding to the metal block, and the chip is electrically and thermally connected to the metal block. The first heat-conduction and insulation substrate is located on a side of the first surface of the board to be disposed on the circuit board. The second heat-conduction and insulation substrate is electrically and thermally connected to the chip.

Abstract: Disclosed is a small animal intraventricular injection compensator for injecting a drug into a desired location through a syringe, the compensator including: a guide part provided with a guide hole into which a needle of a syringe is inserted; a body comprising an upper cavity provided inside thereof and a cradle provided to seat the guide part on an upper side thereof; and a fixation part integrally provided with the body or separately provided, and comprising a lower cavity provided to allow a head accommodation space, which a head of a small animal may enter into or exit from, to be provided inside thereof by corresponding to the upper cavity.

Abstract: The present invention provides, in order to prepare matured hepatocytes analogous in various points to primary hepatocytes, a method for preparing hepatocytes or cells that can be differentiated into hepatocytes from pluripotent stem cells, comprising the steps of: (1) culturing the pluripotent stem cells in a medium containing an activator of an activin receptor-like kinase-4,7; (2) culturing the cells obtained in the step (1) in a medium containing a bone morphogenetic factor and a fibroblast growth factor; (3) culturing the cells obtained in the step (2) in a medium containing an activator of a hepatocyte growth factor receptor and an activator of an oncostatin M receptor; and (4) culturing the cells obtained in the step (3) to obtain hepatocytes or cells that can be differentiated into hepatocytes, wherein in at least one of the steps (2), (3) and (4), cells are cultured on a high-density collagen gel membrane.

Abstract: The invention provides methods to monitor cell free nucleic acids.

Abstract: A long-term cooling system in a nuclear power plant according to the present disclosure may include a boundary section disposed inside a containment to enclose a reactor coolant system, and configured to restrict steam containing radioactive materials generated in the reactor coolant system from leaking into paths other than a discharge part, an In-Containment Water Storage Tank (IRWST) disposed outside the boundary section and configured to store refueling water therein, an emergency cooling tank disposed outside the containment and provided with a condensation heat exchanger, a gas-liquid separator connected to the emergency cooling tank outside the containment, and a return line configured to connect the gas-liquid separator and the boundary section such that condensate generated by condensing the steam within the boundary section through the emergency cooling tank and the gas-liquid separator is discharged toward the boundary section upon an occurrence of a nuclear power plant accident.

Abstract: Disclosed herein are a synchronization apparatus and method for a upstream system. The synchronization apparatus for a upstream system includes one or more processors, and execution memory for storing at least one program that is executed by the one or more processors, wherein the at least one program is configured to receive a signal and calculate a first channel estimation value for the received signal using a predefined pilot, and calculate a second channel estimation value using a predefined complementary pilot and the first channel estimation value.

Abstract: The present invention relates to a magnetic holder for immunoelectron microscopy grids. The holder comprises a frame, a magnet and a hydrophobic layer. The device can use a magnetic force to simultaneously attach the outer rings of nickel grids to the frame, so that a batch operation (such as rinsing, immunolabeling and dyeing) of the nickel grids can be realized. In addition, due to the hydrophobic effect of the hydrophobic layer, the holder can reduce the amount of the liquid carried by the nickel grids in the process of continuously transferring the nickel grids between different types of liquids to almost zero. Compared with the prior art, the magnetic holder effectively reduces the probability of cross-contamination between reagents.