Patents Assigned to INSTITUTE
  • ANTIBODY COMPOSITIONS FOR DISRUPTING BIOFILMS
    Publication number: 20210206841
    Abstract: Provided herein are methods and compositions for disrupting biofilms in vitro and in vivo. Also disclosed are antibodies comprising a specified heavy chain (HC) immunoglobulin variable domain sequence and/or a specified light chain (LC) immunoglobulin variable domain sequence.
    Type: Application
    Filed: January 28, 2021
    Publication date: July 8, 2021
    Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: Steven D. Goodman, Lauren O. Bakaletz
  • METHOD AND APPARATUS FOR GENERATING DATA SET OF UNMANNED AERIAL VEHICLE
    Publication number: 20210209950
    Abstract: A method for generating data sets of a UAV, performed by a data set generation apparatus, may comprise obtaining flight environment information including a moving object; obtaining flight data including first physical information and first sensor information of the UAV in a flight environment based on the flight environment information; obtaining second physical information and second sensor information of the UAV when the moving object exists, based on the flight data, and generating a first data set based on the second physical information and the second sensor information; obtaining third physical information and third sensor information of the UAV when the moving object does not exist, based on the flight data, and generating a second data set based on the third physical information and the third sensor information; and combining the first data set and the second data set to generate a third data set.
    Type: Application
    Filed: December 16, 2020
    Publication date: July 8, 2021
    Applicant: Electronics and Telecommunications Research Institute
    Inventor: Jeong Gi YANG
  • LYCORINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Publication number: 20210206777
    Abstract: A lycorine derivative of Formula (I), and a pharmaceutically acceptable salt, a preparation method, a pharmaceutical composition and use thereof wherein the lycorine derivative has obvious antiviral activity and is useful in the treatment of viral diseases such as hand-foot-mouth disease.
    Type: Application
    Filed: July 27, 2018
    Publication date: July 8, 2021
    Applicants: SHANDONG DYNE MARINE BIOPHARMACEUTICAL CO., LTD, BEIJING DYNE HIGH-TECH PEDIATRIC PHARMACEUTICAL R&D INSTITUTE CO., LTD.
    Inventors: Xiandao PAN, Yajun YANG, Longying SHEN, Wensheng ZHENG, Shuwang HE, Shiqiang YAN, Yajun JING
  • TOPICAL COMPOSITION
    Publication number: 20210205210
    Abstract: The purpose of the present invention is to provide an ointment preparation in which both separation over time and discoloration over time are suppressed. Both separation over time and discoloration over time are suppressed in: a topical composition containing (A) 30-60 weight % of zinc chloride, a specific (B) inorganic powder and a specific (C) additive, and (D) a solvent; and a topical composition containing (A) 30-60 weight % of zinc chloride, a specific (B) inorganic powder, and (D) a solvent.
    Type: Application
    Filed: May 29, 2019
    Publication date: July 8, 2021
    Applicants: JINNO INSTITUTE, OTSUKA PHARMACEUTICAL FACTORY, INC.
    Inventors: Masato SHIGEYAMA, Toshiya NAGIRI, Yuki TAKEUCHI, Yu MIMA, Katsunori SHIRAI, Toshimitsu TERAO
  • SPHERICAL 3D TUMOR SPHEROID
    Publication number: 20210207082
    Abstract: A spherical 3D tumor spheroid according to an aspect has an appropriate diameter, roundness and specificity so as to be suitably used in vitro, and expresses an ECM structure similar to that of in vivo tumor, and thus may be used in evaluating the efficacy of drug for treating various types of tumors.
    Type: Application
    Filed: December 18, 2020
    Publication date: July 8, 2021
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang-Heon KIM, Seung Ja OH, Wooshik CHOI, Inyeong BAE
  • ENERGY-SENSITIVE MULTI-CONTRAST COST-EFFECTIVE CT SYSTEM
    Publication number: 20210204890
    Abstract: Systems and methods for obtaining scattering images during computed tomography (CT) imaging are provided. Two gratings or grating layers can be disposed between the object to be imaged and the detector, and the gratings or grating layers can be arranged such that primary X-rays are blocked while scattered X-rays that are deflected as they pass through the object to be imaged reach the detector to generate the scattering image.
    Type: Application
    Filed: February 17, 2017
    Publication date: July 8, 2021
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Ge WANG, Wenxiang CONG
  • CYANO THIENOTRIAZOLODIAZEPINES AND USES THEREOF
    Publication number: 20210206779
    Abstract: The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.
    Type: Application
    Filed: September 9, 2016
    Publication date: July 8, 2021
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: James E. Bradner, Jun Qi, Minoru Tanaka, Dennis Buckley
  • ANODIZED TITANIUM MATERIAL AND METHOD FOR PRODUCING THE SAME
    Publication number: 20210207283
    Abstract: An anodized titanium material includes a titanium base material and an anodized titanium layer. The anodized titanium layer is provided on a surface of the titanium base material. The anodized titanium layer includes a porous first anodized titanium layer. The anodized titanium layer has a withstand voltage at 25° C. of 500 V or more, a Vickers hardness of 200 or more, a film thickness of 20 ?m or more and less than 80 ?m, an arithmetic average roughness Ra of a surface of less than 1.6 ?m, and a maximum height roughness Rz of the surface is less than 6.3 ?m. In both of a section perpendicular to a thickness direction of the first anodized titanium oxide layer and the surface, no pore sections having a shape capable of including a circle having a diameter of 0.5 ?m or more are observed.
    Type: Application
    Filed: February 8, 2021
    Publication date: July 8, 2021
    Applicants: Yamaguchi Prefectural Industrial Technology Institute, Shimonoseki Mekki Co., Ltd., Tokyo Electron Limited
    Inventors: Takehiko MURANAKA, Kouji NIIMI, Yuuta UENO, Hikaru KIKUCHI, Hideto SAITO, Nobuyuki NAGAYAMA
  • USING DISTRIBUTED POWER ELECTRONICS-BASED DEVICES TO IMPROVE THE VOLTAGE AND FREQUENCY STABILITY OF DISTRIBUTION SYSTEMS
    Publication number: 20210210957
    Abstract: Methods include, in response to a line frequency variation of a power grid, adjusting a voltage setpoint of a voltage regulator coupled to the power grid at a grid edge to maintain a voltage at the grid edge, wherein the adjusting the regulated voltage setpoint is configured to reduce the line frequency variation to stabilize the line frequency of the power grid. Apparatus include a voltage regulator configured to couple to a power grid at a grid edge and to maintain a voltage at the grid edge, wherein the voltage regulator is further configured to adjust a voltage setpoint of a voltage regulator in response to a line frequency variation of the power grid to reduce the line frequency variation and stabilize the line frequency of the power grid.
    Type: Application
    Filed: November 20, 2020
    Publication date: July 8, 2021
    Applicant: Battelle Memorial Institute
    Inventors: Wei Du, Kevin P. Schneider, Francis K. Tuffner, Jing Xie, Thanh T. Vu
  • CONTROLLER FOR VEHICLE AIR CONDITIONER
    Publication number: 20210206273
    Abstract: A controller for vehicle air conditioner includes a base defining a mounting cavity; a knob assembly rotatably mounted to the base, wherein at least a portion of the knob assembly is located in the mounting cavity; and at least one bearing element arranged between the base and the knob assembly. Such a design reduces the friction between the base and the knob assembly and thus reduces the noise.
    Type: Application
    Filed: March 22, 2021
    Publication date: July 8, 2021
    Applicant: HANGZHOU SANHUA RESEARCH INSTITUTE CO., LTD.
    Inventors: Jundi HU, Junjie YANG, Liying ZHANG
  • Method for avoiding collision in synchronous wireless communication system
    Patent number: 11057933
    Abstract: The present invention relates to a method of avoiding collision in a. More specifically, the present invention relates to a method of effectively avoiding collision when resources are allocated to and used by substantial mobile terminals in a synchronous wireless distribution communication system. The method of avoiding collision includes: determining, by a terminal, a slot to be transmitted in a main frequency channel; in a slot prior to the determined slot, performing contention using a contention deputy channel having a different frequency from the main frequency channel; and using the selected slot of the main frequency channel when winning the contention.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: July 6, 2021
    Assignee: Electronics and telecommunications research institute
    Inventor: Hyun Gu Hwang
  • Classification of polyps using learned image analysis
    Patent number: 11055581
    Abstract: Computational techniques are applied to video images of polyps to extract features and patterns from different perspectives of a polyp. The extracted features and patterns are synthesized using registration techniques to remove artifacts and noise, thereby generating improved images for the polyp. The generated images of each polyp can be used for training and testing purposes, where a machine learning system separates two types of polyps.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: July 6, 2021
    Assignee: Baylor Research Institute
    Inventors: Themistocles Dassopoulos, Nikolaos Bourbakis
  • Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
    Patent number: 11053207
    Abstract: Disclosed are a compound represented by general formula I and a preparation method therefor. The compound can be used as indoleamine-2,3-dioxygenase inhibitor to prepare medicines for preventing and/or treating indoleamine-2,3-dioxygenase-mediated diseases.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: July 6, 2021
    Assignee: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    Inventors: Zhaoyin Wang, Wei Guo, Jidong Zhu
  • Additive manufacturing of viscoelastic materials
    Patent number: 11052597
    Abstract: Described is a method of forming a structure having viscoelastic properties. The method can include a) depositing a layer of droplets of a solidifying material and a non-solidifying material, the droplets being deposited according to an occupancy matrix specifying voxels for the solidifying and non-solidifying materials, the solidifying and non-solidifying material being interspersed within the occupancy matrix, the occupancy matrix being generated by a probabilistic function; b) exposing the droplets of solidifying material to ultraviolet radiation to cure the solidifying material; and c) repeating a) and b) to deposit additional layers of droplets of solidifying and non-solidifying materials, thereby forming the structure having viscoelastic properties.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: July 6, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert Bruce MacCurdy, Daniela Rus, Jeffrey Ian Lipton
  • Real-time utterance verification system and method thereof
    Patent number: 11056103
    Abstract: A real-time utterance verification system according to the present invention includes a speech recognition unit configured to recognize an utterance of an utterer, a memory configured to store a program for verifying the utterance of the utterer in real time, and a processor configured to execute the program stored in the memory, wherein, upon executing the program, the processor generates and stores a list of the utterance of the utterer, performs a semantic analysis on each utterance included in the list, and generates, when the utterance is determined to be an inappropriate utterance for a listener as a result of the semantic analysis, utterance restricting information corresponding to the inappropriate utterance.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: July 6, 2021
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Chang Hyun Kim, Young Kil Kim
  • Inhalable nanosensors with volatile reporters and uses thereof
    Patent number: 11054428
    Abstract: In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of disease or other body status. The methods and compositions may be methods or compositions for identification of pathogenic infections or other diseases in patients using an inhalable nanosensor having a volatile reporter. The disclosure is based, in part, on synthetic biomarkers (e.g., inhalable nanosensors) that are capable of distinguishing (e.g., classifying) different disease or status associated enzymes in a subject by examining the effect of those enzymes on a synthetic volatile reporter.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: July 6, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Leslie Wan-Gee Chan, Melodi Nilgun Anahtar, Roderick Russell Kunz
  • Systems and methods for signal communication with scalable, modular network nodes
    Patent number: 11057072
    Abstract: A radio frequency (RF) aperture includes an interface board. An array of electrically conductive tapered projections have bases disposed on a front side of the interface printed circuit board and extend away from the front side of the interface printed circuit board. RF circuitry is disposed at the back side of the interface board and is electrically connected with the electrically conductive tapered projections.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: July 6, 2021
    Assignee: Battelle Memorial Institute
    Inventors: Raphael Joseph Welsh, Douglas A. Thornton, Daniel A. Perkins, Micah Blue, Amy M. Heintz, Daniel G. Loesch
  • Methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene
    Patent number: 11053494
    Abstract: The present invention relates to the delivery of oligomers for treating patients with a 5? mutation in their DMD gene other than a DMD exon 2 duplication. The invention provides methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene resulting in translation of a functional truncated isoform of dystrophin. The methods and materials can be used for the treatment of muscular dystrophies arising from 5? mutations in the DMD gene such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: July 6, 2021
    Assignees: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, THE UNIVERSITY OF WESTERN AUSTRALIA
    Inventors: Kevin Flanigan, Nicolas Wein, Stephen Wilton
  • Kinase inhibitors and methods of use thereof
    Patent number: 11052080
    Abstract: The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3? or GSK3?) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: July 6, 2021
    Assignees: The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation
    Inventors: Florence Fevrier Wagner, Jennifer Q. Pan, Sivaraman Dandapani, Andrew Germain, Edward Holson, Benito Munoz, Partha P. Nag, Michael C. Lewis, Stephen J. Haggarty, Joshua A. Bishop, Kimberly Stegmaier, Michel Weiwer, Versha Banerji
  • Method and apparatus for graph-based computing
    Patent number: 11055157
    Abstract: A method is disclosed including: receiving a graph-based program that identifies a bipartite graph and one or more update function sets, the bipartite graph including a plurality of graph nodes and a plurality of edges, such that each graph node corresponds to one of the update function sets; associating each of a plurality of computing units with a different respective one of the graph nodes; instantiating, by a Publisher Subscriber platform, a plurality of channels, the plurality of channels defining a topology that matches a topology of the bipartite graph; and executing the graph-based program based on the plurality of channels to produce a result.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: July 6, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Devavrat D. Shah, Vinayak Ramesh