Abstract: The present disclosure provides compounds, which in certain embodiments are ACSS2 inhibitors. In certain embodiments, the compounds of the disclosure are useful for treating, ameliorating, and/or preventing certain types of cancer.

Abstract: Disclosed herein are a method and apparatus for processing an application service. The method includes: registering a user using a visual network service and at least one physical entity supporting the visual network service; mapping at least one virtual entity corresponding to the at least one physical entity; in response to the user's entering a visual network service space, displaying the at least one virtual entity on a terminal device of the user; and confirming a user input for the at least one virtual entity and controlling an operation of the at least one physical entity corresponding to the at least one virtual entity.

Abstract: The invention provides a cell library for use in detecting protein expression comprising a plurality of cells, wherein each cell comprises a polynucleotide sequence encoding a detectable marker integrated into the genome of the cell in frame with a protein coding gene selected from a set of target genes, wherein the library comprises more than one cell tagged at each target gene, as well as a cell library for use in detecting protein interactions between a protein of interest and a set of target proteins and a cell library for use in detecting protein modifications. The invention also provides methods of constructing a cell library for use in proteomics, as well as methods for sequencing integration sites of a donor sequence inserted into the genome of a cell. Also provided are systems for analysis of proteins in a cell and kits comprising vectors for tagging a population of cells and for performing proteomics studies.

Abstract: The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds of the present disclosure are inhibitors of kinases (e.g., a cyclin-dependent kinase (CDK) (e.g., CDK7)). The compounds may be selective for inhibiting the activity of a kinase (e.g., CDK7) over certain other kinases (e.g., CDK2, CDK9, CDK12). Also provided are pharmaceutical compositions, kits, methods of use, and uses that involve the compounds. The compounds may be useful in inhibiting the activity of a kinase, down-regulating the transcription of MYC or MCL-1, inhibiting the growth of a cell, inducing apoptosis of a cell, treating a disease, and/or preventing a disease (e.g., proliferative disease, cystic fibrosis).

Abstract: Systems and methods of model or prediction algorithm selection are provided. An autonomous control system may include a perception component that, based on environmental inputs regarding an object(s), a vehicle's operating characteristics, etc., outputs a current state of the vehicle's surrounding environment. This in turn, is used as input to a prediction component comprising a plurality of prediction algorithms. The prediction component outputs a set of predictions regarding the trajectory of the object(s). Accordingly, for each object, a set of trajectories at specific timesteps may be generated by the different prediction algorithms which are input to a planner component. These trajectories may then be analyzed, compared, or otherwise processed to determine which trajectory regarding the object is most accurate. The prediction algorithm or model that produced the most accurate predicted trajectory may then be used for subsequent predictions/timesteps.

Abstract: Provided is a method of managing a data history and a device performing the method. The method of managing the data history includes generating second data based on first data, calculating a second hash value for the second data based on the second data and a first hash value for the first data, and storing the second hash value on a blockchain network to verify the second data, and a history of the first data is verified using the first hash value stored on the blockchain network.

Abstract: Provided are an apparatus and method for recognizing whether an action objective is achieved. The apparatus includes a video feature extraction module configured to receive a video and output a video feature sequence through an operator, such as a convolution operator, an action case memory module configured to compress and store action case information for each action type and each of success and failure groups transmitted from the video feature extraction module and return the action case information according to a query including a pair of an action type and whether the action is successful, and an action success or failure determination module configured to receive a pair of a video feature sequence and an action type identifier and output whether an action of the given video feature sequence is successful in connection with the action case memory module.

Abstract: A method of providing a user-interactive customized interaction for a transformation of an extended reality (XR) real object includes segmenting a target object from an input image received through a camera, extracting a similar target object having a highest similarity to the target object from three-dimensional (3D) model data that has been previously learnt, extracting texture of the target object through the camera and mapping the texture to the similar target object, transforming a shape of the similar target object by incorporating intention information of a user based on a user interaction, and rendering and outputting the transformed similar target object.

Abstract: A phosphor having a favorable emission peak wavelength, narrow full width at half maximum, and/or high emission intensity is provided. Additionally, a light-emitting device, an illumination device, an image display device, and/or an indicator lamp for a vehicle having favorable color rendering, color reproducibility and/or favorable conversion efficiency are provided. The present invention relates to a phosphor including a crystal phase having a composition represented by a specific formula, and having a minimum reflectance of 20% or more in a specific wavelength region, in which the specific wavelength region is from the emission peak wavelength of the phosphor to 800 nm, and a light-emitting device comprising the phosphor.

Abstract: The present subject matter relates to a system (100, 200, 300) for delaying ripening process of agricultural produces (102, 202). The system (100, 200, 300) includes a first air-tight chamber (104, 204, 302) to hold a plant material (124, 228) in contact with a nitrite source (126, 230) and to receive a hypoxia-inducing source to create a hypoxic condition in first air-tight chamber (104, 204, 302) to enable production of nitric oxide by plant material (124, 228). A second air-tight chamber (106, 206) holds agricultural produce (102, 202). The second air-tight chamber (106, 206) comprises a first inlet (132, 236) connected to first outlet (130, 234) of first air-tight chamber (104, 204, 302) to expose agricultural produce (102, 202) to nitric oxide received from first air-tight chamber (104, 204, 302) for delaying ripening of agricultural produce (102, 202).

Abstract: The present invention provides a system and method for high-precision fire simulation-based virtual fire training interaction that features a fire suppression support virtual fire training interaction that combines a scientific fire simulation (FDS) result expression technology used for fire situation analysis and a real-time interaction technology processing dynamic changes in order to have more realistic training in virtual fire training such as fire suppression.

Abstract: A system, method, and computer-program product includes receiving, by a controller node, a request to execute a client process associated with a first programming language and a plurality of threads; launching, by the controller node, a plurality of multi-language worker processes based on a number of threads associated with the client process; and instructing, by the controller node, the plurality of multi-language worker processes to execute the plurality of threads associated with the client process.

Abstract: This application relates to a pellicle for extreme ultraviolet lithography based on yttrium (Y) and used in a lithography process using extreme ultraviolet rays. In one aspect, the pellicle includes a pellicle layer including a core layer formed of an yttrium-based material expressed as Y-M (M is one of B, Si, O, or F).

Abstract: Disclosed are a tungsten hexafluoride preparation method and apparatus based on photoelectric synergy. A photocatalyst and metal tungsten are sequentially filled in a discharge area of a plasma reactor in a direction of gas entry, and the discharge area of the plasma reactor is irradiated with light at the same time; the background gas generates a large amount of plasma in the discharge area, SF6 undergoes decomposition under the synergistic effect of photocatalysis and plasma, SF6 is decomposed to generate fluorine atoms and low-fluorine sulfides such as SF5 and SF4. The generated fluorine ions, SF5, SF4 and low-fluorine sulfides further react with metal tungsten to generate WF6 specialty gas, which not only realizes the utilization of fluorine resources of SF6, but also replaces highly toxic fluorine gas with non-toxic SF6 exhaust gas in the plasma reactor for reaction, thereby ensuring safe operation and low energy consumption.

Abstract: An azimuth ambiguity suppression method for a spaceborne SAR in spatially non-uniform sampling relates to the technical field of radars. The method includes the following steps: step 1: compensating for a phase difference between the channels according to the locations of transmitting and receiving stations for channel echoes; step 2: calculating an equivalent azimuth sampling location of each channel at the moment of each pulse transmission; step 3: sorting the equivalent azimuth sampling locations of all channels and their corresponding echoes after the phase difference between the channels is compensated in ascending order; and step 4: calculating reconstructed echoes from the sorted equivalent azimuth sampling locations and corresponding echoes after the phase difference between the channels is compensated, by using an adaptive weight-conjugate gradient-Toeplitz matrix (ACT) algorithm.

Abstract: Disclosed herein are an evidence collection guidance method and apparatus for file selection. The evidence collection guidance method includes generating pieces of preliminary analysis information that are pieces of collection target information, setting levels of the pieces of preliminary analysis information based on predefined rules, and generating and outputting notification information including summary description information and follow-up measure items related to the pieces of preliminary analysis information corresponding to the levels.

Abstract: A computer-implemented blockchain based voucher method and system, the method including: recording in a blockchain network, with a user computing device of a user with at least one blockchain based voucher, a purchase request that identifies a proposed purchase with an authorized provider, a purchase amount and the voucher, wherein the voucher comprises a sum of cryptocurrency bound by a set of rules earmarking the voucher to be usable only in transactions between the user and any of a set of one or more authorized providers of goods or services, and wherein the purchase amount is a value that is less than or equal to the total value of the voucher; validating, by the blockchain network, eligibility of the purchase request, based on the set of rules binding the voucher; unbinding the set of rules from the purchase amount of the voucher when the proposed purchase is completed.

Abstract: Provided is a hybrid buck converter including a first PMOS transistor and a second PMOS transistor electrically connecting a power supply voltage node with a first switching node, a first NMOS transistor and a second NMOS transistor electrically connecting a ground node with the first switching node, an inductor electrically connecting the first switching node with a second switching node, a third NMOS transistor electrically connecting the second switching node with a first output node, a third PMOS transistor electrically connecting the second switching node with a second output node, a shunt regulator that is driven based on a second output voltage of the second output node, a first PWM controller adjusting, based on a pulse width control of first PMOS transistor and first NMOS transistor, a magnitude of an inductor current, and a second PWM controller adjusting, based on a pulse width control of first PMOS transistor and first NMOS transistor, a magnitude of the second output voltage.

Abstract: A method for a driver prediction system is described. The method includes training a neural network to a learn a set of polynomial basis functions. The method also includes selecting, using a trained neural network, a learned polynomial basis function to perform a prediction of an action of an autonomous dynamic object (ADO) agent. The method further includes computing projection coefficients of the learned polynomial basis function to weigh the learned polynomial basis function. The method also includes using the projection coefficients of the learned polynomial basis function to weigh the learned polynomial basis function to provide a distribution regarding a likelihood of the prediction of the action of the ADO agent.

Abstract: Described herein are methods of treating muscular dystrophy in a subject, comprising administration of a recombinant AAV vector AAVrh74.tMCK.SGCA using a systemic route of administration and at a dose of about 1.0×1012 vg/kg to about 5.0×1015 vg/kg. Further disclosed are methods of expressing alpha-sarcoglycan gene in a cell or in a subject in need thereof, decreasing a serum CK level, and increasing alpha-sarcoglycan positive fibers in muscle tissue of a subject.