Abstract: Current methods for annotating and interpreting human genetic variation typically exploit only a single information type (e.g., conservation) and/or are restricted in scope (e.g., to missense changes). Here, a method for objectively integrating many diverse annotations into a single measure (integrated deleteriousness score, or C-score) for each variant is described. The method may be implemented as a support vector machine (SVM) trained to differentiate high-frequency human-derived alleles from simulated variants. C-scores were precomputed for all 8.6 billion possible human single-nucleotide variants and allow scoring of short insertions-deletions. C-scores correlate with allelic diversity, annotations of functionality, pathogenicity, disease severity, experimentally measured regulatory effects and complex trait associations, and they highly rank known pathogenic variants within individual genomes.

Abstract: A video encoding method includes receiving a source video frame, dividing the source video frame into a coding tree unit, determining a coding unit from the coding tree unit, enabling or disabling a coding mode of the coding unit, determining, if the coding mode is enabled, whether to evaluate a size of a transform unit for the enabled coding mode, and determining a transform unit of the coding unit for the enabled coding mode, wherein the size of the coding unit is defined by a number (N) of samples.

Abstract: The present invention relates to an induced pluripotent stem cell (iPS) model for cardiofaciocutaneous (CFC) syndrome, a method for producing the model, and uses of the iPS model in the analysis of neural development in CFC syndrome. Specifically, the CFC syndrome-derived iPS and generation and differentiation of an embryonic body were induced from the fibroblasts of a CFC syndrome patient, and the CFC syndrome-derived iPS and embryonic body were confirmed to exhibit broken embryonic body shapes and no differentiation into neurons. When a CFC syndrome-derived embryonic body was induced by treating with p-ERK and p-SMAD1 inhibitors, the embryonic body exhibited a normal embryonic body shape and effectively differentiated into neurons. Thus, the CFC syndrome patient-derived stem cell model of the invention can be effectively used in the research for neural development in cardiofaciocutaneous syndrome.

Abstract: A base station that runs a plurality of beams calculates the sum of proportional fairness metrics for each of terminals scheduled for resource allocation in the beams, creates a beam muting list based on the sum of proportional fairness metrics for each beam, and mutes the beams in the beam muting list for blocking power.

Abstract: The present invention pertains to the field of printing plates and discloses a planographic printing plate and preparation method. The planographic printing plate comprises: a metal substrate, a hydrophobic priming coat formed on a surface of the metal substrate and a hydrophilic graphic layer formed on the priming coat, wherein the hydrophobic priming coat is formed by a hydrophobic primer liquid through curing, the hydrophilic graphic layer is formed by inkjet-printing and curing a printing plate-making ink on the hydrophobic priming coat. The planographic printing plate according to the present invention may be printed by using water-based ink, so it can avoid the environmental pollution caused by using solvent-based ink during planographic printing. Further, through the cooperation of the hydrophobic priming coat formed by the hydrophobic primer liquid and the hydrophilic graphic layer formed by the printing plate-making ink, printed matters with desirable image resolution can be obtained.

Abstract: A base station configures beam identifiers for a plurality of transmission beams. The base station configures virtual beam identifiers for the plurality of transmission beams based on the maximum number of transmission beams from the plurality of transmission beams that may spatially overlap one another, and the beam identifiers. The base station allocates resources using the virtual beam identifiers.

Abstract: [Object] An object of the present invention is to provide a system for collecting elements as a basis for generating a social scenario useful for people to make well-balanced good decision. [Solution] A scenario generating apparatus includes: a causality phrase pair DB 70 storing causality phrase pairs; synonimity generators 600, 602 and 604, searching, for each of the causality phrase pairs, causality phrase pairs having a cause phrase with causal consistency with the result phrase of the causality phrase pair, and generating join information for joining causality phrase pairs; join relation DB 610 storing the join information; and a causality joining unit 612 joining, to a result phrase of a causality phrase pair, a causality phrase pair having a cause phrase with causal consistency with the phrase by using the join information, and thereby linking causality. A join relation generator 606 that finds a hidden relation between phrases and linking causality phrase pairs may be provided.

Abstract: Provided is a method for manufacturing a semiconductor package, which includes providing a first substrate, providing, over the first substrate, a second substrate including an active region in which a semiconductor element is disposed and a periphery region surrounding the active region, providing an adhesive membrane between the first and second substrates, and mounting the second substrate on the first substrate, wherein the mounting of the second substrate includes aligning the second substrate on the first substrate by using an alignment member protruding from the periphery region of the second substrate.

Abstract: Disclosed is a 3-dimensional image display device, which includes: an image display panel including a plurality of sub-pixels arranged in a lattice pattern; and an optical plate disposed spaced apart from the image display panel and including a plurality of light transmission regions or a backlight panel disposed spaced apart from the image display panel and including a plurality of light emission units, wherein the plurality of light transmission regions or light emission units are inclined from a vertical direction, wherein the image display panel includes: a reference data row which forms a reference viewing zone; and at least one data row which forms an intervening viewing zone, wherein the reference viewing zone includes a plurality of unit reference viewing zones, and wherein the intervening viewing zone includes at least one unit intervening viewing zone located between the unit reference viewing zones adjacent to each other.

Abstract: A video encoding method includes receiving a source video frame, dividing the source video frame into a coding tree unit, determining a coding unit from the coding tree unit, determining a correlation between components of the coding unit, enabling or disabling a coding mode of the coding unit, determining whether to evaluate a size of a transform unit for an enabled coding mode, and determining a transform unit of the coding unit for the enabled coding mode, wherein the size of the coding unit is defined by a number (N) of samples.

Abstract: Provided is an electroactive structure and method for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.

Abstract: This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in N-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the N-glycan as compared to normal persons, N-glycan structures identified using the changes in N-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis.

Abstract: Provided is a communication method in a wireless communication system using interference alignment. The method includes: transmitting a transmission beam for separated data stream to N1 (natural number) user terminals by using M1 (natural number) antennas, by a first AP in a downlink cell; and receiving a reception beam for separated data stream from N2 (natural number) user terminals by using M2 (natural number) antennas, by a second AP in an uplink cell, wherein the first AP transmits linear independent transmission beams to improve a degree of freedom while the second AP simultaneously receives orthogonal reception beams, by simultaneously reflecting interference alignment between two cells including downlink and uplink cells.

Abstract: The present application provides, among other things, compounds, compositions and methods for treating various diseases including cancer.

Abstract: Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). In certain embodiments, the association of persistent carbene with the substrate may be used to affect certain properties of substrate (e.g., surface chemistry, stability). In some cases, a persistent carbene may be functionalized after association with a portion of a substrate. In some embodiments, a persistent carbene and at least one secondary compound may be associated with a portion of a substrate. Articles and methods of the present invention may be useful for applications involving electronics, sensing, microfabrication, nanotechnology, biomimetic, and drug delivery, amongst others.

Abstract: An apparatus for quantum cryptographic communication includes a light source configured to generate an optical pulse which is transmitted to a plurality of quantum code sending devices, and a quantum entanglement measuring unit configured to receive the optical signal generated from each of the plurality of quantum code sending devices and measure a relation among quantum states of the optical signals received from the plurality of quantum code sending devices; the optical signal being generated by encoding a key to a quantum state of the optical pulse. The apparatus for quantum cryptographic communication may further include a signal direction determining unit, a reflector for reflecting the optical pulse or the optical signal, an arbitrary phase shifter, or a modulator for encoding a digital signal corresponding to the key to the optical pulse.

Abstract: A simulation device of an entire natural gas hydrate exploitation process includes a high pressure reaction kettle, a gas-liquid separation device, a hydrate accumulation simulation subsystem simulating a hydrate accumulation process, a hydrate formation drilling simulation subsystem simulating a hydrate formation drilling process, a hydrate exploitation simulation subsystem simulating a hydrate decomposition and gas production process, and a produced gas collecting and processing simulation subsystem simulating a produced gas collecting and processing process. A method for simulating an entire natural gas hydrate exploitation process includes a hydrate accumulation process, a hydrate formation drilling process, a hydrate exploitation process and a produced gas collecting and processing process.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea compounds (referred herein as “TBAP compounds”) that, inter alia, inhibit RAF (e.g., BRAF, CRAF, etc.). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF, CRAF, etc.); and to treat disorders including proliferative disorders; cancer (including, e.g., malignant melanoma, colorectal carcinoma, pancreatic adenocarcinoma); inflammation; immunological disorders; viral infections; fibrotic disorders; disorders associated with a mutated form of RAF (e.g. BRAF, CRAF, etc.); disorders ameliorated by the inhibition of RAF (e.g., BRAF. CRAF, etc.

Abstract: The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising TNP (N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that TNP known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human hepatoma cell lines, up-regulated glutathione converted in liver cells, and inhibited JNK phosphorylation that is a kind of response against stress increased by acetaminophen. The inventors further confirmed that TNP had the activity of protecting liver cells from the toxicity caused by acetaminophen in an animal model. Therefore, TNP can be efficiently used as an active ingredient for a composition for the prevention and treatment of liver toxicity caused by acetaminophen.

Abstract: The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.