Abstract: Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.

Abstract: A transmit power control method of a terminal in direct communication between terminals is disclosed. The terminal measures a path loss gain of a base station, and compares the measured path loss gain with a predetermined threshold value. The terminal sets a power value for direct communication in the case in which the measured path loss gain is less than or equal to the predetermined threshold value, and performs the direct communication at the set power value.

Abstract: Provided are a data transmission apparatus and method for transmitting data in a Delay-Insensitive (DI) data transmission method supporting a handshake protocol. The data transmission apparatus includes a sender which outputs a binary-valued logic signal based on binary-valued logic, and an encoder which encodes the binary-valued logic signal input through input wires into a multi-valued logic signal based on multi-valued logic and transmits the encoded multi-valued logic signal to a decoder through output wires. Here, the encoder includes a mapping table which stores input variables including the number of input wires and the number of output wires smaller than the number of input wires and the multi-valued logic signal corresponding to the input variables, and encodes the binary-valued logic signal into the multi-valued logic signal with reference to the mapping table.

Abstract: The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for testing a subject for susceptibility to diabetic complications.

Abstract: Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-?1) are provided, particularly recognizing human and mouse TGF-?1 and not recognizing or binding TGF-?2 or TGF-?3. Particular antibodies are provided which specifically recognize and neutralize TGF-?1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-?1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-?1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.

Abstract: A method and apparatus for handover is provided. In a network environment in which a plurality of beams are provided within a base station, a terminal measures signal strength of a serving beam and signal strength of a target beam and transmits a measurement report message when a first condition or a second condition is satisfied. The base station determines inter-beam coordinated scheduling when the signal strength of the serving beam and target beam satisfy the first condition, and determines handover between beams when the signal strength of the serving beam and target beam satisfy the second condition. The base station transmits a message for commanding handover to the terminal when the handover between beams is determined. The terminal then stops communicating with the serving beam and performs handover to the target beam.

Abstract: Apparatus (1) for storing energy includes a high pressure storage vessel (10) for receiving high pressure gas, the high pressure storage vessel (10) including a high pressure heat store including a first chamber housing a first gas-permeable heat storage structure (14); and a low pressure storage vessel (11,12) for receiving low pressure gas, the low pressure storage vessel (11,12) including a low pressure heat store including a second chamber housing a second gas-permeable heat storage structure (16,18. The first heat storage structure (14) has a mean surface area per unit volume which is higher than a mean surface area per unit volume of the second heat storage structure (16,18).

Abstract: Provided are a method of forming an upper electrode of a nanowire array and a nanowire array having an upper electrode formed thereon. The method includes a step of placing a polymeric thin film layer, a step of pressing, a step of treating a mixed solution, a step of etching, and a step of depositing an electrode material, such that the upper electrode is reliably formed in a state in which the polymeric thin film layer is formed on a portion of the nanowire, thereby making it possible to implement various nano-devices based on the nanowire array aligned on a substrate having a large area.

Abstract: The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.

Abstract: The objects of the present invention are to inhibit photobleaching of porphyrins as well as to provide a superior photodynamic diagnostic agent and a photodynamic diagnostic method employing the photobleaching inhibitor for porphyrins. The present invention provides a photodynamic diagnostic agent containing a precursor of porphyrins and a gallic acid. The present invention also provides a photobleaching inhibitor for porphyrins containing a gallic acid.

Abstract: The present invention discloses a method for preparing a soda-lime-silica glass basic formulation and a method for producing soda-lime-silica glass, comprising the steps of: pre-desiliconizing silicon-containing powdery industrial waste with a sodium hydroxide solution; introducing carbon dioxide for carbonation decomposition, and filtering to obtain a silicic acid precipitate and a sodium carbonate solution; drying the silicic acid precipitate to obtain silicon dioxide; adding lime milk into the filtered sodium carbonate for causticization, and filtering to obtain a sodium hydroxide solution and a calcium carbonate precipitate; drying the calcium carbonate precipitate; using said silicon dioxide and part of the calcium carbonate and adding sodium oxide.

Abstract: A large-size circulating fluidized bed boiler, comprising: a furnace having a vertical furnace center line; and at least two groups of cyclones, each cyclone of each group of cyclones having an inlet gas pass communicated with the furnace. A furnace cross section formed by outer sidewalls and located at the inlet gas pass of the cyclone is a polygon having 2×n sides, and n is a positive integer greater than 1. The polygon is axially symmetric with respect to a perpendicular bisector of each side of the polygon, and when n is 2, the polygon is a square. Triangles formed by two endpoints of an inlet of the inlet gas pass of each cyclone at the cross section and an intersection of the furnace center line and the cross section are congruent. A single flow field in communication with each of the inlet is formed in the cross section.

Abstract: Data graphing methods, articles of manufacture, and computing devices are described. In one aspect, a method includes accessing a data set, displaying a graphical representation including data of the data set which is arranged according to a first of different hierarchical levels, wherein the first hierarchical level represents the data at a first of a plurality of different resolutions which respectively correspond to respective ones of the hierarchical levels, selecting a portion of the graphical representation wherein the data of the portion is arranged according to the first hierarchical level at the first resolution, modifying the graphical representation by arranging the data of the portion according to a second of the hierarchal levels at a second of the resolutions, and after the modifying, displaying the graphical representation wherein the data of the portion is arranged according to the second hierarchal level at the second resolution.

Abstract: An apparatus includes a renaming component to homogenized query instructions for retrieving data items from a data set organized using index labels by identifying a declaration instruction associating an object thereof with an index label, replacing the name provided to the object the with an archetypal name based on the index label, and generating change data associating the name with the archetypal name; a hashing component to take an instruction hash of the homogenized instructions; a cache control routine to find a matching instruction hash corresponding to results of earlier database queries in a results cache; and a reversal routine to, in response finding a matching instruction hash, retrieve a cached result from the results cache associated with the matching instruction hash, and replace a name of a different object therein based on the change data and the query instructions to generate a new result of the new database query.

Abstract: This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.

Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. The device may have a reaction cartridge with a reaction chamber to perform techniques such as polymerase chain reaction.

Abstract: A focusing solar light guide module includes a lens array plate and a light guide plate. The lens array plate includes at least one lens. Each lens receiving and focusing a sunlight has an upper curved surface and a lower plane surface. The light guide plate has an upper plane surface parallel to the lower plane surface of the lens array plate and a lower microstructure surface. The lower microstructure surface includes at least one depressed area and at least one connection area parallel to the upper plane surface of the light guide plate. The connection area is connected between the adjacent depressed areas having a depressed point, a first inclined plane and a second inclined plane. The first inclined plane and the second inclined plane are respectively connected between the depressed point and the adjacent connection area.

Abstract: To provide a catalyst for production of a biodiesel fuel, which is capable of producing a biodiesel fuel with high selectivity, at a high yield, and at a low cost even in the presence of a water content and a free fatty acid, and a biodiesel fuel production method using the catalyst. Use of a titanium-containing mesoporous silica containing Ti and Si as skeleton constituent elements and having a pore diameter of 5 nm or greater as a transesterification catalyst enables a biodiesel fuel to be produced with high selectivity at a high yield through transesterification between an oil and an alcohol.

Abstract: The present disclosure provides a millimeter-wave waveguide communication system. The millimeter-wave waveguide communication system may comprise: a clock component, and at least two sets of millimeter-wave receiving/transmitting channels. The clock component is configured to provide a clock signal to sending ends and receiving ends of the two sets of millimeter-wave receiving/sending channels respectively. Each set of millimeter-wave receiving/sending channels comprises: a transmitter component, a receiver component and a transmission waveguide. The transmission waveguide is located between the transmitter component and the receiver component and is configured to provide a channel for millimeter-wave transmission. The top face, side face and/or bottom face of the transmission waveguide, except for active devices and accessories thereof, are plated with a metal conductive wall to form an electromagnetic shield from a transmission waveguide in an adjacent millimeter-wave receiving/sending channel.

Abstract: Disclosed is a discovery method and apparatus for device-to-device (D2D) communication in a cellular mobile communication system. The discovery method performed by the discovery apparatus may include obtaining, from a server managing information associated with terminals providing a service using a D2D communication scheme over a mobile communication network, information associated with a service provided by the terminals, selecting a service of interest based on the information associated with the service, receiving, from a base station, information associated with a discovery radio resource allocated to the terminals providing the service of interest, and discovering the terminals providing the service of interest based on the information associated with the discovery radio resource.