Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.

Abstract: A method for detecting metal ions and chemical/biochemical molecules is provided. The method includes providing a probe, wherein the probe includes: a gold nanocluster; a reducing agent and a chelating agent partially capped on a surface of the gold nanocluster, wherein the probe is formed of reducing gold ions by the reducing agent, and the gold ions and the reducing agent have a molar ratio of 1:0.7 to 1:1.9. The probe may interact with several metal ions of an aqueous solution to produce different changes of fluorescent spectra. Chemical/biochemical molecules can be detected by the fluorescent spectra difference caused by the interaction between the metal ions and the chemical/biochemical molecules.

Abstract: The nitric oxide reducing catalyst contains a negatively charged copper cluster.

Abstract: The present invention relates to a passive device and manufacturing method thereof. A capacitor according to the present invention includes: a capacitor thin film pattern formed on the upper surface of a substrate; a plurality of trenches formed by etching the substrate formed with the capacitor thin film pattern which defines the unit area of the capacitor; an insulation layer, which fills the trench, formed with capacitor interconnection holes for exposing the metal layers formed in the substrate and constituting the capacitor; and a plurality of capacitor electrode interconnection wires formed by filling the capacitor interconnection holes with a conductive material, wherein the lower surface of the substrate is being polished in a way that the insulation layer formed in the trenches is exposed.

Abstract: The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof: where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options.

Abstract: The present invention discloses an oil-in-water emulsion containing no surfactant, which comprises a metabolizable oil phase, an aqueous phase and oil-water amphipathic solid particles dispersed in the aqueous phase and having biocompatibility, wherein the oil phase comprises squalene or/and tocol; the aqueous phase is any one selected from the group consisting of purified water, water for injection, glycerine aqueous solution, buffering salts aqueous solution or clinically usable transfusion, or the combination of at least two selected therefrom; the solid particles have an average particle size in a scale of from nanometer to micrometer. The emulsion of the present invention can be used as vaccine adjuvant, drug delivery carrier or sustained/controlled-release carrier, and have the controllable properties. The resultant emulsion is stable, avoids the use of surfactants and can reduce the human poisoning and environmental pollution.

Abstract: The present disclosure provides a substrate structure for an electronic element, which includes a supporting carrier; a release layer having a first microstructure on a surface thereof, and the release layer having first adhesion to the supporting carrier; and a flexible substrate for disposing the supporting carrier and the release layer thereon, wherein the flexible substrate has second adhesion to the release layer, the first adhesion is greater than the second adhesion, and the surface of the flexible substrate in contact with the surface of the release layer has a second microstructure opposing to the first microstructure. The present disclosure further provides a method for fabricating the substrate structure.

Abstract: Provided are a method and apparatus for refining titanium scraps and sponge titanium, which can remove oxygen from a melt by supplying a deoxidizing gas to the surface of the melt in order to refine titanium scraps and sponge titanium. The method for refining titanium scraps and sponge titanium comprises supplying hydrogen ions and electrons in plasma to a titanium melt to remove oxygen from the titanium melt surface having an oxide layer formed thereon. In addition, the apparatus comprises: a vacuum chamber; a crucible located in the vacuum chamber and configured to perform melting by the magnetic field of an induction coil in a state in which a melt and the inner wall of the crucible; a calcium gas supply means configured to supply calcium gas from the bottom of the crucible to the space between the inner wall of the crucible and the melt.

Abstract: A grounding grid breakpoint diagnostic method for a transient electromagnetic method, based on a transient electromagnetic detection apparatus. The method comprises: (101) disposing a test line at a position above a grounding grid to be diagnosed on the ground, and determining coordinates of a detection point; (102) obtaining information about coordinates of the detection point, and coinciding the center of the transient electromagnetic detection apparatus with the coordinates of the detection point; (103) performing, by the transient electromagnetic detection apparatus, measurement along the test line point by point, so as to obtain measurement data; (104) processing, by using diagram forming software, the measurement data to form a longitudinal resistivity cross-section diagram of the detection point according to a preset formula; (105) determining whether a breakpoint occurs at the detection point according to the longitudinal resistivity cross-section diagram.

Abstract: A system that generates source code of a Web application program. A typical embodiment includes a dictionary table for each language environment that uses identification information on the input/output item as a key to retain, as dictionary data, information made up of initial values of parameters of a parts object, and a dictionary processing unit that acquires the dictionary data corresponding to the identification information on the input/output item from the dictionary table of a specified language environment, and a response processing unit that uses the identification information on the input/output item corresponding to the parts object contained in a processing result as the key to acquire the information on the parameters of the parts object from the dictionary table of the specified language environment and to allow the screen to display a label control and/or an input/output control.

Abstract: A current command value in a period from a time when a relay switch is turned on until charging of an inverter capacitor is completed is set to a value smaller than a value corresponding to the smallest one of rated currents of components included in a circuit, and is set to a value smaller than a maximum current value in a safe operating area of a switching element.

Abstract: An intra prediction method according to the present invention comprises the following steps: deriving neighboring prediction mode information from a left neighboring prediction mode and a top neighboring prediction mode; deriving an intra prediction mode for a target unit to be decoded, using the derived neighboring prediction mode information; and performing intra prediction for the target unit to be decoded, based on the intra prediction mode. According to the present invention, video encoding/decoding efficiency may be improved.

Abstract: A transparent display panel includes a substrate and a pixel array. The pixel array is formed on the substrate and includes a plurality of data lines and a plurality of scan lines. The data lines and the scan lines surround a plurality of pixel regions. Each pixel region defines a transparent region and an opaque region, wherein each transparent region occupies a relative position in the corresponding pixel region and at least three relative positions successively arranged along an axial direction are different.

Abstract: A hybrid powertrain mechanism includes: a first epicyclic train having first and second sun gears and a planetary gear to be coupled to the first and second sun gears; a second epicyclic train having third and fourth sun gears and a planetary gear to be coupled to the third and fourth sun gears; a first electric machine having one end coupled to the second sun gear; a second electric machine having one end coupled to the fourth sun gear; a first clutch having one end coupled to another end of the first electric machine; a second clutch having one end coupled to another end of the first clutch and another end coupled to the third sun gear; and an engine coupled to the first sun gear. Various driving modes are provided by changing the states of the first and second clutches and the operating modes of the first and second electric machines.

Abstract: Systems and methods in accordance with embodiments of the invention efficaciously implement robust gearbox housings. In one embodiment, a method of fabricating a gearbox housing includes: providing an alloy composition from which the gearbox housing will be fabricated from; casting the alloy composition around a solid body so as to form a part characterized by the inclusion of a cavity, where the cast part includes a metallic glass-based material; and nondestructively separating the cast part from the solid body.

Abstract: The purpose of the present invention is to provide a hydrogen-releasing film and a hydrogen-releasing laminated film which are less susceptible to embrittling at an ambient operating temperature of an electrochemical element. This hydrogen-releasing film is characterized by containing a Pd—Cu alloy, and the Cu content in the Pd—Cu alloy being at least 30 mol %.

Abstract: An avalanche photodiode detector is provided with a substrate including an array of avalanche photodiodes. An optical interface surface of the substrate is arranged for accepting external input radiation. There is provided at least one cross-talk blocking layer of material including apertures positioned to allow external input radiation to reach photodiodes and including material regions positioned for attenuating radiation in the substrate that is produced by photodiodes in the array. Alternatively at least one cross-talk blocking layer of material is disposed on the optical interface surface of the substrate to allow external input radiation to reach photodiodes and attenuate radiation in the substrate that is produced by photodiodes in the array. At least one cross-talk filter layer of material can be disposed in the substrate adjacent to the photodiode structures, including a material that absorbs radiation in the substrate that is produced by photodiodes in the array.

Abstract: The invention provides a method for detection of hazardous chemicals in a non-metallic container. The method comprises of irradiating the sample at a predefined location with an electromagnetic radiation of specific wavelength; selectively capturing a certain component of the scattered electromagnetic radiation to obtain a plurality of profiles; and filtering the profiles to obtain a signature specific to at least one hazardous chemical present in the container. The invention provides a system for obtaining a signature specific to the hazardous chemicals in the container.

Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.

Abstract: A multimedia capture system includes a plurality of imaging systems and one or more detection systems. The plurality of imaging systems capture image areas of a scene from at least partially different locations. The one or more detection systems determine a relative position of each of the plurality of imaging systems with respect to the different locations of the scene from where the image areas are captured. The relative position of each of the plurality of imaging systems and the captured image areas are used to generate a multimedia presentation of the scene. The capture system may be worn by an individual or may be on a stationary or mobile support.