Abstract: The present invention relates to the E2EPF UCP-VHL interaction and the uses thereof, more precisely a method for increasing or reducing VHL activity or level by regulating UCP activity or level to inhibit cancer cell proliferation or metastasis or to increase angiogenesis. The inhibition of UCP activity is accomplished by any UCP activity inhibitor selected from a group consisting of a small interfering RNA (RNAi), an antisense oligonucleotide, and a polynucleotide complementarily binding to mRNA of UCP, a peptide, a peptide mimetics and an antibody, and a low molecular compound. In the meantime, the increase of angiogenesis is accomplished by the following mechanism; UCP over-expression is induced by a gene carrier and thus endogenous VHL is reduced, leading to the stabilization of HIF-1? which enhances VEGF activation based on the HIF-1? stabilization.

Abstract: A topical preventative medicament against burns-related systemic inflammatory response syndrome containing a low-molecular-weight chaperone as the main active ingredient.

Abstract: The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.

Abstract: A semiconductor device structure, a method for manufacturing the same, and a method for manufacturing a semiconductor fin are disclosed. In one embodiment, the method for manufacturing the semiconductor device structure comprises: forming a fin in a first direction on a semiconductor substrate; forming a gate line in a second direction, the second direction crossing the first direction on the semiconductor substrate, and the gate line intersecting the fin with a gate dielectric layer sandwiched between the gate line and the fin; forming a dielectric spacer surrounding the gate line; and performing inter-device electrical isolation at a predetermined position, wherein isolated portions of the gate line form independent gate electrodes of respective devices.

Abstract: A method for manufacturing an electrowetting display unit includes the following steps. A first substrate and a second substrate are provided. A first conductive layer is disposed on one side of the first substrate. A second conductive layer is disposed on one side of the second substrate. A polymer layer, which includes a siloxane containing a light-induced cross linkable group and a Si—H bond, is disposed on the first conductive layer. The molecular weight of the monomer of the siloxane is equal to or greater than 5000. A part of the polymer layer is exposed to a light so as to form a plurality of hydrophobic sections. A hydrophilic section is developed by treating a developing agent. The hydrophilic section and the plurality of hydrophobic sections form a pattern layer together. Polar liquid and non-polar liquid are disposed between the pattern layer and the second conductive layer.

Abstract: This disclosure relates to a method and a system of producing nanoparticles and nanoparticle matrices of thermolabile, biocompatible matrix materials, like lipids and biopolymers with controlled properties. A prototype pulse-heat aerosol system is described for single-step production of free, thermolabile nanoparticles with sufficient control over size, morphology and crystallinity with controlled-release properties, for possible therapeutic, cosmetic or diagnostic use. Nanoparticles of the range 50 to 500 nm are obtained and are found suitable for controlled drugs delivery.

Abstract: Provided are a pilot transmitting apparatus and method capable of selectively using an OFDMA scheme and an SC-FDMA scheme. The pilot transmitting apparatus includes a pilot inserter for inserting a pilot signal in a modulated symbol and inserting a cyclic prefix code for the inserted pilot signal, an FFT processor for receiving symbols with a pilot inserted thereto from the pilot inserter and performing an FFT process on the received symbols, an IFFT processor for receiving the transformed data from the FFT processor and performing an IFFT process on the transformed data, a mapping processor for mapping the output of the FFT processor to input positions of the IFFT processor to load the frequency domain transformed data on predetermined sub-carriers, and a cyclic prefix inserter for inserting a cyclic prefix code for the output of the IFFT processor.

Abstract: Optical measurement methods are described that are suitable for determining the relaxation behavior of nanoparticles dispersed in a solution. The particles have optically anisotropic properties and are alignable by an external stimulus, for example, an electric or magnetic field. In this manner the optical detection of certain molecules that can bind specifically to the surface of the nanoparticles and thus change the relaxation behavior of the nanoparticles as well as to provide devices for carrying out the methods is possible.

Abstract: A self-supporting carbon electrode can include, or consist essentially of, nanostructured carbon, for example, oxygen-functionalized nanostructured carbon.

Abstract: The present invention relates to an oil fence and to a method for storing same. The oil fence includes: a vertical support part on which an air chamber, a water chamber, and a ballast are successively disposed in the lengthwise direction thereof; a curtain part connected between the vertical support parts disposed parallel to and spaced a predetermined distance from each other in the widthwise direction thereof; and attenuation bags disposed on the upper and lower portions of the curtain part. Thus, the oil fence may prevent seawater containing oil from overflowing in spite of high waves. Also, the oil fence may stably float on the sea in spite of poor weather conditions and high waves and may be easily stored and unfolded.

Abstract: The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. The invention further provides improved gene therapy methods for treating hematopoietic-related disorders. Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.

Abstract: The present invention describes a method for determination of urinary globotriaosylceramide (Gb3) levels in non-Fabry disease cardiac patients. Determination of Gb3 levels provides a screening method for determining cardiac risk and may offer an alternative therapeutic option for cardiac disease management or cardiac disease risk mitigation by lowering Gb3 levels by the use of pharmacological chaperones or other agents.

Abstract: A benzoxazine-bridged compound is provided. The compound has a low dielectric constant, a high mechanic strength and a high glass transition temperature. The compound has a highly cross-linked structure with a yellow-light photoluminescent emission. Characterization of the present disclosure has been conducted with Fourier transform infrared, nuclear magnetic resonance, molecular mass and elemental analysis.

Abstract: Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.

Abstract: Disclosed herein is an apparatus and method for simulating a submarine landslide. The apparatus includes an inclined flume; a plurality of sedimentary layers which are stacked on top of one another in the flume and tapped; water which is charged into the flume on the sedimentary layers in such a way that the surface of the water is formed in the flume; and a plurality of injectors which are provided in a bottom of the flume so as to be movable upwards or downwards with respect to the flume and inject gas or water into the sedimentary layer. The sedimentary layers are changed in pressure and temperature by the gas or water injected from the injectors into the sedimentary layers so that an artificial slope collapse is caused, whereby a water wave is generated in the flume.

Abstract: [Object] The object is to provide a negative electrode material for a lithium secondary battery, wherein a sulfide-based negative electrode with water-resistant properties can exert excellent cycle characteristics and high output performance while maintaining a high discharge capacity and there is no precipitation of lithium dendrites during charge at low temperature. [Means for Solving Problems] A negative electrode material for a lithium secondary battery comprising sulfur and sulfide glass including the following components (i) and (ii): (i) at least one or more elements selected from a group consisting of Sb, As, Bi, Ge, Si, Cu, Zn, Pd, In and Zr; and (ii) at least one or more elements selected from a group consisting of Se, Te, Ga, Sn, Pb, Cd, Al, Fe, Mg, Ca, Co, Ag, Sr, P and Ba, wherein the ratio of the above components is sulfur: 40-80 mol %, (i): 1-50 mol % and (ii): 1-50 mol %, respectively.

Abstract: An apparatus and method for determining an optimal energy window for optimal positron emission tomography (PET) is disclosed. An optimal energy window determining apparatus may include a data corrector configured to correct data measured from an image quality phantom, an image quality measurer configured to measure an image quality for the corrected data, and an optimal energy window determiner configured to determine the optimal energy window based on the measured image quality. The data corrector may correct the measured data based on a difference between sensitivities measured using different radiopharmaceuticals in at least one energy window.

Abstract: The present invention relates to a shallow trench isolation structure, manufacturing method thereof and a device based on the structure. The present invention provides a method for manufacturing a shallow trench isolation (STI) structure, characterized in comprising the following steps: providing a semiconductor substrate; forming an insulating medium on said semiconductor substrate; etching a part of the insulating medium by using a mask to expose the semiconductor substrate thereunder, the unetched insulating medium forming STI regions; and epitaxially growing a semiconductor layer on said semiconductor substrate between said STI regions as an active region. With the method provided by the present invention, the problem of filling a small-size trench is solved and the problem of STI step height is overcome.

Abstract: The present invention relates to a catalyst component for olefin polymerization, which comprises the reaction product of at least one organo-magnesium compound, at least one titanium-containing compound, at least one hydroxyl group-containing compound, at least one chlorine-containing organo-aluminum, boron, phosphorus or silicon compound, and at least one polybutadiene block copolymer. The catalyst component of the present invention has well-shaped particles, and a narrow particle size distribution; a polymerization reaction of olefins with the catalyst component produces well-shaped polymer particles with a high bulk density (BD) and an excellent comprehensive catalytic performance. The present invention also relates to a preparation method for said catalyst component and the application thereof, particularly in the homopolymerization and copolymerization of olefins such as ethylene, propylene, butene, hexene and octene.

Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament.