Abstract: Compounds of general formula I are disclosed. The meaning of individual substituents is described in the claims. The compounds are useful in treatment of cancers, due to their multi-modal mechanism of action.

Abstract: Provided is a laser diode and a method for manufacturing the same. The diode includes a substrate including a DBR region having a channel hole, an active region, and a phase shift region, an optical waveguide provided on the substrate and extending from the active region to the DBR region, a lower insulation layer disposed on the optical waveguide, upper electrodes disposed on the lower insulation layer, and a heat blocking layer disposed in the channel hole of the DBR region and thermally separating the optical waveguide from the substrate.

Abstract: In a method for analyzing isoaspartic acid by dissociating precursor ions derived from a sample component and generating and analyzing product ions, the method includes: generating product ions by irradiating the precursor ions with hydrogen radicals or radicals having oxidizing ability to dissociate the precursor ions; separating and detecting the product ions according to a mass-to-charge ratio; and specifying product ions derived from isoaspartic acid based on a mass-to-charge ratio of the product ions.

Abstract: Provided are an optical system capable of improving the spatial resolution of hyperspectral imaging and an optical alignment method using the same. The optical system includes a digital micromirror device (DMD) having a rectangular shape, a first cylindrical lens curved to focus and form an image on an axis corresponding to a shorter side of the DMD, and a second cylindrical lens curved in the same axial direction as the axis to collimate light reflected from the DMD.

Abstract: Volatile organic compounds (VOCs) can be sensed using humidity-initiated gas (HIG) sensors.

Abstract: A dehydrogenation reaction device includes a dehydrogenation reactor having a solid chemical hydride and includes an add aqueous solution tank supplying an add aqueous solution to the dehydrogenation reactor. The dehydrogenation reactor includes a heating device, a cooling apparatus, a porous metal foam, or a combination thereof.

Abstract: A fusion protein including a fragment of an anti-mesothelin antibody, an anti-CD3 antibody or an anti-EGFR antibody; a bispecific antibody that is specific to mesothelin and CD3; a trispecific antibody that is specific to mesothelin, CD3 and EGFR are provided. The fusion protein is effective in treating cancer. The bispecific or trispecific antibody can be prepared in a high yield and with high purity, and has excellent tumor killing and growth inhibitory effects, and thus can be effectively used in cancer treatment.

Abstract: Disclosed is a rotary steering drilling apparatus.

Abstract: Disclosed is a method of operating a flow sensor according to an embodiment of the present disclosure, which includes receiving an ultrasonic signal reflected from a particle, generating first and second digital, generating a first Doppler frequency based on the first and second digital signals, a predetermined number of samples, and a first time period, comparing the first Doppler frequency with a second reference frequency, when the first Doppler frequency is less than a first reference frequency, down-sampling the predetermined number of samples to a first sampling frequency or a second sampling frequency, generating a second Doppler frequency based on the first and second digital signals, the number of down-sampled samples, and a second time period determining an output frequency based on the second Doppler frequency when the first Doppler frequency is less than a first reference frequency, and obtaining flow information of the particle based on the output frequency.

Abstract: A hybrid dehydrogenation reaction system includes: an acid aqueous solution tank having an acid aqueous solution; an exothermic dehydrogenation reactor including a chemical hydride of a solid state and receiving the acid aqueous solution from the acid aqueous solution tank for an exothermic dehydrogenation reaction of the chemical hydride and the acid aqueous solution to generate hydrogen; an LOHC tank including a liquid organic hydrogen carrier (LOHC); and an endothermic dehydrogenation reactor receiving the liquid organic hydrogen carrier from the LOHC tank and generating hydrogen through an endothermic dehydrogenation reaction of the liquid organic hydrogen carrier by using heat generated from the exothermic dehydrogenation reactor.

Abstract: The present invention provides a laser, including: a medium, having a ground state, an intermediate state, and an excited state in ascending order of energy; an excitation system, configured to excite electrons in the medium from the ground state to the intermediate state; and an excitation laser, configured to drive electrons in the intermediate state at different spatial positions in the medium to the ground state through a stimulated emission process with a fixed phase relationship, to generate a laser with a shorter relative wavelength. Due to the use of an excitation laser to drive electrons from the intermediate state, the photons generated by the stimulated emission have coherence, thereby forming a laser.

Abstract: Disclosed is an afferent neuron circuit, which includes: a resistance Rc and a volatile threshold switching device TS, wherein the volatile threshold switching device TS is provided with a parasitic capacitor Cparasitic; a first end of the resistance Rc serves as a signal input terminal, and a second end of the resistance Rc serves as a signal output terminal; and a first end of the volatile threshold switching device TS is connected to the signal output terminal, and a second end of the volatile threshold switching device TS is grounded. The afferent neuron circuit provided in the content of the present disclosure has a simple structure and good scalability and is suitable for large-scale integration.

Abstract: Disclosed is a disinfection robot capable of autonomous driving and recognition of a disinfection target. The disinfection robot includes: a recognition unit configured to generate recognition information by recognizing a surrounding environment of the disinfection robot; a movement unit configured to move a position of the disinfection robot; a light source unit configured to emit a light of a predetermined wavelength area for disinfection; an injection unit configured to inject a fluid for disinfection; and a control unit configured to move the disinfection robot through the movement unit based on the recognition information, wherein the control unit is configured to identify a disinfection target from the recognition information and control at least one of the light source unit and the injection unit to perform disinfection to at least one of the surrounding environment of the disinfection robot and the disinfection target.

Abstract: Disclosed are a communication system and an operating method thereof. A plurality of electronic devices for forming a group may be configured to share a homomorphic encryption (HE) key. A server may be configured to generate a Boolean circuit for performing an operation based on input values corresponding to the number of electronic devices. Each of the electronic devices may be configured to transmit an encrypted session ephemeral key to the server through HE. The server may be configured to calculate an HE-evaluated value by applying the encrypted session ephemeral keys as the input values of the Boolean circuit. The server may be configured to transmit the HE-evaluated value and a given random number to each electronic device. Each electronic device may be configured to generate a common session key for the group based on the HE key, the HE-evaluated value and the given random number through homomorphic decryption.

Abstract: A micro-interface strengthening reaction system and method for preparing polyethylene by using a solution process are provided. The system includes a pre-polymerization reactor and a polymerization reactor connected in sequence. The pre-polymerization reactor is provided with a pre-polymerization micro-interface generators, and the polymerization reactor is provided with a micro-interface generator. The system further includes a desolvation tower for removing solvents and impurities from the polyethylene product. A polyethylene inlet is disposed at a middle part of the desolvation tower, and the polyethylene inlet is connected with the flash tank bottom outlet. A nitrogen micro-interface generator for dispersing and breaking high-temperature nitrogen into micro-bubbles is disposed within the desolvation tower.

Abstract: A method and apparatus for allocating a bandwidth based on machine learning in a passive optical network, the method including generating an inference model to predict a consumed bandwidth required for transmission by learning unstructured data of a PON including an OLT and traffic data corresponding to state information of the PON collected from the PON, predicting a consumed bandwidth with respect to a queue corresponding to a class requiring a low-latency service among classes of ONUS connected to the OLT based on the generated inference model, performing a VBA with respect to the queue corresponding to the class requiring the low-latency service based on the predicted consumed bandwidth, and performing a DBA with respect to a queue corresponding to a class not requiring the low-latency service using a transmission bandwidth which remains after the VBA is performed.

Abstract: A piezoelectric system comprises a piezoelectric sensor, a voltage stabilizer, a discharger and an operation sensor. The piezoelectric sensor outputs a sensing signal through a sensor output terminal according to a rate of change of pressure. The voltage stabilizer has a positive terminal electrically connecting with the sensor output terminal. The voltage stabilizer receives the sensing signal, stores the energy of the sensing signal, and keeps the voltage of the sensing signal as a constant when the rate of change of pressure is zero. The discharger has a first terminal connecting with the positive terminal, a second terminal coupled to ground, and a control terminal receiving a trigger signal to control the first terminal to conduct with or not conduct with the second terminal. The operation sensor electrically connects to the control terminal for sensing an operation generating the pressure and outputs the trigger signal accordingly.

Abstract: A method for predicting collision of a machining path includes: a step of reading an NC program; a step of translating a plurality of block information in the NC program; a step of, prior to perform interpolation upon each of the plurality of block information, calculating a safety distance of a next block information with respect to a block information to be interpolated; a step of searching a number of individual block information having an accumulated distance greater than or equal to the safety distance; and a step of performing an anti-collision detection upon each of the individual block information contributing the accumulated distance. In addition, a system for predicting collision of a machining path is also provided.

Abstract: Provided are a method of screening for novel therapeutic targets to develop therapeutic agents for colon cancer, and prognostic biomarkers for colon cancer treatment which are screened using the same.

Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.