Patents Assigned to INSTITUTE
  • Method for producing cyclometalated iridium complex
    Patent number: 11008352
    Abstract: The present invention provides a method for producing a cyclometalated iridium complex, the method including producing a cyclometalated iridium complex by reacting a cyclometalated iridium complex raw material including an organoiridium compound with an aromatic heterocyclic bidentate ligand capable of forming an iridium-carbon bond and an iridium-nitrogen bond, and using as the raw material an organoiridium compound including a substructure represented by the following General Formula (1). The present invention is capable of producing a cyclometalated iridium complex with a high yield without by-production of a halogen-crosslinked iridium dimer. (in General Formula (1), Ir represents an iridium atom, and O represents an oxygen atom).
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: May 18, 2021
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hideo Konno, Junichi Taniuchi, Rumi Kobayashi, Yasushi Masahiro
  • Techniques for automated Bayesian posterior sampling using Markov Chain Monte Carlo and related schemes
    Patent number: 11010451
    Abstract: Techniques for automated Bayesian posterior sampling using Markov Chain Monte Carlo and related schemes are described. In an embodiment, one or more values in a stationarity phase for a system configured for Bayesian sampling may be initialized. Sampling may be performed in the stationarity phase based upon the one or more values to generate a plurality of samples. The plurality of samples may be evaluated based upon one or more stationarity criteria. The stationarity phase may be exited when the plurality of samples meets the one or more stationarity criteria. Other embodiments are described and claimed.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 18, 2021
    Assignee: SAS INSTITUTE INC.
    Inventors: Christian Macaro, Jan Chvosta, Mark Roland Little
  • Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
    Patent number: 11008565
    Abstract: The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: May 18, 2021
    Assignee: SEATTLE CHILDREN'S RESEARCH INSTITUTE
    Inventors: Andrew M. Scharenberg, Michael T. Certo, Kamila Sabina Gwiazda
  • Inhibitors of cancer invasion, attachment, and/or metastasis
    Patent number: 11008325
    Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: May 18, 2021
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Paul B. Fisher, Maurizio Pellecchia, Swadesh K. Das, Timothy P. Kegelman, Bainan Wu, Surya K. De, Jun Wei, Mitchell E. Menezes, Luni Emdad
  • Infrastructure-free NLoS obstacle detection for autonomous cars
    Patent number: 11010622
    Abstract: A method of non-line-of-sight (NLoS) obstacle detection for an ego vehicle is described. The method includes capturing a sequence of images over a period with an image capture device. The method also includes storing the sequence of images in a cyclic buffer. The method further includes registering each image in the cyclic buffer to a projected image. The method includes performing the registering by estimating a homography H for each frame of the sequence of images to project to a view point of a first frame in the sequence of images and remove motion of the ego vehicle in the projected image. The method also includes enhancing the projected image. The method further includes classifying the projected image based on a scene determination. The method also includes issuing a control signal to the vehicle upon classifying the projected image.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: May 18, 2021
    Assignees: TOYOTA RESEARCH INSTITUTE, INC., MASSACHUSETTS INSTITUE OF TECHNOLOGY
    Inventors: Felix Maximilian Naser, Igor Gilitschenski, Alexander Andre Amini, Christina Liao, Guy Rosman, Sertac Karaman, Daniela Rus
  • Composition for preparing anti-wear lubricant for drilling fluid and preparation method of anti-wear lubricant for drilling fluid and drilling fluid
    Patent number: 11008496
    Abstract: This pertains to the technical field of lubricants, and particularly relates to a composition for preparing a wear-resistant drilling fluid lubricant, a preparation method of the wear-resistant drilling fluid lubricant and a drilling fluid. Vegetable oil, nanometer calcium borate, an ether compound and an amine compound may be used as raw materials to prepare drilling fluid lubricant with excellent abrasion resistance by reasonably controlling dosages of the raw materials. The lubricant provided can improve wear resistance, lubricating property, and high temperature resistance of bentonite slurry and water-based drilling fluid.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: May 18, 2021
    Assignees: YANGTZE UNIVERSITY, JINGZHOU JIAHUA TECHNOLOGY CO., LTD., CNPC RESEARCH INSTITUTE OF SAFETY AND ENVIRONMENTAL TECHNOLOGY CO., LTD.
    Inventors: Mingbiao Xu, Fuchang You, Xingchun Li, Jiao Wu, Shanshan Hou, Man Shu
  • Speech processing method and device
    Patent number: 11011170
    Abstract: The present invention provides a speech processing method, which includes: receiving speech information; recognizing the speech information to convert the speech information into a plurality of pieces of text information; displaying at least one pieces of the text information; and receiving a selection signal to respond according to selected text information. The present invention further provides a speech processing device. According to the speech processing method and device provided by embodiments of the present invention, a user can select and confirm by clicking on displayed text information after the speech information is recognized, so that the selected text information is guaranteed to be coincident with a received speech information, thus further increasing accuracy and convenience of the speech processing and providing the user with a good experience effect.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: May 18, 2021
    Assignees: ZHEJIANG GEELY HOLDING GROUP CO., LTD., ZHEJIANG GEELY AUTOMOBILE RESEARCH INSTITUTE CO., LTD.
    Inventor: Shufu Li
  • Transport container automatic clamping mechanism
    Patent number: 11011403
    Abstract: An automatic clamping mechanism capable of automatically securing and releasing a wafer transport container to or from a manufacturing apparatus and having a small height dimension is provided at low cost. A wafer transport container is placed on a container placing table. A semiconductor wafer is loaded into the manufacturing apparatus main body from a wafer loading port while being placed on a container base part of the wafer transport container. An automatic clamping mechanism generates a press force component in a vertical direction at the wafer transport container and secures the wafer transport container to the container placing table by bringing claw parts of a plurality of clamping claws into contact with an inclined contact surface provided on a container lid part of the wafer transport container and pressing the inclined contact surface in a substantially horizontal direction.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: May 18, 2021
    Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, DESIGN NETWORK CO., LTD.
    Inventors: Shiro Hara, Hitoshi Maekawa, Hiroyuki Nishihara, Koji Sagisawa
  • Engineered HCV E2 immunogens and related vaccine compositions
    Patent number: 11008368
    Abstract: The present invention provides novel engineered HCV E2 polypeptide immunogens and related vaccine compositions that display the engineered E2 polypeptides. The invention also provides methods of using such immunogens and vaccine compositions in various therapeutic applications, e.g., for preventing or treating HCV infections.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: May 18, 2021
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Linling He, Jiang Zhu, Erick Giang, Mansun Law, Ian Wilson, Netanel Tzarum
  • Cytochrome P450 BM3 enzyme variants for preparation of cyclopropanes
    Patent number: 11008596
    Abstract: The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: May 18, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Pedro S. Coelho, Eric M. Brustad, Frances H. Arnold, Zhan Wang, Jared C. Lewis
  • Polypeptide exhibiting affinity to antibodies forming non-native three-dimensional structure
    Patent number: 11008365
    Abstract: The present invention relates to a novel polypeptide having affinity for proteins partially including a CH1-CL domain forming a non-native three-dimensional structure and capable of being suitably used for detecting, immobilizing, or removing these proteins and relates to use of the polypeptide. Specifically, disclosed are a polypeptide consisting of an amino acid sequence represented by any one of the following formulas 1 to 3: (1) P-Q-x-I-x-L-x-[IL]-[NT]-[YW] (SEQ ID NO: 1), (2) Y-D-P-E-T-G-T-W-P-Q-x-I-x-L-x-[IL]-[NT]-[YW] (SEQ ID NO: 4), and (3) P-N-S-G-G-G-G-S-Y-D-P-E-T-G-T-W-P-Q-x-I-x-L-x-[IL]-[NT]-[YW] (SEQ ID NO: 7) (wherein x represents an amino acid residue; and brackets represent any one of the amino acid residues within the brackets), and a method of using the polypeptide to detect, purify, or remove a protein partially including a CH1-CL domain forming a non-native three-dimensional structure.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: May 18, 2021
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hideki Watanabe, Shinya Honda
  • Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
    Patent number: 11007245
    Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: May 18, 2021
    Assignees: INDI MOLECULAR, INC., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Blake Farrow, James R. Heath, Heather Dawn Agnew
  • Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
    Patent number: 11007252
    Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: May 18, 2021
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Weijun Shen, Pengyu Yang, Huafei Zou, Peter G. Schultz
  • Intra prediction encoding/decoding method and apparatus for chrominance components
    Patent number: 11012689
    Abstract: Disclosed is an image decoding method using the correlation between color components to perform into prediction of chrominance components. Here, the image decoding method using the correlation between color components to perform intra prediction of chrominance components comprises the steps of: checking image data and a prediction mode in a bitstream; generating a prediction block according to a reconstructed prediction mode; determining compensation settings according to the size of a current block and the reconstructed prediction mode; compensating the prediction block according to the determined compensation settings; and reconstructing the current block by adding reconstructed image data to the prediction block.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: May 18, 2021
    Assignee: B1 INSTITUTE OF IMAGE TECHNOLOGY, INC.
    Inventor: Ki Baek Kim
  • Film composition containing a tannic acid derivative and process for producing said film composition
    Patent number: 11008457
    Abstract: A self-supporting multifunctional film is provided based on natural poly-phenols such as tannic acid. The self-supporting film composition of the invention contains a tannic acid derivative in which 12% to 24% of hydroxyl groups in tannic acid are bonded via urethane bonds that are formed by way of reactions with cyanate groups. Preferably, the film composition further includes a precursor polymer and 45 to 65% by mass of tannic acid and 55 to 35% by mass of the precursor polymer. Preferably, the precursor polymer has a second linear hydrocarbon compound urethane-bonded to both ends of a first linear hydrocarbon compound, and more preferably a diisocyanate group having an oligoethyene glycol as a spacer. Preferably, the ratio of the urethane bonds contained in the precursor polymer to the hydroxyl groups contained in the tannic acid is (12:88) to (24:76) inclusive in terms of molar ratio.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: May 18, 2021
    Assignee: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Masanobu Naito, Joginder Bansal, Debabrata Payra
  • METHOD OF PURIFYING SILICON CARBIDE POWDER
    Publication number: 20210139330
    Abstract: A method of purifying silicon carbide powder includes: providing a container with a surface coated by a nitrogen-removal metal layer, wherein the nitrogen-removal metal layer is tantalum, niobium, tungsten, or a combination thereof; putting a silicon carbide powder into the container to contact the nitrogen-removal metal layer; and heating the silicon carbide powder under an inert gas at a pressure of 400 torr to 760 torr at 1700° C. to 2300° C. for 2 to 10 hours, thereby reducing the nitrogen content of the silicon carbide powder.
    Type: Application
    Filed: December 27, 2019
    Publication date: May 13, 2021
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ta-Ching HSIAO, Chu-Pi JENG, Mu-Hsi SUNG, Kuo-Lun HUANG
  • RECYCLE APPARATUS FOR PHOTOVOLTAIC MODULE
    Publication number: 20210138520
    Abstract: The disclosure provides a recycle apparatus. The recycle apparatus is configured to separate a back sheet and a glass sheet assembly of a photovoltaic module. The recycle apparatus includes a conveyor, a flattening device, and a cutting tool. The conveyor includes a first roller and a second roller opposite to each other. The flattening device is located aside the first roller and the second roller. The cutting tool is located aside the flattening device. The flattening device is located between the first roller and the second roller of the conveyor and the cutting tool. The first roller and the second roller is configured to clamp the photovoltaic module and to feed the photovoltaic module to the flattening device configured to flatten the photovoltaic module and to the cutting tool configured to separate the back sheet from the glass sheet assembly.
    Type: Application
    Filed: October 16, 2020
    Publication date: May 13, 2021
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Teng-Yu WANG, Chih-Lung LIN, Cheng Chuan WANG
  • SEMICONDUCTOR DEVICE AND METHOD OF FABRICATING THE SAME
    Publication number: 20210143182
    Abstract: Provided are a semiconductor device and a method of fabricating the same. The semiconductor device includes a substrate having a first region and a second region, a buffer layer disposed on the substrate, a semiconductor layer disposed on the buffer layer, a barrier layer disposed on the semiconductor layer, a first source electrode, a first drain electrode, and a first gate electrode disposed therebetween, which are disposed on the barrier layer in the first region, a second source electrode, a second drain electrode, and a second gate electrode disposed therebetween, which are disposed on the barrier layer in the second region, and a ferroelectric pattern interposed between the first gate electrode and the barrier layer.
    Type: Application
    Filed: November 11, 2020
    Publication date: May 13, 2021
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Sung-Jae CHANG, Dong Min KANG, Sung-Bum BAE, Hyung Sup YOON, Kyu Jun CHO
  • PYROLYSIS GASIFICATION APPARATUS FOR SOLID REFUSE FUEL
    Publication number: 20210140633
    Abstract: Provided is a pyrolysis gasification apparatus for solid refuse fuel. The apparatus includes: a superheated steam housing formed in a cylindrical shape and installed in a horizontal direction, in which superheated steam is injected into the superheated steam housing; a screw casing formed in a tubular shape extending from one end to the other end inside the superheated steam housing and installed in the horizontal direction inside the superheated steam housing, in which solid refuse fuel (SRF) is introduced into the screw casing; a conveying screw with a plurality of screw blades on an outer peripheral surface, the conveying screw being installed inside the screw casing in the horizontal direction and rotating to convey the solid refuse fuel; and a superheated steam supplier for supplying superheated steam into the superheated steam housing, in which the superheated steam may move through a movement pat.
    Type: Application
    Filed: March 30, 2020
    Publication date: May 13, 2021
    Applicant: KOREA INSTITUTE OF ENERGY RESEARCH
    Inventors: Jeong Geun KIM, Chong Pyo CHO, Seong Ryong PARK
  • METHODS FOR REDUCING ACCUMULATED PATHOLOGIC TAU PROTEIN
    Publication number: 20210137861
    Abstract: Disclosed here is a method for reducing accumulated pathologic Tau proteins in a subject in need thereof, comprising administering to the subject an effective amount of 2,4-disulfonyl ?-phenyl tertiary butyl nitrone (2,4-DSPBN) or a pharmaceutically acceptable salt thereof. The method may further comprise administrating N-acetylcysteine (NAC) to the subject in combination with 2,4-DSPBN.
    Type: Application
    Filed: May 1, 2019
    Publication date: May 13, 2021
    Applicant: HOUGH EAR INSTITUTE
    Inventor: Richard D. KOPKE