Abstract: Provided is a novel compound that has an excellent ?-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent ?-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a ?-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and ?-lactam drugs.

Abstract: An electron emission structure according to embodiments of the inventive concept includes a cathode electrode and electron emission yarns each having a yarn shape and disposed in the cathode electrode. Here, the cathode electrode includes a plurality of first conductive panels spaced apart from each other in a first direction and at least one second conductive panel that crosses the first conductive panels in the first direction. Also, each of the first conductive panels includes at least one groove at an upper portion thereof. The second conductive panel is inserted to the groove of each of the first conductive panels. Each of the electron emission yarns is disposed between the first conductive panels. Each of the electron emission yarns contacts the second conductive panel. Each of the electron emission yarns is mechanically fixed and vertically aligned as well as arranged regularly by the second conductive panel and one pair of adjacent first conductive panels of the first conductive panels.

Abstract: A gripping device and a gripping method are provided. The gripping device includes a gripping component and an imaging element. The imaging element is configured to obtain an imaged result of an object. An action of the gripping component is generated through a training model according to the imaged result and at least one parameter. The gripping component grasps the object according to the action. A first parameter and a third parameter of the at least one parameter refer to the same axis, and a second parameter and the first parameter of the at least one parameter refer to distinct axes.

Abstract: Methods and systems are directed to multiplex detection of a bacterial pathogen in a sample. A first biotinylated lysin-derived cell wall binding domain is complexed with an avidin layer on a surface. A first bacterial pathogen detection complex including a second biotinylated lysin-derived cell wall binding domain, a detection domain, and an avidin linker complexed between the cell wall binding domain and the detection domain is also provided. The cell wall binding domains are derived from an endolysin, autolysin, bacteriocin, or exolysin, and are configured to bind a cell wall of a target bacterial pathogen. The detection domain includes one or more enzymes, fluorescent material, or DNA for emitting a signal for detection. Target bacterial pathogens present in a sample can thus be detected in a sandwich assay exhibiting increased selectivity and reduced limit of detection relative to traditional ELISA.

Abstract: The present disclosure relates to a cathode active material for a secondary battery, a cathode for a secondary battery including the same, a secondary battery including the cathode for a secondary battery and manufacturing methods thereof. More particularly, it is possible to obtain a secondary battery having excellent electrochemical characteristics by electrochemically inducing a structural phase change in the cathode active material of a secondary battery including NaCl as a cathode active material.

Abstract: Provided herein are methods and systems for detecting a target nucleic acid sequence. The method comprises contacting an oligonucleotide comprising the target nucleic acid sequence with a transposon complex; inserting one or more T7 RNA promoters into the oligonucleotide using the transposase; and (c) amplifying the target nucleic acid sequence. The transposon complex may comprise a transposase and a transposon sequence comprising one or more T7 RNA promoters. The target nucleic sequence may be amplified by generating RNA oligonucleotides comprising the target nucleic acid sequence via transcription from the inserted one or more T7 RNA promoters. The amplified target nucleic acid may be detected using a CRISPR Cas13-based detection system.

Abstract: An optical device according to the embodiment of the inventive concept includes a waveguide path including a light generation region, a wavelength variable region, and a light modulation region, a first light waveguide layer provided in the light generation region to generate light, a second light waveguide layer provided in the wavelength variable region and connected to the first light waveguide layer, a ring-shaped third light waveguide layer provided in the light modulation region and connected to the second light waveguide layer, and first and second light modulation electrodes spaced apart from each other with the light modulation region therebetween. Here, the first light modulation electrode, the third light waveguide layer, and the second light modulation electrode vertically overlap each other.

Abstract: An image recognition method, a training system for an object recognition model and a training method for an object recognition model are provided. The image recognition method includes the following steps. At least one original sample image of an object in a field and an object range information and an object type information in the original sample image are obtained. At least one physical parameter is adjusted to generate plural simulated sample images of the object. The object range information and the object type information of the object in each of the simulated sample images are automatically marked. A machine learning procedure is performed to train an object recognition model. An image recognition procedure is performed on an input image.

Abstract: Disclosed herein are a white-box encryption method for preventing a fault injection attack and an apparatus for the same. The white-box encryption method is configured to acquire a first intermediate value by inputting plaintext to a first part, among all of rounds of a white-box-based encryption algorithm, before table redundancy operations are performed, to input the first intermediate value to a second part for performing the table redundancy operations through at least two lookup tables to which different encodings based on a secret key are applied, among all of the rounds, to acquire a second intermediate value by inputting the output values of the at least two lookup tables to at least one XOR lookup table, and to output ciphertext for the plaintext based on a third part for decoding the second intermediate value.

Abstract: A method for producing dicarboxylic acid. The method includes: subjecting a raw material system including a cyclic olefin and a lower monocarboxylic acid to an addition reaction in the presence of an addition reaction catalyst to generate an intermediate product system including cyclic carboxylic acid ester; and subjecting the intermediate product system including cyclic carboxylic acid ester to a ring-opening and oxidation reaction in the presence of an oxidant and an oxidation catalyst to generate a corresponding dicarboxylic acid product. The addition reaction in the dicarboxylic acid synthesis route achieves a high single-pass conversion rate, and the selectivity of the corresponding cyclic carboxylic acid ester is high. The addition-oxidation synthesis route achieves faster reaction rates for both the addition reaction and oxidation reaction, and high yield of corresponding dicarboxylic acid product.

Abstract: The present disclosure relates to a centralized scheduling method and apparatus that considers non-uniform traffic and, more particularly, to a centralized scheduling method and apparatus for performing effective scheduling based on a characteristic of non-uniform traffic in consideration of a traffic distribution in a data center network.

Abstract: A synergized pulsing-imaging network is described. A method of optimizing a magnetic resonance imaging (MRI) system includes optimizing, by a synergized pulsing-imaging network (SPIN) circuitry a pulse sequence based, at least in part, on a loss function associated with a reconstruction network. The method further includes optimizing, by the SPIN circuitry, the reconstruction network based, at least in part, on intermediate raw MRI data and based, at least in part, on a ground truth MRI image data. The intermediate raw MRI data is determined based, at least in part on the pulse sequence.

Abstract: A modeling method of a cutting force model is provided, including: using a cutting tool to cut a unidirectional fiber reinforced polymer along a circular path; using a measurement member to measure the cutting force on the cutting tool corresponding to the angle between the feeding direction of the cutting tool and the fiber direction of the unidirectional fiber reinforced polymer; and obtaining the functions of the cutting force coefficients in a formula according to the measurement result of the measurement member. With the modeling method, a mechanistic force model can be rapidly established to predict approximate cutting forces of the cutting tool in use.

Abstract: The present invention discloses a hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d: The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M?1cm?1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition.

Abstract: Provided are a textile-reinforced concrete road paving apparatus and a method of repairing concrete road pavement using the same. The textile-reinforced concrete road paving apparatus can minimize use of construction equipment by using the textile-reinforced concrete road paving apparatus integrally formed to consecutively cut concrete, dispose a reinforcement material, and construct a repaired cross section so as to reduce a construction period, thereby remarkably reducing construction costs. Further, a textile grid reinforcement material, which is a noncorroding reinforcement material, is applied to form the repaired cross section of the concrete road pavement so as to prevent concrete from being detached due to corrosion. Further, a textile reinforced grid is precisely disposed at a required position, and thus the thicknesses of the primary and secondary concrete pavement are precisely adjusted, and thus construction precision can be increased.

Abstract: A large-scale photovoltaic direct current (DC) series boost grid-connected system with a power balancer, including N photovoltaic DC converters and N?1 power balancers, wherein N?2. The output ends of the photovoltaic DC converters are connected successively in series and then connected to the DC grid, and the input ends of the photovoltaic DC converters are respectively connected to the output ends of the photovoltaic power generation unit. Among the photovoltaic DC converters, which are arranged successively in series, a power balancer is disposed between the input ends of two photovoltaic DC converters adjacent to each other. The N?1 power balancers are arranged corresponding to the set N?1 photovoltaic DC converters respectively to balance the input power of the corresponding photovoltaic DC converter, thereby eliminating a difference between the output voltages of the photovoltaic DC converters.

Abstract: A co-culture device includes: a first body including a first membrane having a first main surface for culturing cells and a second main surface opposite to the first main surface, a first flow path partially defined by the first main surface, the first flow path configured for a first culture medium to flow therethrough, and a second flow path partially defined by the second main surface, the second flow path configured for a second culture medium having a higher dissolved oxygen concentration than that of the first culture medium to flow therethrough; and an oxygen concentration adjuster for adjusting the dissolved oxygen concentration in the first culture medium to be supplied to the first flow path.

Abstract: A power generation system abnormality diagnosis and analysis device for diagnosing a solar power generation system in which plural modules are connected in parallel. The analysis device includes a total current detection module for providing a total current sequence data and an observed voltage value; an environmental information module for providing an environmental information; a FHMM calculation module for performing a FHMM calculation on the sequence data to obtain plural sets of first current inference values and extracting a set of second current inference values from the sets of first current inference values according to the environmental information and a current voltage history database; a database building module for recording an observed voltage value and the set of second current inference values; and a user feedback module for determining whether to issue an abnormality warning according to the set of second current inference values and the observed voltage value.

Abstract: A shielded bridge for a coplanar waveguide (CPW) includes a signal bridge extending from a first terminal of the CPW to a second terminal of the CPW. The signal bridge has a raised central portion that extends over a separate signal conductor. The shielded bridge for the CPW also includes a ground bridge extending from a first ground plane on a first side of the separate signal conductor to a second ground plane on a second side of the separate signal conductor. The ground bridge is positioned between the signal bridge and the separate signal conductor.

Abstract: An IFN-anti-PD-L1 fusion protein, a pharmaceutical composition and a kit containing the same for treating tumors are disclosed. The IFN-anti-PD-L1 fusion protein of the present invention can simultaneously target PD-L1 and IFN receptors, and the activation of IFN signals in a tumor microenvironment (TME) can enhance the PD-1/PD-L1 therapy against tumors by inducing stronger T cell activation. The anti-PD-L1 antibody can be used to specifically deliver immunomodulatory molecules to tumor tissues, and the fusion protein results in the generation of multiple feedforward responses, which can increase the targeting effect, reduce the toxicity, and enhance the response to IFN therapy, thereby maximizing the anti-tumor effect.