Abstract: Disclosed herein are an apparatus and method for gas leakage measurement in a high pressure reactor. In particular, the present invention relates to an apparatus for gas leakage measurement in a high pressure reactor including: a gas inlet; a first valve equipped to one side of the gas inlet; a flowmeter; a pressure gauge measuring an internal pressure of the reactor; a gas outlet; and a second valve, wherein if in internal pressure reaches a preset pressure by closing the second valve and injecting a gas to the reactor through the flowmeter in the state of opening the first valve, the gas leakage status in the reactor is measured through pressure changes in the pressure gauge after closing the first valve.

Abstract: Disclosed is a method for treating a colitis disease in a subject in need thereof, the method comprising administering a composition comprising Lactobacillus sakei K040706 (Accession No: KCCM11472P) as an active ingredient to the subject in an amount effective in treating the colitis disease.

Abstract: In one aspect, a computer-assisted method for the optimization of the design of physical bodies, such as land, air and sea vehicles and robots and/or parts thereof, is provided comprising the steps of: representing the design to be optimized as a mesh, generating update signals to optimize the mesh representation, applying an optimization algorithm until a stop criterion has been reached, and outputting a signal representing the optimized design.

Abstract: A disclosed insert for a circular-shaped petri dish can generate a substantially uniform electric field across the petri dish that is filled with a fluid establishing a salt bridge. The insert includes a circular-shaped bottom plate defining a circular-shaped space; a side channel vertically erecting from a circular periphery of said bottom plate; and a pair of current rectifying chambers each having a generally planar shape communicating with the side channel. In at least some aspects of the invention, portions of the side channel bridging the pair of current rectifying chambers each have a generally concave top profile having a lowest point at the center between the pair of current rectifying chambers such that, when the salt bridge is established, the circular-shaped space defined by the bottom plate exhibits a substantially uniform electric field in a substantially entire area of the space.

Abstract: A light comb generating device according to a disclosed embodiment includes a light source for generating light in a reference wavelength band and outputting the generated light, and an optical comb generator for generating a light comb having a reference comb interval from the output light, wherein the light source changes a wavelength of the output light as much as a reference frequency interval for every reference time interval, the light comb is generated within a wavelength range of the reference frequency interval, and the reference wavelength band may be at least about 3 ?m and no greater than about 30 ?m.

Abstract: Disclosed is a downhole vibration and impact data recording method, comprising: performing analog-to-digital conversion on analog data, outputting digital format data obtained at a sampling rate f1, and performing sampling storage processing and analysis storage processing on the same. The sampling storage processing includes outputting the digital format data obtained at a sampling rate fn through multiple samplings; storing the same continuously into a storage module. The analysis storage processing includes: buffering the digital format data obtained at the sampling rate f1 into a memory; analyzing the same to determine whether an impact event occurs, and if yes, storing the current data in the memory into the storage module, and then jumping back to the buffering step; otherwise, jumping directly back to the buffering step. With the above method, the amount of data storage can be effectively reduced, while the characteristics of the vibration and impact data can be analyzed.

Abstract: The present invention provides antibodies that neutralize MERS-CoV and methods of use thereof. The invented antibody is used to treat MERS-CoV infections and symptoms thereof.

Abstract: In one aspect, the present invention provides a method of inhibiting proliferation of a multiple myeloma cell, the method comprising contacting the cell with BRD9647, thereby inhibiting proliferation of the cell. In another aspect, the present invention provides a method of treating multiple myeloma in a pre-selected subject, the method comprising administering an effective amount of BRD9647 to the subject, wherein the subject is pre-selected by detecting a mutation in an AZIN1 polynucleotide or polypeptide relative to a reference in a biological sample obtained from the subject. In another aspect, the present invention provides a method of modulating benzoylation of an agent in a cell, the method comprising contacting the cell with BRD9647, thereby modulating benzoylation of an agent in the cell.

Abstract: The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof.

Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the Glycosyl-phosphatidylinositol (GPI)-linked GDNF family ?-receptor 4 (GFR?4).

Abstract: A surface with selective wetting properties is described.

Abstract: Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the ?-position or does not possess a carbon in the ?-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane).

Abstract: Disclosed herein is an image deep learning model training method. The method includes sampling a twin negative comprising a first negative sample and a second negative sample by selecting the first negative sample with a highest similarity out of an anchor sample and a positive sample constituting a matching pair in each class and by selecting the second negative sample with a highest similarity to the first negative sample, and training the samples to minimize a loss of a loss function in each class by utilizing the anchor sample, the positive sample, the first and second negative samples for each class. The first negative sample is selected in a different class from a class comprising the matching pair, and the second negative sample is selected in a different class from classes comprising the matching pair and the first negative sample.

Abstract: A method for transmitting a discovery burst according to an exemplary embodiment of the present disclosure may comprise performing first channel-sensing with respect to a shared band to transmit the discovery burst through first window of discovery pattern first duration including the first window to N-th window; in case that the shared band is determined to be not-occupied based on the first channel-sensing, transmitting the discovery burst through the first window of the discovery pattern first duration; performing second channel-sensing with respect to the shared band to transmit the discovery burst through second window of discovery pattern second duration including first window to N-th window; and in case that the shared band is determined to be not-occupied based on the second channel-sensing, transmitting the discovery burst through the second window of the discovery pattern second duration.

Abstract: A heat-resistant and soluble magnesium alloy, and a preparation method having an elemental composition at the following atomic percentage: Lu 0.10% to 8.00%, Ce 0.001 to 0.05%, Al 0.10% to 0.60%, Ca 0.001% to 0.50%, Cu 0.01% to 1.00%, Ni 0.01% to 1.00%, impurity elements <0.30%, and the rest is Mg, and formed in magnesium alloys are high temperature phase of Lu5Mg24, Mg2Cu, Mg2Ni, Mg12Ce, Al11Ce3 and (Mg, Al)2Ca, and Long Period Stacking Ordered (LPSO) phases as Mg—Lu—Al and Mg—Ce—Al. The magnesium alloy has good mechanical performances at 150° C., and a dissolution rate of 30 to 100 mg·cm?2h?1 in a 3% KCl solution at 93° C.

Abstract: The present disclosure includes a compound of formula (1): wherein cancer antigen peptide A is an MHC class I-restricted peptide consisting of 7 to 30 amino acid residues and containing at least one cysteine residue, wherein the cysteine residue of the cancer antigen peptide A binds to R1 via a disulfide bond; and R1 is hydrogen, a group of formula (2), the group of formula (3), or cancer antigen peptide D, wherein the group of formula 2 is wherein Xa and Yd independently represent a single bond or a divalent peptide group consisting of 1 to 4 amino acid residues, provided that the sum of the number of amino acid residues in Xa and Ya is an integer of 0 to 4, and the cancer antigen peptide B is an MHC class II-restricted peptide consisting of 9 to 30 amino acid residues, wherein the amino group of the N-terminal amino acid of the cancer antigen peptide B binds to Ya in the formula (2), and the carbonyl group of the C-terminal amino acid of the cancer antigen peptide B binds to the hydroxyl group in

Abstract: A flexible substrate adjusting device includes a substrate transmission mechanism, a pressure roller, and a force applying assembly. The substrate transmission mechanism has a transmission direction for carrying a first surface of a flexible substrate thereon. The pressure roller is disposed on at least one side of a second surface of the flexible substrate in a non-transmission direction. The force applying assembly is connected to the pressure roller and provides the pressure roller with a pressure to the flexible substrate, wherein when the flexible substrate moves in the transmission direction, the pressure roller generates a friction force in the non-transmission direction with the flexible substrate to adjust flatness or position of the flexible substrate.

Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof are provided and methods involving compounds of Formula (I) as effective inhibitors of CDK8 and/or CDK19 are also provided.

Abstract: Provided is a complex patterning device. The complex patterning device includes a patterning module, on which a master substrate including a master pattern that contacts and is separated from a target substrate and which forms a plurality of target patterns having a reverse image of the master pattern on the target substrate by applying a pressure onto the target substrate, and a punching module including a punching mold that contacts and is separated from the target substrate, in which the plurality of target patterns are formed, and which divides at least any one of the plurality of target patterns by applying a pressure onto the target substrate.

Abstract: Disclosed in the present invention were a fluorosulfonyl-containing compound, an intermediate thereof, a preparation method therefor and use thereof. The fluorosulfonyl-containing compound disclosed in the present invention comprises a cation and an anion, the cation being as shown in Formula (1). The fluorosulfonyl-containing compound of the present invention can react with a substrate to efficiently synthesize a fluorosulfonylation product, has low toxicity, was simple to prepare, was convenient to use, and was in a solid stable state at normal temperature. Furthermore, the compound has a wide range of adaptable substrates, including phenolic compounds and amine compounds, and was the only solid form agent that can achieve such a chemical conversion, and therefore has important academic and application value.