Abstract: The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.

Abstract: A method for establishing a monitoring model of a water content of a winter wheat canopy based on spectral parameters, includes the following steps: measuring a spectral reflectance and a water content of the winter wheat canopy; constructing the spectral parameters through the spectral reflectance; wherein, the spectral parameters comprise spectral transformation forms and “trilateral” parameters; performing correlation analysis on the water content of the winter wheat canopy and the spectral transformation forms and the trilateral parameters, selecting comprehensive spectral parameters with a significant correlation for each growth stage, performing principal component analysis on the comprehensive spectral parameters, separately constructing a water content monitoring model for each growth stage, and combining the water content monitoring model for each growth stage into the monitoring model of the water content of the winter wheat canopy for the whole growth stage.

Abstract: Provided is a composite material including a plurality of porous silicate particles having a glass phase structure, a first active metal adsorbed into the glass phase structure of the porous silicate particles, and a modified layer containing a second active metal formed on the surfaces of the porous silicate particles. The porous silicate particles have an average pore diameter of from 3 nm to 50 nm, and the first active metal includes at least one of sodium, potassium, calcium, and magnesium.

Abstract: An electronic control unit for a vehicle for switching vehicle control from an autonomous driving mode includes one or more processors, network interface hardware configured to communicate with a remote server over a network, and one or more memory modules that store logic. The electronic control unit executes logic to determine that the autonomous driving mode of the vehicle will terminate, determine that a driver is unavailable to take immediate control of the vehicle upon termination of the autonomous driving, transfer control of the vehicle to a remote operator over the network interface hardware for a first time period, generate an alert to the driver to take manual control of the vehicle, and transfer control of the vehicle to one of the driver and the autonomous driving mode after the first time period has elapsed.

Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 ?m to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.

Abstract: The present invention related to a method for preparing carbon nanospheres modified current collector and its application in metal secondary battery. The said method includes the preparation of carbon nanospheres modified current collector by chemical vapor deposition process and the process for loading metal into the modified current collector as an anode. Comparing with the bare Ni, the said anode with modified current collector demonstrates enhanced stripping/plating efficiency, well confinement of Li dendrite, stable long lifespan and strengthen safety.

Abstract: An object of the present invention is to provide a novel sulfur-based positive-electrode active material which can largely improve cyclability of a lithium-ion secondary battery, a positive electrode comprising the positive-electrode active material and a lithium-ion secondary battery comprising the positive electrode. The sulfur-based positive-electrode active material is one comprising: a carbon skeleton derived from a polymer composed of a monomer unit having at least one hetero atom-containing moiety, and sulfur incorporated into the carbon skeleton as the carbon skeleton is formed from the polymer by heat treatment.

Abstract: The present invention relates to a wireless communication method for power saving and a wireless communication terminal using the same, and more particularly, to a wireless communication method for efficiently conducting data transmission/reception of each terminal in a high density environment and a wireless communication terminal using the same. To this end, the present invention provides a wireless communication method for a terminal including receiving a distributed access group parameter for data transmission/reception by a group unit, wherein the distributed access group parameter comprises information about a number of groups assigned to a corresponding BSS, obtaining group information about the terminal based on the distributed access group parameter, and performing data transmission based on the obtained group information, and a wireless communication terminal using the same.

Abstract: The microRNA dyslipidemia inhibitor includes methods of administering a miRNA capable of inhibiting dyslipidemia to a subject in need thereof. The methods of the miRNA dyslipidemia inhibitor may include administration of miRNA-103 to a subject in need thereof. The administration of miRNA-103 may inhibit ANGPTL8 activity, thereby reducing ANGPTL8's inhibition of lipoprotein lipase activity and increasing triglyceride degradation. The administration of miRNA-103 may be used to treat or prevent lipid metabolism disorders including dyslipidemia and dyslipidemia associated diseases, such as hyperlipidemia, atherosclerosis, heart disease, and the like.

Abstract: A metal powder contains not less than 0.10 mass % and not more than 1.00 mass % of at least one of chromium and silicon, and a balance of copper. The total content of the chromium and the silicon is not more than 1.00 mass %. In accordance with an additive manufacturing method for this metal powder, an additively-manufactured article made from a copper alloy is provided. The additively-manufactured article has both an adequate mechanical strength and an adequate electrical conductivity.

Abstract: A MEMS apparatus with heater includes central part, periphery part, gap and first connecting part. Central part includes center of mass, heater and first joint. Heater is disposed inside central part. First joint is located on boundary of central part. Displacement of first joint is produced when central part is heated by heater. Periphery part surrounds central part. Gap surrounds central part, and is located between central part and periphery part. First connecting part connects central part and periphery part along first reference line and includes first inner connecting portion and first outer connecting portion. First inner connecting portion is connected to first joint. First outer connecting portion is connected to periphery part. First reference line passes through first joint, and first reference line is not parallel to line connecting center of mass and first joint.

Abstract: A user location information detection and tracking system includes an IC tag that a user can carry, a user terminal configured to receive identification information outputted from the IC tag, a magnetic field device configured to form a magnetic field in a predetermined area, and a managing device communicably connected to the user terminal. The IC tag outputs at a predetermined timing, as the identification information, tag ID for identifying the IC tag, in response to detection of the magnetic field formed by the magnetic field device, the IC tag outputs, as the identification information, magnetic field identification information for identifying the magnetic field, and in response to the identification information received from the IC tag, the user terminal sends the identification information to the managing device.

Abstract: A method for a 3D scene reconstruction of autonomous agent operation sequences includes iteratively parsing sequence segmentation parts of agent operation sequence images into dynamic sequence segmentation parts and static sequence segmentation parts. The method also includes fitting 3D points over the static sequence segmentation parts to construct a 3D model of the static sequence segmentation parts over multiple frames of the agent operation sequence images. The method further includes removing the 3D model of the static sequence segmentation parts from the agent operation sequence images. The method also includes processing the dynamic sequence segmentation parts from each of the agent operation sequence images over the multiple frames of the agent operation sequence images to determine trajectories of the dynamic sequence segmentation parts.

Abstract: The present application provides bifunctional compounds of Formula (I): or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for Bruton's tyrosine kinase (BTK). The present application also relates to methods for the targeted degradation of BTK through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to BTK which can be utilized in the treatment of disorders modulated by BTK.

Abstract: Provided are an alloy member which is usable in organisms, makes use of features of bio-affinity and biodegradability of magnesium, and is able to realize required duration of biodegradability, and a production method therefor. According to the present invention, the alloy member usable in organisms includes a base body that contains a magnesium alloy, a first protective layer that contains an oxide derived from a component of the base body or a complex of an oxide and a hydroxide derived from a component of the base body, and a second protective layer that contains a hydroxide derived from a component of the base body.

Abstract: A superconducting medium includes a first layer made of a first superconductor and a second layer made of a second superconductor. The first layer has a first thickness less than a first coherence length of the first superconductor. The second layer has a second thickness less than a second coherence length of the second superconductor so as to induce a proximity effect between the first layer and the second layer. The proximity effect can induce desirable properties in the resulting superconducting medium. Controlling the thickness ratio of the first layer to the second layer can also tune the property of the superconducting medium.

Abstract: The present invention relates to a method for analyzing the activation state of a signaling pathway in a cell or tissue separated from a subject through real time single molecule protein-protein interaction analysis, and a method for selecting a personalized medicine or predicting a therapeutic efficacy to a medicine using the same.

Abstract: A novel therapeutic agent effective for the treatment of intellectual disability or autism is disclosed. The therapeutic agent for intellectual disability or autism contains, as an active component(s), at least one selected from the group consisting of tipifarnib and lonafarnib. Examples of the intellectual disability include memory impairment. Examples of the memory impairment include memory impairment caused by abnormality of the Tsc1 gene and/or Tsc2 gene, and epilepsy-induced memory impairment. Also provided is a method of treating intellectual disability or autism, comprising administering an effective amount of at least one selected from the group consisting of tipifarnib and lonafarnib to a patient with intellectual disability or autism.

Abstract: The present invention relates to a parathyroid sensing system, and includes: a modulator for generating a modulation signal having a predetermined frequency; a lock-in amplifier and a light source which receive information on the modulation signal; an excitation filter for transmitting, among light emitted from the light source, only excitation light that excites parathyroid glands; an emission filter connected to a probe and selectively transmitting only fluorescence emitted from the parathyroid glands; a near-infrared sensor for sensing the autofluorescence that has passed through the emission filter, and converting the sensed autofluorescence into an electric signal; and a speaker for generating an alarm through the electric signal. Through the present invention, the locations of the parathyroid glands may be precisely identified even when lights are turned on in an operating room, and convenience may be provided by alerting a surgeon by means of an alarm when the parathyroid glands are detected.

Abstract: Disclosed is a method for transmitting and receiving a downlink channel and a reference signal in a communication system. A method for receiving a downlink signal performed by a terminal comprises the steps of: receiving, from a base station, a control DMRS for a downlink control channel in time-frequency resource region #1; performing demodulation and decoding operations on the downlink control channel in the time-frequency resource region #1 by using channel estimation information #1 on the basis of the control DMRS; and performing demodulation and decoding operations on a downlink data channel by using the channel estimation information #1 in a frequency band A in a time-frequency resource region #2 indicated by scheduling information obtained from the downlink control channel. Therefore, the performance of the communication system can be improved.