Abstract: Compositions and methods for combinatorial drug discovery in nanoliter droplets are described. Novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infection are disclosed.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention provides a multi-mode dispersion energy imaging device and method for a four-component marine interface wave of an ocean bottom seismometer, belonging to the technical field of marine seismic exploration. The method includes the following steps: designing an marine interface wave artificial seismic observation system, designing a reasonable observation system according to the geological condition of the operation area to ensure the resolution of the imaging to perform the marine artificial source seismic operation carrying out the data preprocessing of the seafloor surface wave, and then carrying out the three-component seismometer Scholte wave and the acoustic guided wave dispersion energy imaging, and the one-component hydrophone acoustic guided wave dispersion energy imaging; superposing and normalizing the three-component Scholte wave dispersion energy spectrum and the one-component acoustic guided wave dispersion energy spectrum. The device is implemented based on the method above.

Abstract: A petroleum refining method for upgrading petroleum products improves the efficiency and reduces the costs of upgrading oils, such as lipids, bitumen, crude oil, fracking oils, synthetic oils, and other feeds, to produce useful fuels and chemical precursor streams. Usage of a specific type of zeolite (ZSM-5) catalyst, supercritical water to control coke formation, and a specific response to phase behavior and other catalytic effects optimize the process. A prescribed set of reactor conditions employing supercritical water increases activity of the catalyst in industrial reactions.

Abstract: The present invention relates to a method for predicting a drug-drug interaction and a drug-food interaction by using structural information of a drug and, more particularly, to a method for predicting the mechanism of action and activity of a drug interaction through interaction prediction results expressed by a standardized sentence. When using a method for predicting a drug interaction according to the present invention, a drug interaction can be predicted quickly and accurately, and in particular, activity information of an unknown compound can also be predicted by expressing a prediction result by means of a sentence, and thus the method is very useful for developing a drug exhibiting desired activity without causing adverse effects.

Abstract: The present disclosure discloses an optical device structure including an optical fiber including a core part, a clad part, and a three-dimensional micro hole structure in the clad part, wherein a surface of the three-dimensional micro hole structure is provided with at least a non-flat surface, and a conformal graphene layer is formed on the surface of the three-dimensional micro hole structure, and a method of manufacturing the same.

Abstract: A method for cleanly extracting metallic silver includes: mixing an acidic solution containing Ce4+ and NO3? with a silver-containing material for leaching; after the leaching is completed, carrying out a solid-liquid separation to obtain a leaching solution containing Ce3+ and Ag+; and electrolyzing the leaching solution, wherein an oxidation reaction of Ce3+ occurs at an anode to realize a regeneration of Ce4+ and an electrolytic reduction occurs at a cathode to reduce Ag+ to obtain the metallic silver. Ce4+ is used as a leaching agent and an intermediate oxidant to implement a cyclic operation of solution leaching and electrolytic regeneration on the silver-containing material. Almost no NOx and waste liquid are caused by the extraction process, and the invention is clean and environmentally friendly.

Abstract: One or more embodiments of the present disclosure include systems and methods that use neural architecture fusion to learn how to combine multiple separate pre-trained networks by fusing their architectures into a single network for better computational efficiency and higher accuracy. For example, a computer implemented method of the disclosure includes obtaining multiple trained networks. Each of the trained networks may be associated with a respective task and has a respective architecture. The method further includes generating a directed acyclic graph that represents at least a partial union of the architectures of the trained networks. The method additionally includes defining a joint objective for the directed acyclic graph that combines a performance term and a distillation term. The method also includes optimizing the joint objective over the directed acyclic graph.

Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.

Abstract: A video signal processing method comprises: obtaining, from a bitstream, a skip parameter (cu_skip_flag) indicating whether a skip mode is applied to a current block; when the skip parameter indicates that a mode is not the skip mode, obtaining, from the bitstream, a merge parameter (merge_flag) indicating whether the current block is coded with a merge mode; and determining whether a coded block flag (CBF) parameter (cu_cbf), which indicates whether a syntax element related to transform is obtained from the bitstream, is obtained, according to a value of the merge parameter, wherein, when the value of the merge parameter indicates the merge mode, the CBF parameter is not obtained from the bitstream and is determined to be a preconfigured value.

Abstract: Disclosed is a method of registering a new optical network unit (ONU) to be performed by an optical line terminal (OLT). The method includes transmitting a ranging notification message to a centralized unit (CU)/distributed unit (DU) to register the new ONU, receiving scheduling information for registering the new ONU from the CU/DU in response to the ranging notification message, transmitting a serial number request message to a service region in which ONUs are present based on the received scheduling information, and when the serial number response message is received from the new ONU in response to the serial number request message, registering the new ONU that transmits a serial number request message. The transmitting of the serial number request message is performed through a multi-quiet zone of a short period.

Abstract: A method for reducing power consumption of a terminal that communicates with a base station in a mobile communication system using a multi-carrier structure composed of a primary component carrier and at least one secondary component carrier comprises: receiving a discontinuous reception (DRX) parameter group for multi carriers from the base station; and setting the multi carriers to the same parameter value, by using the received parameter group. The method for reducing power consumption of the terminal further comprises: performing a downlink control channel receive operation on each carrier according to a DRX cycle. As the base station in the mobile communication system using the multi-carrier structure simplifies the DRX process for reducing power consumption of a terminal by reducing signaling load for the multi-carrier control of the terminal, it becomes possible to reduce power consumption of the terminal.

Abstract: A MIMO symbol detection and search method, a decoding circuit and a receiving antenna system are provided. The signal detection and search method includes the following steps. A symbol search tree is obtained, and a plurality of candidate symbols at each layer of the symbol search tree are sorted. The candidate symbols are traversed in sequence at each layer of the symbol search tree. At each layer of the symbol search tree, if a cumulative partial Euclidean distance is greater than or equal to a threshold, un-scanned candidate symbols are excluded. If the cumulative partial Euclidean distance is less than the threshold, the threshold is updated by the cumulative partial Euclidean distance. When all of the candidate symbols have been calculated, an estimated symbol combination is outputted, and the scan of the symbol search tree is terminated.

Abstract: Compositions and methods for the treatment of ocular diseases are disclosed. In accordance with one aspect of the instant invention, methods for treating, inhibiting (e.g., reducing), and/or preventing an ocular disease in a subject are provided. The methods comprise the administration of at least one inhibitor of the induction or activity of tryptophan degradation and/or of the downstream pathways that respond to this process. In a particular embodiment, the methods comprise the administration of an inhibitor of IDO1.

Abstract: The present invention relates to a system for determining a posture of an operator of a device that transmits vibrations to the operator, wherein the system comprises at least one vibration sensor for measuring vibrations at at least one location on the body of the operator and/or the device, and a posture determining means for detecting one or more characteristics of the measured vibrations assigned to a predetermined posture and for determining the predetermined posture as the posture of the operator when the characteristic is detected.

Abstract: The present disclosure provides a tensile force detecting device including a piezoelectric element to generate an electrical signal by a load, the elastic thread connected to the piezoelectric element to support the load applied to the piezoelectric element, and a sewing thread connected to the piezoelectric element to transmit the load to the piezoelectric element.

Abstract: An operation method of a first communication node includes generating a plurality of modulation symbols for information bits; determining a symbol mapping pattern based on a number Nt of antennas of the first communication node, a number NL of spatial layers multiplexed in a same frequency resource, and a number NSSF of modulation symbols belonging to one space-frequency grid; mapping the plurality of modulation symbols to a space-frequency domain based on the symbol mapping pattern; and transmitting the plurality of modulation symbols mapped to the space-frequency domain to a second communication node using the antennas.

Abstract: A quantum simulator includes a pseudo speckle pattern generator, a main vacuum chamber, an atomic gas supply unit, a light beam generator, a photodetector, and an atom number detector. The pseudo speckle pattern generator generates a pseudo speckle pattern in the inside of the main vacuum chamber by light allowed to enter the inside of the main vacuum chamber through the second window. The pseudo speckle pattern generator includes a controller, a light source, a beam expander, a spatial light modulator, and a lens. The controller sets a modulation distribution of the spatial light modulator based on a two-dimensional pseudo random number pattern.

Abstract: This disclosure relates to the surprising and unexpected finding that the well-known cancer protein, Myeloid Cell Leukemia-1 (MCL-1), binds to and modulates the enzymatic activity of Very Long Chain Acyl CoA Dehydrogenase (VLCAD), thereby regulating fatty acid ?-oxidation. This finding is employed in compositions and methods of treating cancer, metabolic diseases, or other conditions characterized by excessive fatty acid ?-oxidation by blocking or reducing the energy production of cells (e.g., cancer) through inhibiting the MCL-1/VLCAD interaction and/or directly inhibiting VLCAD enzymatic activity. In addition, the disclosure features methods for identifying such agents that inhibit the interaction between MCL-1 and VLCAD or that inhibit VLCAD enzymatic activity.