Abstract: The present disclosure provides for and relates to the identification of novel biomarkers for diagnosis and prognosis of prostate cancer or the biochemical reoccurrence of prostate cancer. The biomarkers of the invention show altered methylation levels of certain CpG loci relative to normal prostate tissue, as set forth.

Abstract: An exercise sensing method, an exercise sensing apparatus and an exercise sensing system are provided. The exercise sensing system includes a computing device, a storage device and at least one biophysical quantity sensor disposed on at least one muscle portion of a user. In the method, a current muscle strength of the muscle portion when the user performs an exercise is monitored by the biophysical quantity sensor. An exercise history of the user is accessed to obtain a muscle strength reference value of the muscle portion when the user previously performed the exercise. The current muscle strength is compared with the muscle strength reference value so as to adjust an exercise intensity of the exercise.

Abstract: The present invention relates to a method of directly preparing a dicarbamate compound from a diamine compound, and more particularly to a method of directly preparing a dicarbamate compound by reacting a diamine compound with an alcohol compound in the presence of a mixed gas of carbon monoxide (CO) and oxygen (O2) using a Pd/MOx catalyst configured such that a palladium (Pd) active metal is supported on a metal oxide or metalloid oxide carrier.

Abstract: Peptides are easy to pass through a tissue-blood barrier, have excellent physiological activity in the protective activity of cells, and have an economic advantage due to low production costs. In addition, since there is no side effect of cell proliferation, a pharmaceutical composition containing a peptide of an aspect as an active ingredient can be usefully used in the treatment or prevention of neurological disorders and degenerative brain diseases.

Abstract: An optical phased array, includes, in part, K beam processors each adapted to receive a different one of K optical signals and generate N optical signals in response. The difference between the phases of optical signals aLM and aL(M+1) is the same for all Ms, where M is an integer ranging from 1 to N?1 defining the signals generated by a beam processor, and L is an integer ranging from 1 to K defining the beam processor generating the K optical signals. The transmitter further includes, in part, a combiner adapted to receive the N×K optical signals from the K beam processors and combine the K optical signals from different ones of the K beam processors to generate N optical signals. The transmitter further includes, in part, N radiating elements each adapted to transmit one of the N optical signals.

Abstract: A video signal processing method and apparatus for encoding or decoding a video signal is disclosed. More particularly, a video signal processing method and a video signal processing apparatus using the same are disclosed, wherein a method for processing a video signal comprises the steps of: obtaining a set of control point motion vectors for prediction of a current block; obtaining the motion vector of each sub-block of the current block using control point motion vectors of the set of control point motion vectors; obtaining a predictor of the each sub-block of the current block using the motion vectors of the each sub-block; obtaining a predictor of the current block by combining predictors of the each sub-block; and restoring the current block using the predictor of the current block.

Abstract: A method of generating point cloud predictor includes: obtaining an encoding unit, wherein the encoding unit is generated from a current three-dimensional (3D) image, obtaining a current 3D block in the current 3D image according to the encoding unit, obtaining a reference 3D block in a reference 3D image according to the current 3D block, wherein the reference 3D image is associated with the current 3D image, obtaining a reference two-dimensional (2D) unit in a reference 2D image according to the reference 3D block, wherein the reference 2D image is generated from the reference 3D image, and generating and outputting a predictor according to a variation degree between the encoding unit and the reference 2D unit.

Abstract: Deformable sensors and methods for modifying membrane stiffness are provided. A deformable sensor may include a membrane coupled to a housing to form a sensor cavity. The deformable sensor may further include a rotational element having an adjustable vertical position and a modifiable rotation. The rotational element may be supported at a base of the sensor cavity. The rotational element may be configured to establish and withdraw contact with respect to the membrane to modify stiffness of the membrane. The rotational element may further be configured to modify stiffness of the membrane by withdrawing the rotational element from the membrane.

Abstract: Disclosed is a hierarchical generated audio detection system, comprising an audio preprocessing module, a CQCC feature extraction module, a LFCC feature extraction module, a first-stage lightweight coarse-level detection model and a second-stage fine-level deep identification model; the audio preprocessing module preprocesses collected audio or video data to obtain an audio clip with a length not exceeding the limit; inputting the audio clip into CQCC feature extraction module and LFCC feature extraction module respectively to obtain CQCC feature and LFCC feature; inputting CQCC feature or LFCC feature into the first-stage lightweight coarse-level detection model for first-stage screening to screen out the first-stage real audio and the first-stage generated audio; inputting the CQCC feature or LFCC feature of the first-stage generated audio into the second-stage fine-level deep identification model to identify the second-stage real audio and the second-stage generated audio, and the second-stage generated au

Abstract: A Streptococcus canis Cas9 (ScCas9) ortholog and its engineered variants, possessing novel PAM specificity, is an addition to the family of CRISPR-Cas9 systems. ScCas9 endonuclease is used in complex with guide RNA, consisting of identical non-target-specific sequence to that of the guide RNA SpCas9, for specific recognition and activity on a DNA target immediately upstream of either an “NNGT” or “NNNGT” PAM sequence. A novel DNA-interacting loop domain within ScCas9, and other Cas9 orthologs, such as those from Streptococcus gordonii and Streptococcus angionosis facilitates a divergent PAM sequence from the “NGG” PAM of SpCas9.

Abstract: A feature data encoding method, an encoder, a feature data decoding method, and a decoder are provided. The feature data encoding method includes following steps. A transform unit is divided into a plurality of sub-blocks and N sub-transform units. A reference origin and a LSC are determined in an i-th sub-transform unit of the sub-transform units, and an original coordinate of the last significant coefficient of the i-th sub-transform unit is modified to a specific coordinate. The i-th sub-transform unit is scanned from a specific sub-block of the i-th sub-transform unit, and significant feature coefficients in the i-th sub-transform unit are individually encoded as coded data.

Abstract: A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.

Abstract: A device may be configured with a housing having a reservoir and an outlet separated by a heat rupturable membrane. The membrane may serve to separate a material held within the reservoir from the outlet until the membrane is ruptured. The membrane may include a heater configured to selectively rupture the membrane when actuated. The heater may be physically removed and/or thermally insulated from at least one of an environment surrounding the device and the reservoir.

Abstract: The present specification discloses a method of decoding an image. The method of decoding an image according to the method includes: obtaining transform skip information of a current block from a bitstream; obtaining multiple transform selection information of the current block on the basis of the transform skip information from the bitstream; and performing inverse transform on the current block on the basis of the multiple transform selection information, wherein the multiple transform selection information is used to set each of a horizontal transform type and a vertical transform type.

Abstract: The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.

Abstract: Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for engineering Cas9 and Cas9 variants that have increased activity on target sequences that do not contain the canonical PAM sequence. In some embodiments, fusion proteins comprising such Cas9 variants and nucleic acid editing domains, e.g., deaminase domains, are also provided.

Abstract: Titanium-containing alloys are generally described. The titanium-containing alloys are, according to certain embodiments, nanocrystalline. According to certain embodiments, the titanium-containing alloys have high relative densities. The titanium-containing alloys can be relatively stable, according to certain embodiments. Inventive methods for making titanium-containing alloys are also described herein. The inventive methods for making titanium-containing alloys can involve, according to certain embodiments, sintering nanocrystalline particulates comprising titanium and at least one other metal to form a titanium-containing nanocrystalline alloy.

Abstract: The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; R2 is hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R3, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R2, R3, R4 is H; X1, X2, X3, X4, X5 and X6 are independently N or C; with the proviso that in each ring maximal one X is N.

Abstract: Low-loss terahertz switches with nanometer resolution positioning and feedback are disclosed. In one embodiment, the switch uses a U-bend waveguide surrounded by an electromagnetic band gap and is implemented in a fully metal-machined fashion in combination with a piezo-electric motor and an optical linear encoder. In another embodiment, the switch comprises a MEMS device.