Patents Assigned to INSTITUTE
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Patent number: 11492435Abstract: A method for preparing a biomass-based conductive hydrogel by 3D printing is provided. Firstly, a cellulose-based macromonomer, a rosin-based monomer, an acrylic acid monomer and an initiator are mixed in a certain proportion, stirred, and dissolved at 25-70° C. Then, diisocyanate in an amount of 5-10 wt % of a total mass of the monomers is added to the mixed solution and mixed uniformly to prepare a 3D printing photosensitive resin solution. An SLA light-curing 3D printer is used to print a hydrogel precursor 1 with a complex shape. Next, the hydrogel precursor 1 is heated to obtain a hydrogel precursor 2 with a dual-curing network. Finally, the obtained hydrogel precursor 2 is swelled in a 1-15 wt % alkaline solution at 5-60° C. for 0.1-10 hours to obtain the biomass-based conductive hydrogel.Type: GrantFiled: May 26, 2020Date of Patent: November 8, 2022Assignee: INSTITUTE OF CHEMICAL INDUSTRY OF FOREST PRODUCTS CAFInventors: Fuxiang Chu, Jifu Wang, Chuanwei Lu, Chunpeng Wang
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Patent number: 11491352Abstract: A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.Type: GrantFiled: June 4, 2019Date of Patent: November 8, 2022Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ki Joo Pahk, Hyung Min Kim, Byung Chul Lee, Inchan Youn
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Patent number: 11492590Abstract: Non-genetically engineered mammalian cells modified by sortase-mediated conjugation of an agent thereto are provided. Methods of conjugating agents to non-genetically engineered mammalian cells using sortase are provided. Methods of using the cells, e.g., for diagnostic and/or therapeutic purposes, are provided.Type: GrantFiled: April 11, 2019Date of Patent: November 8, 2022Assignee: Whitehead Institute for Biomedical ResearchInventors: Lee Kim Swee, Hidde L. Ploegh
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Patent number: 11494891Abstract: Disclosed are a method of inspecting and evaluating a coating state of a steel structure, and a system therefor. A plurality of vision images and thermal images are acquired. While acquiring the thermal images, a desired region is heated. After the thermal images and the vision images in a dynamic state are reconstructed into a time-spatial-integrated thermal image and a time-spatial-integrated vision image in a static state, respectively, an overlay image is generated by overlaying the two images. A deterioration region of a coating is detected, and coating deterioration is classified by characteristics. A size of the coating deterioration region is quantified. A thickness of the coating is inspected by analyzing thermal energy measured from the time-spatial-integrated thermal image. A coating grade is calculated by comprehensively evaluating a coating deterioration inspection result and a coating thickness inspection result. A state evaluation report for the steel structure is automatically created.Type: GrantFiled: December 21, 2020Date of Patent: November 8, 2022Assignee: Korea Advanced Institute of Science and TechnologyInventors: Hoon Sohn, Soonkyu Hwang, Hyeonjin Kim, Hyung Jin Lim
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Patent number: 11494931Abstract: A drilling calibration method, apparatus, device and medium based on image recognition includes lifting a top drive to a position of a derrick, and receiving and recognizing a target image acquired by an image acquisition apparatus of an operating terminal; calculating a quantity of pixels from the top drive to a rotary table surface in the target image by a data processing unit of the operating terminal; and receiving a height of the top drive measured by a diastimeter by the operating terminal. The height of the top drive is a height from the top drive to the rotary table surface. A pixel relationship table may be established between the quantity of the pixels from the top drive to the rotary table surface and the height of the top drive by a calibration unit of the operating terminal to finish drilling calibration.Type: GrantFiled: November 24, 2020Date of Patent: November 8, 2022Assignee: INSTITUTE OF GEOLOGY AND GEOPHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Changmin Fu, Xiaotian Wang, Qingyun Di
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Patent number: 11494627Abstract: A dynamic-tile neural network accelerator allows for the number and size of computational tiles to be re-configured. Each sub-array of computational cells has edge cells on the left-most column that have an added vector mux that feeds the cell output back to an adder-comparator to allow Rectified Linear Unit (ReLU) and pooling operations that combine outputs shifted in from other cells. The edge cells drive external output registers and receive external weights. The weights and outputs are shifted in opposite directions horizontally between cells while control and input data are shifted in a same direction vertically between cells. A column of row data selectors is inserted between sub-arrays to bypass weights and output data around sub-arrays, while a row of column data selectors are inserted between sub-arrays to bypass control and input data. Larger tiles are configured by passing data directly through these selectors without bypassing.Type: GrantFiled: July 8, 2021Date of Patent: November 8, 2022Assignee: Hong Kong Applied Science and Technology Research Institute Company LimitedInventors: Tao Li, Xiaoqing Shan, Ka Lung Tim Wong, Xuejiao Liu, Yu Liu
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Patent number: 11493490Abstract: In an electronic nose apparatus and method based on spectrum analysis, 1) a gaseous sample is dissolved into a solvent in an impinger, and the sample dissolved into the solvent is introduced into an RF resonator, and 2) RF having various absorption spectra according to materials are generated in the RF resonator, and the type of gas is determined through spectrum analysis so that an electronic nose is implemented. In this way, it is possible to overcome the resolution of gas chromatography (GC) and a sensor array and a limited number of multi-channel sensors (the number of channels).Type: GrantFiled: April 7, 2020Date of Patent: November 8, 2022Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Hyo Bong Hong, Jae Chan Jeong, Seung Min Choi
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Patent number: 11493994Abstract: An input device, method, and system enabling a switch input operation of various equipment by moving a body part other than hands and feet. Input by body movement, such as a wink, is achieved by an input device including: a detector which includes a first contact electrode placed at a first position of a body part and a second contact electrode placed at a second position of the body part, the detector configured to measure a biological signal between the first contact electrode and the second contact electrode, and to detect a low-frequency component inclusive of the biological signal; and a discrimination processor configured to determine, based on a signal from the detector, presence or absence of an input movement of the body part in a vicinity of the first position, and/or presence or absence of an input movement of the body part in a vicinity of the second position.Type: GrantFiled: July 12, 2019Date of Patent: November 8, 2022Assignee: National Institute of Advanced Industrial Science and TechnologyInventor: Ryohei Hasegawa
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Patent number: 11492363Abstract: The present invention relates to a method for preparing size-modulated UiO-66, which is achieved by modulating the concentrations of reactants, and a catalyst with improved activity of hydrolyzing chemical warfare agents prepared by the method.Type: GrantFiled: April 26, 2019Date of Patent: November 8, 2022Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kyung Youl Baek, Chong Min Koo, Soon Man Hong, Seung Sang Hwang, Sangho Cho, Jin Young Seo, Do Xuan Huy, Younghan Song, Sejin Kim, Changju Sung, Yeojin Ahn
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Patent number: 11492580Abstract: Described herein is a beads-free bioprocessor as an automated and cost-effective T cell processing and manufacturing platform. T cells are a core component in CAR T cell therapies for cancer treatment, but are difficult to manufacture to scale in clinically relevant quantities. The 3D bioprocessor provides an alternative device that is scalable, beads-free, easy-to-use, and cost-effective for using CAR T cell therapy in cancer immunotherapy. Besides CAR T cell application, this platform technology has potential for many other applications such as cancer cell isolation.Type: GrantFiled: May 12, 2020Date of Patent: November 8, 2022Assignees: Southwest Research Institute, The Trustees of the University of PennsylvaniaInventors: Jian Ling, Kreg A. Zimmern, Michael C. Milone
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Patent number: 11491170Abstract: A method for manufacturing a functional material that contains plasmalogen, the method including treating an animal tissue containing plasmalogen with protease, and extracting the animal tissue treated with protease with an extraction liquid containing ethanol.Type: GrantFiled: April 18, 2019Date of Patent: November 8, 2022Assignee: INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOODInventors: Takehiko Fujino, Shiro Mawatari
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Patent number: 11492500Abstract: In certain embodiments, the invention is directed to apparatus comprising a liquid-impregnated surface, said surface comprising an impregnating liquid and a matrix of solid features spaced sufficiently close to stably contain the impregnating liquid therebetween or therewithin, and methods thereof. In some embodiments, one or both of the following holds: (i) 0<??0.25, where ? is a representative fraction of the projected surface area of the liquid-impregnated surface corresponding to non-submerged solid at equilibrium; and (ii) Sow(a)<0, where Sow(a) is spreading coefficient, defined as ?wa??wo??oa, where ? is the interfacial tension between the two phases designated by subscripts w, a, and o, where w is water, a is air, and o is the impregnating liquid.Type: GrantFiled: April 26, 2017Date of Patent: November 8, 2022Assignee: Massachusetts Institute of TechnologyInventors: J. David Smith, Rajeev Dhiman, Kripa K. Varanasi
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Patent number: 11491999Abstract: A method for controlling an operating mode of a vehicle is presented. The method includes determining a current range of the vehicle while the vehicle is operating in a first operating mode. The method also includes determining a distance to a destination. The method further includes controlling the vehicle to operate in a second operating mode instead of the first operating mode when the range is less than the distance to the destination.Type: GrantFiled: May 8, 2019Date of Patent: November 8, 2022Assignee: TOYOTA RESEARCH INSTITUTE, INC.Inventors: Hiromitsu Urano, Kentaro Ichikawa, Junya Ueno
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Patent number: 11491664Abstract: A robotic platform manipulating peripheral nerve system includes a manipulator and a recorder. The manipulator includes a rotating guide, a plurality of rotating movers and a plurality of manipulating units. The rotating guide has an opening portion through which the recorder records, and has a guide rail at a side. The rotating movers are combined with the rotating guide and move along the guide rail. The manipulating units are respectively fixed to the rotating movers, and a manipulating part performs the operation being connected to an end of each of the manipulating units.Type: GrantFiled: September 10, 2019Date of Patent: November 8, 2022Assignees: Korea Institute of Science and Technology, Research & Business Foundation Sungkyunkwan UniversityInventors: Keehoon Kim, Yong Seok Ihn, Donghyun Hwang, Sehyuk Yim, Sang Rok Oh, Jinwoo Jeong
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Patent number: 11491658Abstract: A robot automatically annotates items by training a semantic segmentation module. The robot includes one or more imaging devices, and a controller comprising machine readable instructions. The machine readable instructions, when executed by one or more processors, cause the controller to capture an image with the one or more imaging devices, identify a target area in the image in response to one or more points on the image designated by a user, obtain depth information for the target area, calculate a center of an item corresponding to the target area based on the depth information, rotate the imaging device based on the center, and capture an image of the item at a different viewing angle in response to rotating the view of the imaging device.Type: GrantFiled: November 21, 2019Date of Patent: November 8, 2022Assignee: Toyota Research Institute, Inc.Inventor: Yutaka Takaoka
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Patent number: 11492644Abstract: Expression of exogenous SNAI2, EYA1 and SIX1 genes in a cell, tissue or organ not normally having nephron progenitor activity, induces or re-programs that cell to have or subsequently develop nephron progenitor activity. Nephron progenitors induced 5 by expression of SNAI2, EYA1 and SIX1 may be used for the production of nephron cells and tissues that are useful in treatment of kidney disorders, kidney regeneration, kidney transplantation, bioprinting and nephrotoxocity testing.Type: GrantFiled: May 24, 2018Date of Patent: November 8, 2022Assignees: MURDOCH CHILDRENS RESEARCH INSTITUTE, VANDERBILT UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OE VETERANS AFFAIRSInventors: Melissa Little, Jessica Vanslambrouck, Lauren Woodard, Matthew Wilson
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Patent number: 11492358Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I) in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.Type: GrantFiled: February 26, 2021Date of Patent: November 8, 2022Assignees: The Broad Institute, Inc., Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventors: Sarah Anna Liesa Johannes, Philipp Buchgraber, Ulrich Klar, Clara Christ, Kai Thede, Joachim Kuhnke, Manfred Moewes, Knut Eis, Amaury Ernesto Fernandez-Montalvan, Nicolas Werbeck, Ursula Mönning, Philip Lienau, Ulrike Sack, Arne Scholz, Michael H. Serrano-Wu, Christopher Lemke, David McKinney, Mark Fitzgerald, Christopher Nasveschuk, Kiel Lazarski, Steven James Ferrara, Laura Furst, Guo Wei, Patrick Ryan McCarren
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Patent number: 11495707Abstract: Provided is an AlGaN unipolar carrier solar-blind ultraviolet detector that is based on the AlGaN polarization effect and that uses the double heterojunction of the p-AlzGa1-zN/i-AlyGa1-yN/n-AlxGa1-xN (0.45=<x,z<y) as the main structure of the detector. It makes full use of the polarization built-in electric field pointing from n-type AlGaN to p-type AlGaN to enhance the electric field strength of the i-type absorption region and enhance the efficiency of carrier absorption and separation. At the same time, the valence band step of the p-AlzGa1-zN/i-AlyGa1-yN heterojunction is used to effectively restrict holes from entering the absorption region to recombine with electrons, thereby increasing the carrier lifetime. Furthermore, during device manufacturing the structure is such designed that makes it difficult for photo-generated holes to participate in the photoconductivity so as to realize unipolar conduction of electrons, thereby obtaining a high response speed and high gain current.Type: GrantFiled: May 19, 2021Date of Patent: November 8, 2022Assignee: CHANGCHUN INSTITUTE OF OPTICS, FINE MECHANICS AND PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Dabing Li, Ke Jiang, Xiaojuan Sun, Yang Chen, Yuping Jia, Hang Zang
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Patent number: 11492610Abstract: Disclosed herein include systems, methods, compositions, and kits for multiplexing single-cell RNA-sequencing (scRNA-seq) samples. In some embodiments, the methods comprise chemically tagging cells with identifying sample tags (e.g., barcoded DNA oligonucleotides).Type: GrantFiled: March 7, 2019Date of Patent: November 8, 2022Assignee: California Institute of TechnologyInventors: Jase Gehring, Lior S. Pachter, Siyu Chen, Jong Hwee Park
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Patent number: 11493646Abstract: Provided are an underwater radiation monitoring system and method. The monitoring system includes a plurality of sensors configured to measure a value of underwater radiation in a measurement area in which underwater radiation is to be measured, the plurality of sensors being installed in the measurement area by being arranged in a form which is set on the basis of information about the measurement area; and an electronic device configured to identify a value of underwater radiation in the measurement area on the basis of the values of underwater radiation measured by the plurality of sensors, wherein at least one first sensor among the plurality of sensors is connected to the electronic device to collect measured values obtained from the at least one first sensor and a plurality of second sensors excluding the at least one first sensor and to transmit the collected measured values to the electronic device.Type: GrantFiled: October 26, 2020Date of Patent: November 8, 2022Assignee: KOREA ATOMIC ENERGY RESEARCH INSTITUTEInventors: Sung Hee Jung, Jin Ho Moon, Jang Guen Park