Abstract: An electrode and a lithium secondary battery including the same. By preparing an electrode including an electrode active layer formed using a structure capable of supporting an electrode active material, safety and charge and discharge properties of a battery are improved due to morphological characteristics of the electrode active material being supported inside the structure.
Type:
Grant
Filed:
March 28, 2019
Date of Patent:
July 5, 2022
Assignees:
LG ENERGY SOLUTION, LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Byoungkuk Son, Jang Wook Choi, Byung Gon Kim, Minchul Jang, Eunkyung Park, Junghun Choi, Donghyeon Kang
Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.
Type:
Grant
Filed:
January 5, 2017
Date of Patent:
July 5, 2022
Assignees:
Keio University, Tokyo Institute of Technology
Abstract: Technologies are provided for generation of programmable pulse signals using inverse chaotic maps, without reliance on a clocking signal. Some embodiments of the technologies include an apparatus that can receive a sequence of bits having a defined number of bits, where the sequence of bits represent a desired continuous pulse signal having a programmable width in time-domain. The apparatus can also can receive a precursor continuous pulse signal having an arbitrary width in time-domain that fits within the dynamic range of the apparatus. The apparatus can generate the desired continuous pulse signal by transforming the precursor continuous pulse signal using the sequence of bits and an inverse chaotic map.
Abstract: Disclosed are methods and compositions for treating traumatic brain injury (TBI). A brain injury-specific 4-amino acid peptide (sequence CAQK), identified by in vivo phage display screening in mice with acute brain injury, shows selective binding to mouse and human brain injury lesions, and when systemically injected, specifically homes to sites of injury in penetrating and non-penetrating (controlled cortical impact) brain injury models. Significantly, the peptide alone produces therapeutic effect and so can be used in the absence of any other therapeutic compound.
Type:
Grant
Filed:
December 6, 2018
Date of Patent:
July 5, 2022
Assignee:
Sanford Burnham Prebys Medical Discovery Institute
Inventors:
Erkki Ruoslahti, Sazid Hussain, Aman Preet Singh Mann, Pablo Scodeller
Abstract: Systems and methods are disclosed for the measurement of patient outcomes in a rehabilitation setting. In one exemplary method, an assessment relating to self-care is provided, an assessment relating to mobility is provided, and an assessment relating to cognition is provided, wherein the assessments have been pre-selected using item response theory.
Type:
Grant
Filed:
September 26, 2018
Date of Patent:
July 5, 2022
Assignee:
REHABILITATION INSTITUTE OF CHICAGO
Inventors:
Chih-Hung Chang, Andrew Bodine, James A. Sliwa
Abstract: A domain adaptation-based object recognition apparatus includes a memory configured to store a domain adaptation-based object recognition program and a processor configured to execute the program. The processor learns a generative model for generating a feature or an image similar to a gallery image on the basis of domain adaptation in association with an input probe image and learns an object recognition classification model by using a learning database corresponding to the gallery image and the input probe image, thereby performing object recognition using the input probe image.
Type:
Grant
Filed:
March 30, 2020
Date of Patent:
July 5, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Hyung Il Kim, Yong Jin Kwon, Jin Young Moon, Jong Youl Park, Sung Chan Oh, Ki Min Yun, Jeun Woo Lee
Abstract: This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
Type:
Grant
Filed:
September 23, 2019
Date of Patent:
July 5, 2022
Assignee:
California Institute of Technology
Inventors:
Brian M. Stoltz, Yoshitaka Numajiri, Beau P. Pritchett, Koji Chiyoda
Abstract: The present disclosure relates to a system and a method for fine manipulation. The system for fine manipulation includes a tossing mechanism, a setting mechanism, and a leaf uniformly distributing mechanism. The tossing mechanism comprises a tossing machine, a leaf distributing assembly, a first feeding conveyor assembly, and a first receiving conveyor assembly. The setting mechanism comprises a setting assembly, a second feeding conveyor assembly, and a second receiving conveyor assembly. The setting assembly includes a setting belt and a setting belt driving device configured to drive the setting belt to move. The leaf uniformly distributing mechanism comprises a leaf uniformly distributing device and a lifting driving assembly. The leaf uniformly distributing device includes a shifting arm, a rotary table and a rotary table driving assembly. The lifting driving assembly can drive the leaf uniformly distributing device to move up and down.
Type:
Grant
Filed:
April 28, 2018
Date of Patent:
July 5, 2022
Assignees:
CHANGSHA XIANG FENG INTELLIGENT EQUIPMENT LIMITED BY SHARE LTD., TEA RESEARCH INSTITUTE, GUANGDONG ACADEMY OF ARGRICULTURAL SCIENCES
Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X1, X2, X3, X4, X5, W1, W2, W3, and W4 are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. In one aspect, the invention relates to selective HDAC3 inhibitors useful for protecting ?-cells and improving insulin resistance. The selective HDAC3 inhibitors are also useful for promoting cognitive function and enhancing learning and memory formation.
Type:
Grant
Filed:
August 16, 2017
Date of Patent:
July 5, 2022
Assignees:
The Broad Institute, Inc., The General Hospital Corporation
Inventors:
Edward Holson, Florence Fevrier Wagner, Stephen J. Haggarty, Yan-Ling Zhang, Morten Lundh, Bridget Wagner, Michael C. Lewis, Tracey Lynn Petryshen
Abstract: Methods of expressing a neuropeptide in a neuron of a subject are described. Methods of altering a behavior in a subject in need thereof are described. Kits are described. Vectors are described.
Abstract: A catalyst for catalytic oxidation of furfural to prepare maleic acid is composed of a carbon nitride doped with a potassium salt. A method for preparing the catalyst includes mixing the potassium salt, a precursor of the carbon nitride and a solvent to obtain a mixture, and drying and calcining the mixture to obtain the catalyst. A use of the catalyst in catalytic oxidation of furfural to prepare maleic acid, wherein the maleic acid is prepared by the step of oxidizing furfural in a solvent in the presence of the catalyst. The invention has the advantages that by using the method provided by the invention to prepare maleic acid, the conversion rate of furfural can be 99% or more and the yield of maleic acid can be up to 70.40%.
Abstract: Provided is a focusing device that includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (FOV) of the focusing device may be widened.
Type:
Grant
Filed:
September 25, 2019
Date of Patent:
July 5, 2022
Assignees:
SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventors:
Amir Arbabi, Seunghoon Han, Andrei Faraon, Hyeonsoo Park
Abstract: A system and method for optimizing passive control strategies of oscillatory instabilities in turbulent systems using finite-time Lyapunov exponents are disclosed. The method includes receiving data from one or more measuring devices connected to the turbulent flow system incorporating a control strategy in the flow field. One or more flow characteristics are determined from the data obtained from the measuring devices. The method involves computing critical dynamics from backward time finite-time Lyapunov exponent (FTLE) field based on the one or more flow characteristics. Next, one or more regions of critical dynamics associated with impending oscillatory instabilities in the turbulent flow system are identified. The identified region of critical dynamics is disrupted the control the onset of oscillatory instabilities in the turbulent flow system.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
July 5, 2022
Assignee:
INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IIT Madras)
Abstract: Methods and systems for remote support of autonomous operation of vehicles have been disclosed. State indicators are generated by a first state display based on state data from a portion of vehicles assigned to a respective first level control station. A second state display is generated for a second control station and displays state indicators for the state data of the vehicles. A remote support interface including the first state display and image data received from a first vehicle of the vehicles is generated. Instruction data to the first vehicle is transmitted using the remote support interface and based on an indication that the first vehicle needs remote support, the instruction data modifying the autonomous operation of the first vehicle. A workload between the first level control stations is allocated by assigning the vehicles using the state indicators of the second state display.
Type:
Grant
Filed:
March 16, 2020
Date of Patent:
July 5, 2022
Assignees:
Nissan North America, Inc., Florida Institute for Human & Machine Cognition, Inc.
Inventors:
Liam Pedersen, Maarten Sierhuis, Hans Utz, Mauro Della Penna, Jeffrey Bradshaw, Matthew Johnson, Michael Vignati, Lawrence Bunch
Abstract: A process for creating a stabilized diode laser device is disclosed, where the stabilized diode laser device includes a unibody mounting plate and several chambers aligned along a transmission axis. Various optic components are placed in the chambers, and based on a transmission through the chambers, the optic components are aligned and secured within the chambers.
Type:
Grant
Filed:
October 6, 2020
Date of Patent:
July 5, 2022
Assignee:
Battelle Memorial Institute
Inventors:
Andrew P. Bartko, Ryan W. Daly, Theodore J. Ronningen, Brad Ross, Karen Walczak
Abstract: Disclosed is a post-processing method for improving anti-wear and friction-reducing properties of a CrN coating. According to the method, the CrN coating is subjected to a thermal cycling treatment in a temperature range of ?20° C. to 60° C. under a humidity environment of 60%-80% R.H. The post-processing method can substantially improve the anti-wear and friction-reducing properties of the CrN coating, so that friction pair parts deposited with the coating achieve a stable operation for a long time.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
July 5, 2022
Assignee:
NINGBO INSTITUTE OF MATERIALS TECHNOLOGY & ENGINEERING, CHINESE ACADEMY OF SCIENCES
Abstract: Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.
Type:
Grant
Filed:
May 22, 2019
Date of Patent:
July 5, 2022
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Chanhyuk Kim, Jun Y. Axup, Hwayoung Yun, Peter G. Schultz, Jennifer Ma, Jiayin Shen, Pengyu Yang
Abstract: A computing device classifies unclassified observations. A first batch of unclassified observation vectors and a first batch of classified observation vectors are selected. A prior regularization error value and a decoder reconstruction error value are computed. A first batch of noise observation vectors is generated. An evidence lower bound (ELBO) value is computed. A gradient of an encoder neural network model is computed, and the ELBO value is updated. A decoder neural network model and an encoder neural network model are updated. The decoder neural network model is trained. The target variable value is determined for each observation vector of the unclassified observation vectors based on an output of the trained decoder neural network model. The target variable value is output.
Abstract: The disclosure provides a method for predictive soil mapping based on solar radiation in large flat area, comprising: Step 1, capturing the response process of the earth's surface heat: after an observation day or an observation period is selected, a curve graph depicting a dynamic response of the surface heat to solar radiation captured by using a remote sensor of a moderate-resolution imaging spectrometer; Step 2, constructing environmental covariates: quantitative analysis is performed for the dynamic response curve graph obtained in Step 1 by a mathematical method, and characteristic parameters are extracted and taken as environmental covariates; and Step 3: a machine learning model is established for the predictive soil attribute mapping. This method solves the challenge of effective soil mapping in flat areas, significantly improves the accuracy and efficiency of predictive soil mapping in flat areas, reduces the cost in time and economy of soil survey mapping.
Type:
Grant
Filed:
August 18, 2021
Date of Patent:
July 5, 2022
Assignees:
INSTITUTE OF SOIL SCIENCE, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF FORENSIC SCIENCE OF CHINA
Abstract: A new and distinct variety of apple tree is described. The variety results from a limb sport found in Washington, United States. The fruit of the apple tree of this new variety have an attractive appearance, characterised by a high proportion of red over color and an over color pattern that is a solid flush with weakly defined stripes.
Type:
Grant
Filed:
December 3, 2021
Date of Patent:
July 5, 2022
Assignee:
The New Zealand Institute for Plant and Food Research Limited
Inventors:
Kenneth Charles Breen, Nicholas Anderson