Abstract: The invention includes a system and method for predicting the performance of production animals by analysis of heart and lung sounds to determine likelihoods the animals will develop BRD or other diseases or ailments. Vital signs of animals are recorded during an adrenergic sympathetic “flight or fight” situation. A cardio-pulmonary rate ratio is determined for each animal by dividing a normalized adjusted heart rate value by a normalized adjusted respiratory value. From the ratios calculated for each animal in a group, a ratio range is established. Ratio values at a lower end of the ratio range indicate higher relative respiration rates and poor lung performance due to disease. Ratio values at an upper end of the range may indicate low cardiac output and an inability to tolerate rapid weight gain. Ratio values at either end of the range may indicate compromised cardio-pulmonary function.
Abstract: A system for external fish parasite monitoring in aquaculture, the system comprising: —a camera (52) suitable to be submerged in a sea pen suitable for containing fish, the camera being arranged for capturing images of the fish; and —an electronic image processing system (86) configured for identifying external fish parasites on the fish by analyzing the captured images, characterized by a camera and lighting rig (10) having a vertical support member (14), an upper boom (16) articulated to a top end of the support member (14) and carrying an upper lighting array (22), a lower boom (18) articulated to a lower end of the support member (14) and carrying a lower lighting array (24), and a housing (20) attached to the support member and carrying the camera (52), wherein the upper and lower lighting arrays (22, 44) are configured to illuminate, from above and from below, a target region inside a field of view of the camera (52).
Type:
Grant
Filed:
December 19, 2018
Date of Patent:
April 25, 2023
Assignee:
Intervet Inc.
Inventors:
Russel Howe, Zachary Lizer, James Wallace Sarrett, Peter Jon Abrahamson, Jascha Tucker Little
Abstract: The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.
Type:
Application
Filed:
December 17, 2020
Publication date:
April 13, 2023
Applicant:
Intervet Inc.
Inventors:
Michael Berger, Michael R. Linder, Carolin Schneider, Janina Tanzler, Ulrich Sondern
Abstract: The invention derives from the discovery that the immunogenicity of piscine orthoreovirus (PRV) can be significantly increased by inactivating the virus in a way different from the prior art: by incubation with an aziridine the vaccine potency against challenge infection by cohabitation is much improved over prior art approaches. This allowed the development of an effective inactivated vaccine against infection and disease caused by PRV.
Type:
Application
Filed:
December 15, 2020
Publication date:
April 6, 2023
Applicant:
Intervet Inc.
Inventors:
Johanna Jacoba Elisabeth Bijlsma, Sven Leininger, Stephane Villoing
Abstract: The present invention relates to methods of treating or preventing chewing lice infestations of ruminant animals by subcutaneously administering an isoxazoline compound of formula (I).
Type:
Application
Filed:
December 15, 2020
Publication date:
March 30, 2023
Applicant:
Intervet Inc.
Inventors:
Peter Andrew O'Neill, Petr Fisara, Annie Flochlay-Sigognault, Hartmut Zoller, Bruno Huyghe
Abstract: The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus protein antigens and an Infectious Bursal Disease virus protein antigen, and methods of their use in poultry vaccines.
Type:
Grant
Filed:
June 15, 2017
Date of Patent:
March 7, 2023
Assignee:
Intervet Inc.
Inventors:
Stephanie Cook, Mohamad Morsey, Ian Tarpey, Iwan Verstegen, Paulus Jacobus Antonius Sondermeijer, Paul Vermeij
Abstract: The present invention provides antibodies to canine IL-4 receptor alpha that have a highbinding affinity for canine IL-4 receptor alpha, and that can block the binding of canine IL-4 and/or IL-13 to canine IL-4 receptor alpha. The present invention further relates to epitopes of canine IL-4 receptor alpha that bind to the antibodies to canine IL-4 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.
Abstract: The present invention provides antibodies to canine IL-4 receptor alpha that have a high binding affinity for canine IL-4 receptor alpha, and that can block the binding of canine IL-4 and/or IL-13 to canine IL-4 receptor alpha. The present invention further relates to epitopes of IL-4 receptor alpha that bind to the antibodies to canine IL-4 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.
Abstract: The present invention describes a recombinant herpesvirus of turkeys (rHVT) that can be used as a vector vaccine for poultry against infection and disease from multiple poultry pathogens. Specifically the rHVT expresses an infectious bursal disease virus (IBDV) viral protein 2 (VP2) gene and a Newcastle disease virus (NDV) fusion (F) protein gene from a first and a second expression cassette inserted in the unique small (Us) region, and expresses an avian influenza vims (AIV) haemagglutinin (HA) gene from a third expression cassette inserted in the unique long (UL) region of the genome of said rHVT either between the UL40 and UL41 genes, or between the UL44 and UL45 genes. This rHVT can be used to vaccinate poultry against MDV, IBDV, NDV and AIV.
Type:
Application
Filed:
December 18, 2020
Publication date:
February 2, 2023
Applicant:
Intervet Inc.
Inventors:
Martijn Alexander Langereis, Iwan Verstegen
Abstract: The invention is based on the finding that incubating a Cryptosporidium gp40 protein with an aziridine, significantly increases its immunogenicity. When used as a vaccine, this allows a reduction of the dose, which improves economic feasibility and safety. Consequently the aziridine-treated gp40 can now be used as a safe and effective subunit-vaccine for humans or non-human-animals against Cryptosporidiosis. Specifically for new-born ruminants a vaccination by way of colostral transfer was found to be very effective in reducing clinical signs of Cryptosporidiosis, especially diarrhoea.
Type:
Application
Filed:
December 17, 2020
Publication date:
January 19, 2023
Applicant:
Intervet Inc.
Inventors:
Markus Hendrikus Van Roosmalen, Koen Gevers
Abstract: The present invention is drawn to new oral live canine parainfluenza virus vaccines and related multivalent vaccines. Methods of using the vaccine alone or in combination with one or more other protective immunogens in multivalent vaccines are also provided.
Type:
Application
Filed:
December 17, 2020
Publication date:
January 12, 2023
Applicant:
Intervet Inc.
Inventors:
Rhonda L. LaFleur, Jennifer C. Dant, Ian Tarpey, Zhichang Xu
Abstract: The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-di-chlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoro-methyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.
Abstract: The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).
Type:
Application
Filed:
June 21, 2022
Publication date:
January 5, 2023
Applicant:
Intervet Inc.
Inventors:
Thorsten Meyer, Ralf Warrass, Joachim Ullrich, Michael Berger, Michael Linder
Abstract: A method for external fish parasite monitoring in aquaculture, comprising the steps of: —submerging a camera (52) in a sea pen containing fish, the camera having a field of view; —capturing images of the fish with the camera (52); and—identifying external fish parasite on the fish by analyzing the captured images, characterized in that a target region within the field of view of the camera (52) is illuminated from above and below with light of different intensities and/or spectral compositions.
Type:
Grant
Filed:
December 19, 2018
Date of Patent:
December 27, 2022
Assignee:
Intervet Inc.
Inventors:
Russel Howe, Zachary Lizer, James Wallace Sarrett, Peter Jon Abrahamson, Jascha Tucker Little
Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10). The tensioning device (S) has a ramp (52) which is rotatable by means of a motor (12) and has a ramp track (53) extending along a helical line, wherein the ramp track (53) ascends from a first plateau along a region of inclination (S1, S2) to a second plateau and descends from the second plateau to the first plateau via a transition flank (46).
Type:
Grant
Filed:
March 26, 2019
Date of Patent:
December 27, 2022
Assignee:
Intervet Inc.
Inventors:
Frank Altermann, Dominic Kamenzin, Thomas Schmidt, Manuel Mattes, Robin Sauter, Daniel Seeh
Abstract: The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.
Abstract: The present invention discloses antibodies including caninized antibodies against canine PD-L1 with specific properties. The present invention further relates to epitopes of canine PD-L1 that bind to these antibodies, as well as to anti-canine PD-L1 antibodies that bind these epitopes. The invention further discloses the use of the caninized anti-canine PD-LI antibodies of the present invention in the treatment of cancer in dogs.
Type:
Application
Filed:
August 15, 2022
Publication date:
December 8, 2022
Applicant:
Intervet Inc.
Inventors:
Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
Abstract: The invention pertains to a serine protease antigen which induces antibodies against a protein having at least 69% sequence identity with the Heamophilus parasuis protein according to SEQ ID No: 1, for use in a prophylactic method to protect a pig against an infection with Haemophilus parasuis by administering a vaccine to the pig, wherein the vaccine comprises the serine protease antigen. The invention also pertains to a vaccine, a method to manufacture such a vaccine and a method to protect a pig against H. parasuis.
Type:
Application
Filed:
November 19, 2020
Publication date:
December 8, 2022
Applicant:
Intervet Inc.
Inventors:
Antonius Arnoldus Christiaan Jacobs, Theodora Johanna Van Kasteren-Westerneng, Johanna Jacoba Elisabeth Bijlsma