Abstract: A novel human monoclonal antibody specifically recognizing cancer cells such as non-small cell lung cancer, pancreatic cancer and gastric cancer cells is produced by hybridomas which are obtained by fusing lymphocytes derived from a cancer tissue of a cancer patient with mouse myeloma cells. An anti-cancer drug is obtained by using the antibody alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein. More specifically, an anti-cancer drug is obtained by using an antibody, in which variable region of its heavy chain comprises the amino acid sequence of SEQ ID NO: 115 and variable region of the light chain comprises the amino acid sequence of SEQ ID NO: 117, alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein.

Abstract: A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a re-polymerizable oligomer. A producing process of polylactic acid, wherein the re-polymerizable oligomer obtained by the above-mentioned depolymerization process is polymerized in the presence of a hydrolase or a polymerization catalyst.

Abstract: There is provided composite nano-particles comprising nano-crystal particles dispersed stably and individually in suspension in high concentration without mutual aggregation of the nano-particles. A determined amount of pure water or deionized water is poured into a reactor, into which is introduced nitrogen gas at rate of 300 cm3/min for a given time while agitating with a stirrer to remove dissolved oxygen in the pure water, allowing to stand in an atmosphere of nitrogen. Next, the inside of the reactor is maintained in an atmosphere of nitrogen and sodium citrate as a dispersion-stabilizing agent, an aqueous solution of MPS as a surface-modifying agent, an anion aqueous solution for co-precipitation as a nano-crystal and a cation aqueous solution are added, in that order. Then, an aqueous solution of sodium silicate is added to the reactor, which is then allowed to stand in the dark place in an atmosphere of nitrogen after agitation.

Abstract: The invention relates to methods of selecting a cardiomyocyte from a cell population derived from a whole heart or a differentiated cell population derived from a stem cell without genetic alteration. Specifically, the invention relates to a method of selecting a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, on the basis of a relative content of cellular mitochondria and/or a relative mitochondrial transmembrane potential of the cell. The invention also relates to methods of enriching a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, producing a cardiomyocyte without genetic alteration of a cardiomyocyte, and evaluating the ratio of a cardiomyocyte in a cardiomyocyte-containing cell mixture.

Abstract: A UWB repeater preferably applied to a relay of stream data, which does not require frequency conversion and has less delay in relay. The UWB repeater includes a receiving antenna, a receiver, a transmitter, a transmitting antenna, and a relay controller. The relay controller is provided with a switch unit, a delay, and a transmitting/receiving timing controller. UWB pulse signals demodulated by the receiver are power-amplified by the transmitter and transmitted after being delayed by the delay unit for timing that does not overlap the receiving timing. The transmitting/receiving timing controller turns on the switch unit during the period of pulse receiving timing and enables a relay of the receiving pulses, and turns off the switch unit during the period of relaying of pulses, and can prevent sneak path signals between the transmitting side and the receiving side.

Abstract: A plurality of types of liquid with different electrical conductivity flow through a micro channel having a plurality of channels. When an electric field is applied thereto, an electrokinetic driving flow generated in the micro channel attracts objective submicron particles to one side. Therefore, the particles are completely separated in a single operation by use of the micro channel having extremely simple structure, without the necessity of special machining of the channels and the like.

Abstract: A motor driving system includes an AC power supply 1, an AC reactor 2, a power converter 3 and a motor 4. A microsurge suppressor 5 is inserted on a power supply line from the power converter 3 to the motor 4 and the similar microsurge suppressor 6 is inserted on a power supply line from the AC reactor 2 to the power converter 3. The microsurge suppressor 5 includes a multi-layer printed wiring board having two terminals connected to the power converter 3 and the motor 4 and a capacitor for bypassing a surge, and the terminal 4 on the side of the motor of the multi-layer printed wiring board is directly connected to a terminal of the motor 4. The capacitor for bypassing a surge is connected between the terminal of the motor 4 and the end on the side of a second terminal of second wiring.

Abstract: A diffraction grating of the present invention includes a first block (101) and a second block (102). The first block (101) is made up of a plurality of input waveguides (103), a slab waveguide (104), a delay waveguide array (105) and narrow grooves (106): each of which being filled with resin. The second block (102) is made up of a plurality of input waveguides (107), a slab waveguide (108) and a plurality of output waveguides (109). Since a circuit is cut off at the ends of the arrayed waveguides, a relative phase can easily be measured. The resin has undergone a refractive-index adjustment and compensates a phase error.

Abstract: The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease mutant APP can be induced by ecdysone treatment, a gene that protects the neurons from cell death was successfully isolated. The gene encodes a secretory polypeptide consisting of 24 amino acids, and this polypeptide suppresses neuronal death caused by the expression of APP mutants and presenilin mutants. The polypeptide also suppressed cell death of primary neuronal culture caused by A?. Furthermore, by mutating the amino acids of the polypeptide, the neuronal death suppression activity of the polypwptide was successfully and significantly enhanced. These polypeptides and derivatives thereof are useful as pharmaceuticals to prevent neuronal death associated with Alzheimer's disease, and as seed compounds for developing novel pharmaceuticals for Alzheimer's disease.

Abstract: The invention provides a depolymerization method for a polymer containing an ester bond in a main chain, by causing a solid acid catalyst to an on a polymer containing an ester bond in a main chain to depolymerize the polymer, thereby obtaining a re-polymerizable monomer and/or oligomer as a depolymerization product, and a method for producing a polymer containing an ester bond in a main chain, by polymerizing the re-polymerizable monomer and/or oligomer obtained by the depolymerization method.

Abstract: Powdery fullerene is milled in an oxygen atmosphere, whereby mechanical impacts are applied to the fullerene and a carbon cage of the fullerene is dynamically distorted to the extent that an energy for conversion of atmospheric oxygen to a singlet excited state is accomplished from the distorted carbon cage to atmospheric oxygen. Singlet oxygen, i.e. an efficient oxidant in various industrial fields, is generated by solid-state reaction under stable conditions without necessity of photo-irradiation. The singlet oxygen also enables efficient oxidation of fullerene itself.

Abstract: The object of the present invention is to provide a phosphor which is excellent in transparency, light transmittance, luminescence efficiency and luminescent intensity and at the same time, processes for producing the phosphor. Preferred embodiments of the invention include a phosphor characterized in that phosphor particles represented by the general formula [(L)a(M)b(N)cOd:Y] are covered with an organic compound bearing at least one functional group at a terminal or side chain, wherein L is a metallic element such as Zn; M is a metallic element such as Al; N is Si or Ge; O is oxygen; Y is at least one activating agent such as Mn2+, Eu2+, Cu2+ or Yb2+; and a, b, c and d are each a value satisfying the relationships 0<a?2, 0?b?2, 0?c?2 and 2a+3b+4c=2d.

Abstract: The invention provides an optical switch including a substrate which has conductivity or semiconductivity, an optical waveguide layer which is formed on the substrate, and a control electrode which is formed on the optical waveguide layer. The optical waveguide layer includes an incident-side channel waveguide to which a light signal is incident and plural outgoing-side channel waveguides branched from the incident-side channel waveguide. The control electrode forms a reflection plane reflecting the incident light signal near a crossover portion of the plural outgoing-side channel waveguides by applying voltage to the optical waveguide layer with the substrate to control a refractive index of the optical waveguide layer, and switches propagation paths of the light signal.

Abstract: The present invention provides a UWB transmitter and receiver, the transmission rate of which is increased, and the SN ratio of which is improved. By investigating the polarity of an echo at ½ position of the chip period Tc, the chip period is shortened to Tc/2 where the polarity of the echo is the same and a pulse signal of the same polarity is continued, whereby it becomes possible to increase the transmission rate. Because the echo and the pulse signal are caused to overlap each other, the SN ratio can be improved.

Abstract: An ultrasonic flowmeter casts an ultrasonic pulse toward a measurement line ML, processes ultrasonic echo signals, and calculates the position and speed of each ultrasonic reflector positioned along the measurement line ML by analyzing the ultrasonic echo signals subjected to signal processing. The flowmeter filters the ultrasonic echo signals. A trigger oscillator of the flowmeter controls signal transmission/reception timing according to an adjustable sequence wherein one cycle is formed of three consecutive sets of emissions of an ultrasonic pulse and reception of ultrasonic echo signals, and a waiting period of time.

Abstract: A hand pattern switch device recognizes a hand pattern from an image of a hand in an image pickup zone and detects a hand motion. One of controlled objects is selected based on the recognized hand pattern and/or hand motion. In accordance with the selected object, a mode of detection of operation information based on hand motion is changed. In a moved distance detecting mode, a moved distance of the hand in the zone is detected as operation information, and in a stop time detecting mode, a stop time of the hand at a stop position to which the hand has been moved in the zone is detected as operation information. The image pickup zone is at a location which is located laterally to a steering wheel and to which a driver can extend his/her arm without changing a driving posture.

Abstract: In order to provide a low-loss optical switch that is low in power consumption by providing the same as a self-holding type, and high speed and highly practicable, an optical switch of the present invention is composed of a quartz substrate (101), first and second input waveguides (102a and 102b), a first directional coupler (103), first and second arm waveguides (104a and 104b) of a Mach-Zehnder interferometric circuit, a second directional coupler (105), first and second output waveguides (106a and 106b), and a phase change material portion (100). A control light (for an amorphous to crystal transition) pulse (pulse width: 20 ns, pulse intensity: 5 mW) having a wavelength of 0.78 microns is irradiated. As a result of the control light pulse irradiation, the phase change material portion (109) changes in phase to a crystal state, and the optical switch transits to a bar condition.

Abstract: As anti-RNA polymerase (RNAP) antibodies are detected with high frequency in patients suffering from cutaneous scleroderma where skin sclerosis progresses rapidly, supervenes scleroderma renal crisis at a high rate, and associates with clinical entities whose prognoses are extremely bad, it is intended to provide a convenient method of detecting an anti-RNAP antibodies, which is extremely useful in diagnosing and classifying clinical entities of scleroderma, and predicting organ failure, in particular scleroderma renal crisis.

Abstract: The invention provides a method for processing a transparent material, which is applicable to universal materials and by which the propagation loss of an optical function device produced by changing the refractive index is slight. Femtosecond laser pulses are condensed by a lens, and a glass material being fused quartz is relatively moved, wherein a waveguide is formed by forming a continuous high refractive index area. Prior art optical pulses depicted in FIG. 1(a) are one-by-one femtosecond laser pulses at a pulse interval which is slightly shorter or longer than a thermal diffusion time (1 ?s) of a substance. Optical pulses according to the invention, which are depicted in FIG. 1(b) are irradiated while using, as a set, two femtosecond laser pulses with a pulse interval which is around the electron lattice energy relaxation time (1 through 100 ps) of a substance.

Abstract: A magnetic resonance imaging system includes a high-frequency magnetic field generating unit for generating and applying a high-frequency magnetic field to a subject placed in a static magnetic field, a gradient magnetic field generating unit for generating a gradient magnetic field to be superimposed on the static magnetic field, and a sequencer for controlling the high-frequency magnetic field generating unit and the gradient magnetic field generating unit to acquire, within a specified part of the heartbeat of the subject, MR data that pertains to a plane through which an axis substantially identical to the body axis of the subject in a k-space extends, and to cause the plane to rotate, at every heartbeat, about the axis substantially identical to the body axis.