Abstract: Provided is a method of differentiating a pluripotent stem cell of mammalian origin into a desired cell type by predicting the direction of cell differentiation to be caused by induction of expression of a transcription factor. A human gene expression correlation matrix using human cells has been newly created, and further, it has been confirmed that human pluripotent stem cells can be differentiated into a desired cell type by introducing, into the human pluripotent stem cells, a transcription factor cocktail selected from the matrix.

Abstract: An activity recognition system for identification of an activity of a subject includes a transmitter configured to transmit a radio wave, a receiver configured to receive the radio wave by an array antenna, a feature quantity extracting part configured to extract a feature quantity from a signal received by the array antenna, and an identifying part configured to identify the activity based on the feature quantity, wherein the feature quantity extracting part is configured to calculate a first feature quantity that represents a change of the signal by using a signal received at an observation start time point as a reference signal and to calculate a second feature quantity that represents a change of the signal by using an immediately preceding signal as a reference signal, and the identifying part is configured to identify the activity based on the first feature quantity and the second feature quantity.

Abstract: Using the medium of the present invention for inducing a cornea endothelial substitute cell from an iPS cell, the medium containing an insulin-like growth factor and a STAT3 activator, and not containing a basic fibroblast growth factor or a ROCK inhibitor, and the method of the present invention for inducing corneal endothelial substitute cells from iPS cells by using the medium, it becomes possible to efficiently produce corneal endothelial substitute cells, particularly to efficiently produce corneal endothelial substitute cells from iPS cells. Furthermore, it becomes possible to stably produce large amounts of corneal endothelial substitute cells by inducing differentiation of iPS cells into corneal endothelial substitute cells more efficiently.

Abstract: The disclosure provides a composition for inhibiting the growth and/or invasion of tumor cells, an enhancer of an anti-tumor effect of a drug for the purpose of removing immunosuppression caused by cancer, or the like, which is characterized by being used for a specific subject.

Abstract: Provided is technology for more appropriately realizing a human physical-act using a robot. This position/force control device comprises: an act time information retaining means for retaining a time interval or a time stamp of an act, in addition to act information when the act is recorded; a control reference information generation means for generating, from the recorded act information, information to serve as a control reference when the act is replicated; a control timing determination means for determining, from the recorded act time information, a timing for outputting the control reference information when the act is replicated; and a position/force control means for replicating the act on the basis of the generated control reference information and the determined control timing.

Abstract: A vibration control device moves an object by controlling an actuator. The vibration control device controls a position and speed of the actuator, generates a model by modeling the object; and calculates an inverse system output based on the model and the control to provide positive feedback of a position of the object based on the inverse system output.

Abstract: Provided is a method of differentiating a pluripotent stem cell of mammalian origin into a desired cell type by predicting the direction of cell differentiation to be caused by induction of expression of a transcription factor. A human gene expression correlation matrix using human cells has been newly created, and further, it has been confirmed that human pluripotent stem cells can be differentiated into a desired cell type by introducing, into the human pluripotent stem cells, a transcription factor cocktail selected from the matrix.

Abstract: The anti-tumor peptide provided by the present invention is a synthetic peptide having both amino acid sequences represented by the following (1) and (2): (1) an amino acid sequence constituting the transmembrane domain of transmembrane protein 141 (TMEM 141), or a modified amino acid sequence having deletion, replacement, or addition of one, two, or three amino acid residues of the amino acid sequence; and (2) an amino acid sequence functioning as a cell membrane penetrating peptide (CPP).

Abstract: To produce and/or maintain naïve pluripotent stem cells capable of highly expressing genes important for maintaining an undifferentiated state, which could not be achieved by known methods for producing pluripotent stem cells. The present invention can produce naïve pluripotent stem cells capable of maintaining an undifferentiated state by introducing and allowing transient expression of six genes (Oct3/4, Klf4, c-Myc, Sox2, Nanog, and Klf2) among the so-called initializing factors, and further performing culturing in a medium containing LIF, an MEK inhibitor, a GSK3 inhibitor, a cAMP production promoter, a TGF-? inhibitor and a PKC inhibitor. Thus, the problem of the present invention can be solved.

Abstract: The object of the present invention is to provide a novel pharmaceutical for suppressing cancer stem cells. In the present invention, a mitochondria inhibitor comprising a 2-nitroimidazole derivative is applied to the cancer stem cell as an active ingredient.

Abstract: The present invention provides a method for evaluating tumorigenicity of a test cell, including transplanting the cell into anterior chamber of an eye of an experimental animal, and observing the presence or absence of tumor formation. According to the present invention, tumorigenicity can be evaluated in a short period and conveniently.

Abstract: An object of the present invention is to provide means capable of exhibiting one or more of a physical strength improving effect and an anti-fatigue effect. The invention provides a composition containing Bacteroides uniformis or a treated product thereof, wherein the composition is used for improving one or more of physical strength and fatigue resistance.

Abstract: Provided are a method and a reagent for improving the activity of PETase. The method includes adding a surfactant, when a PETase (a) an aromatic polyester-degrading enzyme consisting of the amino acid sequence as set forth in SEQ ID NO: 2 or 4 in the sequence listing; or PETase (b) an aromatic polyester-degrading enzyme consisting of an amino acid sequence comprising a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence as set forth in SEQ ID NO: 2 or 4 in the sequence listing, and having an aromatic polyester-degrading activity is allowed to act on PET so as to degrade the PET.

Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.

Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.

Abstract: To produce and/or maintain naïve pluripotent stem cells capable of highly expressing genes important for maintaining an undifferentiated state, which could not be achieved by known methods for producing pluripotent stem cells. The present invention can produce naïve pluripotent stem cells capable of maintaining an undifferentiated state by introducing and allowing transient expression of six genes (Oct3/4, Klf4, c-Myc, Sox2, Nanog, and Klf2) among the so-called initializing factors, and further performing culturing in a medium containing LIF, an MEK inhibitor, a GSK3 inhibitor, a cAMP production promoter, a TGF-? inhibitor and a PKC inhibitor. Thus, the problem of the present invention can be solved.

Abstract: From distance measurement data obtained by a distance measurement, according to a moving body approximate ellipses and quadratic functions along an xy-axis and yx-axis are calculated. An approximate ellipse close to the shoulder width and thickness of a user is selected, and quadratic functions having the smallest approximation error to the distance measurement data are selected. Thus, the position and orientation of the user are estimated from the selected approximate curves. That is, if an approximate curve based on one shape or coordinate system does not match the user, the position and orientation of the user are estimated from an approximate curve based on another shape or coordinate system. Therefore, even if the positional relation between the distance measurement sensor and user changes variously, the position and orientation of the user can be detected.

Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.

Abstract: An atom, molecule, atomic layer molecular layer is adhered to a carbon nanotube surface, or the surface is doped with the atom, molecule, atomic layer, or molecular layer, to form a deep localized level so that an exciton is localized. Alternatively, an atom, molecule, inorganic or organic substance of an atomic or molecular layer, a metal, a semiconductor, or an insulator is absorbed to, deposited on, or encapsulated in the carbon tube inside surface to make permittivity of the portion undergoing the absorption, deposition, or encapsulation higher than that of a clean portion free of the absorption, deposition, or encapsulation so that binding energy of the exciton in the clean portion is high, or reduce a band gap of the portion undergoing the absorption, deposition, or encapsulation so that the exciton is confined and localized in the clean portion or the position undergoing the absorption, deposition, or encapsulation.

Abstract: A hemofiltration device capable of surely performing highly-efficient hemofiltration. The hemofiltration device of the present invention is adapted to be implanted in a mammalian body for filtering blood, and includes a blood flow path layer having a blood flow path, a filtrate flow path layer having a filtrate flow path disposed along the blood flow path, and a filtration membrane interposed between the blood flow path layer and the filtrate flow path layer, for filtering the blood flowing through the blood flow path. A filtrate outlet of the filtrate flow path is provided at a position closer to a blood outlet than to a blood inlet of the blood flow path. The blood inlet, blood outlet, and filtrate outlet are provided only on one side or separately on opposite sides of a main body portion in the direction in which the layers are stacked.