Patents Assigned to Kobe University
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Patent number: 12313590Abstract: A method and a device are provided for measuring a zeta potential with reproducibility, high reliability and high accuracy, by predicting an equilibrium value from the change over time of a streaming potential. In measurement of the zeta potential of a sample surface using a streaming potential method, an external pressure is changed in a step-wise manner, and a pressure change profile is set having a rising part or a falling part which is of a shorter time than the relaxation time T required for response to a change in the streaming potential accompanying the change in external pressure, and a steady part in which pressure is held at a steady state for a time longer than the relaxation time T. An asymptotic value of the streaming potential extrapolated from the transient response of the streaming potential occurring from the pressure change profile is used to calculate the zeta potential.Type: GrantFiled: August 30, 2023Date of Patent: May 27, 2025Assignees: Kobe University, Murata Manufacturing, Co., Ltd.Inventors: Minoru Mizuhata, Izaya Okae
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Patent number: 9691148Abstract: According to one embodiment, a medical imaging analyzer includes an imaging unit, a calculator, and an analyzer. The imaging unit divides an area including an object of a subject to be captured into a plurality of partial areas such that the partial areas overlap each other to form an overlapping area, and administers a contrast agent to each of the partial areas to capture a plurality of time-series images. The calculator calculates, based on the transition of the pixel value in one of the time-series images having the overlapping area, the transition of the pixel value in the other time-series image having the overlapping area. The analyzer analyzes the time-series images based on the transition of the pixel value in the one and the other of the time-series images to obtain the hemodynamics of the subject.Type: GrantFiled: November 13, 2015Date of Patent: June 27, 2017Assignees: TOSHIBA MEDICAL SYSTEMS CORPORATION, KOBE UNIVERSITYInventors: Yasuko Fujisawa, Naoki Sugihara, Shigeharu Ohyu, Yoshiharu Ohno
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Publication number: 20160145148Abstract: Provided are a glass body for pressure forming enabling press forming in a low-temperature range without the need of a special mold material, and a method for manufacturing the same. A glass body for pressure forming 1 having a porosified layer 1b formed by porosifying a surface thereof and having a Vickers hardness of 85 N/mm2 or less on the porosified surface. The porosified layer 1b can be manufactured by phase-separating the glass body by spinodal decomposition, acid-treating the phase-separated glass body and then treating the acid-treated glass body with alkali or hot water to porosify the surface of the glass body.Type: ApplicationFiled: February 2, 2016Publication date: May 26, 2016Applicants: KOBE UNIVERSITY, ASAHI GLASS COMPANY, LIMITEDInventors: Kenji IMAKITA, Minoru FUJII, Kenji KITAOKA
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Publication number: 20160071271Abstract: According to one embodiment, a medical imaging analyzer includes an imaging unit, a calculator, and an analyzer. The imaging unit divides an area including an object of a subject to be captured into a plurality of partial areas such that the partial areas overlap each other to form an overlapping area, and administers a contrast agent to each of the partial areas to capture a plurality of time-series images. The calculator calculates, based on the transition of the pixel value in one of the time-series images having the overlapping area, the transition of the pixel value in the other time-series image having the overlapping area. The analyzer analyzes the time-series images based on the transition of the pixel value in the one and the other of the time-series images to obtain the hemodynamics of the subject.Type: ApplicationFiled: November 13, 2015Publication date: March 10, 2016Applicants: Toshiba Medical Systems Corporation, Kobe UniversityInventors: Yasuko FUJISAWA, Naoki SUGIHARA, Shigeharu OHYU, Yoshiharu OHNO
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Patent number: 8569232Abstract: Disclosed are method for treating diabetes, a protein for treatment of diabetes, and pharmaceutical composition comprising the same. The protein is human mature chemerin, which can be used to treat diabetes, in particular type 2 diabetes, inter alia to treat diabetes in a patient who is concurrently administered with insulin.Type: GrantFiled: October 17, 2008Date of Patent: October 29, 2013Assignees: Kobe University, JCR Pharmaceuticals Co., Ltd.Inventors: Yutaka Takahashi, Kazuo Chihara
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Publication number: 20120082976Abstract: Disclosed are a novel method of screening for insulin secretion-potentiating agents as well as means for performing such screening. The means include a DNA encoding fluorescent-labeled Epac2 comprising two different DNAs encoding two different fluorescent proteins which emit fluorescent light with wavelength differing from each other and a DNA encoding Epac2 which are fused together in-frame, and the cells transformed with the DNA. Also disclosed is a method of screening insulin secretion-potentiating agents comprising bringing a candidate compound into contact with cells transformed with the said DNA, and detecting whether the compound binds to Epac2.Type: ApplicationFiled: April 15, 2010Publication date: April 5, 2012Applicant: KOBE UNIVERSITYInventors: Susumu Seino, Changliang Zhang, Megumi Kato, Tadao Shibazaki
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Patent number: 8116938Abstract: A first observer gain of an actual damping force estimating observer 21 calculates a dynamic characteristic compensating signal, and a second observer gain of an actual vehicle model state amount estimating observer 23 calculates a vehicle model compensating signal, from an output deviation corresponding to a difference between a sprung speed (observation output) provided from a vehicle 2 and an estimated sprung speed (estimated observation output) provided from a vehicle approximation model of the actual vehicle model state amount estimating observer 23. The dynamic characteristic compensating signal is input into a dynamic characteristic providing unit of the actual vehicle model state amount estimating observer 23, and is used for adjustment of the setting of the dynamic characteristic providing unit. Therefore, it is possible to curb time lag occurrence in a control, and thereby perform a vibration control with improved accuracy.Type: GrantFiled: August 27, 2009Date of Patent: February 14, 2012Assignees: Hitachi Automotive Systems, Ltd., Kobe UniversityInventors: Noriaki Itagaki, Nobuyuki Ichimaru, Takahide Kobayashi, Tatsuya Gankai, Takanori Fukao
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Patent number: 8086377Abstract: The present invention provides a suspension control apparatus capable of an excellent vibration control by a model thereof designed to incorporate nonlinearity and a time-lag element of a control damper. The present invention employs the backstepping method which is one of nonlinear control methods, and is designed so as to incorporate the nonlinearity of a damper 4. In addition, a nonlinear controller 5 uses a damping force Fu obtained by expressing the dynamics of a damping force characteristic variable portion [damping force Fu(v, i)] by a first-order lag system, so as to compensate the dynamics of the damper 4, whereby a control system is formed so as to incorporate the time-lag element of the control damper. As a result, it is possible to reduce time lag, and to practically adjust a control force according to the characteristics of the control damper.Type: GrantFiled: May 19, 2009Date of Patent: December 27, 2011Assignees: Hitachi, Ltd., Kobe UniversityInventors: Noriaki Itagaki, Nobuyuki Ichimaru, Takahide Kobayashi, Tatsuya Gankai, Takanori Fukao
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Publication number: 20110231109Abstract: The present invention aims at creating an accurate mass spectrum with a high resolving power based on a plurality of multi-turn time-of-flight (TOF) spectra, while reducing the amount of computation to assure the real-time processing. First, a plurality of TOF spectra each obtained for a different timing when ions are ejected from the loop orbit are measured (S2 and S3). At this point, the concept of the coincidence detection method is utilized to determine what mass-to-charge ratio a peak appearing on the TOF spectra originates from. From the information on the peak of interest in one TOF spectrum and other data, the time range in which a corresponding peak appears on other TOF spectra is set, and the existence or nonexistence of the peak in that range is determined (S5). In the case where the corresponding peak is found on most of the other TOF spectra, the m/z is deduced from the peak on the TOF spectrum with the highest resolving power and a mass spectrum is created (S6 and S7).Type: ApplicationFiled: March 14, 2011Publication date: September 22, 2011Applicants: SHIMADZU CORPORATION, KOBE UNIVERSITYInventors: Osamu FURUHASHI, Kiyoshi OGAWA, Shigeki KAJIHARA, Tohru KINUGAWA
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Publication number: 20110046055Abstract: Disclosed are method for treating diabetes, a protein for treatment of diabetes, and pharmaceutical composition comprising the same. The protein is human mature chemerin, which can be used to treat diabetes, in particular type 2 diabetes, inter alia to treat diabetes in a patient who is concurrently administered with insulin.Type: ApplicationFiled: October 17, 2008Publication date: February 24, 2011Applicants: KOBE UNIVERSITY, JCR PHARMACEUTICALS CO., LTD.Inventors: Yutaka Takahashi, Kazuo Chihara
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Publication number: 20080077130Abstract: A high frequency incision tool for an endoscope includes a flexible insulating tube configured to be inserted into and pulled out of a treatment tool insertion channel of the endoscope, a conductive wire connectable with a high frequency power supply, the conductive wire being inserted and arranged in the flexible insulating tube, a protruded portion formed to be partially protruded forward at a distal end portion of the flexible insulating tube, the protruded portion having a rounded leading edge, and a high frequency electrode provided as a portion of the conductive wire that is exposed out of the flexible insulating tube, the high frequency electrode including at least a portion, closest to the leading edge, which is substantially perpendicular to a virtual plane including therein an axis line of the flexible insulating tube and the leading edge.Type: ApplicationFiled: September 24, 2007Publication date: March 27, 2008Applicants: PENTAX Corporation, Kobe UniversityInventors: Hiroaki SHIBATA, Takaaki TATEBAYASHI, Yoshinori MORITA
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Patent number: 6675114Abstract: A system and method (and storage media) for identifying the category of the source noise and sound by using the physical factors derived from the autocorrelation function (ACF) and the interaural crosscorrelation function (IACF) which are ever changing in the time domain based on the model of human auditory brain function system. A method for evaluating a sound comprises the steps of: using the sound recorder to capture and record the acoustic signal; calculating the ACF from the acoustic signal using a CPU; calculating ACF factors extracted from the calculated ACF using the CPU; and identifying the kinds of the noise based on the ACF factors. Thereby the unknown noise source can be identified what it is (such as automobile noise, and factory noise), and can be identified its type such as type of cars or type of machines.Type: GrantFiled: July 10, 2002Date of Patent: January 6, 2004Assignee: Kobe UniversityInventors: Yoichi Ando, Hiroyuki Sakai
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Publication number: 20030218749Abstract: While a Doppler-fee absorption spectrum of an iodine molecule and an etalon mark are obtained, the thus measured Doppler-free two-photon absorption spectrum of the mixed sample of the homologues and isomers of the dioxin to be quantitatively analyzed is compared with that as analytical curves with respect to locations and intensities of spectrum peaks, kinds and contents of the homologues and isomers of the dioxin in the mixture are determined.Type: ApplicationFiled: April 18, 2003Publication date: November 27, 2003Applicant: KOBE UNIVERSITYInventor: Hajime Kato
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Publication number: 20030009245Abstract: The invention provides an evolution strategy computing system, method and program having an enhanced self-adaptiveness in evolutionary process by introducing an effect of genetic drift to improve a searching robustness using inactive strategy parameters.Type: ApplicationFiled: March 20, 2002Publication date: January 9, 2003Applicant: KOBE UNIVERSITYInventors: Kanji Ueda, Kazuhiro Ohkura
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Patent number: 6393036Abstract: A device for and a method of pulsing and amplifying a singlemode laser light for use in a pulse oscillation laser is disclosed. The device comprises a singlemode laser for generating the laser light of the singlemode, an optical resonator into which the outputted laser light is introduced from the singlemode laser, and a controller for controlling the length of resonator by changing the length of the optical resonator based on a control waveform signal, which is an asymmetrical triangular repeated waveform signal. The laser pulse light of the singlemode to which optical strength is amplified from the optical resonator, is outputted by changing the length of resonator.Type: GrantFiled: January 13, 2000Date of Patent: May 21, 2002Assignee: Kobe UniversityInventor: Hajime Kato