Abstract: One or more embodiments of the present invention are to provide a new means of improving the productivity of a target protein. The present inventors have identified a novel protein consisting of the amino acid sequence set forth in SEQ ID NO: 2 through an exhaustive analysis of the nucleotide sequence of chromosomal DNA of a yeast belonging to the genus Komagataella. Activation of a gene encoding the novel protein provides a cell having an improved productivity of a target protein.

Abstract: The purpose of the present invention is to provide a spinal fusion implant capable of preserving turning properties of vertebral bodies, and in addition, capable of preventing false screwing (false insertion) of screws. Connection plates 3 constituting a spinal fusion implant 101 each have, on a ventral-side surface 3b, a convex-shaped portion 8 that is fitted into a concave-shaped portion of an intervertebral joint 53. In addition, a center hole 3d through which a center rod 4 is slidably inserted is formed on a side surface of the connection plate 3, such that the center of the hole is positioned closer to the back side than a virtual line L1 connecting midpoints on arc-shaped contour lines C of the concave-shaped portions of the adjacent intervertebral joints 53 when viewed from the head side of a human body.

Abstract: One objective of the present invention is to provide a novel simple and efficient transformation method for gram-positive bacteria, the transformation method being capable of introducing a large-sized DNA into a host DNA of the gram-positive bacteria without damage. In addition, another objective of the present invention is to provide a method in which desired DNA segments are accumulated in a chromosome of a recipient (recipient bacteria) to enable an artificially designed huge DNA to be constructed, and in which a transformed cell does not cause any problems in terms of controlling the natural environment. The present invention relates to a transformation method for gram-positive bacteria by conjugative transfer, characterized to use a helper plasmid having an origin of DNA transfer (oriT) region is inactivated. Preferably, the helper plasmid is a plasmid in which an oriT region is inactivated from pLS20cat.

Abstract: A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.

Abstract: The objective of the present invention is to provide a method for producing a halogenated carbonyl safely and efficiently. The method for producing a halogenated carbonyl according to the present invention is characterized in comprising the step of applying ultrasound to a composition containing a C1-4 halogenated hydrocarbon having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen to decompose the C1-4 halogenated hydrocarbon.

Abstract: Provided is a measurement device including an application unit, a detection unit, and a calculation unit. The application unit applies a first magnetic field, which is generated by applying a pulse current to a coil or applying currents with a plurality of frequencies to the coil in order, to an object. The detection unit detects a second magnetic field which is generated by applying the first magnetic field to the object. The calculation unit calculates a distribution of a magnetic field source m in the second magnetic field. The calculation unit may further generate an imaging signal for displaying the calculated distribution of the magnetic field source m, as an image. The display unit displays the image indicating the distribution of the magnetic field source m by using the imaging signal.

Abstract: The present invention provides an odorant composition having good palatability allowing peoples to feel comfortable using a small number of chemical compounds. An odorant composition according to an embodiment of the present invention consists of: when the total mass of ingredients contained in the odorant composition is 100.0% by mass, 40.0% by mass or more and 97.5% by mass or less of an ingredient (A) composed of aldehydes; 1.0% by mass or more and 20.0% by mass or less of an ingredient (B) composed of a ketone(s); and the balance being an ingredient (C) composed of a chemical compound(s) other than the ingredient (A) and the ingredient (B). The aldehydes of the ingredient (A) are: an essential ingredient (A1) composed of nonanal; and an optional ingredient (A2) selected from the group consisting of decanal, heptanal, octanal, benzaldehyde, undecanal, hexanal, and combinations thereof.

Abstract: The present invention provides a method for selecting a promoter that functions in an organelle, the method comprising: (1) the step of preparing sequence information obtained by RNA sequencing analysis; (2) the step of mapping the sequence information prepared in the step (1) onto a sequence of organellar DNA; (3) the step of calculating the amount of change in RNA expression in each region based on the mapping information obtained in the step (2); (4) the step of selecting regions in which the amount of change obtained in the step (3) is within a range of preset reference values; and (5) the step of identifying a region, among the regions selected, as a promoter functioning in an organelle.

Abstract: A sampling apparatus 1 samples a culture medium in a bioreactor 11. A pump 21 circulates the culture medium in the bioreactor 11 via a flow path 41 by leading out the culture medium from the bioreactor 11 into the flow path 41 and introducing the culture medium from the flow path 41 into the bioreactor 11. A valve 22 is provided in the middle of the flow path 41, and switches a flow path such that the culture medium circulated in the flow path 41 flows out to a branch flow path 42 to be sampled.

Abstract: Provided is a radio wave transmission cover having a manufacturability at low cost and a suppressed peeling of layer, which comprises a resin substrate; a transparent film layer serving as an exposed portion; a transparent ion-exchange resin layer disposed between the resin substrate and the transparent film layer; an adhesive layer disposed between the resin substrate and the transparent ion-exchange resin layer; and a discontinuous film of Ag particles formed on a surface on the resin substrate side of the transparent ion-exchange resin layer, wherein a transparent ion-exchange resin of the transparent ion-exchange resin layer has a resin skeleton with an ion-exchangeable functional group, and a distance Ra between a Hansen solubility parameter (HSP) value of the transparent ion-exchange resin and a HSP value of the transparent film is 20 or less, and a method for manufacturing the same.

Abstract: A measurement device applies a pulse current or a current of a plurality of frequencies to a laminated body having a plurality of layers having different electrical conductivities. The device acquires in-plane distribution information indicating distribution of a magnetic field of a first plane outside the laminated body. A processor generates three-dimensional magnetic field distribution information indicating a three-dimensional distribution of magnetic field on an outside of the laminated body based on the in-plane distribution information, and generates information on an inside of the laminated body by processing the three-dimensional magnetic field distribution information on the outside of the laminated body. The in-plane distribution information includes information indicating response characteristics to a change in the current applied by the current applying unit.

Abstract: The object is to provide a method for inducing pili formation in bacterium of genus Bifidobacterium and a method for promoting intestinal colonization of the bacterium. 3-Phenylpropionic acid and/or 3-(4-hydroxyphenyl)propionic acid are an active ingredient of a composition for inducing the pili formation in the bacterium of genus Bifidobacterium and a composition for promoting the intestinal colonization of the bacterium.

Abstract: A tissue traction device includes a first needle connected to a distal end of a first thread; a second needle connected to a distal end of a second thread; an elongated main body connected to the first thread and extending between the first thread and the second thread, the main body including a first hole; and a tube disposed at a proximal end of the main body, wherein the second thread is inserted through the first hole to be advanceable and retractable at a position between the second needle and a distal end of the tube, and the tube and the second thread are configured to be relatively movable in a longitudinal direction of the tube.

Abstract: Provided is an antitumor agent targeting SIRP?, which inhibits binding between CD47 and SIRP?, the antitumor agent being more effective. The present invention also provides an antitumor agent capable of more effectively exhibiting an antitumor effect when used in combination with an immune checkpoint inhibitor or an antibody drug. The antitumor agent includes as an active ingredient a substance that molecularly targets an IgV domain, which is an extracellular domain of SIRP?. The antitumor agent of the present invention, including as an active ingredient a substance that molecularly targets an IgV domain of SIRP? protein, activates M1-type macrophages, which have cytotoxicity to cancer cells, and immunocompetent cells to provide an effective antitumor effect.

Abstract: A force sensor that is a MEMS sensor includes: a plurality of detectors arranged in a circle and each including an element disposed in part of a surface layer of a base component including a semiconductor; an elastic component including resin and disposed sandwiching the plurality of detectors from both sides; and a probe that is connected to an end of each of the plurality of detectors at a center portion of the circle in which the plurality of detectors are arranged, extends up to a position that protrudes from the elastic component, and to which force is applicable directly without passing the elastic component.

Abstract: The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).

Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA of a monocot cell, comprising a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in the given double stranded DNA and a nucleic acid base converting enzyme are bonded, with said double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into said targeted site, without cleaving at least one strand of said double stranded DNA in the targeted site, wherein the double stranded DNA is contacted with the complex by introducing a nucleic acid encoding the complex into the monocot cell.

Abstract: The objective of the present invention is to provide a method for producing an isocyanate compound safely and efficiently. The method for producing an isocyanate compound according to the present invention is characterized in comprising the steps of irradiating a high energy light to a halogenated methane at a temperature of 15° C. or lower in the presence of oxygen, and further adding a primary amine compound to be reacted without irradiating a high energy light.

Abstract: The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently even without using a base. The method for producing a carbonate derivative according to the present invention is characterized in comprising the step of irradiating a high energy light to a composition comprising the halogenated methane and the hydroxy group-containing compound in the presence of oxygen, wherein a molar ratio of a total usage amount of the hydroxy group-containing compound to 1 mole of the halogenated methane is 0.05 or more.

Abstract: The purpose of the present invention is to provide a recombinant host cell which is capable of efficiently and easily producing a benzylisoquinoline alkaloid (BIA), in particular, tetrahydropapaveroline, 3-hydroxycoclaurine, 3-hydroxy-N-methylcoclaurine and/or reticuline, and a method for efficiently and easily producing these BIAs using the host cell. The present invention pertains to a recombinant host cell for producing a benzylisoquinoline alkaloid (BIA), in particular, tetrahydropapaveroline (THP), 3-hydroxycoclaurine, 3-hydroxy-N-methylcoclaurine and/or reticuline, in which a wild-type aromatic aldehyde synthase (AAS) or a mutant thereof and a wild-type aromatic amino acid decarboxylase (AAAD) or a mutant thereof are expressed.