Abstract: A virus inactivation method is provided. The method includes irradiating a solution containing an artificially expressed antibody or antibody fragment with ultraviolet rays in the presence of a radical scavenger. The irradiating only aggregates 5% or less of the antibody or antibody fragment. A wavelength of the ultraviolet rays is 200 nm or longer and 315 nm or shorter. An irradiation amount of the ultraviolet rays is 300 mJ/cm2 or more. An irradiation time of the ultraviolet rays is 3 minutes or less. A concentration of the radical scavenger in the solution is 0.03 mM or more.

Abstract: The objective of the present invention is to provide a method for producing a carbonyl halide efficiently to the used halogenated methane. The method for producing a carbonyl halide according to the present invention is characterized in comprising the steps of preparing a mixed gas comprising oxygen and a halogenated methane having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo, and flowing the mixed gas and irradiating a high energy light to the flowed mixed gas.

Abstract: Provided is a medical immobilization device that contributes to reducing the burden on a patient, while being capable of firmly immobilizing the patient. A medical immobilization device 10 is a device for immobilizing a specific site 1 of the body of a patient with the patient lying on their back. The medical immobilization device 10 comprises a block 3 made of a material that allows radiation to pass through, and the block 3 comprises holder portions 2a to 2c in which at least a region from the lower surface to both sides of the specific site 1 fit. All or part of the upper part of the block 3 is open.

Abstract: A sampling apparatus 1 samples a culture medium in a bioreactor 11. A pump 21 circulates the culture medium in the bioreactor 11 via a flow path 41 by leading out the culture medium from the bioreactor 11 into the flow path 41 and introducing the culture medium from the flow path 41 into the bioreactor 11. A valve 22 is provided in the middle of the flow path 41, and switches a flow path such that the culture medium circulated in the flow path 41 flows out to a branch flow path 42 to be sampled.

Abstract: The invention provides a miniaturized cytidine deaminase-containing complex for modifying DNA formed by combining a nucleic acid sequence recognition module and cytidine deaminase, wherein the nucleic acid sequence recognition module specifically binds to a target nucleotide sequence of double-stranded DNA, the cytidine deaminase is composed of an amino acid sequence composed of a region of amino acid residues at positions 30-150 of SEQ ID NO: 1, an ortholog thereof, an amino acid sequence having mutations of one or several amino acids therein, or an amino acid sequence having at least 90% similarity thereto, and the targeted site of the double-stranded DNA is modified.

Abstract: The invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and a nucleic acid base converting enzyme are linked, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.

Abstract: An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.

Abstract: It is an object to provide a combination therapy effective in cancer immunotherapy. The object is achieved by providing an anti-tumor agent, including a transformed Bifidobacterium containing DNA encoding a WT1 protein and DNA encoding a GNB/LNB substrate-binding membrane protein derived from a Bifidobacterium, the transformed Bifidobacterium being designed to display the WT1 protein as an antigen on a surface of the transformed Bifidobacterium, the anti-tumor agent being for use in combination with an immunosuppression inhibitor. The transformed Bifidobacterium can be used as an oral tumor vaccine.

Abstract: In the design of a mechanical component for a mechanical device driven by a feedback controlled electric motor, the user is enabled to easily know how the properties of mechanical component affect the generation of abnormal vibrations of the mechanical device. In a design assist apparatus (1), the processor (11) is configured to set a plurality of parameters of a mathematical model of an analysis target component selected from one or more mechanical components (24, 56, 58) forming the mechanical device, compute a pole of a transfer function of the mechanical device associated with one or more vibration modes of the mechanical device according to the parameters, and create a stability determination diagram including an isoline of a real part of the pole of the transfer function.

Abstract: The present invention provides an organelle transformant screening method. More specifically, the present invention provides an organelle transformant screening method utilizing inhibition of a lipid synthetic pathway.

Abstract: A method for producing a hollow fine particulate containing a fluorine-containing resin and having a large average particle size. The method includes dispersing a solution containing a fluorine-containing monomer, a phase separation promoter, and a non-polymerizable solvent into water to provide a dispersion, and polymerizing the fluorine-containing monomer to provide a hollow fine particulate containing a fluorine-containing resin.

Abstract: The present invention addresses the problem of providing a novel method which is for preparing a DNA fragment for microbial cell transformation, and by which the combinatorial library of a long-chain DNA can be efficiently constructed and confirmation of the genotype of the obtained clone is facilitated.

Abstract: A draw solute for forward osmosis membrane process, comprising an addition polymer obtained by addition polymerization of an alkylene oxide having 2 to 10 carbon atoms to an amine compound.

Abstract: An organic fine particle comprising a core polymer and a shell polymer. The core polymer has a Tg or a melting point of 15° C. or more, the core polymer has a water contact angle of 100° or more, all monofunctional monomers constituting the core polymer are a hydrophobic core monomer of which homopolymer has a water contact angle of 100° or more, the shell polymer has a Tg or a melting point lower than Tg or the melting point of the core polymer, the shell polymer has a water contact angle of less than 100°, and all monofunctional monomers constituting the shell polymer are a water-insoluble shell monomer of which homopolymer is water-insoluble. Also disclosed is a surface coating structure including the organic fine particle and a water-repellant composition including a dispersion of the organic fine particle.

Abstract: An embodiment of the present invention is to provide a bioabsorbable medical material having adhesiveness to a biological tissue and improved degradability. A bioabsorbable medical material according to an embodiment of the present invention contains a crosslinked polymer material forming a specific shape, and a disintegration delaying material retained by the crosslinked polymer material. The crosslinked polymer material has degradability in water, the degradability being suppressed in the presence of an acid. The disintegration delaying material releases 0.5 mol%/day or greater of an acid until the seventh day upon contact with water at 37° C.

Abstract: The balloon catheter of the present invention is provided with a balloon base at a front end of a tubular catheter body having a predetermined length. The balloon base includes a cylindrical base having a larger diameter than an outer diameter of the catheter body, and a lumen having substantially the same diameter as the outer diameter of the catheter body is formed on the base over an entire length with both ends opened. A central axis of the lumen is inclined at a predetermined angle with respect to a central axis of the base concentric with a central axis of the catheter body, and an outer peripheral surface is formed in parallel with the central axis of the base. The balloon is provided on the outer peripheral surface of the parallel base to obliquely inflate with respect to the central axis of the catheter body during inflation.

Abstract: The objective of the present invention is to provide a composite separation membrane which is excellent in not only a liquid permeable performance and a separation performance relatively but also a durability and which is particularly useful as a membrane for liquid treatment, and a method for treating a liquid by using the composite separation membrane. The composite separation membrane according to the present invention is characterized in comprising a supporting base material and a complex layer, wherein the complex layer is placed on the supporting base material, the complex layer comprises oxidized metal nanosheets, graphene oxide and an alkanolamine, and at least one of the alkanolamine is present between the oxidized metal nanosheets.

Abstract: Provided is a novel cancer gene therapeutic means. More specifically, provided is a nucleic acid having a structure in which (A) a nucleic acid encoding a protein having a CD44 extracellular function, (B) a nucleic acid encoding a protein having a Notch core region function, and (C) a nucleic acid encoding a protein having an HIF-3?4 function are linked in the order of (A)-(B)-(C).

Abstract: The present disclosure addresses the problem of providing at least a composition for suppressing obesity and the problem is solved by a composition for suppressing obesity comprising a prenylflavonoid represented by general formula (1), as an active ingredient, below.

Abstract: An object of the present invention is to provide a phosphorus adsorbent that is inexpensive and can exert high phosphorus adsorption performance. The present invention relates to a phosphorus adsorbent comprising incinerator ash, cement, and lanthanum.